AIIMS Nagpur inaugurates Autopsy complex

Nagpur: The long-awaited establishment of an autopsy facility at All India Institute of Medical Sciences (AIIMS), Nagpur has finally come to fulfilment, with the premier institution recently inaugurating one at the campus. 

This significant progress brings a sense of relief to the bereaved families who previously had to go through the difficult process of transferring their deceased relative body to another hospital and enduring the wait for the post-mortem examination.

This state-of-the-art advanced facility at the renowned institute will now allow for post-mortem examinations to be carried out. Family members coming to the institute will no longer have to travel to the Government medical college and hospital (GMCH) for postmortem examinations of their deceased kin. 

Also read- AIIMS Nagpur Becomes First AIIMS To Get NABH Accreditation, PM Modi Congratulates The Team

The new facility was inaugurated in an unprecedented event by Dr. (Prof.) M. Hanumantha Rao, Executive Director, AIIMS, Nagpur on December 19.

The Department of Forensic Medicine & Toxicology, AIIMS, Nagpur has sought permission to get post-mortem examinations. As per the approval letter medicolegal postmortem on the dead bodies in the jurisdiction of the Police station of Sonegaon, Hingana, Hingna MIDC, Beltarodi, Butibori MIDC, Buttibori, Bela will be conducted at the Autopsy Block of AIIMS Nagpur.

Dr. Manish Shrigiriwar, Professor and head of the Department of Forensic Medicine & Toxicology, extended a warm welcome to all the dignitaries by presenting them with beautiful flower bouquets. The esteemed guests included Mr Vijay Kumar Nayak (Deputy Director (Admin)), Mr B. K. Agrawal (Financial Advisor), Dr Sanjiv Choudhary (Dy. Medical Superintendent), and Dr Ganesh Dakhale (Dean Examination), who graced the occasion with their presence.

Previously, the autopsies of such deaths were conducted at Government Medical College, Nagpur, which unfortunately resulted in unavoidable delays, causing both the Police and the relatives to suffer throughout the entire process.

However, with the opening of the new facility, the post-mortem will be conducted at the premier institute putting the relatives and the police at ease. According to a TOI news report, Sonegaon, Beltarodi, MIDC, Hingna, MIDC Bori, Buti Bori and Bela police stations will now send bodies to conduct the procedure to AIIMS in Mihan.

Soon, the hospital will have two autopsy tables, cold storage for keeping eight bodies, a workstation for organ dissection, a room for performing the panchanama, a separate space for waiting relatives and a help desk for handling queries as reported by the daily.

In addition, AIIMS has ambitious plans to establish the autopsy facility as one of the finest in the country. It will feature cold storage for 80 bodies, along with a camera facility to showcase the procedures to post-graduate students at the viewers’ gallery.

Dr Harshal Thube skillfully hosted the inaugural ceremony, and the success of the program was greatly attributed to the efforts of Dr Ashok Jiwane, Dr Jayesh Dudhe, Dr Jishnu V, Dr Animesh Gupta, Dr Priyanshu Garg, Dr Avinash Kumar Anand, Mr Shobhit Kapse, Miss. Prachi, Miss. Sandhya Wani, Miss. Vaishnavi, Mr. Sanket Giri, Mr. Lokshankar Megdarat, and Mr. Ishwar Chachane.

The institute has been in communication with the state home department to obtain approval for their proposed post-mortem facility, according to TOI sources. Approximately three months ago, the state’s Medical Education and Drug Department (MEDD) inspected the ‘autopsy block’, which was followed by a visit from the city police chief, Amitesh Kumar. After receiving the police chief’s No Objection Certificate (NOC), AIIMS obtained clearance from the local gram panchayat to carry out the medico-legal procedures.

Apart from this, AIIMS Nagpur also inaugurated its “Heart Failure Clinic” on December 19 which will open every Thursday from now on. The heart failure clinic was launched in the presence of Dr Ravinulata Venkata Kumar, Professor of Cardiovascular and Thoracic Surgery; and Director and Vice-Chancellor of Sri Venkateshwara Institute of Medical Sciences (SVIMS), Tirupati.

