Explosion at Hi-Tech Medical College Hospital, 3 employees injured

Bhubaneswar: In an unfortunate incident, at least three employees of the Hi-Tech Medical College and Hospital here were injured in an explosion while filling gas in an outdoor Air conditioner on Friday.

Hospital sources said all of them sustained minor injuries and were undergoing treatment in the hospital. They were out of danger.

Also Read:Explosion at Markandeya Sahakari Hospital oxygen plant in Solapur, 1 dead

The hospital authorities denied about any fire incident.

As per a media report in Odisha TV, “There was no oxygen cylinder blast in the hospital. The explosion took place during AC gas filling. Three to four persons sustained minor injuries in the mishap and they are currently under treatment in the hospital,” Hi-Tech hospital PRO told OTV.

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UP: Medical colleges instructed to install solar plants

Lucknow: The medical colleges in Uttar Pradesh will produce additional electricity through solar plants.

UP Deputy Chief Minister Brajesh Pathak, who also holds the health portfolio, said: “Principals of medical colleges have been instructed to install solar plants on campuses. This will help in obtaining uninterrupted power supply.”

Also Read:Odisha: Govt to set up solar rooftop plants at 32 District headquarters hospitals,7 Medical colleges

The state has 35 medical institutions in the government sector, including King George’s Medical University, Lohia Institute, and Meerut Medical College, which generate electricity using solar plants.

Pathak said that if all colleges generate excess electricity, they can enter into a contract with the Uttar Pradesh New and Renewable Energy Development Agency (UPNEDA) for the sale of excess electricity.

“Generating solar power will also contribute to improving patient care through uninterrupted power supply,” added Pathak.

He also mentioned plans to upgrade the modular operating theatre at King George’s Medical University, and the Cardiology Institute at GSVM Memorial Medical College in Kanpur is set to initiate a DNB course in vascular surgery.

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Roche enters into agreement to acquire LumiraDx Point of Care technology combining multiple diagnostic modalities on single platform

Basel: Roche has announced the entry into a definitive agreement to acquire select parts of the LumiraDx group related to LumiraDx’s innovative Point of Care technology. Following closing of the transaction, which is expected by mid-2024, the acquired entities will be fully integrated into Roche Diagnostics.

“The addition of the LumiraDx technology to our diagnostics portfolio will enable us to transform testing at the point of care.” said Matt Sause, CEO Roche Diagnostics. “LumiraDx has developed a highly versatile platform that delivers strong performance across multiple disease areas and technologies. We believe this will enable better patient access to timely results in decentralised healthcare settings worldwide.”

Veronique Ameye, Chief Executive Officer of LumiraDx added, “Since our founding, we have sought to transform community-based healthcare by consolidating multiple Point of Care tests on a single instrument. We are thrilled that Roche will continue this important work and increase its reach around the globe. This will enable more patients to get fast and easy access to better diagnostic testing.”

The acquired technology platform offers a wide range of immunoassay and clinical chemistry tests, with great potential for additional high medical value tests in the future. These are capable of being stored at room temperature which enables convenient handling in a range of decentralised healthcare settings. 

The transaction is subject to certain conditions including antitrust and regulatory approvals.

Under the terms of the agreement, at the closing of the transaction Roche will pay a purchase price of USD 295 million (subject to customary closing adjustments) and an additional payment of up to USD 55 million for the reimbursement of amounts to fund the Point of Care technology platform business until the closing of this acquisition. The transaction is part of a pre-packaged UK administration sale, with the full support of LumiraDx group’s senior secured lender.

Read also: Roche Xolair gets USFDA priority review for children, adults with food allergies

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COVID-19 JN.1 Variant: Safdurjung hospital reserves 50 isolation beds, 9 ICU beds

New Delhi: Amid the rise in COVID-19 cases due to the JN.1 sub-variant in various states, after AIIMS, Safdarjung Hospital in the national capital has also reserved beds for patients and made other arrangements including oxygen and testing. 

The hospital administration has reserved 50 beds for isolations, and 9 ICU beds. Apart from this, complete arrangements have also been made in the hospital regarding oxygen, PPE kits, and COVID testing.

