Patiromer Promising in Optimizing HF Treatments for Patients with Hyperkalemia, DIAMOND Trial Reveals

USA: Recent findings highlight the role of patiromer in improving treatment outcomes for patients with heart failure and hyperkalemia.

The study, published in the Journal of the American College of Cardiology, revealed that in individuals with heart failure with reduced ejection fraction (HFrEF) and a history of hyperkalemia (HK), the addition of patiromer facilitates the optimization of renin-angiotensin system (RAS) inhibitors and mineralocorticoid antagonists (MRAs), which are essential components of heart failure management.

Hyperkalemia, characterized by elevated potassium levels in the blood, poses significant challenges in managing patients on RAS inhibitors and MRAs. These medications are crucial for treating heart failure, as they help improve heart function and reduce the risk of hospitalization and mortality. However, the occurrence of hyperkalemia often leads to the discontinuation or dose reduction of these therapies, undermining their benefits.

Against the above background, Bertram Pitt, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA, and colleagues aimed to evaluate the characteristics and usage of RAS inhibitors and MRAs in patients receiving patiromer during the run-in phase of the DIAMOND study (Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure).

Patients with HFrEF and hyperkalemia (HK) or a history of HK participated in a run-in phase of up to 12 weeks, during which patiromer facilitated the optimization of RAS inhibitors and MRAs to reach at least 50% of the recommended RAS inhibitor dose, 50 mg/day of MRA, and normokalemia. Those who met these criteria and entered the randomized group were compared with the run-in failure group, consisting of patients who did not meet the randomization criteria.

Based on the research, the following findings were revealed:

  • Of 1,038 patients completing the run-in, 878 were randomized, and 160 were run-in failures.
  • 40.7% of patients had HK entering run-in with a similar frequency in the randomized and run-in failure groups (40.3% versus 42.5%).
  • From the start to the end of the run-in, in the randomized group, there was an increase in target RAS inhibitor and MRA use in patients with HK (RAS inhibitor: 76.8% to 98.6%; MRA: 35.9% to 98.6%) and past HK (RAS inhibitor: 60.5% to 98.1%; MRA: 15.6% to 98.7%).
  • Despite not meeting the randomization criteria, there was an increase after run-in in the run-in failure group in target RAS inhibitor (52.5% to 70.6%) and MRA use (15.0% to 48.1%).
  • This increase was observed in patients with HK (RAS inhibitor: 51.5% to 64.7%; MRA: 19.1% to 39.7%) and past HK (RAS inhibitor: 53.3% to 75.0%; MRA: 12.0% to 54.3%).

In their analysis during the run-in phase of the DIAMOND trial, the authors found that most patients with HFrEF and hyperkalemia or a history of HK could rapidly and safely optimize their RAS inhibitor and MRA therapy while achieving or maintaining normokalemia with the help of patiromer. Notably, neither hypotension nor worsening kidney function posed significant barriers to the optimization of these therapies in this high-risk population. Furthermore, among patients who were unable to be randomized in this uncontrolled segment of the study, the majority were still able to initiate, maintain, or uptitrate their RAS inhibitor and MRA doses alongside patiromer.

“These findings suggest that patiromer could play a vital role in enhancing and sustaining the use of RAS inhibitors and MRAs in patients with HFrEF and HK or a history of HK,” the researchers concluded.

Reference:

Pitt, B., Anker, S. D., Lund, L. H., Coats, A. J., Filippatos, G., Rossignol, P., Weir, M. R., Friede, T., Kosiborod, M. N., Metra, M., Böhm, M., Ezekowitz, J. A., Bayes-Genis, A., Mentz, R. J., Ponikowski, P., Senni, M., Piña, I. L., Pinto, F. J., Van der Meer, P., . . . Butler, J. (2024). Patiromer Facilitates Angiotensin Inhibitor and Mineralocorticoid Antagonist Therapies in Patients With Heart Failure and Hyperkalemia. Journal of the American College of Cardiology, 84(14), 1295-1308. https://doi.org/10.1016/j.jacc.2024.05.079

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Daprodustat Treatment for Renal Anemia associated with ischemic stroke: Insights from Three Patient Cases

Japan: In a recent report published in Cureus Journal, three cases of ischemic stroke occurring in patients undergoing daprodustat therapy for renal anemia have raised significant concerns among healthcare professionals.

