Zydus gets 2 USFDA observations for Ahmedabad oncology injectable site

Ahmedabad: Zydus Lifesciences has announced that the US Food and Drug Administration (USFDA) has issued two observations for the company’s oncology injectable site situated at SEZ 1, near Matoda, Ahmedabad.

The GMP follow-up inspection was conducted from 9
th of June to 18th of June 2025.
“The inspection is closed with 2 observations and none of them were related to data integrity,” Zydus stated in a BSE filing.
“The Company will closely work with the USFDA to address and respond to the observations in
an expeditious manner,” the company added.
Read also: USFDA inspection: Zydus gets EIR for Dabhasa API manufacturing facility

Zydus Lifesciences Ltd. is an innovative, global lifesciences company that discovers, develops, manufactures, and markets a broad range of healthcare therapies. The group employs 27,000 people worldwide, including 1,400 scientists engaged in R & D. Over the last decade, Zydus has introduced several innovative, first-in-class products in the market for treating unmet healthcare needs with vaccines, therapeutics, biologicals and biosimilars.

Read also: Zydus Lifesciences to acquire India, Sri Lanka rights for Agenus cancer immunotherapy BOT/BAL

Powered by WPeMatico

Jaundice patient declared dead wakes up before funeral; doctor served notice

Thane: In a shocking incident straight out of a movie, a 64-year-old man who was declared dead by a laparoscopic surgeon at a private hospital in Ulhasnagar in Thane district suddenly began breathing and woke up just as his family was preparing for his final rites. He was immediately taken to a nearby hospital, where he regained consciousness 30 minutes later.

The surgeon cum owner of the Shivneri Hospital located in Ulhasnagar, Dr Prabhu Ahuja has been issued a show cause notice by the health department of the Ulhasnagar Municipal Corporation (UMC) after taking took suo motu cognizance of the matter on Monday. 

In the notice, the doctor has been asked to provide a satisfactory explanation for declaring a living person dead without conducting a proper medical examination. Authorities have stated that if his response is found unsatisfactory, a committee will be formed to investigate the matter. If he is found guilty, his licence can be cancelled.

Also read- Odisha Govt issues show-cause notices to 244 doctors over prolonged absence

It has been reported that the doctor quickly issued a death certificate without bringing the man inside the hospital or conducting a proper medical examination to confirm his death. Believing he had passed away, the family began preparations for his last rites, only to find the man alive and gaining consciousness shortly afterwards.

As per Hindustan Times news report, the incident occurred on Thursday night when Abhiman Girdhar Tayde, who was receiving treatment for jaundice at JJ Hospital in Mumbai, suddenly collapsed at his residence. Alarmed, his son Sachin Tayde and other family members rushed him to Shivneri Hospital in an autorickshaw. There, Dr Ahuja examined him briefly while he was still in the vehicle and pronounced him dead.

Tayade’s family took the ‘body’ home and began preparations for the funeral. However, before the rituals could begin, a relative noticed Tayade’s abdomen moving slightly. The family was shocked to realise he was breathing. They shifted him to Criticare Hospital, where doctors confirmed that Tayade was alive and began treatment. Tayade later regained consciousness within 30 minutes. 

Later, Sachin confronted Dr Ahuja, requesting a written death certificate to expose his misdiagnosis. Without hesitation, the doctor issued the certificate, unaware that his patient was, in fact, alive and recovering.

Following the incident, the family did not file a complaint against the doctor, but the UMC took suo motu action and issued a show cause notice to the doctor. The senior citizen is currently out of danger and recovering from jaundice. 

When asked about his misdiagnosis, Dr Ahuja admitted his mistake and apologised. He told media persons that when the relatives brought the patient, he saw that he was unconscious and there was no sound coming from his heart or body. At that time, due to the construction work going on nearby, he could not hear properly due to the loud noise, which led to the misdeclaration.