Senior pulmonologist and former Safdarjung Hospital HOD, Dr Neeraj Gupta, said, “JN.1 is a variant of Omicron. It is a very mild virus. The only advantage this virus has because of this mutation is that it crosses our immune barriers and is able to infect us with a normal infection. Like any viral infection, this is also mild; it is not of a very severe nature, and we are not expecting any admissions or higher admission rates.” 

Also Read:COVID subvariant JN.1: AIIMS Delhi advises not to panic, need to remain alert

He further said that normally, patients with comorbidities or any severe condition that decreases the immune system are going to have more morbidity, which may lead to mortality.

“We had one patient of Covid, which was rapid antigen positive when the patient got admitted, and now the patient is negative, so we don’t really know whether it’s genuine or not, but we are testing all the patients who are suspected of Covid-like symptoms, and still now we have not detected any,” Dr Gupta said.

He said they have not detected any positive case till now, but are ready with all the kits, and have all the arrangements for treatment of any COVID patients, including isolation beds.

“We have about 50 beds for isolation and 9 ICU beds, which are ready for all the deployments. There are also adequate PPE kits or medicines available, including oxygen. And if any eventuality comes in, we are ready for it but I do not really anticipate any such rush because, in time, Omicron also did not get so many admissions,” he added.

He further said, “I will want people to beware. Take all the precautions, including avoiding any exposure to excessive cold. Try to remain healthy and exercise when the Sun comes out. Take a nutritious diet and exercise all Covid-appropriate behaviour, like wearing masks in public, and this will also prevent them from many pollution-related issues.”

Meanwhile, Delhi’s Health Minister, Saurabh Bharadwaj, visited Lok Nayak Jai Prakash Narayan Hospital on Thursday to assess the preparedness. The hospital has reserved 20 beds for COVID-19 patients, but there hasn’t been a confirmed case in the hospital yet.

Separate help desks have been set up for COVID-19 patients, along with a dedicated testing centre in the hospital. Immediate treatment will be given upon confirmation of Covid. Directives have been issued to maintain readiness in all Delhi government hospitals. The Delhi Health Minister is continuously monitoring the situation.

“Currently, the entire ward is empty as there have not been any confirmed case of a COVID patient in the hospital yet. However, continuous screening of patients with COVID-related symptoms is ongoing. As soon as any COVID-related patient is confirmed, they will be immediately admitted, and treatment will commence. Almost all preparations in the hospital have been completed, and further preparations will be made as per the evolving situation,” said Saurabh Bharadwaj.

The Health Minister, during this briefing, mentioned that directives have been issued to all hospitals under the Delhi government to maintain all preparations for dealing with COVID-19.

“Although there isn’t any situation causing panic in Delhi presently, it doesn’t mean that hospital administrations should be lax. All hospitals must remain prepared to deal with COVID,” he added.

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High Frequency of Adding Salt to Food increases Risk of Incident CKD

In a groundbreaking study researchers from the U.S.A reported the effect of adding salt to foods on chronic kidney disease. They found that increased addition of salt to foods, reported by self, lead to an increased risk of chronic kidney disease in general population.

The study results were published in the journal JAMA Network Open.

The frequency with which individuals report adding salt to their food may indicate their enduring preference for salty tastes. High salt intake has been linked to a heightened risk of cardiovascular diseases (CVD). However, it is currently unclear whether self-reported salt addition to foods correlates with an elevated risk of chronic kidney disease (CKD). Hence researchers from New Orleans and Boston conducted a cohort study to prospectively examine the association of self-reported frequency of adding salt to foods with incident CKD risk in a general population of adults.

This cohort study, based on a population from the UK Biobank, focused on individuals aged 37 to 73 years who did not have CKD when the study began. Recruitment took place between 2006 and 2010, with participants then monitored over time for disease development. Participants’ self-reported habits of adding salt to their food were classified as never/rarely, sometimes, usually, or always. The main outcome was incident CKD occurrences identified using specific diagnostic codes. Hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were computed using Cox proportional hazards models. These models took into account various potential variables, including age, gender, racial background, ethnicity, the Townsend Deprivation Index, baseline factors like eGFR, BMI, smoking habits, alcohol consumption, regular exercise, high cholesterol levels, diabetes, history of CVD, hypertension, infectious and immune-related diseases, as well as the use of nephrotoxic medications at the study’s onset.

