Jaslok Hospital unveils groundbreaking results in Parkinson’s disease management

Mumbai: On the eve of World Parkinson’s Day, Jaslok Hospital and Research Centre is proud to announce the unveiling of groundbreaking findings from the World’s First Comprehensive Clinical Trial aimed at slowing the progression of Parkinson’s disease. 

Led by Principal Investigator Dr Paresh Doshi, this landmark trial marks a significant milestone in Parkinson’s care, potentially revolutionizing management approaches and enhancing the quality of life for patients and caregivers worldwide.

Parkinson’s Disease (PD) affects over 10 million people globally, with a particularly high prevalence in Asia, notably in India. The disease significantly impairs motor functions and quality of life due to the degeneration of dopaminergic neurons. Current treatments focus primarily on symptom management, leaving a critical gap in altering the disease’s progression.

Also Read:8-year-old Yemeni boy undergoes rare thyroid cancer surgery at Jaslok Hospital

This pioneering trial explores the potential of transformative approaches such as dance and music therapy, along with mindfulness meditation, in managing PD symptoms and improving overall well-being. The study, conducted at Jaslok Hospital and Research Centre, engaged 28 individuals diagnosed with mild to moderate PD over a duration of six months.

Methodology: After obtaining informed consent from the patient, patients were randomly assigned by a computer-generated algorithm either to a therapy or a control group. The group chosen for therapy was offered either dance or music as their preferred form of therapy option. The philosophy is that people who love music may not like dance, and people who like to dance may prefer dance over music. Both groups of therapy were also given guided meditation by an expert trainer in the field of meditation. Several Parkinson’s Disease related scorings were performed to evaluate the motor function, behaviour, mood, and cognitive functions of these patients before the trial and on the completion of the trial. The control group was also evaluated in the same manner. Both groups continued their usual medical management. A patient diary was maintained to ensure adequate compliance, and patients who could not follow the required schedule were excluded from the trial.

Results:

We assessed two main areas of primary results. The first was the quality of life (measured by Parkinson’s disease Questionnaire-PDQ39), and the second was the gold standard used to determine the impact of any treatment on the progression of Parkinson’s disease (Unified Parkinson’s diseae rating scale – UPDRS). Additionally, we included two other data points to evaluate the impact of this treatment on the caregivers: PDQ-Carer change and Zarit Burden Interview Change.

All these four endpoints showed significant improvement, which was statistically significant, as seen in the below graph.

These results confirm the following:

That any therapy which the patient prefers, i.e. dance or music; along with meditation, has a definitive impact on the progress of the Parkinson’s disease and also on the quality of life of the patient. This also translates into better well-being and improved quality of life for the caretakers. Notably, the benefits observed in this trial extend beyond the intervention period, indicating the potential for long-lasting effects.

The results underscore the importance of exploring alternative therapies in managing PD comprehensively. Future directions include longer-term studies and investigations into diverse populations.

Additional key findings

Besides the above results, there was improvement seen in other areas like mood (Beck depression scale), memory function (MMSE), Balance (TUG and Berg Balance test) and Anxiety (Anxiety scale).

Commenting on this Prof. (Dr.) Paresh Doshi, Prinicipal Investigator of the trial and the Director of Neurosurgery and Stereotactic and Functional Neurosurgical program at Jaslok Hospital and Research Centre says, “These results mark a significant leap forward in Parkinson’s care. Our trial demonstrates the potential of alternative therapies in not just managing symptoms, but in potentially slowing the progression of this debilitating disease. Through innovative approaches like dance and music therapy, we are paving the way for a brighter future for Parkinson’s patients and caregivers worldwide.”

Explaining about the uniqueness of this trial, Dr. Doshi highlights that:

1. This is the first trial to have a blinded randomised evaluation of patients undergoing treatment and not undergoing therapy ever presented or studied in the world.