The highly skilled cardiac team of AIIMS, Nagpur will conduct this heart failure clinic every Thursday. This team comprises cardiologists, Dr Arijit Kumar Ghosh, Dr Sagar Makode, and Dr Gunjan Godeshwar; cardiac anaesthetist Dr Omshubham Asai; and cardiac-vascular and thoracic surgeons, Dr Pravin Salunkhe, Dr Hemant Kumar Bodhankar, and Dr Frankleena Parage.

The heart failure clinic aims to deal with problems encountered by heart failure patients. This will facilitate the optimization of anti-failure medical therapy, rehabilitation, reduction of patient admission rate, and duration of hospitalization.

Also read- ICMR Designates AIIMS Nagpur As Nodal Centre For HINI Study

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Carrot intake reduces cancer risk by 10 to 20 per cent, meta-analysis reveals

UK: A recent study published in Critical Reviews in Food Science and Nutrition has revealed a robust association between carrot consumption and reduced cancer risk; the authors recommend encouraging carrot consumption and further investigation of the causal mechanisms in randomized clinical trials.

A meta-analysis of 80 prospective cohort studies showed that carrot intake lowers cancer risk by 10%-20%. Findings apply across a wide range of exposure types, geographical regions, and cancer types.

“Carrot intake across 50 prospective cohorts with 52,000 cancer cases revealed a relative risk reduction of 10% (relative risk, 0.90) compared to controls,” reported Charles C Ojobor, Newcastle University, Newcastle upon Tyne, UK, and colleagues reported.

Carrots are the main dietary source of potential anti-cancer compounds, including polyacetylenes, while β-carotene showed no benefits in controlled cancer trials.

The meta-analysis was performed to quantify the association between carrot intake and cancer incidence across all types of cancer focusing on high-quality (prospective) data. Secondarily, the researchers sought to estimate dose dependency, to facilitate the development of quantitative recommendations, and also to allow comparison of separate datasets to assess the robustness of the outcomes.

Specifically, the analysis aimed to ‘provide evidence for a dose–response relationship and for consistency of the association across studies’, as required by the European Food Safety Authority (EFSA) as one prerequisite for a health claim for carrot consumption to lower the cancer risk.

For this purpose, the researchers performed a meta-analysis of 50 prospective cohort studies capturing a wide variety of cancer types (colorectal, breast, prostate, lung, and other types), geographic regions (Asia, Europe, USA, other regions), and exposure types (alpha-carotene intake by plasma level and carrot intake from Food Frequency Questionnaire).

The intake of beta-carotene (another compound in carrots) was not evaluated because previous randomized clinical trials showed limited benefits in cancer reduction.

The researchers reported the following key findings:

  • Compared to controls, carrot intake across 50 prospective cohorts with 52,000 cancer cases finds a relative risk reduction of 10% (relative risk, 0.90).
  • Alpha-carotene (another compound found in carrots) plasma levels evaluated in 30 prospective cohorts with 9331 cancer cases found a relative risk reduction of 20% (relative risk, 0.80).
  • Studies of both types of exposure (carrots and alpha-carotene plasma levels) showed a significant linear dose-response relationship whereby one serving per week lowers risk by 4±2% and five servings per week lowers risk by 20±10%.

“These results provide enhanced support for cost-effective and safe public health recommendations and interventions to increase carrot intake, as part of the overall consumption of vegetables and fruits, to reduce the risk of cancer and other diet-related diseases,” the researchers wrote.

“The results also underscore the need to determine the roles of a wider range of vegetable phytochemicals, specifically isocoumarins and polyacetylenes, in pre-clinical studies regarding cancer-related effects,” they concluded.

Reference:

Ojobor CC, O’Brien GM, Siervo M, Ogbonnaya C, Brandt K. Carrot intake is consistently negatively associated with cancer incidence: A systematic review and meta-analysis of prospective observational studies. Crit Rev Food Sci Nutr. 2023 Dec 17:1-13. doi: 10.1080/10408398.2023.2287176. Epub ahead of print. PMID: 38104588.