Daprodustat, a medication FDA-approved for treating anemia in chronic kidney disease (CKD) patients, is known for stimulating erythropoiesis by inhibiting the hypoxia-inducible factor prolyl hydroxylase enzyme. While generally considered safe, these cases highlight potential neurological risks associated with the therapy.

Therefore, the researchers suggest discontinuing daprodustat to reduce the risk of recurrent ischemic strokes.

Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are being increasingly utilized for treating renal anemia. While ischemic stroke is a rare but serious adverse event associated with HIF-PH inhibitor therapy, its clinical characteristics have not yet been documented.

In the study, Naohiro Uchio, Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan, and colleagues present three patients who experienced ischemic strokes while undergoing daprodustat therapy.

In two cases, hemoglobin levels surpassed the target of 13 g/dL for renal anemia (Cases 1 and 2). Notably, two patients suffered strokes within two months of starting daprodustat (Cases 2 and 3). One patient, despite being on dual antiplatelet therapy, also experienced an ischemic stroke (Case 3). Fortunately, none of the patients had a recurrence, likely due to the cessation of daprodustat treatment. This leads to the suggestion that daprodustat therapy may significantly contribute to the risk of developing ischemic strokes.

Commenting on the mechanism behind these occurrences, the authors noted that the exact causes of thromboembolism associated with HIF-PH inhibitor therapy remain unclear. However, it is believed that HIF-PH inhibitors have multiple effects, particularly their role in promoting erythropoiesis.

“These inhibitors stimulate the transcription of the erythropoietin gene, which can trigger hypoxia-induced responses leading to increased red blood cell production. Consequently, the erythropoietic effects of HIF-PH inhibitor therapy are thought to contribute to thromboembolism. Currently, only a limited number of risk factors have been identified, including excessive or rapid increases in hemoglobin levels and iron deficiency,” the researchers wrote.

The findings revealed that the occurrence of ischemic stroke poses a significant challenge in managing patients on daprodustat therapy for renal anemia, as highlighted by the authors.

“Such strokes may arise during periods of excessive hemoglobin elevation exceeding 13 g/dL or within the first two months following daprodustat initiation, likely due to heightened erythropoietic stimulation. Therefore, upon the onset of an ischemic stroke, it is crucial to discontinue daprodustat to prevent recurrence and prioritize patient safety,” the authors concluded.

Reference:

Uchio N, Komaki S, Hao, et al. (April 10, 2024) Ischemic Stroke During Daprodustat Therapy for Renal Anemia: A Report of Three Cases. Cureus 16(4): e57990. doi:10.7759/cureus.57990

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Low interpregnancy interval and air pollution have synergistic effect on Low Birth Weight outcomes, claims study

Researchers found that short interpregnancy intervals and exposure to air pollution during pregnancy are two risk factors for low birth weight (LBW). Recently, a research study was conducted in Nantong, China, to explore the combined effects of IPI with air pollution exposure on birth weights. The investigation showed that shorter IPIs are synergistic with high levels of air pollutants, therefore implying that optimizing birth spacing and controlling air pollution will improve birth outcomes. The study was published in BMC Public Health by Lu X. and colleagues.

This was a retrospective cohort study based on birth records from Jiangsu Maternal Child Information System that focused on the live births in Nantong from January 2020 to June 2021. According to the definition, IPI was considered as time elapsed from the delivery of a previous live birth up to the date of the last menstrual period of the subsequent pregnancy. The above was estimated based on a hybrid kriging-LUR-RF model for exposure to ambient air pollutants during pregnancy, including PM2.5 and PM10, ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). An innovative air pollution score was generated by summing the concentrations of five pollutants, weighted by LBW regression coefficients, excluding CO.

A total of five multivariate logistic regression models were applied to analyze the impacts of IPI, air pollution, and their interaction on LBW, including an interaction of IPI and PM2.5 in terms of RERI, AP, and S, which were calculated to quantify the additive interaction effect.