Dr Mohini Dharma, health officer, told TOI, “In this case, we haven’t received any complaint from the Tayde family, but as suo moto, we have served notice to Dr Ahuja asking him to give clarification on the entire issue. If the clarification is not satisfactory, then we will form a committee who will probe the entire case, and as per the findings, further action will be taken.”

Also read- Manipal Hospitals Pune gets show-cause notice for holding body over unpaid bill

Powered by WPeMatico

Paras Health Celebrates National Surgeons Day with Heartfelt Tributes

New Delhi: To mark National Surgeons’ Day, Paras Health celebrated the selfless commitment of its surgical teams with a heartfelt event, held simultaneously across all its hospital units. 

Themed ‘More than Hands: The Heart Behind Every Surgery’, the initiative recognised the important role of surgeons in transforming lives and reinforced Paras Health’s position as a centre of surgical excellence.

The celebrations took place across all Paras Health hospitals. During the ceremony, the surgeons were honoured with certificates and mementos to recognise their medical skill, leadership, and dedicated service in the operating theatre.

Also Read:Paras Health expands footprint in Punjab, opens 10th hospital in Ludhiana

Senior surgeons also led brief scientific sessions showcasing complex cases, medical advancements, and innovative approaches to care, highlighting the depth of surgical expertise within Paras Health. These were followed by moving patient testimonials, shared both in person and through video, underscoring the life-changing impact of timely surgical intervention.

Vineet Aggarwal, Group Chief Operating Officer, Paras Health, on the initiative said, “Surgeons are the backbone of any hospital, yet their contributions often go unseen outside the operating room. At Paras Health, we believe it’s important to not only recognise their skill but also acknowledge the emotional strength, long hours, and high-stakes decisions they handle every day.

This Surgeons’ Day, we celebrated the people behind the procedures, those who carry out life-saving work with dedication, precision, and heart. Honouring them across all our units is a reflection of the culture we are building, one that values excellence and empathy equally.”

Through this initiative, Paras Health reaffirmed its commitment to creating a healthcare ecosystem that supports not only patient outcomes but also the well-being of the doctors. As it continues to grow and strengthen its patient-first philosophy, the organisation remains dedicated to empowering the people who make healing possible, especially its surgeons.

Also Read:Paras Healthcare lays foundation stone of 300-bed Hospital in Gurugram

Powered by WPeMatico

One-Hour Plasma Glucose Better at Predicting Prediabetes Than Standard Tests: Study

USA: Researchers have found in a new study that one-hour plasma glucose (1-h PG) levels may be a more accurate predictor of future prediabetes than fasting plasma glucose (FPG) and two-hour PG, highlighting a potential gap in current ADA diagnostic criteria. The study has been published in Diabetes Care.

Led by Dr. Muhammad Abdul-Ghani from the Diabetes Division at the University of Texas Health Science Center, San Antonio, the research analysed data from the long-running San Antonio Heart Study to explore how well 1-h PG concentrations during an oral glucose tolerance test (OGTT) can predict the onset of prediabetes among individuals with initially normal glucose tolerance (NGT).

The analysis included 1,557 adults who were free of type 2 diabetes at the beginning of the study. Each participant underwent an OGTT at baseline and a follow-up OGTT after an average of 7.5 years. Using American Diabetes Association criteria, the researchers evaluated how well the 1-h PG values could forecast the likelihood of progression to prediabetes.