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Tirzepatide significantly lowers albuminuria across all administered doses in patients with type 2 diabetes: Study

Greece: Tirzepatide, across all administered doses, probably leads to a significant reduction in albuminuria, while its use is linked with a neutral effect on creatinine clearance as a measure of kidney function, a recent systematic review and multilevel meta-analysis has suggested. The findings were published online in the Diabetes, Obesity and Metabolism on December 20, 2023.

“In patients with type 2 diabetes mellitus (T2DM), tirzepatide showed a significant and dose-dependent reduction in urine albumin-to-creatinine ratio,” the researchers reported.

“The reduction in albuminuria was consistent across all doses (15, 10, and 5 mg), highlighting a dose-response relationship.”

The researchers showed a neutral effect on the estimated glomerular filtration rate (eGFR), indicating no adverse impact on renal function.

Paschalis Karakasis, Aristotle University of Thessaloniki, General Hospital “Hippokration”, Thessaloniki, Greece, and colleagues aimed to summarize the available evidence from published randomized controlled trials (RCTs) regarding the effect of tirzepatide on renal function and albuminuria levels in patients with type 2 diabetes in a systematic review.

For this purpose, the researchers searched the online databases until 20 October 2023. They performed double-independent study selection, data extraction and quality assessment. Evidence pooling was done with a three-level mixed-effects meta-analysis. The analysis included 9533 participants from eight RCTs.

The researchers reported the following findings:

  • All RCTs had a low risk of bias, according to the Cochrane Collaboration tool (RoB2).
  • Tirzepatide was associated with a significantly greater reduction in urine albumin-to-creatinine ratio compared with controls [mean difference (MD) −26.9%; level of evidence (LoE) moderate]. This effect remained significant in participants with baseline urine albumin-to-creatinine ratio ≥30 mg/g [MD −41.42%; LoE moderate].
  • Based on subgroup analysis, the comparative effect of tirzepatide was significant against placebo and the insulin regimen, whereas no difference was observed compared with semaglutide.
  • The beneficial effect of tirzepatide on albuminuria levels remained significant across all investigated doses (5, 10 and 15 mg), showing a dose-response relationship.
  • A neutral effect was observed on the estimated glomerular filtration rate [MD 0.39 ml/min/1.73m2; LoE moderate].

“Our results suggest that tirzepatide probably leads to a significant reduction in albuminuria across all administered doses, while its use is associated with a neutral effect on creatinine clearance as a measure of kidney function,” the researchers concluded.

Reference:

Karakasis P, Patoulias D, Fragakis N, Klisic A, Rizzo M. Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta-analysis. Diabetes Obes Metab. 2023 Dec 20. doi: 10.1111/dom.15410. Epub ahead of print. PMID: 38116693.

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Computer-assisted implant surgery crucial tool in zygomatic implant placement

Computer-assisted implant surgery crucial tool in zygomatic implant placement suggests a new study published in Journal of Prosthetic Dentistry.

Digital technology can improve the success of zygomatic implant (ZI) surgery. However, the reliability and efficacy of computer-assisted zygomatic implant surgery (CAZIS) need further analysis.

The purpose of this scoping review was to provide an overview of the placement accuracy, implant survival, and complications of CAZIS.

A systematic search of English and Mandarin Chinese publications up to May 2023 was conducted in PubMed, Web of Science, Embase, and Wanfang database. The nonpeer-reviewed literature was searched in the trial register (clinicaltrials.gov). Clinical studies and cadaver studies on CAZIS were included. After data extraction and collection, the findings were critically reviewed, analyzed, interpreted, and discussed.

Results

Forty-one studies met the inclusion criteria. After excluding publications with duplicate data, retaining the most recent, 28 articles were included in this scoping review. Of these, 18 were on static computer-assisted zygomatic implant surgery (sCAZIS), 8 on dynamic computer-assisted zygomatic implant surgery (dCAZIS), and 2 on robot-assisted zygomatic implant surgery (rAZIS). Excluding the outliers, the mean deviations of ZIs in the sCAZIS group (with 8 articles reporting implant placement accuracy, 183 ZIs involved) were: 1.15 ±1.37 mm (coronal deviation), 2.29 ±1.95 mm (apical deviation), and 3.32 ±3.36 degrees (angular deviation). The mean deviations of dCAZIS (3 articles, 251 ZIs) were: 1.60 ±0.74 mm (coronal), 2.27 ±1.05 mm (apical), and 2.89 ±1.69 degrees (angular). The mean deviations of rAZIS (2 articles, 5 ZIs) were: 0.82 ±0.21 mm (coronal), 1.25 ±0.52 mm (apical), and 1.46 ±0.35 degrees (angular). Among the CAZIS reported in the literature, the implant survival rate was high (96.3% for sCAZIS, 98.2% for dCAZIS, and 100% for rAZIS, specified in 14 of 21 clinical studies). The incidence of complications was low, but, because of the few relevant studies (4/21 specified), valid conclusions regarding complications could not be drawn.