Results

The study had analyzed 10,512 singleton live births with an LBW rate of 3.7%. The association between IPI and LBW followed an L-shaped risk curve, which indicated that a shorter IPI was linked to higher LBW risk. Exposure to air pollutants during pregnancy increased the risk of LBW. For each interquartile range increase in air pollutant levels, the ORs for LBW were:

  • PM2.5: OR = 1.16 (95% CI: 1.01-1.32)

  • PM10: OR = 1.30 (95% CI: 1.06-1.59)

  • Ozone (O3): OR = 1.22 (95% CI: 1.06-1.41)

  • Air pollution score: OR = 1.32 (95% CI: 1.10-1.60)

In the first trimester, the study reported a high additive interaction between IPI and PM2.5 exposure. The highest risk of LBW, such as compared to pregnancies with normal IPI and low PM2.5 exposure, was found among those with a short IPI and high PM2.5 exposure, which presented a relative risk of 3.53 (95% CI: 1.85-6.49).

This study presents a synergistic effect of short interpregnancy intervals and air pollution on low birth weight, highlighting both the rational spacing of births and the control of air pollution as crucial points to increase the birth outcomes. Addressing these factors as a whole would make pivotal progress in developing means by which the incidence of LBW could be reduced and healthier pregnancies supported.

Reference:

Lu, X., Zhang, Y., Jiang, R., Qin, G., Ge, Q., Zhou, X., Zhou, Z., Ni, Z., & Zhuang, X. (2024). Interpregnancy interval, air pollution, and the risk of low birth weight: a retrospective study in China. BMC Public Health, 24(1). https://doi.org/10.1186/s12889-024-19711-3

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Pseudoendocrine sarcoma: rare new entity with unique radiologic and pathologic characteristics.

Pseudoendocrine sarcoma is a rare, recently described intermediate grade sarcoma of uncertain phenotype that most commonly affects the paraspinal location in older patients with a distinctive endocrine/paraganglioma-like morphology and unique CTNNB1 point mutation. While these tumors appear as epithelial or even benign endocrine tumors, these lack markers for such and are highlighted by nuclear expression of beta-catenin.

Zachary Corey et al reported a rare case report; An 82-year-old female presented to an outside health center with a painful right chest wall mass. A subsequent chest radiograph and ultrasound-guided core needle biopsy were performed. Pathologic diagnosis was initially unclear, as this new sarcoma entity is rare and newly described and can mimic a benign or metastatic epithelial or endocrine tumor. This patient’s biopsy and imaging studies were sent to authors’ institution for consultation. AP chest radiograph revealed a subtle right upper chest wall soft tissue density mass without osseous destruction and therefore was difficult to discern. Following the vague suggestion of a mass and corresponding soft tissue density noted on chest radiograph, an ultrasound-guided core needle biopsy was performed. The preprocedural ultrasound revealed an oval, well-circumscribed, homogeneous hypoechoic intramuscular mass. No internal calcification or cystic components were identified. Internal vascularity was observed within the mass on color Doppler imaging with possible feeding vascular pedicles, a subtle clue to diagnosis, in addition to the circumscription and location and presentation, requiring pathology and molecular to confirm the final diagnosis.

The histopathologic features of this small 3-cm mass reveal a lobular, well delineated, and circumscribed ovoid-shaped tumor with a pseudocapsule. There was a combination of pseudoendocrine/paraganglioma-like features with peripheral capillary vessels, creating the zellballen pattern, admixed with a trabecular (also pseudoendocrine/paraganglioma-like) appearance composed of round to ovoid cells with well-dispersed chromatin and distinctive cytoplasmic borders. The cells demonstrated focal clear cell to cytoplasmic vacuole-appearing features within myxoid stroma that lacked the zellballen pattern, without extracellular psammomatous calcifcations, hyaline globules, metaplastic bone, or necrosis. Mitoses were not significantly increased, and there were no atypical mitoses. Immunostaining was initially ordered by the original pathologist and was positive for nonspecific CD10 and CD99, with mild to focally moderate MIB-1 (indicating intermediate grade sarcoma) and negative for keratin, EMA, MUC4, synaptophysin, chromogranin, and S100 protein (no sustentacular cells), CD34, SMA, desmin, CD68, CD138, CD117, DOG1, GATA-3, CAIX, MITF, Melan-A, and TFE3, excluding endocrine tumors such as benign paraganglioma or malignant adrenal cortical carcinoma and epithelial and melanocytic tumors. A comprehensive sarcoma NGS fusion panel that included BCOR, FUS (SEF), GLI1, NOTCH1/2, PHF1, and STAT6 was negative, failing to reveal a specific diagnosis. The case was sent in consultation and during consultative workup, a nuclear beta-catenin was ordered to exclude this new entity and was positive and a desmoid hotspot panel revealed a unique somatic point mutation for CTNNB1 (c98C>G, p.Ser33Cys in exon 2, hotspot point mutation S33C), supporting the diagnosis of pseudoendocrine sarcoma, the second only of these tumors to exhibit this exact hotspot point mutation. Based on the clinicoradiologic, morphologic, and phenotypic features with CTNNB1 hotspot mutation, a final diagnosis of pseudoendocrine sarcoma was rendered. The patient was treated by complete excision of the mass. Follow-up of more than 4 years demonstrated no evidence for local recurrence or metastasis.