The key findings of the study were as follows:

  • At a 7.5-year follow-up, nearly 25% of individuals with normal glucose tolerance (NGT) at baseline progressed to prediabetes.
  • 22.5% of participants with 1-hour plasma glucose (1-h PG) levels below 155 mg/dL progressed to prediabetes, compared to 42.5% of those with 1-h PG levels above 155 mg/dL.
  • The 1-h PG level was the strongest predictor of future prediabetes risk among all glucose measures.
  • A 1-h PG threshold of 120 mg/dL showed 61% sensitivity and 67% specificity in identifying individuals at high risk of developing prediabetes.
  • Participants with 1-h PG levels between 120–155 mg/dL who developed prediabetes exhibited significant insulin resistance and metabolic abnormalities typical of insulin resistance syndrome.
  • The authors suggested using the term “pre-prediabetes” to describe individuals with 1-h PG in the 120–155 mg/dL range, due to their higher risk of glucose deterioration.
  • Elevated 1-h PG levels may serve as an early marker of metabolic dysregulation, appearing well before the onset of clinically defined prediabetes.
  • Early identification of individuals with elevated 1-h PG levels could enable targeted interventions to prevent disease progression.

The authors concluded that a rise in 1-hour plasma glucose (1-h PG) levels occurs before the onset of prediabetes and can help identify individuals with 1-h PG between 120–155 mg/dL who are at a higher risk of developing prediabetes. They suggest referring to this group as “pre-prediabetes” to emphasize their elevated risk of worsening blood sugar levels.

The authors recommend incorporating 1-h PG measurements into clinical practice to improve risk assessment and guide targeted preventive strategies.

Reference:

Muhammad Abdul-Ghani, Mohamed Abu-Farha, Tamam Abdul-Ghani, Alberto Chavez-Velazquez, Auora Merovci, Ralph A. DeFronzo, Fahad Alajmi, Michael Stern, Fahd Al-Mulla; One-Hour Plasma Glucose Predicts the Progression From Normal Glucose Tolerance to Prediabetes. Diabetes Care 2025; dc242832. https://doi.org/10.2337/dc24-2832

Powered by WPeMatico

Higher Protein Intake May Benefit Bone and Muscle Health in Rheumatic Disease: Study

New research emphasizes the importance of adequate—and possibly higher than currently recommended—protein intake for individuals with rheumatic diseases (RD) such as psoriatic arthritis, rheumatoid arthritis, osteoarthritis, and gout. Increased protein consumption has been linked to improvements in both lean and bone mass, suggesting that current dietary guidelines may need to be adjusted to better support musculoskeletal health in this population. This study was conducted by Gabriel P. and colleagues published in The Journal of Nutritional Physiology.

In a comprehensive analysis of 3,972 individuals with psoriatic arthritis, rheumatoid arthritis, osteoarthritis, and gout in the National Health and Nutrition Examination Survey (NHANES), the results indicate that ingesting greater than 0.8 g/kgBM/day of protein can have positive implications for musculoskeletal health. The research highlights the significance of specific nutritional measures in the treatment of rheumatic diseases, which are notorious for leading to muscle loss and decreased bone mineral density (BMD).

People with rheumatic diseases are at increased risk of losing both muscle and bone mass because of chronic inflammation and decreased mobility. In earlier studies, there was a suggestion of a protective effect of dietary protein, but the exact associations of protein consumption and musculoskeletal outcomes within RD populations were unknown. The present research focused on filling this gap by analyzing both absolute (grams/day) and relative (grams per kg body mass per day) protein consumption and their relationships with lean and bone mass.

Results

  • The outcomes showed a statistically significant linear relationship between absolute protein consumption and lean mass, and an increment of 50 g/day in the intake of protein was associated with an increase in lean mass by 1.54 kg (95% CI: 0.78 to 2.30, p < 0.001).

  • There was a non-linear relationship between relative protein consumption, and lean mass gain decreased with increasing intakes above about 1.6 g/kgBM/day (p < 0.001).

  • For BMD at the femoral neck, absolute and relative protein intakes had non-linear correlations.

  • Protein consumption exceeding 150 g/day or 1.2 g/kgBM/day did not provide additional increases in BMD (absolute protein consumption: p < 0.001; relative: p = 0.005).

  • Neither was any significant relationship observed between protein consumption and whole-body or lumbar spine BMD.