2. This is the first-ever trial in the world that has evaluated not only Parkinson’s disease but also the caregivers’ burden in the management of Parkinson’s disease through dance and music therapy.

3. This trial laid a lot of emphasis on the quality of life, which was one of the principal trial endpoints which again has been very rarely evaluated for this form of treatment.

4. This level of detailed evaluation of motor disability, mood, behaviour, and cognition has always been performed in surgical interventional trials or medical interventional trials but never in any trials where no intervention accept therapy like dance and music were offered.

“At Jaslok, we are committed to pushing the boundaries of medical research to improve patient outcomes. This groundbreaking trial reaffirms our dedication to innovation and patient-centered care. By harnessing the power of alternative therapies, we are not just treating Parkinson’s disease, but transforming lives. Our mission is to continue leading the way in redefining standards of care and making a tangible difference in the lives of those affected by Parkinson’s.” says Dr Milind Khadke, Director Medical Services at Jaslok Hospital.

As we unveil these remarkable findings on the eve of World Parkinson’s Day, Jaslok Hospital and Research Centre reaffirms its commitment to advancing Parkinson’s care through innovative research and patient-centered approaches.

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NEET 2024 for BDS admissions: Here are Top 10 NIRF-Ranked Dental Colleges In India

New Delhi- The National Eligibility and Entrance Test for Undergraduate Courses, also known as NEET UG, is scheduled to be held on May 5, 2024, from 2:00 pm to 5:20 pm in offline mode. NEET UG is the biggest entrance exam in India so far for admission to MBBS and BDS courses.

Every year lakhs of aspiring students eagerly wait for this examination and seek admission to top-ranked dental colleges in India for BDS courses.

Here is the list of the top 10 medical colleges in India ranked by the National Institutional Ranking Framework (NIRF) with cut-off percentages-

NIRF RANK

NAME OF THE INSTITUTE

STATE

1

Saveetha Institute of Medical and Technical Sciences

Chennai, Tamil Nadu

2

Manipal College of Dental Sciences, Manipal

Manipal, Karnataka

3

Dr. D. Y. Patil Vidyapeeth

Pune, Maharashtra

4

Maulana Azad Institute of Dental Sciences

Delhi, Delhi

5

A.B.Shetty Memorial Institute of Dental Sciences

Mangaluru, Karnataka

6

SRM Dental College

Chennai, Tamil Nadu

7

Sri Ramachandra Institute of Higher Education and Research

Chennai, Tamil Nadu

8

Manipal College of Dental Sciences, Mangalore

Mangalore, Karnataka

9

Siksha `O` Anusandhan

Bhubaneswar, Odisha

10

Jamia Millia Islamia, New Delhi

New Delhi, Delhi

The National Testing Agency (NTA) is going to conduct the NEET UG 2024 exam across the country and in 14 cities across the world and scrapping computerized draw procedure for deciding the rank of joint scorers in the National Eligibility-cum-Entrance Test (NEET) exam, which was introduced earlier this year, the National Testing Agency (NTA) once again opted for its old policy.

The revised Information Bulletin for the NEET-UG 2024 exam, which was uploaded by NTA on its website, specified that NTA will allot ranks to joint scorers based on their performance – the proportion of incorrect and correct answers in Biology, Chemistry and Physics.

When two or more candidates secure the same score in the NEET exam, their ranks are decided in compliance with the tie-breaking policy.

Medical Dialogues had earlier reported that 24 lakh registrations have been done from all over India this year.

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MUHS Invites Applications For MSc Pharmaceutical Medicine, MBA Health Care Administration, MPH courses, all admission details here

Maharashtra- The Maharashtra University of Health Sciences (MUHS) has started the centralised online admission process for Master of Science in Pharmaceutical Medicine, MBA (Health Care Administration) and MPH (Master of Science in Public Health) courses conducted by the University for the academic year 2024-25.