CAZIS has demonstrated clinical efficacy with high implant survival rates and placement accuracy. Of the 3 guided approaches, rAZIS showed the smallest 3-dimensional deviation

Reference:

Clinical efficacy of computer-assisted zygomatic implant surgery: A systematic scoping review. Wenying Wang, Xinbo Yu, Feng Wang, Yiqun Wu. Published:November 24, 2023DOI:https://doi.org/10.1016/j.prosdent.2023.10.032

Keywords:

Computer-assisted, implant, surgery, crucial, tool, zygomatic, implant placement, Journal of Prosthetic Dentistry, Wenying Wang, Xinbo Yu, Feng Wang, Yiqun Wu

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Firework Bans linked to Lower Ocular Trauma finds JAMA Study

In a recent case-control study explored the connection between local legislation on fireworks and the occurrence of vision-threatening injuries. The findings  of this study were published in the Journal of American Medical Association revealed important details about the impact of firework bans on ocular trauma during the Independence Day holiday.

Fireworks are known for their dazzling displays, but the accompanying risks to eye health have been a cause for concern. The study mainly aimed to evaluate the odds of firework-related ocular trauma in areas where fireworks are either permitted or banned.

This analysis was conducted at a level 1 trauma center in Seattle which spanned over eight years from 2016 to 2022. The case-control study involved 230 patients presenting with ocular trauma, with 94 who sustained firework-related injuries. The odds of such injuries were found to be significantly higher among residents in areas where fireworks were legally permitted compared to those living in areas where they were banned (OR, 2.0 [95% CI, 1.2-3.5]; P = .01).

The study also underscored the higher odds of patients under 18 years (OR, 3.1 [95% CI, 1.7-5.8]; P < .001) and male patients (OR, 3.3 [95% CI, 1.5-7.1]; P = .004). Also, firework injuries were more likely to be vision-threatening (57%) compared to non–firework-related injuries (40%) (OR, 2.1 [95% CI, 1.2-3.5]; P = .01).

The study highlights that residents in areas where fireworks are banned may experience a slightly lower risk of firework-related ocular trauma. While the findings imply that local firework bans could contribute to a modest reduction in these injuries, the study team emphasize the need for further studies to identify more effective measures that could help in minimizing the risks associated with fireworks.

Reference:

Harrison, L., Yee, P., Sundararajan, M., Ding, L., & Feng, S. (2023). Local Firework Restrictions and Ocular Trauma. In JAMA Ophthalmology. American Medical Association (AMA). https://doi.org/10.1001/jamaophthalmol.2023.5698

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Miniscrew sliding mechanics tied to changes in dimensions of upper dentition

Miniscrew sliding mechanics during space closure tied to changes in both sagittal and vertical dimensions of upper dentition suggests a new study published in the Head & Face Medicine.

This study aimed to investigate vertical changes in the maxillary central incisor and the maxillary first molar, along with alterations in the mandibular plane angle during space closure using miniscrew sliding mechanics.

Twenty adult patients treated at Peking University Hospital of Stomatology between 2008 and 2013 were included. Digital dental models and craniofacial cone-beam computed tomography (CBCT) scans were obtained at the start of treatment (T0) and immediately after space closure (T1). Stable miniscrews were used for superimposing maxillary digital dental models (T0 and T1), and vertical changes in the maxillary first molar and the maxillary central incisor were measured. Three-dimensional changes in the mandibular plane were assessed through CBCT superimposition.

