Quitting smoking after cancer diagnosis improves survival across wide variety of cancers: JAMA

Smokers who are diagnosed with cancer now have more incentive to quit, as researchers from The University of Texas MD Anderson Cancer Center have found survival outcomes were optimized when patients quit smoking within six months of their diagnosis.

Study results, published today in JAMA Oncology, found a 22%-26% reduction in cancer-related mortality among those who had quit smoking within three months after tobacco treatment began. The best outcomes were observed in patients who started tobacco treatment within six months of a cancer diagnosis and were abstinent from smoking three months later. Survival for these patients increased from 2.1 years for smokers to 3.9 years for abstainers.

“While smoking cessation is widely promoted across cancer centers for cancer prevention, it remains under-addressed by many oncologists in their routine care,” said principal investigator Paul Cinciripini, Ph.D., chair of Behavioral Science and Executive Director of the Tobacco Research and Treatment Program at MD Anderson. “Our research underscores the critical role of early smoking cessation as a key clinical intervention for patients undergoing cancer treatment.”

Tobacco use remains the leading preventable cause of death and disease in the U.S. According to the Surgeon General, smoking at or following a cancer diagnosis increases both all-cause and cancer-specific mortality, as well as risk for disease progression and tobacco-related second primary cancers. Each year, about 480,000 Americans die from tobacco-related illnesses.

The average smoker makes several attempts to quit before successfully beating the addiction. MD Anderson’s Tobacco Research and Treatment Program tackles the barriers to cessation at an individual and population level, and conducts research designed to change clinical practice by addressing knowledge gaps among health care providers on treating tobacco addiction.

In the current study, researchers followed a cohort of 4,526 current smokers who had been diagnosed with cancer and were receiving cessation treatment at MD Anderson. The patients included men and women aged 47 to 62. More than 95% of visits in the study were provided via telemedicine. Abstinence was defined as self-reported no smoking in the seven days before each assessment, at the three-, six- and nine-month follow-up marks. The primary outcome was survival recorded by the MD Anderson tumor registry.

“This is a call to action for experts, regulatory bodies and institutions to prioritize smoking cessation as an integral part of first-line cancer care,” Cinciripini said. “MD Anderson has made a significant investment in clinical care and research related to tobacco use, which at the individual patient level translates to a better quality of life and a longer one, for those who quit smoking. The earlier the engagement in tobacco cessation treatment the greater impact on a patient’s lifespan.”

Reference:

Cinciripini PM, Kypriotakis G, Blalock JA, et al. Survival Outcomes of an Early Intervention Smoking Cessation Treatment After a Cancer Diagnosis. JAMA Oncol. Published online October 31, 2024. doi:10.1001/jamaoncol.2024.4890

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Courts Should Exercise Caution While Issuing Orders to Keep Seats Vacant at Medical Colleges: SC

New Delhi: The Supreme Court recently held that even though courts have power to make orders directing to keep medical seats vacant at medical colleges, they should exercise great caution while doing so.

“If provisional admission seats are not to be given casually, the said principal should also apply for directions to keep seats vacant. Only if there is a cast iron case for the petitioner and the petitioner is bound to succeed in cases where the error of the respondent authorities is so gross as to negate any other conclusion, interim orders keeping seats vacant could be made,” opined the top court bench comprising Justices BR Gavai and KV Vishwanathan.

Further, the Court opined that even in rare and exceptional cases where orders are made to keep the seats vacant, the courts should make every possible endeavour to dispose of the matter before the completion of the counselling for admissions.

“Additionally, even if the Writ Petition/Appeal succeeds, but if the matter could not be disposed off before the deadline the seat may still go vacant. It should not be forgotten that while the recurring and non-recurring expenditure for a college remains the same, a vacant seat will deprive the college of the fees to that extent, not just for one year but for the whole course, which could be four, five or more years,” the Supreme Court bench pointed out.

Such observations were made by the Supreme Court while considering the cases of two medical colleges, which were ordered by the High Court to keep medical seats vacant. Ultimately, these institutes suffered losses due to the said seats remaining vacant.

However, while considering their cases, the Supreme Court recently paved the way for monetary reimbursement by adjusting the fees proposed by the colleges for successive batches.

Both these colleges were ordered by the Director of Medical Education to keep one MBBS seat vacant with a direction that the said seat would not be included in the College Level Counselling (CLC) Round for the academic year 2023-2024. These directions were issued based on an interim order dated 22.09.2023 passed by the High Court.