On this, MUHS has released an information brochure detailing the Eligibility, seat intake, list of documents required and important dates of the above-mentioned courses as follows:-

IMPORTANT DATES

1

Date of availability of application form and information Brochure on MUHS website.

Schedule

First Date

Last Date

08/04/2024

20/05/2024

2

Last date for submission of Online forms.

20/05/2024

3

Last date of receipt of hard copy of Online application Forms along with self-attested Photo Copy of necessary documents to the University.

28/05/2024

4

Scrutiny of the applications.

28/05/2024 to 31/05/2024

5

Issue of Admit Card for CET.

04/06/2024

6

Date and Time of CET Test.

09/06/2024 11.00 a.m. to 12.30 p.m.

7

CET Result.

Information will be published from time to time on the University website.

8

Display of the provisional Merit List.

9

Submission of grievance regarding provisional merit list.

10

Display of the final merit list & first-round allotment.

11

Documents verification confirmation of Admission for the First (I) Admission Round at the respective study centre.

12

Reporting to admitted college.

15/07/2024

13

Admission Cut-Off date.

a) MBA(HCA)

b) MPH

c) Master of Science in Pharmaceutical Medicine

(20/08/24).

DOCUMENTS

The details of original documents to be submitted by the candidate at the time of admission along with two sets of self-attested Xerox copies are as follows:

S.NO

LIST OF DOCUMENTS

1

a) Nationality Certificate issued by District Magistrate, Additional District Magistrate, Chief Metropolitan Magistrate

or

b) Photocopy of a Valid Passport duly attested by the Head of the Department

or

c) Domicile Certificate

or

d) Birth Certificate having endorsed with nationality as Indian on it.

2

Common Entrance Test 2024 Mark sheet & online allotment letter of the respective round.

3

Passing/Degree Certificate of qualifying examination.

4

Internship Completion Certificate (If applicable).

5

Caste Certificate (If Applicable).

6

Caste Validity Certificate (If applicable) (requirement as per government regulation from time to time).

7

Income and asset certificates are to be produced by Economically Weaker Sections (EWS).

8

Non-Creamy Layer Certificate valid up to 31/03/2025 for the Categories VJ (A), NT-B, NT-C, NT-D, OBC, SEBC caste (If applicable).

9

College leaving Certificate (LC/TC).

10

Attempt Certificate of all examinations in Degree course from the Head of the Institute (If applicable).

11

Gazette for name change (If applicable).

12

Migration Certificate issued by the respective University (If applicable ).

13

Self-Educational Gap Certificate (after qualifying Degree) Affidavit by student certified by Executive Magistrate/Notary.

(If applicable).

14

Medical Fitness Certificate as per Brochure format.

15

Disability Certificate (If applicable).

16

Self-declaration form for self-attestation.

17

Undertaking regarding registration in voter list.

18

S.S.C. Certificate.

19

H.S.C. Certificate.

20

First to final year mark sheet of qualifying degree.

21

For In-service candidate NOC (No Objection Certificate) from the concerned authority.

ELIGIBILITY CRITERIA

PROGRAM

ELIGIBILITY CRITERIA

DURATION

Master of Science in Pharmaceutical Medicine

a) Pharmacy Graduates.

b) All Health Science Graduates (MBBS/BDS/BAMS/BHMS/BUMS/BPTh/BPO/BOTh/BASLP/PB Sc (Nursing) / B. Sc. Nursing, B.Sc. (Paramedical Technology).

OR

Health Science Degree of any Statutory University.

c) B.Sc. (Life Sciences)- Bio-

Chemistry/Microbiology/Botany/ Zoology Chemistry/ Physiology / Pharmacology/ Biotechnology.

The candidate who has completed their Bachelor of Sciences (B.Sc.) degree from the University in which there is no provision of specialisation in the final year at the undergraduate (UG) level, but has studied at least one subject mentioned above in their curriculum at each of the I, II and III years are eligible for the course.