Results

The maxillary central incisor exhibited an average extrusion of 2.56 ± 0.18 mm, while the maxillary first molar showed an average intrusion of 1.25 ± 1.11 mm with a distal movement of 0.97 ± 0.99 mm. Additionally, the mandibular plane angle decreased by an average of 0.83 ± 1.65°. All three indices exhibited statistically significant differences.

During space closure using the miniscrew sliding technique, significant changes occurred in both the sagittal and vertical dimensions of the upper dentition. This included extrusion of the maxillary central incisors, intrusion of the maxillary first molars, and a slight counterclockwise rotation of the mandibular plane.

Reference:

Su, H., Zhuang, Z., Han, B. et al. Vertical changes in the hard tissues after space closure by miniscrew sliding mechanics: a three-dimensional modality analysis. Head Face Med 19, 52 (2023). https://doi.org/10.1186/s13005-023-00388-9

Keywords:

Miniscrew, sliding, mechanics, during, space, closure, tied, changes, both, sagittal, vertical, dimensions, upper dentition, Su, H., Zhuang, Z., Han, B, Head & Face Medicine

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E-cigarette use during late pregnancy not tied to increased risk of SGA birth among adolescents

A recent cohort study delving into the prevalence and impact of e-cigarette and cigarette use among pregnant adolescents in the United States has unearthed significant trends and potential implications for birth outcomes. Examining data from 2016 to 2021, the study, based on the Pregnancy Risk Assessment Monitoring System, scrutinised the habits and subsequent risks associated with these tobacco products.

This study was published in JAMA Network Open by Xiaozhong Wen and colleagues.The study encompassed a cohort of 10,428 pregnant adolescents between the ages of 10 to 19 years, each having comprehensive data available regarding their usage of e-cigarettes or cigarettes, along with the occurrences of small-for-gestational-age (SGA) births. The exposure under scrutiny centred on the self-reported use of e-cigarettes and cigarettes by adolescents during the last trimester of their pregnancies.

  • Prevalence Shifts:

Exclusive E-cigarette Use: Increased from 0.8% in 2016 to 4.1% in 2021.

Exclusive Cigarette Use: Decreased from 9.2% in 2017 to 3.2% in 2021.

Dual Use: Fluctuated between 0.6% and 1.6%.

  • Sociodemographic Differences:

Ethnic Disparities: White pregnant adolescents had higher e-cigarette use rates compared to other racial groups.

Increasing Use: Particularly noticeable among adolescents of White ethnicity.

  • Association with SGA Birth:

E-cigarette Use: No significant increase in the risk of SGA birth.

Cigarette Use: Showed a more than 2-fold higher risk of SGA birth compared to non-users.

Dual Use: Also associated with a higher risk, but not statistically significant.

The study implies a notable surge in e-cigarette use among pregnant adolescents, particularly among those identifying as White. While cigarette use demonstrated a clear association with increased risk of SGA birth, e-cigarette use during late pregnancy did not show a statistically significant correlation. However, the uncertainty surrounding this non-significant association suggests the need for further comprehensive research with larger sample sizes.

Reference:

Wen, X., Liu, L., Moe, A. A., Ormond, I. K., Shuren, C. C., Scott, I. N., Ozga, J. E., Stanton, C. A., Ruybal, A. L., Hart, J. L., Goniewicz, M. L., Lee, D., & Vargees, C. Use of E-cigarettes and cigarettes during late pregnancy among adolescents. JAMA Network Open, 6(12), e2347407. https://doi.org/10.1001/jamanetworkopen.2023.47407 

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Microbiome Changes Linked to Kidney Stone Formation

A recent study by Lawson Health Research Institute and Western University, published in the journal Microbiome, has unveiled a significant link between alterations in the microbiome across various body sites and the development of kidney stones.

Researchers investigated the gut, urinary, and salivary microbiomes in 83 individuals who had experienced kidney stones, comparing them with 30 healthy controls. The findings revealed distinct changes in all three microbiomes associated with kidney stone formation.

Dr. Jeremy Burton, Lawson Scientist and Research Chair of Human Microbiome and Probiotics at St. Joseph’s Health Care London, emphasized the increasing prevalence of kidney stone disease, affecting roughly 10% of the population. Dr. Burton highlighted the study’s intent to advance understanding and potential treatments by exploring connections between kidney stones and various microbiomes beyond the gut.