The authors commented – “In summary, this is the twenty-sixth case of newly described pseudoendocrine sarcoma in the chest wall/soft tissue of an elderly woman, diagnosed by having a benign endocrine-like appearance with a complete workup that excluded other entities. The distinctive clinical features, morphologic and phenotypic features with negative markers-favored an intermediate grade sarcoma that was originally negative for a complete sequencing workup. However, the final recognition of this rare novel entity was by a combination of observations by surgeons, radiologists, and pathologists to recognize this rare entity and obtain the final positive nuclear beta-catenin and distinctive CTNNB1 point mutation. Important are the unique features of the current case and the radiologic vascularity that corresponds to microscopic pathologic (Zellballen) vascular features, which resulted in proper diagnosis and management of this potentially metastasizing intermediate grade sarcoma.”

Further reading:

Pseudoendocrine sarcoma: a rare new entity with unique radiologic and pathologic/molecular characteristics

Zachary Corey et al Skeletal Radiology

https://doi.org/10.1007/s00256-024-04753-w

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Biological complications may lead to higher rates of abutment loss than technical complications regardless of type of abutment, finds study

Biological complications may lead to higher rates of abutment loss than technical complications regardless of type of abutment, finds study published in the Clinical Oral Implants Research.

Tooth- and implant-supported fixed dental prostheses are well-documented and aesthetic treatment alternatives, and after a comprehensive periodontal treatment, a protocol with a good long-term prognosis if the maintenance program is strictly followed. A study was done to reexamine a pre-existing patient cohort in order to obtain estimated long-term survival and complication outcomes of fixed dental prostheses. For this study, patients treated with fixed dental prostheses between 1978 and 2002 were reexamined between 2019 and 2020. The restorations were divided in single crowns and fixed dental prostheses supported by teeth (TSC, FPTDP) and implants (ISC, FPIDP). Survival and complication rates were obtained. Kaplan–Meier functions were used to model complication probabilities, and average hazard ratios of different strata were compared using weighted Cox regression. Results: The mean observation time of 40 patients and 223 reconstructions was 20.3 (±9.7, 1.2–36.2) years. The estimated survival rates were 84% (CI: 77%–92%) for TSC, 63% (CI: 51%–79%) for FPTDP, 87% (CI: 71%–100%) for ISC, and 64% (CI: 34%–100%) for FPIDP after 25 years. Biological complications included carious lesions (10.6%), periodontitis (7.9%), and peri-implantitis (6.8%). Technical complications included chipping (20.2%) and loss of retention (10.8%). Biological complications lead to abutment loss in more than two-thirds of cases, regardless of the type of abutment (tooth or implant). Technical complications are less associated with abutment loss than biological complications.

Reference:

Bischof, F. M., Mathey, A. A., Stähli, A., Salvi, G. E., & Brägger, U. (2024). Survival and complication rates of tooth- and implant-supported restorations after an observation period up to 36 years. Clinical Oral Implants Research, 00, 1–15. https://doi.org/10.1111/clr.14351

Keywords:

Biological, complications, may, lead, higher, rates, abutment, loss, technical, complications, regardless, type, abutment, finds, study, Bischof, F. M., Mathey, A. A., Stähli, A., Salvi, G. E., & Brägger, U, Clinical Oral Implants Research

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Thumb Amputation due to gangrene- Expert Evidence Vital in Determining Medical Negligence, says Court

New Delhi: Observing that expert opinion plays a vital role in determining negligence, the National Consumer Disputes Redressal Commission (NCDRC) recently exonerated an Odisha-based hospital accused of medical negligence while providing treatment to a patient suffering from a snake bite injury.