Findings:

  • In a cohort comprising 465,288 individuals with average [SD] age of 56.32 [8.08] years; 255,102 females [54.83%] and 210,186 males [45.17%]), those who frequently added salt to their foods tended to have a higher BMI, a greater Townsend Deprivation Index score, and a lower baseline eGFR than those who added salt less often.
  • Furthermore, individuals who regularly added salt were more inclined to be current smokers and to have diabetes or CVD at the study’s outset compared to their counterparts who seldom added salt.
  • Over a median (IQR) tracking period of 11.8 (1.4) years, 22,031 CKD incidents were recorded.
  • After accounting for various factors, a greater self-reported salt addition frequency was notably linked to an elevated CKD risk.
  • Specifically, compared to those seldom or never adding salt, the risk was higher for those who sometimes added salt (adjusted HR [aHR], 1.04; 95% CI, 1.00-1.07), usually added salt (aHR, 1.07; 95% CI, 1.02-1.11), and always added salt (aHR, 1.11; 95% CI, 1.05-1.18) to their food (P for trend < .001).
  • Moreover, factors like eGFR, BMI, and physical activity levels influenced these associations, with more significant effects seen in participants with higher eGFR, lower BMI, or reduced physical activity. 
    Thus, the present study summarized that an increased self-reported habit of adding salt to foods correlates with an elevated risk of CKD. These results advocate for minimizing salt addition to foods as a potential approach to prevent CKD. Further post hoc analyses or subsequent studies in clinical settings are essential to confirm these observations.
    Further reading: Tang R, Kou M, Wang X, et al. Self-Reported Frequency of Adding Salt to Food and Risk of Incident Chronic Kidney Disease. JAMA Netw Open. 2023;6(12):e2349930. doi:10.1001/jamanetworkopen.2023.49930

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    Delhi Health Minister visits LNJP Hospital, takes stock of Covid preparedness

    New Delhi: Delhi Health Minister Saurabh Bharadwaj visited the LNJP Hospital on Thursday to take stock of its preparedness for COVID-19 and asserted that the facility is fully geared to deal with any exigencies. 

    Bharadwaj told PTI Video that arrangements for conducting RT-PCR tests have been made outside the hospital and there is modern equipment at the health facility. He said no Covid patient is admitted in the hospital at present.

    Also Read:COVID JN.1 Surge: Lady Hardinge Hospital reserves 48 beds for patients

    “Following the oxygen shortage that was seen during the Covid wave in Delhi and across the country, the hospital now has piped oxygen supply through a centralised system,” he said.

    Asked if the Delhi government is planning to reserve any beds for Covid patients, the minister said only four people are currently hospitalised with the infection in the city.

    “If you reserve beds, where will those patients who have surgeries planned or have suffered from strokes or heart attacks go? We are monitoring the situation and, if need be, will reserve beds. There are only four patients who have been hospitalised,” he said.

    Later in a statement, he said a separate ward has been set up at LNJP Hospital for Covid patients with approximately 20 beds and all necessary facilities arranged to address issues related to the viral disease.

    “Currently, the entire ward is empty as there hasn’t been any confirmed case of a Covid patient in the hospital yet. However, continuous screening of patients with Covid-related symptoms is ongoing,” Bharadwaj said.

    “As soon as any Covid-related patient is confirmed, they will be immediately admitted and treatment will commence. Almost all preparations in the hospital have been completed and further preparations will be made, as per the evolving situation,” he added.

    Delhi on Wednesday reported its first case of COVID-19 sub-variant JN.1. The 52-year-old female patient was vaccinated against the virus.

    The patient has now recovered and returned home, Bharadwaj said, adding that although this variant is considered less dangerous than the previous ones, “it’s crucial not to be negligent”.

    “Vaccination was for the old variants (of the virus). The new variants have bypassed vaccines. But the latest variant is causing a mild disease. People should understand that this is a new variant,” Bharadwaj said.

    The health minister mentioned that directives have been issued to all hospitals under the Delhi government to maintain preparations for dealing with COVID-19.