Later, both these pleas were dismissed denying relief to the petitioner students. Consequently, the colleges were caught in the crossfire in their attempt to intervene. Having failed in the High Court, the courts filed a plea before the Supreme Court seeking a compensatory seat in the subsequent academic year. Their case was that because the seat was kept on hold, they were deprived of the opportunity to fill that seat. Their grievance was that the consequential loss had befallen solely on them due to an act of the court.

The colleges contended that the seat which was directed to be kept vacant became wasted since the pleas could not be disposed of before the cut-off date for admissions. They contended that the vacant seat would result in underutilization of resources, wastage of resources causing financial harm to them and resulting in meritorious candidates being denied admission to that seat.

While the colleges prayed to the Supreme Court top grant a compensatory additional seat for the ensuing academic year, the authorities contended that the authorities did not have any role in the matter and it was the order of the Court which was duly carried out and no liability could be fastened on them.

While considering the matter, the Apex Court referred to the interim order directing one seat in the counselling to be kept vacant as “cryptic” noting that in both these matters, neither the prima facie case nor the balance of convenience and irreparable loss aspects were discussed.

“This Court had time and again reiterated that in cases where the court is inclined to grant interim relief, at least a brief prima-facie assessment as to why the case warranted an interim protection needs to be discussed. Equally, the balance of convenience and the irreparable harm aspects are also to be briefly discussed in the order. These are well settled principles for adjudication of interim reliefs. The High Court, in both the matters before us, has wholly ignored these principles,” noted the Supreme Court bench.

Apart from this, the Court also pointed out that it repeatedly held that a medical seat has life only in the year it falls due and that too till the cut-off date is fixed. It pointed out that there are stringent regulations of the National Medical Commission (NMC) providing that admission can only be made by the medical colleges within the sanctioned capacity for which permission/recognition has been granted.

“No doubt, in rare and exceptional circumstances, courts can direct increase in seats for the same academic year not exceeding one or two seats, if it finds that for no fault attributable to the candidate and for the fault on the part of the authorities, the candidate has suffered. This Court has also held that if in the same year, the candidate cannot be accommodated, the Court can mould the relief and direct the admission to be granted in the next academic year,” it observed.

Besides, the Court also noted that it has frowned upon the grant of provisional admission unless the court is fully satisfied that the petitioner has a cast iron case which is bound to succeed or the error is so gross or apparent that no other conclusion is possible, adding that “Even there, the court has opined that a short notice to the respondent ought to be given and after hearing the other side, in an exceptional case fulfilling the criteria prescribed necessary orders can be made.”

At this outset, the Court opined that seats should not be kept vacant casually and such interim orders keeping seats vacant should be made only if there is a cast iron case for the petitioner.

“Though courts have power to make orders directing seats to be kept vacant in such cases, great caution and circumspection should be shown in exercising the power. In appropriate cases, even where the said exceptional criterion as set out above is met, the court will be justified in directing the petitioner to provide security, to the concerned college-institution where the seat is ultimately directed to be kept vacant or on whom ultimately the liability of the vacant seat would fall. The security is to guarantee that in the event of the Writ Petition/Appeal being dismissed and the seat going unfilled for the academic year the Petitioner/Appellant would make good the loss which the college may incur financially,” noted the top court bench, adding that even when such orders are made to keep the seats vacant, the Courts should make every possible endeavour to dispose of the matter before completion of the counseling.

“…these safeguards are essential to restitute the colleges which may have suffered for no fault of theirs. It is well settled that if on account of an act of a party persuading the court to pass an order, which at the end has been held not sustainable and if in the process one party has gained an advantage which it would not have otherwise earned or the other party had suffered an impoverishment, restitution can be made. This Court had held that the principle of restitution is not excluded from its application to interim orders,” the Supreme Court bench further observed.

“This Court has also held that the maxim actus curiae neminem gravabit will apply in such a scenario, and orders of restitution can be passed directing the party which obtained the advantage to compensate the party which suffered the disadvantage,” noted the Court.

Applying these principles to the facts of the present case, the Supreme Court bench found that the vacant seat ordered could not be filled because by the time the pleas were disposed of, the counselling had concluded and the cut-off date for admissions was also over. Noting that the colleges will have to carry the vacant seat for the entire duration of the MBBS course, the Court observed that while in the first case, the plea was dismissed, in the second case, at the student’s behest, the High Court order was set aside and the student was accommodated for the succeeding academic year. However, even in that case, the seat could not be filled and continued to remain vacant.