2 Years

M.B.A. (Health Care Administration)

M.B.A. (HCA)

All Health Science Graduates i.e.

(MBBS/BDS/BAMS/BHMS/BUMS/BPTh/

BPO/BOTh/BASLP/PBBSc (Nursing)/

B.Sc. Nursing) B.Sc. (Paramedical Technology).

OR

Health Science Degree of any Statutory University.

2 Years (Semester Pattern).

M.P.H. (Master of Science in Public Health)

All Health Science Graduates i.e.

(MBBS/BDS/BAMS/BHMS/BUMS/BPTh/

BPO/BOTh/BASLP/PBBSc (Nursing)/

B.Sc. Nursing) B.Sc. (Paramedical Technology).

OR

Health Science Degree of any Statutory University.

2

Years (Yearly Pattern)

SEAT INTAKE

The total vacant seats in the above three courses across the three institutes are 150.

COURSE NAME

Master of Science in Pharmaceutical Medicine

M.B.A. (Health Care Administration)

M.P.H. (Master in Public Health)

LOCATION

Department of PharmaceuticlMedicine, MUHS, Nashik.

School of Health Care Administration,3rd floor, District Hospital, Aundh, Pune.

Department of Public Health, 3rd floor, District Hospital, Aundh, Pune.

INTAKE

60

60

30

To view the information Brochure, click the link below

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Chhattisgarh HC takes suo moto cognizance of closure of Thyroid testing at Bilaspur District Hospital

Raipur: Taking cognizance of the closure of thyroid testing services at the District Hospital in Bilaspur, the Chhattisgarh High Court recently directed the Additional Chief Secretary, Health and Family Welfare Department of Chhattisgarh to submit a personal affidavit detailing the existing facilities at the hospital.  

The Division Bench, led by Chief Justice Ramesh Sinha and Justice Rajani Dubey, has taken suo moto cognizance of the issue through a Public Interest Litigation (PIL). 

This issue was taken to court after the crucial thyroid testing service at the hospital remained unutilised for the past three months. The suspension of the facility due to a shortage of reagents has adversely affected patients, particularly pregnant women and those relying on the hospital’s Outpatient Department (OPD) and inpatient services. 

Also Read- Telangana High Court Takes Suo Moto Cognizance Of Rotten Dead Bodies At Gandhi Hospital Morgue

Despite several appeals being made to the Chhattisgarh Medical Services Corporation regarding the issue the hospital management received no improvement in their action. The corporation failed to take action to address the reagent shortage. 

This has compelled patients to seek testing services from private labs, resulting in financial burdens. The lack of a pathologist at the Hamar Lab within Bilha Matru Shishu Hospital has further compounded the problem, forcing patients to turn to private labs for various tests.

The matter of the renewal of reagents for the hormonal testing machine at the District Hospital was neglected until the court intervened and made the Chief Secretary, Director (health services), CMHO Bilaspur, Divisional Commissioner and District Collector respondents in the matter.

As per the TOI news report, the critical circumstances have resulted in an astonishing influx of patients, averaging between 60 to 70 individuals per day, who are seeking medical aid at the maternal and child hospital located within the District Hospital premises. Within the last three months, a total of 4263 patients have opted for private laboratories to undergo essential diagnostic tests.

Taking note of the matter, the court directed the government to provide a personal affidavit detailing the existing facilities at the hospital and scheduled the next hearing on April 22. 

Also Read: Formulate SOP for medical termination of pregnancy beyond 24 weeks: Bombay HC tells Maha Govt

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Delay in Cancer Diagnosis: NCDRC upholds compensation order against doctor for medical negligence

New Delhi: The National Consumer Disputes Redressal Commission (NCDRC) recently held an Andhra Pradesh-based doctor guilty of medical negligence for the delay in cancer diagnosis of a patient who was suffering from breast pain.

