Marijuana use during pregnancy on the rise, 6% of pregnant women report using marijuana in new research

A new study from the University of Georgia College of Public Health found that about 6% of pregnant women reported using marijuana during the last month, and many did not associate it with health risks. The study highlights the importance of education surrounding marijuana use during pregnancy, said lead researcher Mohammad Rifat Haider.

Published in The American Journal on Addictions, the study utilized responses from the National Survey on Drug Use and Health. Among 4,338 pregnant mothers, 5.7% reported using marijuana during the last month.

Within that group, 70.9% perceived little to no risk associated with marijuana use during pregnancy, even though it has been associated with low birth weight, premature birth and neurodevelopmental effects.

While other substances, like alcohol or illegal drugs, have clearly identified adverse effects, marijuana has some conflicting perceptions, said Haider, an assistant professor in health policy and management. It can be seen as helpful in reference to cancer patients seeking to minimize nausea, but studies have also shown harmful side effects of continued use.

During pregnancy, however, the evidence clearly points to negative effects, Haider said.

2 of 3 pregnant women who used pot live in states where medical marijuana is legal

Marijuana use is legal for recreational use in 25 states and or medical purposes in 14 more. Two-thirds of the pregnant women who reported using marijuana lived in a state where medical marijuana was legal at the time of the survey.

Most of the pregnant women who used marijuana were also in their first trimester, and use decreased as the pregnancy progressed. Women in their first trimester may have seen medical marijuana as a way to combat morning sickness, Haider said.

“Marijuana is seen as a cure for nausea, but that’s not the way it should be dealt with in pregnancy because it is harmful for the mother and the fetus,” Haider said.

Women should consult physician to combat nausea, not turn to marijuana

Rather than turn to medical marijuana, women should talk to their OBGYN about prescription drugs that can limit nausea and vomiting, Haider said.

And doctors should be prepared to address misconceptions about how marijuana can affect these symptoms during pregnancy.

“When medical marijuana is available, when it is legal, it is available in the pharmacy. It is widely available,” he said. “So we need to be extra cautious in those states and make solid policy that helps make pregnant women aware of the detrimental effects or marijuana use.”

Improved education around pot use in pregnancy crucial

Another factor associated with marijuana use was mental health disorders or major depressive episodes. This is seen with many other substances, Haider said, where if there are unmet health needs, individuals are more likely to experience a substance use disorder.

All of these numbers highlight a need for improved education efforts around marijuana use in pregnancy. Doctors should be prepared to screen individuals for past substance use including regular marijuana use, and they should provide information on potential adverse effects of marijuana, especially in states where medical marijuana is legal.

“Long story short, this is a very vulnerable population, and evidence shows that during pregnancy, marijuana use is detrimental for both mother and child,” Haider said. “There needs to be policy direction from the state to have these discussions.”

Reference:

Haider MR, Karim S, Jayawardhana J, Hansen NB, Haile ZT. Association between state-level medical marijuana legalization and marijuana use during pregnancy: A population-based study. Am J Addict. 2024 Sep 29. doi: 10.1111/ajad.13651.

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Study reveals links between many pesticides and prostate cancer

Researchers have identified 22 pesticides consistently associated with the incidence of prostate cancer in the United States, with four of the pesticides also linked with prostate cancer mortality. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

To assess county-level associations of 295 pesticides with prostate cancer across counties in the United States, investigators conducted an environment-wide association study, using a lag period between exposure and prostate cancer incidence of 10–18 years to account for the slow-growing nature of most prostate cancers. The years 1997–2001 were assessed for pesticide use and 2011–2015 for prostate cancer outcomes. Similarly, 2002–2006 were analyzed for pesticide use and 2016–2020 for outcomes.

Among the 22 pesticides showing consistent direct associations with prostate cancer incidence across both time-based analyses were three that had previously been linked to prostate cancer, including 2,4-D, one of the most frequently used pesticides in the United States. The 19 candidate pesticides not previously linked to prostate cancer included 10 herbicides, several fungicides and insecticides, and a soil fumigant.

Four pesticides that were linked to prostate cancer incidence were also associated with prostate cancer mortality: three herbicides (trifluralin, cloransulam-methyl, and diflufenzopyr) and one insecticide (thiamethoxam). Only trifluralin is classed by the Environmental Protection Agency as a “possible human carcinogen,” whereas the other three are considered “not likely to be carcinogenic” or have evidence of “non-carcinogenicity.”