  • These results imply that moderately increased protein intake—above the generally advised 0.8 g/kgBM/day—will be adequate to enhance lean mass and possibly bone health in patients with RD.

Protein intakes greater than 0.8 g/kgBM/day are found to be useful in enhancing lean and bone mass in patients of rheumatic diseases. The results suggest the importance of testing and providing enough protein as one of the chief nutritional objectives in the management of RD. Although greater intake levels have positive effects, very high intakes do not generate further enhancement, focusing on the benefits of balanced meal planning in this susceptible group.

Reference

Esteves, G. P., Swinton, P., Sale, C., Gualano, B., Roschel, H., & Dolan, E. (2025). Non-linear associations between protein intake and lean and femur bone mass in individuals with rheumatic diseases: findings from the NHANES 2007–2018. The Journal of Nutritional Physiology, 100004, 100004. https://doi.org/10.1016/j.jnphys.2025.100004

Powered by WPeMatico

Targeting SBP Below 130 mmHg May Lower Hospitalizations in HFpEF Without Increasing Serious Risks: Meta-analysis

Japan – Targeting a systolic blood pressure (SBP) below 130 mmHg may significantly reduce hospitalizations in patients with heart failure with preserved ejection fraction (HFpEF), a recent systematic review and meta-analysis published in Hypertension Research has revealed. The study, led by Dr. Chisa Matsumoto from the Department of Cardiology at Tokyo Medical University in Fukuoka, Japan, offers important guidance for clinicians ahead of the upcoming Japanese Society of Hypertension 2025 (JSH2025) guidelines.

HFpEF accounts for approximately half of all heart failure cases and remains a clinical challenge, particularly when it comes to optimal blood pressure management. To address this, Dr. Matsumoto and her team systematically reviewed randomized controlled trials (RCTs) published since 2012 that examined the impact of tight BP control, specifically targeting SBP <130 mmHg, on clinical outcomes in HFpEF patients.

The analysis included six RCTs that collectively assessed various interventions such as mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitors (ARNIs), intensive BP control strategies, and comprehensive heart failure management approaches. These studies had follow-up periods of at least six months and demonstrated significant BP reduction in intervention groups, achieving SBP below 130 mmHg.

The study led to the following findings:

  • Maintaining systolic blood pressure (SBP) below 130 mmHg was associated with a 20% reduction in the risk of heart failure-related hospitalizations (RR: 0.80).
  • There was a trend toward reduced all-cause mortality, though it did not reach statistical significance.
  • There was a 35% increased risk of hypotension reported (RR: 1.35).
  • There was no significant increase in serious adverse events or renal dysfunction, suggesting overall safety was not compromised despite the lower SBP target.

Even though none of the trials were specifically designed to use SBP <130 mmHg as the primary intervention target, the consistent benefits observed across different treatment modalities support the adoption of this threshold in clinical practice for HFpEF patients.

“Based on our findings, we advocate aiming for an SBP under 130 mmHg in HFpEF management, provided that patients are carefully monitored for hypotension,” said Dr. Matsumoto. “Given the heterogeneity of HFpEF, personalized treatment strategies and close clinical observation remain essential.”

The authors call for future trials that directly assess SBP targets and investigate how different antihypertensive agents might be tailored to the complex needs of HFpEF patients.

The study provides timely evidence to inform treatment decisions and guideline development, emphasizing a cautious yet proactive approach to blood pressure control in heart failure care.

Reference:

Matsumoto, C., Nagai, M., Shinohara, K., Morikawa, N., Kai, H., & Arima, H. (2025). Systolic blood pressure lower than 130 mmHg in heart failure with preserved ejection fraction: A systematic review and meta-analysis of clinical outcomes. Hypertension Research, 1-14. https://doi.org/10.1038/s41440-025-02240-w

Powered by WPeMatico

Cool Drinks Linked to Afib Episodes: Survey Finds Lifestyle Impact

USA: Researchers have found in a cross-sectional survey that many individuals with atrial fibrillation (AFib) experienced fewer episodes by avoiding cold drinks and foods like ice water, smoothies, and ice cream. Strategies included letting beverages reach room temperature and avoiding straws. Despite patient-reported improvements, healthcare providers often dismissed the “cold drink heart” (CDH) phenomenon.