Accordingly, to serve the justice, the Supreme Court bench granted liberty to the medical colleges to make a representation to the Fee Fixation Committee/Fee Fixation Authority of the State highlighting the vacancy caused due to the interim order of the High Court.

“If such a representation is made, the Fee Fixation Committee/Fee Fixation Authority shall, while fixing the fees for college (for future batches) reckon the deficit in fees that has resulted due to the single vacant seat and fix the fees by adding such amount to the total fees proposed to be fixed which will restitute the colleges monetarily,” it ordered.

“Considering that it is a single seat and since the fee will be spread over for a period of five years, the financial impact on whom the burden will fall will be marginal, in proportion to the total fee payable. On the current facts, we find that this is the best possible option, to neutralize the effect of the interim orders which have operated to the prejudice of the colleges,” noted the top court.

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/supreme-courtjudgement07-nov-2024-260300.pdf

Also Read: Even a single Medical seat must not remain vacant: SC slams MCC, Centre over 1,456 vacant NEET PG seats

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Delhi HC Grants Interim Relief to Mankind, Restrains AquaKind Labs from Using ‘KIND’ in Trademark

New Delhi: In relief to Mankind Pharma, the Delhi High Court has granted an ex-parte interim injunction restraining AquaKind Labs LLP from using the “KIND” suffix in their trade name “Aquakind.”

This ruling followed a trademark infringement lawsuit filed by Mankind Pharma Limited, which claimed that AquaKind Labs’ use of the name was deceptively similar to its registered trademark “MANKIND,” potentially causing confusion in the pharmaceutical market.

Mankind filed a lawsuit in the Delhi High Court, seeking to restrain AQUAKIND Labs LLP from using its trade name “AQUAKIND,” claiming it infringes on Mankind Pharma’s registered trademarks. The plaintiff, represented by Senior Advocate Chander M. Lail and a team of lawyers, argued that the defendants’ use of “AQUAKIND” is not only visually and phonetically similar to the well-known “MANKIND” trademark but also threatens to cause confusion in the pharmaceutical market.

The plaintiff has been using the “MANKIND” trademark since 1986, first under the name ‘Mankind Pharma’ and later as Mankind Pharma Limited, incorporated in 1991. Over the years, the company has developed a significant portfolio of trademarks incorporating the “KIND” suffix, which has become synonymous with high-quality pharmaceutical products. Mankind Pharma holds registrations for over 300 trademarks with the “KIND” suffix, including names such as HEPAKIND, GLYKIND, and METROKIND, establishing a solid market presence.

The dispute arose when Mankind Pharma discovered that AQUAKIND Labs had started using the trademark “AQUAKIND” for pharmaceutical products, which the plaintiff claims is deceptively similar to its own trademark. The plaintiff argued that this similarity is likely to cause confusion among consumers, especially since both companies operate in the same pharmaceutical space.

Mankind Pharma’s lawsuit also highlighted the malicious intent behind the defendants’ adoption of “AQUAKIND.” The company asserted that the use of a similar name is a deliberate attempt by the defendants to capitalize on the goodwill associated with “MANKIND” and “KIND.” Furthermore, the plaintiff emphasized that such confusion in the pharmaceutical industry could have harmful consequences, as incorrect associations between similar products could jeopardize consumer safety.

As part of the case, Mankind Pharma sought an injunction to prevent the defendants from using the “AQUAKIND” trademark and is also requesting damages and the rendition of accounts for the alleged infringement.

Examining the case, the court observed that the plaintiff, Mankind Pharma, had successfully demonstrated a prima facie case for the grant of an injunction. The court further noted that if no ex parte ad interim injunction were issued, the plaintiff would suffer irreparable harm. The balance of convenience, according to the court, clearly tilted in favor of the plaintiff and against the defendants. It observed;

“The plaintiff has demonstrated a prima facie case for grant of injunction and, in case, no ex parte ad interim injunction is granted, the plaintiff will suffer an irreparable loss. Further, balance of convenience also lies in favour of the plaintiff, and against the defendants.”