“This research demonstrates the importance of studying environmental exposures, such as pesticide use, to potentially explain some of the geographic variation we observe in prostate cancer incidence and deaths across the United States,” said lead author Simon John Christoph Soerensen, MD, of Stanford University School of Medicine. “By building on these findings, we can advance our efforts to pinpoint risk factors for prostate cancer and work towards reducing the number of men affected by this disease.”

Reference:

Simon John Christoph Soerensen, Pesticides and prostate cancer incidence and mortality: An environment-wide association study, Cancer, https://doi.org/10.1002/cncr.35572

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Turmeric compound may reduce risk of age-related macular degeneration: JAMA

Curcuma-based nutritional supplements (CBNS) have been scientifically established to possess antioxidant and anti-inflammatory properties. These could possibly decrease the onset and progression of age-related macular degeneration (AMD), which is the most common cause of vision loss among the elderly. AMD, especially its advanced forms, causes blindness and requires treatments like intravitreal anti–vascular endothelial growth factor (VEGF) therapy. A recent study was published in JAMA Ophthalmology by Alsoudi A. and colleagues.

The study involved data from more than 1.8 million participants, including 66,804 patients who had been exposed to CBNS and 1,809,440 patients who had not. All participants were at the age of 50 or older and had no diagnosis of AMD before the inception of the study. The demographic factors and comorbidities were adjusted to reduce possible bias by applying propensity score matching (PSM). In secondary analysis, patients with early nonexudative AMD were also included, in order to assess the role of CBNS in developing advanced forms of AMD from early nonexudative AMD.

The participants were stratified by the use of CBNS and then assessed to determine the relative risk for the development of different forms of AMD; nonexudative AMD, exudative AMD, advanced nonexudative AMD, and geographic atrophy (GA). Other secondary results have been incorporated, namely blindness and intravitreal anti-VEGF therapy.

  • In patients 50 years of age or older with no prior diagnosis of AMD, use of CBNS was associated with reduced relative risk (RR) of developing nonexudative AMD (RR, 0.23; 95% CI, 0.21-0.26; P < 0.001), exudative AMD (RR, 0.28; 95% CI, 0.24-0.32; P < 0.001), and advanced nonexudative AMD or GA (RR, 0.11; 95% CI, 0.07-0.17; P < 0.001).

  • CBNS use was associated with roughly half the risk of blindness (RR, 0.46; 95% CI, 0.36-0.59; P < 0.001) than among those who did not use CBNS.

  • The risk of intravitreal anti-VEGF therapy was considerably lower in CBNS users (RR, 0.15; 95% CI, 0.13-0.17; P < 0.001).

  • These associations were also consistent across age-specific subgroups, including patients at 60 and 70 and older.

  • CBNS was related to a lower progression to advanced nonexudative AMD or GA among those with early nonexudative AMD (RR, 0.58; 95% CI, 0.41-0.81; P < 0.001).

The findings indicate a good association between CBNS and reduced risk in the incidence and progression to the late stages of AMD. Outcomes show additive potential on reducing AMD risk for subjects already at some increased level of risk. Future research would be justified, not only in monitoring long-term safety measures but also gaining a better understanding of how CBNS mechanisms prevent the onset of AMD.

Reference:

Alsoudi, A. F., Wai, K. M., Koo, E., Mruthyunjaya, P., & Rahimy, E. (2024). Curcuma-based nutritional supplements and risk of age-related macular degeneration. JAMA Ophthalmology. https://doi.org/10.1001/jamaophthalmol.2024.4400

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An old drug with new tricks: Exploring the cancer-fighting promise and limitations of hydroxychloroquine

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been “repurposed” to fight cancer. Despite its effectiveness at blocking the resupply of needed resources to cancer cells, clinical trial results have been disappointing, in part because cancer cells eventually become resistant to the drug.

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Medicaid funding for addiction treatment hasn’t curbed overdose deaths, study finds

For generations, the federal government has largely refrained from paying for mental health and substance use treatment in large residential facilities.

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Exposure to flame-retardant chemicals during pregnancy associated with varying childhood obesity risks

Exposure to organophosphate esters (OPEs)—chemicals found in everyday products that use plastics and flame retardants—during pregnancy may have varying effects on the risks of childhood obesity, according to a new study.