The study, published in the Journal of Cardiovascular Electrophysiology and led by Dr. Daniel D. DiLena from Kaiser Permanente Northern California, sheds light on a relatively under-recognized AFib trigger. The research focused on the “cold drink heart” phenomenon, a term used to describe atrial fibrillation episodes that are triggered specifically by the intake of cold consumables.

The investigators conducted a mixed-methods study involving a detailed patient survey supplemented by chart reviews. Participants were either approached during emergency department visits for AFib or reached out to the study team directly. The survey collected data on demographics, clinical history, and the nature of AFib episodes, particularly those linked to cold consumption.

The key findings were as follows:

  • A total of 101 patients participated in the study, with 75% being male.
  • The median age at onset of cold drink-triggered atrial fibrillation (CDH) was 44.5 years.
  • 51.5% of respondents reported that their AFib episodes occurred exclusively after consuming cold drinks or foods.
  • Many patients experienced a rapid onset of arrhythmia following cold ingestion.
  • A significant number of episodes were associated with recent physical exertion.
  • 86.4% of participants reported a reduction or complete elimination of AFib episodes after avoiding cold consumables.
  • Among patients with only CDH-triggered episodes, 100% experienced prevention of recurrence through lifestyle modifications.

Despite these clear patterns observed by patients, the medical community appears to have limited awareness of the phenomenon. According to the survey, more than half of the participants (52.4%) felt that their experiences with CDH were dismissed or not taken seriously by healthcare providers. This disconnect underscores the need for increased clinician awareness and a more patient-centered approach to managing AFib.

The findings point toward a potential non-pharmacological strategy for certain AFib patients. Avoiding specific triggers, such as cold drinks, could offer a simple and effective way to manage arrhythmia recurrence in affected individuals.

While these observations are promising, the researchers emphasize the need for further investigation to establish definitive clinical guidance. Controlled studies are warranted to validate CDH as a recognized trigger and to develop tailored management approaches.

The authors concluded, “The study brings attention to a unique but impactful trigger of AFib and highlights the importance of listening to patient-reported experiences in shaping personalized care strategies.”

Reference:

DiLena, D. D., Zhang, J. Y., Rauchwerger, A. S., Reed, M. E., Marcus, G. M., Warton, E. M., & Vinson, D. R. Characterizing Patients With Cold Drink-Triggered Atrial Fibrillation. Journal of Cardiovascular Electrophysiology. https://doi.org/10.1111/jce.16753

Powered by WPeMatico

Full-zirconia implant Restorations Show High Survival but Frequent Technical Complications, suggests study

Researchers have found in a new study that Full-zirconia implant-supported restorations with angulated screw channel abutments demonstrated a 97% survival rate over 5 years in posterior maxillary and mandibular regions, but were associated with a high rate of technical complications.

Implant-supported restorations in the posterior region are subjected to various complications that could be prevented by changing either the design or the material. The aim of this prospective case series study was to evaluate full-zirconia implant-supported restorations with angulated screw channel abutments in the molar region of the maxilla and mandible and their effect on hard and soft peri-implant tissues, during a 1-year follow-up period. Thirty consecutive patients with a single missing molar, sufficient bone height, and implant site free of infection were included. Each patient was to receive a parallel-walled implant with conical connection according to a two-staged surgical protocol. After 3 months, a full-contour screw-retained zirconia restoration with angulated screw channel abutment was provided. Clinical and radiographic examinations were performed 1 and 12 months after placement of the restoration. Patients’ satisfaction was scored prior to treatment and after 12 months with the restoration in function. Primary outcome measure was success of the restoration. Results: All patients could be evaluated after 12 months. Success of the restorations was 100%. From loading to the 12-month follow-up, the mean marginal bone loss was 0.16 mm (SD: 0.26). Mean scores for plaque, calculus, peri-implant mucosa, bleeding, and pocket probing depth were low, depicting healthy peri-implant conditions. Patients’ satisfaction was high and had improved after treatment. Full-contour zirconia implant-supported restorations with angulated screw channel abutments in the molar region have an excellent clinical performance after 1 year of function.