“…the continuous therapy and reluctance to even record the advice for further diagnostic investigations to find out the nature and prognosis of the lesions already noted in the Mammography Report would certainly suggest clear negligence on the part of the Petitioner as the Consulting Physician/ Family Doctor of the Complainant, since the lump originally seen at the earlier stage in the investigations had grown very rapidly till the surgery was performed four months later,” noted the Apex Consumer Court, upholding the Rs 6 lakh compensation slapped on the doctor by the District Commission.

The history of the case goes back to 2011 when the patient consulted the doctor as she was suffering from pain in her right breast. The doctor, after clinical examination, prescribed medicines and advised her to undergo a pathological test for diagnosis. Accordingly, the patient underwent a mammography test.

Meanwhile, despite the subsequent medication, the pain persisted and the doctor recommended surgery to remove the lump in the right breast. Consequently, on 11.05.2011, the patient underwent surgery for the removal of the lump and a piece of it was sent for biopsy to a Diagnostic Centre in Rajahmundry. 

Post-surgery, the patient followed the instructions for care given by the treating doctor. However, since there was still no relief from the pain, she sought further consultation at G.S.L Cancer Hospital, as per the treating doctor’s referral.

The biopsy report revealed infiltrative duct cell carcinoma, with the tumor deemed inoperable due to its growth. Subsequently, at NIMS Hospital, Hyderabad, her right breast was surgically removed. Allegedly, it was only post-surgery, upon consultation with doctors at NIMS Hospital and GSL Hospital, that the patient realized the alleged improper treatment by the treating doctor.

It was claimed by the petitioner that the issue of cancer was initially indicated in the report dated 27.01.2011 indicating negligence by the treating doctor. Subsequent treatments included weekly chemotherapy at NIMS Hospital and radiotherapy at GSL Cancer Hospital, Rajahmundry, resulting in side effects such as hair loss and loss of appetite, impacting her ability to care for her family.

Since the doctor did not agree to pay the damages, the patient approached the District Consumer Court and filed a complaint. While considering the matter, the District Commission in 2015 directed the doctor to pay the complainant Rs 5 lakh towards compensation, Rs 1 lakh towards mental agony and Rs 5,000 towards litigation costs.

The order of the District Commission was challenged before the State Commission, Andhra Pradesh, which upheld the order of the District Forum. Challenging this, the doctor approached the Apex Consumer Court.

Approaching the NCDRC, the counsel for the treating doctor claimed that the lower Fora erred in allowing the complaint without duly considering the impeccable track record of the treating doctor spanning four decades of medical practice. Further, it was contended that negligence was wrongly attributed to the treating doctor without considering the comprehensive evidence, including that of an Oncology Surgeon.

It was also claimed by the doctor’s counsel that due to the complainant’s young age and her relatively small size of lump according to the Mammogram and Ultrasound, diagnosing cancer was challenging. It was also submitted that the treatment provided by the treating doctor was 2.5 years before the complainant’s death, with the cause of death remaining undisclosed.

Apart from this, the doctor’s counsel also argued that the absence of an explanation for the 2-month gap between the Complainant’s discharge from the petitioner’s hospital and the subsequent surgery suggested a potential exacerbation of the disease during this period.

On the other hand, the counsel for the complainants argued that there was a delay in the correct diagnosis and administration of treatment by the treating doctor from 10.01.2011 to 26.05.2011. This delay adversely affected the outcome of the treatment, particularly considering the young age of the patient and the aggressive nature of the disease with poor diagnosis/biological factors.

The complainants also submitted evidence by an expert doctor, who emphasized the negative impact of the treatment delays. The counsel for the complainants submitted that the doctor’s admission during evidence undermined her own defence since she admitted to not recording suspicions about the mass in the medical records and the prescribed antibiotics and anti-inflammatory drugs initially, followed by iron tablets after blood investigations.