During her treatment at the hospital, the patient developed gangrene on her right thumb, which was amputated consequently. Even though the patient alleged negligence by the hospital, the Apex Consumer Court noted that there was no expert opinion that was brought on record. 

Therefore, the Commission observed that in the absence of any expert opinion that was brought on record to establish any negligence, the hospital could not be held responsible for any medical negligence.

“The hospital provided necessary medical attention and administered treatment. The thread was removed at the OP Hospital and the injury was also treated. The negligence in tying a thin thread tightly was on the part of the parents of the Complainant and the gangrene so developed was unrelated to the treatment by OPs,” observed NCDRC.

The history of the case goes back to 1999 when the complainant suffered a bleeding injury on her right thumb caused by a snake bite and was taken to Nehru Satabdi Central Hospital, Mahanadi Coalfields Ltd., Talcher. She was admitted to the casualty department as a ‘non-entitled patient’ on a payment basis and was treated as an indoor patient in the Paediatric ward/ICU for around 15 days. 

It was alleged by the complainant that despite being under the care of the hospital doctors, the treating doctor failed to provide proper treatment for the snake bite, leading to the development of gangrene. 

Consequently, the gangrenous right thumb was amputated on 10.05.1999 and allegedly, she was discharged without being completely cured, with the right thumb remaining in a compromised condition.

Following her discharge, the patient allegedly had to undergo further treatment to heal the wound from the amputation at Sisu Bhawan, Cuttack, incurring substantial expenses. Further, she alleged that the amputation significantly impacted her daily life, ability to write, body image and marriage prospects. 

Filing the consumer complaint, she claimed that she lost a valuable part of her body due to the deficiency and negligence in the treatment provided by the hospital and its doctors and for this she sought compensation of Rs 5 lakhs.

Responding to the District Forum, the hospital and doctors submitted that at the time of admission to the hospital, a black thread was tightly tied around the root of her right thumb and it was recorded by the Casualty Medical officer. The patient was drowsy and had a very weak pulse, inadequate respiratory effort, flaccid limbs, and a bluish right thumb. 

The hospital and its doctors attributed the thumb’s discolouration to the tightly tied black thread, which was removed by the hospital staff before cleaning and dressing the wound. Thereafter, she was administered IV fluids and oxygen before being transferred to the ICU on artificial ventilation and further observation.

Anti-snake venom and necessary injections were given to stabilize her condition, and she was discharged on 05.06.1999. However, her right thumb had to be amputated on 30.05.1999, due to the gangrene. The hospital and doctors contended that the patient’s right thumb had already turned blue at the time of her arrival at the hospital because the black thread tied had stopped the blood supply to the thumb. They claimed that the thread, being very thin, created significant pressure on the same spot, leading to gangrene. Whereas, in the normal course, to prevent snake venom from spreading, if at all necessary, a wide band is suggested.

Therefore, it was the contention of the hospital and its doctors that it was the negligence on the part of the complainant’s parents, not the alleged improper treatment, that caused the gangrene to develop in the first place. 

Partly allowing the complaint, the District Commission observed that no black thread was applied to the root of the petitioner’s right thumb after the snake bite and concluded that the gangrene was caused by the hospital and doctors’ negligent treatment, leading to the thumb’s amputation. Therefore, the District Commission directed them to pay Rs 3 lakh as compensation and Rs 1,000 as the cost of litigation.

Upholding the District Commission’s order, the State Consumer Court enhanced the amount of compensation to Rs 10 lakhs and further directed the hospital and doctors to pay Rs 25,000 as the cost of litigation.

Challenging this, the hospital filed a plea before the Apex Consumer Court. While considering the matter, NCDRC noted that admittedly, the Complainant approached the hospital with a history of snake bite. 