    “Although there isn’t any alarming situation in Delhi at the moment, as a precautionary measure, instructions have been given to all hospitals to ensure readiness. This is to handle any emergencies more effectively in the future,” he said.

    “We hope that there won’t be any such issues but it’s essential for us to remain vigilant and cautious. In this context, directives have been given to all hospitals to maintain their preparedness,” the minister stated.

    If any negligence is found in any hospital, strict action will be taken against the administration, Bharadwaj said.

    Earlier, LNJP Hospital Medical Director Dr Suresh Kumar said there is no reason to panic.

    “This (JN.1) is a sub-variant of Omicron. The symptoms are mild and rarely do people get a severe infection. However, those who have diabetes, a liver-related disease or are on dialysis should get themselves tested if they show symptoms,” he said.

    “If you are immunocompromised, you should wear a mask while visiting crowded places or hospitals. Opt for a balanced diet, including fruits,” he added.

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    Potassium magnesium citrate bests potassium chloride for Prevention of thiazide induced hyperglycemia

    USA: A recent study published in Hypertension has shown potassium magnesium citrate (KMgCit) to be superior to potassium chloride (KCl) in preventing thiazide diuretic (TD)-induced hyperglycemia in patients with hypertension without diabetes. Potassium chloride is the common form of potassium supplement used in clinical practice.

    Thiazide diuretics are the first-line hypertension treatment because of their consistent benefit in lowering blood pressure (BP) and cardiovascular (CV) risk. TD is also known to cause an excess diabetes risk, which may limit long-term use. Potassium depletion is suggested to be the main mechanism of TD-induced hyperglycemia, TD also triggers, but also triggers magnesium (Mg) depletion.

    There has been no investigation of the role of Mg supplementation in modulating metabolic side effects of TD. Considering this, Wanpen Vongpatanasin, University of Texas Southwestern Medical Center, Dallas, TX, and colleagues aimed to determine the effect of KMgCit on fasting plasma glucose and liver fat by magnetic resonance imaging during thiazide diuretic therapy.

    For this purpose, they conducted a double-blind RCT comprising 60 nondiabetic hypertension patients to compare the effects of KCl versus KMgCit during chlorthalidone treatment. Each patient received chlorthalidone alone for three weeks before randomization. The primary endpoint was the change in fasting plasma glucose following 16 weeks of KMgCit or KCl supplementation from chlorthalidone alone. The mean age of subjects was 59±11 years.

    The study revealed the following findings:

    • Chlorthalidone alone induced a significant rise in fasting plasma glucose, and a significant fall in serum K, serum Mg, and 24-hour urinary citrate excretion.
    • KMgCit attenuated the rise in fasting plasma glucose by 7.9 mg/dL versus KCl, which was not observed with KCl.
    • There were no significant differences in liver fat between the 2 groups.

    “These findings suggest that potassium magnesium citrate may offer a superior alternative to potassium chloride, typically used in clinical practice, in maintaining serum potassium during thiazide-diuretic treatment while avoiding thiazide-induced hyperglycemia,” the researchers wrote.

    ‘This action may improve cardiovascular safety and tolerability in patients with hypertension treated with this drug class,” they concluded.

    Reference:

    Vongpatanasin W, Giacona JM, Pittman D, Murillo A, Khan G, Wang J, Johnson T, Ren J, Moe OW, Pak CCY. Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone. Hypertension. 2023 Dec;80(12):2611-2620. doi: 10.1161/HYPERTENSIONAHA.123.21932. Epub 2023 Oct 17. PMID: 37846572.

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    AI chatbot useful tool for providing nutritional information but cannot replace nutritionists: JAMA

    Taiwan: A recent study published in JAMA Network Open has shed light on the accuracy and consistency of artificial intelligence (AI) in providing nutritional information.

    The researchers found that artificial intelligence can be a convenient and useful tool for people who want to know their foods’ macronutrients and energy information. They, however, specified that AI chatbots cannot replace nutritionists but can provide real-time analysis of foods, and the capacity to harness AI technology in a supportive role may fundamentally transform the communication between nutritionists and patients.

