Biocon launches Liraglutide for diabetes, obesity in UK

Bengaluru: Biocon Limited, an innovation-led global biopharmaceutical company, has announced the launch of its GLP-1 peptide, Liraglutide, for diabetes and obesity, in the United Kingdom (U.K.).

The drug-device combination will be marketed in the U.K. under the brand names Liraglutide Biocon for
diabetes (gVictoza) and Biolide for chronic weight management (gSaxenda).

The launch follows the approval from the Medicines and Healthcare Products Regulatory Agency (MHRA), U.K.,
earlier this year, making Biocon Limited the first generics company to obtain approval for gLiraglutide in a
major regulated market.


Siddharth Mittal, Chief Executive Officer and Managing Director, Biocon Limited, said, “The launch of our
gLiraglutide for diabetes and obesity in the U.K. marks a significant milestone for Biocon. Making this GLP-1
peptide more accessible and affordable to patients dealing with these conditions is testament to our
unwavering commitment to enhancing healthcare outcomes across the globe. The timely launch will offer
healthcare providers and patients affordable access to this drug and help fulfil an unmet need. The launch also
underpins Biocon’s scientific and manufacturing capabilities in developing and bringing to market complex,
vertically integrated, GLP-1 formulations. We will continue to focus our efforts towards expanding the reach of
gLiraglutide into other European markets, the U.S. and select MoW geographies, as well as enhancing our
pipeline of GLP-1 peptide products.”

Glucagon-like peptide-1 (GLP-1) are medications that help lower
blood sugar levels and promote weight loss. They are physiological hormones that have multiple actions on
glucose, mediated by the GLP-1 receptors released from gut enteroendocrine cells and control meal-related
glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. GLP-1 also inhibits
gastric emptying and food intake actions, maximizing nutrient absorption while limiting weight gain.

Liraglutide is a synthetic analog of GLP-1 peptide and is administered as a once-daily
injection. It was approved for medical use in the European Union in 2009, and in the United States in 2010.
Liraglutide was approved by the US FDA in 2014, and by the EMA a year later, for adults who are either obese
or overweight with atleast one weight-related condition. In 2019, it was approved by the US FDA for the
treatment of children who are ten years or older with type 2 diabetes, making it the first non-insulin drug
approved to treat type 2 diabetes in children since metformin was approved in 2000.

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Forearm DXA Scan: A Valuable Supplement for Osteoporosis Detection in Older Adults, Study Finds

Italy: A recent systematic review and meta-analysis explored the correlation between bone mineral density (BMD) measured at the forearm and at the lumbar spine or femoral neck, highlighting the potential role of distal forearm dual-energy X-ray absorptiometry (DXA) scans in osteoporosis assessment.

The findings were published online in BMC Musculoskeletal Disorders on February 14, 2025. 

The researchers revealed that forearm BMD scans show a strong correlation with BMD measurements of the lumbar spine and femoral neck, highlighting their role as a valuable supplementary tool for osteoporosis detection. The meta-analysis of 5,941 participants reported pooled effect sizes of 0.603 for the lumbar spine and 0.641 for the femoral neck, reinforcing the clinical utility of forearm DXA, especially in older adults where lumbar or hip scans may not be feasible.

Osteoporosis is a major global health concern, contributing to increased fracture risk and reduced quality of life. While DXA scans of the lumbar spine and femoral neck are the gold standard for assessing bone mineral density, they are not always feasible in elderly patients due to degenerative changes, mobility issues, or the presence of surgical implants. Despite this, current osteoporosis guidelines do not consider forearm DXA a standard diagnostic tool, except in specific cases.

To address this gap, Chiara Ceolin, Geriatrics Division, Department of Medicine (DIMED), University of Padua, via Giustiniani 2, Padova, Italy, and colleagues conducted a systematic review and meta-analysis to evaluate the correlation between forearm BMD and BMD measurements at the lumbar spine and/or hip sites, assessing its potential as a supplementary diagnostic method.

For this purpose, the researchers registered the protocol in PROSPERO and adhered to PRISMA guidelines. They systematically searched major databases until August 2024 for studies assessing forearm DXA scans in detecting osteoporosis compared to central sites like the femoral neck and lumbar spine. A meta-analysis was conducted on studies reporting correlation coefficients between these measurements. Three reviewers independently assessed study quality using QUADAS-2 criteria, and a narrative synthesis was performed to summarize key findings across different patient groups.

Key Findings

  • Thirteen studies published between 1992 and 2023 were included, involving 5,941 participants.
  • Forearm DXA scans showed strong correlations with lumbar spine and femoral neck BMD, with pooled effect sizes of 0.603 (95% CI 0.579–0.627) and 0.641 (95% CI 0.600–0.680), respectively.
  • Forearm BMD demonstrated good predictive value for central osteoporosis.
  • Despite some variations in results, forearm DXA scanning proved to be a valid alternative, particularly in cases where lumbar or femoral assessments are difficult to perform.

The researchers demonstrated a strong correlation between forearm BMD and standard DXA measurements, highlighting the distal forearm as a valuable supplementary site for osteoporosis detection.