“It is also undisputed that, immediately after the snake bite incident, apparently to prevent the venom to spread within her body, a thread was fastened on her thumb. It is clear that she was administered necessary treatment and the as per the protocol for snake bite. It is, however, the grievance of the Complainant that the treatment of the OPs has led to the formation of gangrene on her right thumb which resulted in its amputation. She contended that the presence of the black thread in question was an afterthought of the OPs to evade liability as the same found no mention in the MRD Sheet,” the Commission further noted.

In this regard, the hospital and the doctors argued that the State Commission merely relied on the testimony of the complainant’s father and the fact that her right thumb had already turned blue upon her arrival at the hospital because the black thread tied had stopped blood supply to the thumb was not considered.

The Commission noted that the Complainant’s main contention was that the presence of the thread being fastened on the right thumb was not recorded in the Medical Record Department Sheet (MRD).

In this regard, NCDRC noted, “Clearly, MRD is a systematic documentation of a patient’s medical history and the treatment and care given to a patient. Its purpose is to serve as a basis for planning future patient care. Moreover, the MRD sheet in question had a set format with questions relating to the name, age etc. of the patient and had to be answered in the manner so required. It is not the purpose of the MRD sheet to mention each and every detail. Therefore, in the absence of scope for recording extra details on such format, the Complainant’s contention that the presence of thread fastened on the thumb was not recorded in MRD is untenable.”

On how the Complainant sustained the ligature injury, the Commission noted that the ‘nurse chart’ at the ICU, which was brought on record, showed that ‘a ligature (thread) was cut and dressing done’. 

“The same had also been noted in the order of the State Commission. Clearly, this thin thread that was fastened on her right thumb is not part of the treatment administered by the doctors. It existed before she was brought to the OP Hospital and was removed subsequently. That part was also dressed as there was some injury because of fastening of the thread. Therefore, it is clear that the thread was tied to the Complainant prior to the admission,” the Commission observed.

Regarding the treatment provided, the Commission noted that the hospital and doctors asserted that every anti-venom vial is provided with literature enclosed, prescribing the dosage in which it is to be administered.

“It is no new fact that medicines are often not a 100% of a particular component but a composition of various elements in particular proportions which when taken together help cure the ailment. In treatment for snake bite cases, there are multiple options of venom veil available in different dosages. The best person to assess which medication to administer is the treating doctor. As long as the treatment method adopted and the medicine administered are as per protocol, it cannot be said that a wrong treatment was given,” noted the Commission.

Holding that there was no medical negligence or deficiency by the hospital and the doctors, the Commission further observed,

“OPs placed medical literature on record which shows that proper medicines were administered for the treatment of snake bite. Therefore, the argument that there is negligence on the part of the OPs merely because medicine was not administered in the same doses prescribed in the medical literature put on record by the Complainant holds no ground, when an alternate and acceptable procedure had been followed with due care and caution. The medical reports brought on record and the testimonies of the doctors make it evident that there was no medical negligence or deficiency in service by OPs.”

The NCDRC bench also referred to the Supreme Court order in the case of Jacob Mathew where it was held by the Apex Court that as long as a doctor follows a practice acceptable to the medical profession of that day, he cannot be held liable for negligence merely because a better alternative course or method of treatment was also available. 

Further noting that there was no expert opinion that was brought on record to establish any negligence, the Apex Consumer Court exonerated the hospital and its doctors and ordered, “Based on the discussion above, clearly no negligence on part of OPs is established. Therefore, the orders of the learned State Commission dated 22.07.2022 and the learned District Forum dated 21.02.2000 are not based on due appreciation of facts and circumstances of the case and, therefore, set aside.”

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/ncdrc-order-254457.pdf

Also Read: Eye injury due to dengue fever, not delay by ophthalmologist: NCDRC relief to Delhi Hospital in medical negligence case

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NEET PG Pattern Change: NBE Submits Response Before Supreme Court, Next hearing on Sept 30

New Delhi: After the Supreme Court’s direction last week, the National Board of Examinations in Medical Sciences (NBEMS) submitted its response before the Apex Court regarding the allegations of discrepancies and last-minute changes in the National Eligibility-and-Entrance Test Postgraduate (NEET-PG) Examination 2024.