The study involved participants who had formed kidney stones, hadn’t been exposed to antibiotics in the last 90 days, and were undergoing surgical stone removal at St. Joseph’s.

Dr. Kait Al, the study’s lead author and Postdoctoral Research Fellow at Western’s Schulich School of Medicine & Dentistry, explained the employed testing method, shotgun metagenomic sequencing, enabling the identification of bacteria present in the gut along with their genetic functionalities. Simpler sequencing methods were applied to oral and urinary samples.

Historically, it was believed that specific gut microbes, such as Oxalobacter formigenes, played a role in reducing kidney stone formation by breaking down oxalate, a key component in stone formation. However, this study suggests a more intricate relationship between the microbiome and kidney stones, beyond the scope of previously identified factors.

Dr. Al emphasized the complexity of the situation, indicating that in individuals with kidney stones, the microbial network appeared disrupted, resulting in decreased production of essential vitamins and metabolites, not only in the gut but also in the urinary tract and oral cavity.

The research also uncovered evidence linking kidney stone formation to increased exposure to antimicrobials, revealing higher instances of antibiotic-resistant genes among those affected.

Dr. Burton, also an Associate Professor in the Department of Microbiology and Immunology at Schulich Medicine & Dentistry, highlighted the study’s revelation of an unhealthy microbiome among kidney stone patients, potentially impacting kidney health due to increased toxin excretion from the gut.

While more research is required, these initial findings emphasize the paramount importance of maintaining a healthy microbiome. Encouraging a microbiome-friendly diet and minimizing antibiotic use may play a role in averting kidney stone development, according to the research team.

Reference:

Al, K. F., Joris, B. R., Daisley, B. A., Chmiel, J. A., Bjazevic, J., Reid, G., Gloor, G. B., Denstedt, J. D., Razvi, H., & Burton, J. P. Multi-site microbiota alteration is a hallmark of kidney stone formation. Microbiome,2023;11(1). https://doi.org/10.1186/s40168-023-01703-x

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Trends in abdominoplasty: More outpatient surgery and concomitant liposuction

Researchers have found in a new research that Abdominoplasty continues to be a safe and effective procedure, with more cases performed on an outpatient basis and increased use of concomitant liposuction.

The new 16-year analysis has been published in  Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). 

“Taking advantage of quality-improvement data submitted by US Board-certified plastic surgeons, our study provides new insight on the evolution of the abdominoplasty technique,” comments lead author Michael J. Stein, MD, MAS, FRCSC, FACS of Lenox Hill Hospital, New York, N.Y.

Shifts in ‘tummy tuck’ techniques and outcomes from 2005 to 2021

Abdominoplasty – sometimes called “tummy tuck” – is a cosmetic surgical procedure to improve the appearance of the abdomen. In 2022, ASPS Member Surgeons performed nearly 162,000 abdominoplasty procedures, according to ASPS statistics.

To assess the evolution of practice patterns and surgical techniques, Dr. Stein and colleagues analyzed data from the Continuous Certification process of the American Board of Plastic Surgery (ABPS). In that process, plastic surgeons submit information on specific “tracer procedures” as evidence of ongoing improvement in clinical practice.

The researchers analyzed data on 8,990 abdominoplasty cases submitted by 390 ABPS-certified plastic surgeons between 2005 and 2021. To assess trends over time, cases were divided into early (2005-14) and recent (2015-21) cohorts.

The study period saw an increased rate of outpatient abdominoplasty, without an overnight hospital stay, from 77% to 81%; and increased use of heparin to prevent blood clot-related complications. Patients treated in more recent years were more likely to undergo multiple surgical procedures, particularly liposuction to reduce fat in the abdominal tissue flap.

‘Abdominoplasty remains a safe and reliable procedure’

Other technical changes included decreased use of wide tissue undermining, vertical plication of the abdomen, and postoperative of surgical drains – although all these techniques continued to be used in most abdominoplasty cases. The researchers note that while the observed changes are statistically significant, they are “best appreciated as positive or negative practice trends between cohorts, rather than clinically significant changes in practice.”