“Forearm DXA scans could aid in diagnosing osteoporosis, especially in older adults where lumbar or femoral assessments are unreliable. However, further research is needed to validate these findings across diverse patient groups,” they concluded.

Reference:

Papa, M.V., Ceolin, C., Simonato, C. et al. The correlation between bone mineral density measured at the forearm and at the lumbar spine or femoral neck: a systematic review and meta-analysis. BMC Musculoskelet Disord 26, 151 (2025). https://doi.org/10.1186/s12891-025-08376-7

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Violence against doctors- HC slams Delhi Police Commissioner for non-registration of FIR of doctor, upholds Rs 50,000 fine

New Delhi: The Delhi High Court recently upheld the National Human Rights Commission‘s (NHRC) order directing the Delhi Police Commissioner to pay Rs 50,000 compensation to a senior doctor for not registering an FIR regarding a complaint involving instances of violence against him.

Earlier, the NHRC on 27.09.2023 had recommended that the Commissioner release Rs 50,000 compensation to the doctor. Following this, the order was challenged by the Police Commissioner before the Delhi High Court.

However, while considering the matter recently, the HC bench comprising Justice Sachin Datta noted that instead of complying with the NHRC directions, the petitioner resorted to taking refuge behind an inquiry conducted after the NHRC passed the order “which again seeks to attribute the inaction of the petitioner/police authorities to the reluctance of the complainant to pursue any complaint pursuant to the incident on 24.11.2021. As noticed above, the same is wholly misconceived.”

“For all the above reasons, this Court finds no merit in the present petition; the same is accordingly dismissed. Pending application also stands disposed of,” ordered the Delhi High Court bench.

The issue goes back to 2021 when after receiving a call from the doctor’s clinic saying that certain miscreants had entered the area, the police had reached the clinic. After reaching the clinic, the investigating officer (IO) met with the doctor and questioned about the incident. The petitioner claimed that the doctor declined the medical examination and refrained from providing any written complaint. It was alleged that the staff members present at the location also refused to submit any written statement as a result of which the IO could not file an FIR.

On the next day, the doctor submitted a complaint to the NHRC, alleging that certain miscreants had illegally trespassed into his clinic and outraged the modesty of his female staff. He further argued that despite making a PCR call, the police officials/investigating officer failed to take action.

While the doctor claimed that the investigating officer failed to take action even though he had made a call, the Delhi Police Commissioner submitted that the doctor refused to provide any written complaint as a result of which the IO could not file an FIR.

After receiving the complaint, NHRC took cognizance of the issue and directed the Deputy Commissioner of Police (DCP), South District, Delhi, to submit an Action Taken Report (ATR) within four weeks. Thereafter, a report dated 10.01.2023 was submitted from the office of DCP, vigilance Delhi. Consequently, the NHRC also issued a show-cause notice to the doctor. Another show-cause notice was issued to the Police Commissioner asking the Commissioner to explain why NHRC should not be held liable to pay Rs 50,000 as compensation to the doctor for the non-registration of the FIR.

In its order, NHRC directed the Commissioner of Police to pay Rs 50,000 compensation to the doctor for non-registration of FIR. In its order, the NHRC observed that violence against medical practitioners is a serious matter and a cognizable offence under the Delhi Medicare Service Personnel and Medicare Service Institutions (Prevention of Violence and Damage to Property) Act, 2008. 

“Police grossly failed to register an FIR because all the allegations of criminally trespass, outraging of modesty of female staff and criminal intimidation are Cognizable offences under IPC Moreover, violence against medical personnel is also a cognizable offence under The Delhi Medicare Service Personnel and Medicare Service Institutions (Prevention of Violence and Damage to Property) Act, 2008,” NHRC had mentioned in its order.

Further, the NHRC observed that the Commissioner’s justification stating that the petitioner did not want to file a complaint was cursory and it failed to inspire confidence.

The NHRC order was challenged by the Commissioner before the Delhi HC, which observed that the Commissioner’s reliance on the alleged statement of the doctor to the effect that the complainant was not desirous of pursuing the matter was misplaced.

To justify the inaction, the Commissioner had relief on an inquiry allegedly prepared in the aftermath of the visit at the complainant doctor’s address. As per the Commissioner, the inquiry report was placed before the NHRC. However, the NHRC disregarded it while passing the order, argued the Commissioner.

While considering the matter, the Court observed that such averment was misleading as NHRC’s order was passed after the alleged inquiry was conducted. The Court noted that the NHRC order provided detailed reasons as to why the petitioner’s contention that the complainant was not desirous of pursuing the matter did not inspire confidence.

“Instead of complying with the directions of the NHRC, the petitioner resorted to taking refuge behind an inquiry conducted after the impugned order was passed by the NHRC which again seeks to attribute the inaction of the petitioner/police authorities to the reluctance of the complainant to pursue any complaint pursuant to the incident on 24.11.2021. As noticed above, the same is wholly misconceived,” noted the HC bench.

