Global study finds heart failure drug spironolactone fails to lower cardiovascular risk in dialysis patients

A large international study has found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis, despite earlier smaller studies suggesting benefit.

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Experts recommend SGLT-2 and GLP-1 only for adults at moderate to high risk of heart and kidney problems

SGLT-2 inhibitor and GLP-1 receptor agonist drugs should be used in all or almost all adults with type 2 diabetes at higher risk of cardiovascular and kidney complications, and in the majority of adults at moderate risk of complications, says a panel of international experts in The BMJ.

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ADHD medication linked to reduced risk of suicide, drug abuse, transport accidents and criminal behavior

Drug treatment for people with newly diagnosed attention deficit hyperactivity disorder (ADHD) is associated with significantly reduced risks of suicidal behaviors, substance misuse, transport accidents, and criminality, finds a study published by The BMJ.

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Broad COVID-19 vaccination makes economic sense, especially for older adults, modeling study finds

As the nation gears up for the rollout of an updated COVID-19 vaccine, a new study shows the economic benefits of continued broad vaccination in adults.

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Arginine dentifrices significantly reduce childhood caries, clinical trial finds

A study in JDR Clinical & Translational Research demonstrates that arginine dentifrices reduce dental caries in children with active caries as effectively as or more effectively than a sodium fluoride dentifrice, depending on the arginine concentration.

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Specialized imaging improves overall prostate cancer survival by identifying benefits of salvage radiotherapy

A study from Denmark shows for the first time that men with biochemically recurrent prostate cancer who undergo PSMA PET/CT before salvage radiotherapy have improved survival rates compared to those who do not.

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For professional fighters, childhood disadvantage is linked to more brain changes later

Athletes who participate in combat sports like boxing and mixed martial arts and grow up in disadvantaged neighborhoods may be more likely to show signs of brain changes associated with neurodegeneration than athletes from affluent neighborhoods, according to a study published on August 13, 2025, in Neurology Open Access.

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How small changes in walking technique may help treat knee osteoarthritis

Gait analysis and pain measures show that subtly adjusting the angle of the foot during walking may reduce knee pain caused by osteoarthritis. This approach may also slow progression of the condition, an incurable disease in which the cartilage cushion inside a joint breaks down.

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Routine AI assistance may lead to loss of skills in health professionals who perform colonoscopies

The introduction of artificial intelligence (AI) to assist colonoscopies is linked to a reduction in the ability of endoscopists (health professionals who perform colonoscopies) to detect precancerous growths (adenomas) in the colon without AI assistance, according to a paper published in The Lancet Gastroenterology & Hepatology.

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Patients still view doctor’s white coat as symbol of professionalism and trust, review suggests

Patients are still more likely to trust doctors and consider them more professional when they wear white coats, although women doctors in this attire are often misidentified as nurses or medical assistants, finds a review of the available research on the topic, published in the open-access journal BMJ Open.

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