Reference:

Pol CWP, Raghoebar GM, Maragkou Z, Cune MS, Meijer HJA. Full-zirconia single-tooth molar implant-supported restorations with angulated screw channel abutments: A 1-year prospective case series study. Clin Implant Dent Relat Res. 2020 Feb;22(1):138-144. doi: 10.1111/cid.12872. Epub 2019 Dec 3. PMID: 31793193; PMCID: PMC7064919.

Keywords:

Full-zirconia, implant, Restorations, Show, High, Survival, Frequent, Technical, Complications, Pol CWP, Raghoebar GM, Maragkou Z, Cune MS, Meijer HJA, angulated screw channel; dental implants; posterior; restoration; zirconia.

Powered by WPeMatico

Decoding Doppler: How Fetal Heart Monitoring Shapes Perinatal Health?

Recent systematic review evaluated the association between peripartum fetal Doppler sonography findings and perinatal outcomes in term pregnancies (37-42 weeks). The review included studies focusing on Doppler assessments of selected fetal blood vessels conducted at labor admission or during labor, excluding high-risk pregnancies. Following PRISMA guidelines, the study selection process was detailed, with a total of 37 studies evaluated, primarily prospective, involving 11,505 pregnancies.

Key Findings on Doppler Parameters

Key findings highlighted a strong association between Doppler parameters and adverse perinatal outcomes. Specifically, the presence of umbilical vein (UV) pulsations indicated a high likelihood of fetal distress (FD) with an odds ratio (OR) of 28. Low corrected UV blood flow rates were linked to increased odds of fetal distress (OR 1.64) and NICU admission (OR 3.61) but did not correlate with meconium-stained amniotic fluid or low Apgar scores. The cerebroplacental ratio (CPR) emerged as a predictive factor, showing abnormal CPR associated with fetal distress (OR 3.19) and adverse outcomes such as low Apgar scores. Methodological quality assessment revealed that 29.7% of included studies had a low risk of bias, with many studies affected by selection and confounding biases. The review utilized random-effects meta-analyses to address the anticipated heterogeneity across studies, reflecting differences in study designs, populations, and Doppler assessment protocols.

Study Limitations and Future Research Needs

The analysis found that abnormal Doppler findings are consistently linked to poor perinatal outcomes, yet most included studies had low methodological quality and small sample sizes, particularly for rare outcomes such as perinatal mortality. This emphasizes the need for future research to determine whether incorporating fetal Doppler sonography into labor management can lead to enhanced perinatal care outcomes compared to existing monitoring methods. Significantly, the review calls for well-designed, randomized controlled trials to ascertain the efficacy of intrapartum Doppler assessments in improving perinatal outcomes, especially given the inherent challenges in conducting such studies in settings with low incidences of severe morbidity. Overall, while the findings underscore the potential utility of Doppler sonography in identifying at-risk fetuses, the need for rigorous, high-quality research to confirm these associations and inform clinical practice is apparent.

Major Points

– A systematic review evaluated the relationship between peripartum fetal Doppler sonography findings and perinatal outcomes specifically in term pregnancies (37-42 weeks), analyzing a total of 37 studies which included 11,505 pregnancies and complied with PRISMA guidelines.

