Study shows cancer vaccine blocks tumor progression at early lesion stage

A cancer vaccine that had little success in clinical trials for patients with advanced tumors could potentially have efficacy if administered earlier in the treatment cycle, according to a study from Vanderbilt researchers.

Powered by WPeMatico

The way sensory prediction changes under anesthesia could reveal how conscious cognition works

Our brains constantly work to make predictions about what’s going on around us, for instance to ensure that we can attend to and consider the unexpected. A new study examines how this works during consciousness and also breaks down under general anesthesia. The results add evidence for the idea that conscious thought requires synchronized communication—mediated by brain rhythms in specific frequency bands—between basic sensory and higher-order cognitive regions of the brain.

Powered by WPeMatico

Unveiling immune system responses that induce and maintain autoimmune pancreatitis

Autoimmune pancreatitis (AIP) is a clinical condition characterized by inflammation of the pancreas, caused by the body’s hypersensitivity to its own proteins. AIP is typically accompanied by other organ inflammations such as autoimmune sialadenitis and cholangitis, together categorized as systemic autoimmune disorder, called IgG4-related disease (IgG4-RD). When induced repeatedly with polyinosinic-polycytidylic acid (poly(I:C)), murine models of AIP (MRL/MpJ mice) were similar to the human AIP with IgG4-RD.

Powered by WPeMatico

Scurvy: Not just an 18th-century sailors’ disease

Scurvy, or vitamin C deficiency, is not just an 18th-century seafarers’ disease, as a case study of a 65-year-old woman with mobility issues and social isolation shows. In an article published in Canadian Medical Association Journal, clinicians describe how scurvy should be considered in patients with abnormal bleeding and nonspecific symptoms.

Powered by WPeMatico

New model shows potential for human papillomavirus vaccination switch to 1-dose gender-neutral approach

Canadian vaccination programs could switch to a 1-dose gender-neutral human papillomavirus (HPV) vaccination approach and eliminate cervical cancer, suggests new modeling in Canadian Medical Association Journal.

Powered by WPeMatico

Machine learning model can diagnose Meniere disease

A machine learning model based on pure-tone audiometry features can diagnose Meniere disease (MD) and predict endolymphatic hydrops (EH), according to a study published online Aug. 28 in Otolaryngology-Head and Neck Surgery.

Powered by WPeMatico

Rwanda will deploy Marburg vaccine under trial as death toll rises to 12

Rwandan health authorities will begin a vaccine study against the Marburg hemorrhagic fever, officials said Sunday, as the East African country tries to stop the spread of an outbreak that has killed 12 people.

Powered by WPeMatico

Scientists develop mRNA vaccine that protects mice against intestinal C. difficile bacteria

A large team of microbiologists, pathologists and infectious diseases specialists affiliated with several institutions in the U.S. has developed an mRNA vaccine that has thus far been found able to protect mice against intestinal Clostridioides difficile bacterial infections.

Powered by WPeMatico

Kolkata Junior doctors start fast unto death, says State Govt failed to fulfil demands

Kolkata: Junior doctors in West Bengal have initiated a hunger strike, protesting the brutal rape and murder of the postgraduate trainee doctor at RG Kar Medical College Hospital. The fast began on Saturday evening, following the state government’s failure to address their demands within a stipulated deadline.

With three days left before the Durga Puja festivities start, the doctors had on Friday begun a sit-in demonstration at the Dorina Crossing in Dharmatala in the heart of Kolkata, setting a 24-hour deadline for the state government to fulfil their demands.

According to the PTI report, a junior doctor said, “The state government has failed the deadline and hence we are starting the fast unto death, which will continue till our demands are fulfilled. To maintain transparency, we have installed CCTV cameras at the dais where our colleagues are holding the fast.”

Also Read:West Bengal: Doctors give 24 hour ultimatum to govt, threaten hunger strike

“We joined duty last night but will not eat anything,” he said, adding that at present six junior doctors were sitting on fast.