“Abdominoplasty remains a safe and reliable procedure over the study period, with a slight but statistically significant decrease in adverse events in the recent cohort,” Dr. Stein and coauthors conclude. “Careful pre-operative evaluation of patients should identify risk factors that increase the risk of complications.”

Senior author and past ASPS President Dr. Alan Matarasso of Manhattan Eye, Ear and Throat Hospital has contributed to similar reviews using ABPS Continuous Certification data for other “tracer” procedures-most recently including a report on trends in cosmetic breast augmentation. Fellow authors include Drs. Arun Gosain and Peter Rubin.

Dr. Matarasso comments: “While not without potential sources of bias, the use of ABPS Continuous Certification data – with mandatory reporting of large numbers of common procedures by Board-certified plastic surgeons-provides unique insights into trends in surgical practice and benchmarks to inform further safety and quality improvement efforts.” 

Reference:

Stein, Michael J. MD, MAS1; Weissman, Joshua P. BBA2; Harrast, John MS3; Rubin, J. Peter MD4; Gosain, Arun K. MD2,5; Matarasso, Alan MD1. Clinical Practice Patterns in Abdominoplasty: 16-Year Analysis of Continuous Certification Data from the American Board of Plastic Surgery. Plastic and Reconstructive Surgery 153(1):p 66-74, January 2024. | DOI: 10.1097/PRS.0000000000010500.

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Low eosinophil counts may predict infection among critically ill patients: Study

France: A prospective study in hospitalized older adults published in BMC Geriatrics has shed light on the association between low eosinophil count and acute bacterial infection.

In the prospective monocentric study, a low eosinophil count was independently associated with diagnosing acute bacterial infection in 156 older inpatients in geriatric departments.

“Our study shows an independent association of low eosinophil count with acute bacterial infection among hospitalized older adults: OR 3.03 for eosinophil count 0–0.07 G/L compared to eosinophil count > 0.172 G/L,” Edouard Baudouin and colleagues from France reported in their study.

“Eosinophil count < 0.01 G/L had better specificity (84%) than CIBLE score > 87, eosinophil/neutrophil ratio, eosinophil count < 0.04 G/L, and C reactive protein (CRP) 72%, 74%78% and 49% respectively.”

There is a significant increase in the incidence of sepsis with age, including a high incidence of bacterial infection in older adults. The CIBLE score and eosinopenia have been proposed in critically ill adults and internal medicine wards. The research team aimed to assess whether a low eosinophil count was associated with acute bacterial infection among hospitalized older adults. They also determined the most efficient eosinophil count cut-off to differentiate acute bacterial infection from other inflammatory states.

For this purpose, they performed a prospective study from July 2020 to July 2022 in geriatric wards of the University Paul Brousse Hospital in Villejuif, France, including patients (aged 75 years or older), suffering from biological inflammation or fever. Acute bacterial infection was evaluated using biological identification and/or radiological and clinical data.

The study led to the following findings:

· Of 156 included patients, Eighty-two (53%) patients suffered from acute bacterial infection (mean age 88.7).

· Low eosinophil count was independently associated with acute bacterial infection: OR 3.03 and 6.08 for eosinophil count 0–0.07 G/L and 0.07–0.172 G/L respectively (vs. eosinophil count > 0.172 G/L).

· Specificity and sensitivity for eosinophil count < 0.01 G/L and CIBLE score were 84%-49% and 72%-62%, respectively with equivalent AUCs.

The findings showed that eosinophil < 0.01 G/L is a routinely used, simple and inexpensive tool that can easily participate in the medical decision to postpone antibiotic treatment.

The researchers, however, cautioned that “This result is not intended to be used as diagnosis tool nor to replace gold standard.”

“However, compared to the CIBLE score or other scores that need specific calculation tools, this is a daily routine exam and may be used to avoid iatrogenic effects and overprescription in this population,” they added.

“There is a need for further studies to assess the clinical benefits in a larger population,” they concluded.

Reference:

Mésinèle, L., Pujol, T., Brunetti, N. et al. Association between low eosinophil count and acute bacterial infection, a prospective study in hospitalized older adults. BMC Geriatr 23, 852 (2023). https://doi.org/10.1186/s12877-023-04581-y

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