    In a digital world, people are increasingly depending on the internet for nutrition-related and food-related information. A recent report, however, showed that almost half of online, nutrition-related information was of low quality (48.8%) or inaccurate (48.9%). The ability of AI chatbots to streamline the navigation of public information and provide conversational texts to users has transformed electronic health. However, there is no clarity on their ability to handle nutrition-related questions.

    To clarify the same, Yen Nhi Hoang, Taipei Medical University, Taipei, Taiwan, and colleagues investigated the reliability of AI in providing the macronutrient and energy content of 222 food items using different languages (English and Traditional Chinese) as inputs in a cross-sectional study.

    The researchers followed the STROBE reporting guideline and did not need approval from the institutional review board or informed consent because it did not involve human participants following the Common Rule.

    The study aimed to compare the reliability of ChatGPT-3.5 (chatbot 1) and ChatGPT-4 (chatbot 2) in providing information on the macronutrient and calorie content (proteins, fats, and carbohydrates) for eight menus (222 food items) designed for adults. A search was conducted using the following prompt: “As a dietitian, please draw a table to calculate line by line the energy (kcal)/carbohydrates (g)/lipids (g)/proteins (g) of the following food items (raw, not cooked).”

    The consistency of AI responses was determined based on the coefficient variation (CV) for each food item in five repeated measurements. The accuracy of responses was assessed by cross-referencing the AI answers with nutritionists’ recommendations based on the food composition database of the Taiwanese Food and Drug Administration.

    AI response accuracy was determined if answers were within ±10% or ±20% of the ground truth level energy (kilocalories) or macronutrients (grams). Differences in energy (kilocalories) and macronutrients (grams) between AI and nutritionists and between the 2 versions (3.5 and 4) were compared using A Student paired t-test.

    The study led to the following findings:

    • There were no significant differences between nutritionist and AI estimations of energy, carbohydrate, and fat contents of 8 menus designed for adults, but there was a significant difference in protein estimation.
    • Both chatbots provided accurate energy contents for approximately 35% to 48% of the 222 food items within ±10%, with a CV of less than 10%.
    • Chatbot 2 performed better than Chatbot 1, but it overestimated protein.

    “AI chatbots are designed to be probabilistic, however, the findings of this cross-sectional study suggest that AI can be a convenient and useful tool for people who want to know the macronutrient and energy information of their foods,” the researchers wrote.

    Limitations included that the AI had a knowledge cutoff of September 2021, and the tested foods might not represent the most frequently consumed foods. Users need to be aware that AI is not a search engine, and answers provided by AI chatbots can be impacted by input language, chatroom environment, and clarity of the prompt.

    Reference:

    Hoang YN, Chen Y, Ho DKN, et al. Consistency and Accuracy of Artificial Intelligence for Providing Nutritional Information. JAMA Netw Open. 2023;6(12):e2350367. doi:10.1001/jamanetworkopen.2023.50367

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    Pancreatic replacement therapy may improve maladaptive behaviour in preschool children with autism

    USA: Findings from a recent study published in JAMA Network Open have suggested improvement in maladaptive behaviours in preschool children with autism spectrum disorder (ASD), such as agitation or irritability with high-protease pancreatic replacement therapy. 

    “Children who have ASD often have several co-occurring maladaptive behaviours, such as irritability. We wanted to know whether these maladaptive behaviours can be addressed by an intervention with a low risk of side effects,” said Deborah A. Pearson, PhD, professor of psychiatry and behavioral sciences at McGovern Medical School at UTHealth Houston and lead author on this paper. Pearson is also the director of the Developmental Neuropsychology Clinic at UTHealth Houston.

    Pearson said many children with ASD are selective about the foods they eat, often preferring carbohydrates like bread and pasta over protein. Some amino acids necessary for building neurotransmitters such as serotonin and dopamine, which are associated with behavioural and cognitive function, can only be obtained from food through protein digestion.

    A total of 190 children, ages 3-6, participated in the study. In the first double-blind phase of the trial, 92 children were randomized to the active treatment arm and took 900 mg of a microencapsulated high-protease pancreatic porcine enzyme that was sprinkled on their food three times daily. In the other arm, 98 children had a placebo sprinkled on their food for 12 weeks. In the second open-label phase, all of the children received the active medication for 24 weeks.