The six doctors who were sitting on the fast were identified as Snigdha Hazra, Tanaya Panja and Anustup Mukhopadhyay of Kolkata Medical College and Hospital, SSKM’s Arnab Mukhopadhyay, Pulastha Acharya of NRS Medical College and Hospital, and Sayantani Ghosh Hazra of KPC Medical College.

The state would be held responsible if any doctor fell ill during the fast, the junior doctor said.

“We have the support of the people, and that is the reason we are not scared of any sort of hindrances by the administration. We will continue our hunger strike until our demands are met,” he added, news agency PTI reported.

A large number of common people and a few celebrities were present at the protest site in the evening.

The junior doctors had on Friday night called off their ‘total cease work’, which had crippled healthcare services at state-run medical colleges and hospitals.

Earlier in the day, the medics alleged the police were not allowing them to set up the dais.

Kolkata Police had denied the junior doctors’ request for permission for the sit-in, stating that the road witnesses heavy traffic flow.

The protesting doctors had also alleged that they were baton-charged by the police on Friday night.

Promising “necessary action”, Kolkata Police in an e-mail asked them to identify the police personnel involved and lodge a complaint.

“With reference to the allegation of physical assault, the matter is being enquired. However, you are requested to direct the doctor/person who has allegedly been assaulted to lodge a formal complaint at the concerned Police Station, necessary action will be taken in accordance with the law,” the mail said.

The protesters emphasised that securing justice for the deceased woman medic remains their foremost priority.

Among the other nine demands, they called for the immediate removal of Health Secretary NS Nigam, as well as accountability for the alleged administrative incompetence and corruption within the Health Department, adds PTI.

Other demands include the establishment of a centralised referral system for all hospitals and medical colleges in the state, the implementation of a bed vacancy monitoring system, and the formation of task forces to ensure essential provisions for CCTV, on-call rooms, and washrooms at their workplaces.

Furthermore, they are advocating increased police protection in hospitals, the recruitment of permanent women police personnel, and the swift filling of vacant positions for doctors, nurses, and other healthcare workers.

The junior doctors began their strike in response to the tragic incident that occurred on August 9, when a fellow medic was raped and murdered. They temporarily halted their protests on September 21 after receiving assurances from the state government regarding their concerns.

Powered by WPeMatico

UP: MBBS student found dead on campus under suspicious circumstances, probe on

Shahjahanpur: In a shocking incident, a 24-year-old second year medical student of Varun Arjun Medical College was found dead lying in a pool of blood behind the hostel on the campus under suspicious circumstances on Sunday morning. 

The police are investigating the possibility of suicide or criminal activity, given that the student was found in suspicious circumstances. Superintendent of Police Rajesh S said that Prima facie it appears that either he fell on his own or someone pushed him.

Also read- Motilal Nehru Medical College MS orthopaedics medico allegedly commits suicide, 3 doctors booked

The student was a native of Gorakhpur who was living on the ground floor of the hostel which is a three-storey building. It is unclear how the incident had taken place and the police are investigating the matter. 

“He was a second-year MBBS student at the college. He is a resident of Gorakhpur. Today his body was found lying behind the hostel, after which the police were informed,” the college principal, Colonel (retired) Dr Ravindra Nath Shukla, told PTI.

When the police arrived at the campus, they conducted preliminary investigation and sent his body for post-mortem. As part of the investigation, the police have sealed the student’s room and are reviewing CCTV footage from the area. 

To gather more details about the matter, the police are questioning fellow students and local residents. “We are doing everything we can to get to the bottom of this,” SP Yash told India today

Shocked over the sudden mysterious death of the student, one of the student told the daily, “This is terrifying. We don’t know what happened, but it’s very unsettling to think that something like this could happen right here.”

Also read- MGM Indore MBBS student commits suicide, parents allege harassment by roommates

Powered by WPeMatico