In its order, the court prohibited the defendants—AQUAKIND Labs LLP and its affiliates—from selling, advertising, or dealing in any goods or services under the trade name “AQUAKIND” or any trademark that could be confused with Mankind Pharma’s registered trademarks, “MANKIND” and its related “KIND” variants. It noted;

“Accordingly, till the next date of hearing, the defendants, their proprietors, partners or directors, as the case may be, its principal officers, servants, distributors, dealers and agents, and all others acting for and on behalf of the defendants, are restrained m selling, offering for sale, advertising, directly or indirectly dealing 4fiyf gqOds and services under the impugned trade mark/ trade name “AQUAKIND”/ “AQUAKIND LABS LLP’ and or any other trade mark/trade name as may be identical to or deceptively similar with the plaintiff’s registered trademarks “MANKIND” and/ or “KIND” formative trademarks and their variants thereof, so as to cause infringement as well as passing off of the plaintiff s trademarks.”

Additionally, the court addressed the need for evidence preservation and appointed two Local Commissioners to inspect the defendants’ premises. These commissioners are tasked with seizing any infringing products and gathering financial records that relate to the sale of these products.

The case has been scheduled for further proceedings in December 2024, with a final hearing set for March 2025.

To view the original judgement, click on the link below:

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NMC Imposes Stricter Penalties for Violating PGMER in NEET PG Admissions

Medical Colleges running postgraduate medical courses may lose double the number of seats for one or more years if they violate the Postgraduate Medical Education Regulations (PGMER) rules, 2023.

Laying down the rules and regulations for postgraduate medical admission, the Apex Medical Education Regulatory Body i.e. NMC on December 29, 2023 released the PGMER 2023 Regulations.

For more information, click on the link below:

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Secondhand clothes can be swimming in germs—what vintage shoppers need to know

Demand for secondhand and vintage clothing has surged within the last few years. Pre-owned fashion is seen by many consumers as a cheaper, more environmentally friendly way to expand their wardrobe.

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1 in 5 people could have long COVID

More than 1 in 5 Americans likely suffer from long COVID, a new AI-assisted review has found.

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Fasting, eating earlier in the day or eating fewer meals—what works best for weight loss?

Globally, 1 in 8 people are living with obesity. This is an issue because excess fat increases the risk of type 2 diabetes, heart disease and certain cancers.

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Canada reports first case of bird flu in a person

A teenager in British Columbia has become the first person in Canada to test positive for bird flu, authorities said Saturday.

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Brick by colorful brick: LEGO helps bridge gap between midwifery and medical students

Normally a staple of the childhood toybox, new research has found that LEGO bricks can be an effective ice breaker between midwifery and medical students.

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Rajasthan HC Raises Concern over State Govt’s Laxity in Providing Separate Wards for Transgenders

Jaipur: The Rajasthan High Court (HC) has expressed serious concerns over the lack of separate wards and facilities for transgender individuals in government hospitals and care centres across the state.

During a hearing on a public interest litigation (PIL) filed by the Sambhali Trust, the court scheduled the matter for final disposal on November 14.

Sambhali Trust which advocates for the rights of the Transgender community, is represented by the counsel Shivani Singh. During the court hearing, Singh argued that the current healthcare infrastructure in Rajasthan fails to provide essential welfare facilities to the transgender communities. The division bench, comprising justices Shree Chandrashekhar and Madan Gopal Vyas, heard this argument.

Also Read: Non-inclusion of disability, transgender rights in CBME Curriculum: Centre serves notice to NMC

In her argument she also highlighted the discrimination present in hospitals, noting that they provide wards and amenities only for men and women, leaving transgender individuals without access to inclusive medical infrastructure. She further emphasized that the lack of such infrastructure only exacerbates the challenges faced by the transgender community.

The transgender community often faces unique societal perceptions and stigma. Singh pointed out that this discrimination within healthcare settings makes it difficult for them to access adequate care in a supportive environment. Noting this, She emphasized the need for dedicated facilities for transgender individuals.

The bench observed that under Section 15 of the Transgender Persons (Protection of Rights) Act, 2019, healthcare in hospitals and health institutions is a legal right for transgender individuals to access.

However, Singh argued that these provisions are not fully implemented in Rajasthan. She pointed out that while other states like Maharashtra have already made strides in this direction by establishing dedicated hospital wards for transgender people, Rajasthan has yet to take such steps.

Also Read: Gauhati High Court orders Assam Govt to address issues with Reconstructive Surgery Facility for Transgenders

As per the recent media report by the Hindustan Times, the court also noted, “We observe that, due to laxity on the part of the respondent-State in filing a response in the present proceeding, the right to file a counter affidavit was forfeited on September 19, 2024. This matter has since appeared on the board multiple times. Despite this, state counsel Anita Rajpurohit requested a further adjournment.”

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