– Key Doppler parameters, including the presence of umbilical vein (UV) pulsations and low corrected UV blood flow rates, were identified as significant indicators of fetal distress (FD), with odds ratios (OR) of 28 and 1.64 respectively. Additionally, low UV blood flow rates were associated with increased NICU admissions (OR 3.61), while no correlation was found with meconium-stained amniotic fluid or low Apgar scores.

– The cerebroplacental ratio (CPR) was highlighted as a critical predictive factor; abnormal CPR values were associated with a heightened likelihood of fetal distress (OR 3.19) and negative outcomes, including low Apgar scores.

– Methodological quality assessment of the included studies indicated that 29.7% had a low risk of bias, with many studies exhibiting selection and confounding biases, signaling the need for caution in interpreting the findings.

– While abnormal Doppler findings were consistently related to adverse perinatal outcomes, the majority of studies suffered from low methodological quality and small sample sizes, particularly concerning rarer outcomes like perinatal mortality, which indicates a gap for further investigation.

– The review calls for well-structured, randomized controlled trials to determine the effectiveness of intrapartum Doppler assessments in enhancing perinatal outcomes and addresses the challenges of conducting such studies in low morbidity settings, underscoring the necessity for high-quality research to validate these findings and guide clinical practices.

Reference –

B. Packet et al. (2025). Peripartum Fetal Doppler Sonography And Perinatal Outcome: A Systematic Review And Meta-Analysis. *BMC Pregnancy And Childbirth*, 25. https://doi.org/10.1186/s12884-025-07586-0.

Powered by WPeMatico

Intermittent sodium zirconium cyclosilicate Treatment May Prevent Hyperkalemia in CKD Patients: Study

Researchers have found in a new study that Intermittent use of sodium zirconium cyclosilicate (SZC) may help prevent hyperkalemia in patients with chronic kidney disease (CKD). However, additional studies are needed to determine whether this translates into better long-term clinical outcomes.

Hyperkalemia is a common complication of chronic kidney disease (CKD) that often requires urgent dialysis and increases healthcare costs. Daily sodium zirconium cyclosilicate (SZC) is a safe and effective treatment for the control of serum potassium levels in CKD patients. We studied the efficacy and safety of intermittent SZC therapy for the prevention of hyperkalemia in CKD patients.

In a retrospective study, we analyzed patients in the Hospital Authority Clinical Data Analysis and Reporting System (CDARS) receiving sodium zirconium cyclosilicate (Lokelma®) therapy once to thrice weekly for at least 3 months from January 2021 to June 2023. Outcome measures included plasma potassium levels, hyperkalemia episodes, hospital admissions, and renal function changes, which were compared to the 6 months period before the initiation of SZC treatment. Results: They studied 36 adult CKD patients. SZC treatment significantly reduced plasma potassium levels from 5.10 (inter-quartile range [IQR] 4.91–5.40) to 4.73 (IQR 4.50–5.10) mmol/l (p = 0.0003). The median incidence of any hyperkalemia reduced from 5.0 (IQR 2.0–8.0) to 1.9 (IQR 0.0–4.7) episode per patient-year (p = 0.0001), and the incidence of urgent treatment for hyperkalemia decreased from 2.0 (IQR 0.0–4.0) to 0.0 (IQR 0.0–1.5) episode per patient-year (p = 0.007). The number of emergency room attendance and hospitalization were not significantly reduced. Intermittent SZC treatment may help prevent hyperkalemia in CKD patients. Further research is necessary to ascertain if this benefit translates into impro

Reference:

Ng, J.KC., Fung, WS., Chan, GK. et al. Intermittent sodium zirconium cyclosilicate for the prevention of hyperkalemia in chronic kidney disease. BMC Nephrol 26, 260 (2025). https://doi.org/10.1186/s12882-025-04194-0

Keywords:

Intermittent , SZC Treatment, May, Prevent, Hyperkalemia, CKD Patients, Ng, J.KC., Fung, WS., Chan, GK, Potassium, Renal failure, Dialysis

Powered by WPeMatico