However, the Apex Court bench took note of the fact that there was no appearance on behalf of the Central Government. Therefore, the bench comprising the Chief Justice of India (CJI) DY Chandrachud, Justices JB Pardiwala and Manoj Misra has asked any of the ASGs to assist the Court.

Adjourning the matter, the Supreme Court bench has listed the further hearing for Monday i.e. September 30, 2024.

Also Read: NEET PG 2024: SC Seeks response from NBE on Last Minute Change of Exam Pattern

“We will keep on Monday. The Union of India (UOI) has to be there. Non appears, we request presence of any of the ASGs to assist this court,” the CJI was quoted noting today by Edex Live.

Medical Dialogues had earlier reported that during the last hearing of the case, while considering the plea, the Supreme Court on September 20 had expressed displeasure over the last-minute changes in the exam pattern by the National Board of Examinations (NBE).

Terming it to be “unusual”, the Apex Court bench comprising CJI DY Chandrachud, Justices JB Pardiwala and Manoj Misra had issued notice to the NBE, Union Government, asking them to file their counter within a week.

After several controversies, NBE conducted the NEET-PG 2024 exam on August 11 and its results were declared on August 23. Medical Dialogues had earlier reported that recently the NEET-PG 2024 candidates filed a plea before the Supreme Court pointing out how the exam format was changed just one month before the scheduled date and the exam was converted into a two (2) session examination with separate papers for each session which is against NBE’s guidelines of having one common examination.

Previously, the petitioner’s counsel pointed out that NBE has not released either the question papers or the answer keys. She further added that without knowing the correct answers, it would not be possible for the candidates to assess their performances transparently. She submitted that when the scorecard was released, it did not tally accurately for many candidates.

Regarding the issue of non-disclosure of exam question-answers, the plea stated, “There is a clear lack of transparency in conduct of examinations of NEET PG 2024 since none of the documents which can allow a student to check his/her performance are supplied by the Respondents i.e. neither the (a) question paper, nor (b) the Response sheet filled in by candidates, nor (c) Answer Key is supplied to the students, and merely a score card has been provided along with list of attempted correctly/attempted wrongly sections. The students on perusal of the score cards have found discrepancy in the total number of questions that they attempted which are found to be different than what is stated in the score cards issued to them. Thus, there is a basic flaw in the conduct of the examinations which goes to the root of the matter. However, there is no redressal of the above, and an unfettered power has been vested in the Respondents to conduct examinations, without the necessary checks and balances.”

The petitioners also raised grievances against the new marks normalisation method. On this issue, the plea mentioned, “A new procedure for normalization of scores (based on a system applied in AIIMS which has a different kind of paper) was introduced by the Respondents for calculation of scores obtained by candidates in Session 1 and session 2 and for tie breaking it would be counted to the 7th decimal, which is completely arbitrary as two classes of candidates have been created without any reasonable nexus with object being sought to be achieved i.e. getting the best suited candidates their opted specializations.”

“The normalisation procedure has completely altered the ranks that students expected to obtain based on their performance in the examination and it has led to clumping of students at each decimal, which would not have happened in case of counting of actual marks. Thus, the specialities will be exhausted on account of some superficial criteria prescribed by the Respondents, which is not reflective of the best candidates available,” it added.

Also Read: Supreme Court Seeks NBE’s Response on Plea Seeking Disclosure of Answer Keys

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Black infants with heart abnormalities more likely to die in first year, research finds

Some babies are born with abnormalities involving the structure of the heart, known as congenital heart disease (CHD). While many studies have shown that more babies with congenital heart disease are surviving past their first birthday as deaths from CHD have significantly decreased in the United States, a research abstract found that race impacts these survival rates.

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Parents open to firearms counseling from doctors: Ensuring secure storage remains a challenge

Firearms are the leading cause of death in children in the United States and are linked to over half of youth suicides. Secure storage of firearms (stored locked, unloaded, and separate from the ammunition) can significantly decrease the rates of child and adolescent firearm-related suicides.

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Childhood opioid prescription rates vary by patient’s background, research finds

Children born to greater socioeconomic backgrounds are significantly more likely to be prescribed opioids, according to research presented during the American Academy of Pediatrics 2024 National Conference & Exhibition at the Orange County Convention Center from Sept. 27–Oct. 1.

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