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The elimination of the causative agent and the facilitation of tissue regeneration are the fundamental objectives of periodontal therapy. Various adjunctive agents have been investigated to optimize treatment outcomes with surgical interventions. Periostin is a matricellular protein predominantly expressed in periodontal tissues, playing a key role in tissue remodeling, inflammation, and wound healing. The human placental extract has been used in periodontal surgery and compared with open flap debridement alone, with gingival crevicular fluid (GCF) periostin levels assessed to gauge periodontal wound healing. Sixteen systemically healthy patients diagnosed with Stage III Grade C periodontitis were enrolled in the study. Participants were randomly assigned to either the test group (n = 8) or the control group (n = 8), with a total of nine males and seven females distributed across the groups. The test group underwent open flap debridement (OFD), followed by applying human placental extract gel absorbed into a gelatin sponge, while the control group received only OFD. Clinical parameters were assessed at baseline and 3 month post-treatment. GCF periostin levels were measured at baseline, 6 weeks, and 3 months. Results: The test group demonstrated a mean probing pocket depth (PPD) reduction of 4.75 ± 1.28 mm, compared to 3.12 ± 1.12 mm in the control group, with the difference being statistically significant. The relative attachment level (RAL) gain was 4.37 ± 1.18 mm in the test group and 2.75 ± 0.70 mm in the control group; however, this difference was not statistically significant. At 3 months, the mean healing index score was 4.50 ± 0.53 in the test group and 3.62 ± 0.51 in the control group, with a statistically significant intergroup difference. The Plaque Index (PI), Gingival Index (GI), and Gingival Bleeding Index (BI) showed moderate reductions at 3 months; however, intergroup differences were not statistically significant, except for BI, where the difference at 3 months was -0.180. The adjunctive use of placental extract gel in surgical periodontal therapy demonstrated beneficial effects on healing outcomes. In addition, periostin shows promise as a biomarker for periodontal wound healing.

Reference:

Rathana, M., Paramashivaiah, R., Prabhuji, M.L.V. et al. Role of placental extracts in enhancing periodontal flap surgery healing: insights from periostin biomarker analysis. Eur J Med Res 30, 623 (2025). https://doi.org/10.1186/s40001-025-02891-y

Keywords:

Placental, Extract, Gel, Enhances, Periodontal, Healing, Periostin, Emerges, Promising, Biomarker, Rathana, M., Paramashivaiah, R., Prabhuji, M.L.V, Periodontitis, Surgical periodontal therapy, Human placental extract, Periostin, Wound healing, Marker

According to Omcomnews report, a total of 82 people have been identified as having consumed ganja (cannabis). This includes 32 students of Telangana’s Medicity Medical College. This was revealed when the authorities conducted a drug test of 24 students, and nine of them, including two girls, tested positive. All of them stayed in the college hostel.

Following this, EAGLE officials, along with the college management, counselled the students in the presence of their parents. Currently, the nine students who tested positive have been sent to a de-addiction centre; the next 30 days will be crucial for their recovery and reintegration.

As per Omcomnews news report, the consumption of drugs by the medical college students came to light when the EAGLE arrested two people, including a woman, on charges of drug trafficking. They were found supplying ganja (cannabis) to several consumers, including doctors. The drug suppliers were identified as Arfat Ahmed Khan (23), resident of Risala Bazar, Bolarum, Hyderabad, and Zarina Banu (46), resident of Bidar, Karnataka.

The drug addict, Khan, got into drug trafficking to satisfy his addiction. He contacted Banu and purchased a large quantity of ganja for local sale in Hyderabad. Between August 2024 and August 2025, he transferred a large amount of marijuana to her UPI account.

After interrogation, the police found six kg of ganja worth Rs 1.5 lakh from them, which has now been seized. Based on the confession of the accused, the Eagle team identified the consumers, including medicos. Eagle’s investigation also revealed Bano’s involvement in drug trafficking since 2010. She was previously also found involved in four other cases.

Meanwhile, following the incident, the anti-drug agency has announced that surprise inspections will continue in all institutions.