    According to the 12-week results, parents of children in the active treatment arm reported significant decreases in their child’s symptoms of irritability, hyperactivity/noncompliance, and inappropriate speech, relative to parents of children in the placebo arm. In the second 24-week phase, significant decreases were reported in all of the above behaviours, as well as in lethargy/social withdrawal. No serious adverse events were associated with the treatment.

    “This study demonstrated that pancreatic enzymatic replacement- which is thought to enhance the supply of essential amino acids necessary for the synthesis of neurotransmitters-was associated with improved behavioural function in preschoolers with ASD, with minimal side effects,” Pearson said.

    Reference:

    Pearson DA, Hendren RL, Heil MF, McIntyre WR, Raines SR. Pancreatic Replacement Therapy for Maladaptive Behaviors in Preschool Children With Autism Spectrum Disorder. JAMA Netw Open. 2023;6(11):e2344136. doi:10.1001/jamanetworkopen.2023.44136.

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    Stabilized super-oxidized hypochlorous acid spray may expedite healing in patients undergoing hair restoration surgery

    Hair restoration surgeries have witnessed a transformative breakthrough with the introduction of stabilized, super-oxidized hypochlorous acid (HOCl). This compound, renowned for its potent efficacy against a spectrum of microorganisms, is proving to be a game-changer in both intraoperative and postoperative care for hair transplant procedures.

    The trial results were published in the Journal of Drugs in Dermatology.

    Also Read: Extreme pubic hair removal to cause recurrent urinary tract infections

    Stabilized HOCl is no ordinary solution; it stands out for its remarkable effectiveness against bacteria, fungi, and viruses. Moreover, its application enhances tissue oxygenation, a crucial factor in facilitating optimal wound healing. This makes it an ideal candidate for surgeries involving thousands of small wounds, characteristic of hair restoration procedures. Hence, researchers conducted a trial to assess the perceived efficacy of stabilized, super-oxidized hypochlorous acid (HOCl) in hair transplant surgical procedures intraoperative and postoperative.

    In a multi-site study involving 35 patients undergoing either repeat or initial hair restoration surgery, surgeons integrated a 500 mL trigger spray bottle of HOCl liquid into their surgical protocols. This innovative approach aimed to harness the potential benefits of stabilized HOCl before, during, and after the surgery. Patients were also equipped with a ten-day supply of HOCl for postoperative care, emphasizing its integral role in the entire recovery process.

    Findings:

    The results of this groundbreaking study are nothing short of impressive.

    Statistical analysis revealed a significant 56% reduction in erythema, a common skin redness associated with wound healing when compared to standard wound healing regimens.

    More than half of the patients (54%) experienced a marked improvement in pruritus, the itching sensation often accompanying wound healing.

    Notably, patient compliance reached an outstanding 97%, showcasing the acceptance and ease of incorporating HOCl into their postoperative routines.

    Surgeons, the architects of these transformative procedures, reported an overall efficacy that exceeded expectations.

    Importantly, there were no reported incidents of donor or recipient tissue necrosis, highlighting the safety profile of the HOCl application.

    Also Read: Wheelchair users at higher risk of complications, readmissions after total shoulder arthroplasty

    As the field of hair restoration evolves, with surgeries involving a substantial number of grafts, the demand for optimal intraoperative and postoperative care has intensified. The stabilized hypochlorous spray is emerging as a revolutionary solution for wound cleansing and healing, offering theoretical benefits such as reduced tissue necrosis through enhanced oxygenation. This not only raises the bar for the standard of care in hair transplant procedures but also holds promise for a more comfortable recovery experience for patients. Thus, this innovative approach to hair transplant surgery, harnessing the power of stabilized HOCl, marks a paradigm shift in patient care.

    Further reading: Topical Stabilized Super-Oxidized Hypochlorous Acid for Wound Healing in Hair Restoration Surgery: A Real-Time Usage-Controlled Trial Evaluating Safety, Efficacy, and Tolerability. J Drugs Dermatol. 2023;22(12):1191-1196. doi:10.36849/JDD.7172.

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