Noting that the action of the officer to record the complainant’s statement regarding his complaint before the NHRC was an attempt to circumvent the consequences of the complaint, the HC bench observed,

“It is quite incongruous that the statement of the complainant, would be recorded by the very same officer against whom the complainant has lodged the complaint. There was no occasion for the very same officer to approach the complainant and question the complainant as to whether the latter was desirous of pursuing his complaint before the NHRC. The action of the concerned delinquent officer, to record the statement of the complainant/respondent no.2 with regard to the latter’s complaint in the NHRC, is nothing short of an attempt to obtain a self serving exculpatory statement to circumvent / avoid the consequences of the complaint submitted to the NHRC.”

Further taking note of the fact that the Commissioner sought a writ of certiorari, the HC bench relied on the Central Council For Research In Ayurvedic Sciences &Anr. v. Bikartan Das (2023), where the Apex court bench while exercising the jurisdiction under the write of certiorari, the High Court does not function as an appellate tribunal and thus cannot reassess the evidence.

The Court further observed, “First, when exercising this power, the High Court does not function as an appellate tribunal. This means it cannot reassess or re-evaluate the evidence upon which a tribunal/statutory authority has based its decision. The scope of judicial review in such cases is limited to examining the legality of the decision. Second, a writ of certiorari can only be issued if there is an error of law that is apparent on the face of the record. The writ is a high prerogative remedy and cannot be granted as a matter of right. The power conferred under Article 226 of the Constitution is discretionary, and the High Court has the flexibility to pass orders in the interest of justice, equity, and public good. While the law must be upheld, it should also be tempered with equity.”

Relying on the HC order in Kiran Singh vs. National Human Rights Commission & Ors (2025 LiveLaw (Del) 106), the Court observed, that “the petitioner is bound by the said directions of NHRC, unless the impugned order is set aside by the Court.”

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/delhi-hc-upholds-nhrc-order-276480.pdf

Also Read: GMC Kozhikode 2017 Medical Negligence Case: Patient seeks Rs 1.9 crore compensation

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Tirunelveli Medical College criticized for poor biomedical waste disposal practices

A recent incident involving the burning of a large volume of biomedical, plastic, and paper waste at Tirunelveli Medical College Hospital (TvMCH) has sparked outrage among residents of nearby areas. The residents from MGR Nagar, Periyar Nagar, and Indra Nagar filed a formal complaint with the hospital dean, Dr. Revathy Balan, demanding immediate action to stop the practice.

In response, the residents also threatened to lay siege to the hospital on Wednesday. The waste was burnt near the Regional Cancer Centre block, an area that is particularly sensitive due to the presence of vulnerable patients. The burnt materials included blood sample containers, saline bottles, cannulas, used gloves, expired tablets, as well as plastic, food, and paper waste.

For more information, click on the link below:

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Facing mental health issues, Woman doctor allegedly commits suicide

Bhubaneswar: In an unfortunate incident, a clinical associate of Ladies Clinic and Nursing Home, Cuttack, allegedly committed suicide by hanging herself from the ceiling at her residence in Daraghabazar in Cuttack, Odisha. 

A preliminary report from the police investigation indicates that the doctor identified as Dr Alaka Rath was suffering from mental distress for a considerable time. Therefore, it is suspected that this may have led her to take her own life. However, the police have yet to confirm the cause behind this tragic incident. 

Also read- Battling depression, 65-year-old doctor jumps to death from 42nd floor

As per Ommcom news report, the incident came to light on Friday morning when the doctor who had been living with her family was found dead in her room. After her parents witnessed the shocking scene, they immediately alerted the police. 

Moments after receiving the information, the police reached the spot and conducted a preliminary investigation, which revealed her mental condition. Later, they sent her body for post-mortem

A case has been registered in this regard, and an investigation is underway. The details surrounding the doctor’s death remain mysterious, and more details are awaited.

Also read- MJN Medical College Final year MBBS medico found hanging in hostel room

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Large population study identifies long-term health risks after COVID-19 hospitalization

A French nationwide study has revealed that survivors of COVID-19 hospitalization face an increased risk of death or organ-related disorders for up to two-and-a-half years after discharge.

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Gene therapy developed for maple syrup urine disease shows promise

A study led by UMass Chan Medical School researchers has demonstrated that a gene therapy to correct a mutation that causes maple syrup urine disease (MSUD) prevented newborn death, normalized growth, restored coordinated expression of the affected genes and stabilized biomarkers in a calf as well as in mice.

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Critical illness is more common than expected in African hospitals, but low-cost treatments offer hope

One in eight patients in hospitals in Africa is critically ill, and one in five of the critically ill die within a week, according to a study appearing in The Lancet. The researchers behind the largest study of critical illness in Africa to date conclude that many of these lives could have been saved with access to cheap life-saving treatments.

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Fat transport deficiency explains rare childhood metabolic crises

Researchers studying a protein linked to a rare, severe disease have made a discovery that sheds light on how cells meet their energy needs during a severe metabolic crisis. The findings could lead to new treatments for the disease and open new avenues of research for other conditions involving impaired fat metabolism.

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Discovery of lung-based blood stem cells may transform transplant therapies

Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

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