Therefore, it was argued that the failure to prescribe further diagnostic tests such as MRI, CT Scan, and FNAC, coupled with the absence of estrogen testing before surgery, were instances of negligence. It was contended that the absence of a biopsy and FNAC recommendation, along with reliance solely on a normal mammogram, was deemed inadequate for ruling out breast cancer.

While considering the matter, the top consumer court took note of the orders passed by both the District and State Commission and observed,

“Both of them have come to the conclusion that there was negligence/ deficiency in service on the part of the Petitioner/Opposite Party who did not advise appropriate investigations in time, which resulted in a fast progression in the disease of Breast Cancer for which the deceased Complainant had actually been suffering. In fact, the Ld. State Commission in its Order has noted that when the pain and affliction being suffered by the deceased Complainant persisted in spite of the conservative treatment prescribed by the Petitioner, no investigations were advised on no less than 5 different occasions between 10.1.2011 to 24.3.2011.”

“The defence raised in her Written Version that she had orally advised such investigations, but the Complainant herself was reluctant to undergo the same, cannot be regarded as a credible excuse for not writing the advice or not recording the oral advise and reluctance of the Complainant as claimed in the relevant Prescription slips. Furthermore, even in the Mammography and SonoMammography Report dated 27.1.2011 (Annexure-P1), it was noted that the “…Right Breast shows two small irregularly oval hypoechoic lesions….., multiple internal echoes….” and the final impression was “SMALL EVOLVING ABSCESSES- RIGHT BREAST”. About 4 months later on 26.5.2011 ultimately the Biopsy Report of the Right Breast Lump established Cancer,” noted the Apex consumer court.

Holding that the treating doctor was negligence, the NCDRC bench noted,

“In the given facts and circumstances, the continuous therapy and reluctance to even record the advice for further diagnostic investigations to find out the nature and prognosis of the lesions already noted in the Mammography Report would certainly suggest clear negligence on the part of the Petitioner as the Consulting Physician/ Family Doctor of the Complainant, since the lump originally seen at the earlier stage in the investigations had grown very rapidly till the surgery was performed four months later.”

Clarifying that NCDRC cannot go into re-appreciation of evidence, the consumer court upheld the order passed by the District and State Commission. “Consequently, this Commission finds no grounds whatsoever to interfere with the concurrent decisions of both the Ld. Fora below. The Revision Petition is therefore dismissed. Parties to bear their own costs,” it noted.

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/ncdrc-rs-6-lakh-compensation–236102.pdf

Also Read: NCDRC Grants Rs 9.77 Crore Relief to Surgeons, says MBBS doctors can perform Hair Transplant Procedures:

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Subcutaneous infusion of levodopa-carbidopa beneficial for Parkinson’s disease

Subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) increases on time without troublesome dyskinesia among patients with Parkinson disease, according to a study published online March 15 in The Lancet Neurology.

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ACC: Ticagrelor monotherapy cuts bleeding risk in acute coronary syndrome

Treatment with ticagrelor alone results in a lower rate of clinically relevant bleeding compared with ticagrelor and aspirin among patients with an acute coronary syndrome who had percutaneous coronary intervention and remained event-free for one month on dual antiplatelet therapy, according to a study published online April 7 in The Lancet to coincide with the annual meeting of the American College of Cardiology, held from April 6 to 8 in Atlanta.

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Some breast cancer patients can retain lymph nodes, avoiding lymphedema

Removal of armpit lymph nodes can leave many breast cancer patients with lingering lymphedema, a painful and unsightly swelling of the arm.

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Brain scans of Philly jazz musicians reveal secrets to reaching creative flow

Flow, or being “in the zone,” is a state of amped-up creativity, enhanced productivity and blissful consciousness that, some psychologists believe, is also the secret to happiness. It’s considered the brain’s fast track to success in business, the arts or any other field.

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AACR: At-home HPV testing boosts cervical cancer screening participation

Mailed at-home self-sampling for human papillomavirus (HPV) testing increases cervical cancer screening participation in underscreened populations by almost threefold, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.

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