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Heart transplant patients need more support in managing severe symptoms, researcher says

When a patient with heart failure has received a new heart and survives—the transplantation is deemed a success. However, health care overlooks heart recipients who suffer from long-term and often severe symptoms, such as pain and fatigue. New research at Lund University in Sweden shows that simple support in symptom management can make a considerable difference to the patients’ well-being.

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Study finds pharmacy closures impact anticonvulsant medication refills

A new study, out today in the Journal of the American Medical Association, has found that pharmacy closures in communities around Colorado significantly impact patient access to anticonvulsant medications, typically used to treat epilepsy, neuropathic pain and psychiatric disorders. Missing doses of this class of medication can result in increased mortality, pain and emergency room visits.

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RG Kar Case: Court frames charges against accused Sanjay Roy, Trial Set to Begin on November 11

Kolkata: In a recent development, the Sealdah Court in West Bengal on Monday framed charges against Sanjay Roy in connection with the rape and murder of a medical student at RG Kar Medical College and Hospital

The charges were framed under sections of the Bhartiya Nyay Sahita, and the trial is set to begin on November 11. This case has drawn significant attention due to its serious nature, and the court’s decision marks a major step in the legal proceedings against the accused.

In the wake of this shocking incident, junior doctors have called for the Central Bureau of Investigation (CBI) to take strict action and ensure capital punishment for those responsible. Speaking to ANI, Dr Rajdeep, a junior doctor, emphasized the need for severe consequences, stating, “We want the CBI to take strict action against those involved. Capital punishment should be given to all the accused.” He also urged the CBI to compile a comprehensive chargesheet that includes names not initially mentioned.

Also Read:Kolkata Doctor Rape-Murder Case: CBI files charge sheet, Sanjay Roy sole accused

As November 9 marks 90 days since the incident, Dr. Rajdeep affirmed that protests will continue until justice is served. “On November 9, we will exhibit all the major events that have taken place so far in this case. I want to say that we will not stop; the protest will continue,” he asserted.

Earlier on October 22, junior doctors protesting over the case ended their hunger strike after a two-hour meeting with Chief Minister Mamata Banerjee at the state secretariat, Nabanna. The tragedy unfolded on August 9, when the second-year medical student was found dead in the seminar hall of RG Kar Medical College and Hospital. The incident has ignited protests across West Bengal, with doctors nationwide expressing solidarity with the junior doctors in Kolkata.

Also Read:RG Kar Doctor Rape-Murder Case: CCTV reveals accused Sanjay Roy in corridor with Bluetooth device around his neck

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Natco Pharma names Imtiyaz Basade as Senior Vice President – RAD, Pharma Division, Kothur Unit

Telangana: Natco Pharma has announced that Imtiyaz Basade has been appointed as Senior
Vice President – RAD, Pharma Division, Kothur Unit w.e.f. 4th November, 2024.

Imtiyaz Basade has 35+ years of experience in
understanding of business and products, analytical ability,
eye for detail and computer literacy and knowledge of
recent trends. He was involved in planning and
implementation of activities related to mergers and
demergers, product acquisitions and divestments. He was
also involved in policy framing of the new regulations with
aid of industry associations, secretaries of respective
ministries and Indian FDA. His managerial competencies
are planning, communication and implementation skills,
foresight and strategic thinking, system orientation and
leadership skills. He has attended international meetings
with various agencies like, EDQM, MoH of South Africa,
Morocco, Zimbabwe, Kenya, Thailand, Malaysia, WHO
Geneva.
Prior to joining with NATCO Pharma Limited Imtiyaz
Basade worked with Mylan Laboratories Limited, Orchid
Chemicals & Pharmaceuticals Ltd., Wockhardt Limited,
Ranbaxy Laboratories Ltd., Dr Reddy’s Laboratories Ltd.,
Lupin Laboratories Ltd., Fulford (India) Ltd., and Pfizer Ltd.
He did Master’s in Pharmacy from University Department
of Chemical Technology, Bombay University.

Natco Pharma Limited was incorporated in Hyderabad in the year 1981 with an initial investment of INR 3.3 million. With a modest beginning of operations as a single unit with 20 employees, Natco today has eight manufacturing facilities spread across India with modern research laboratories, capabilities in New Drug Development, etc.

Read also: NATCO Pharma Canada arm invests over Rs 67 crore in biotech company eGenesis

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