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A new study published in the journal of BMC Nephrology showed that in patients receiving peritoneal dialysis (PD), the platelet-to-albumin ratio (PAR) is a separate predictor of cardiovascular disease and all-cause mortality. The long-term survival rate of patients receiving PD is still poor, despite the fact that peritoneal dialysis is an effective treatment for renal replacement. A poor prognosis for a number of illnesses is linked to the platelet-to-albumin ratio, which was recently shown to be a measure of nutritional and inflammatory conditions. Nevertheless, nothing is known about the relationship between serum PAR and the prognosis of PD patients. The purpose of this study was to assess the predictive power of PAR for cardiovascular disease (CVD) and all-cause mortality in PD patients.

Patients enduring Parkinson’s disease (PD) were recruited for this multicenter cohort research between January 1, 2009, and September 30, 2018. The quartiles of the patients’ baseline PAR were used to create four groups. Mortality from all causes and CVD was the main outcome. The relationship between the PAR and death from all causes or from CVD was assessed using Cox proportional hazards models. The performance of PAR and other inflammatory markers was compared using the receiver operating characteristic (ROC) curve. The incremental predictive value of PAR in comparison to the baseline model for predicting all-cause and CVD mortality was examined using the C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

The study included a total of 2825 patients, which included 747 death cases over the 47.5 ± 28.3-month follow-up period, 415 of which were due to CVD. Placement in Q4 was linked to a higher risk of both CVD and all-cause death as compared to Q1. According to the adjusted limited cubic spline analysis, there was a linear connection between the PAR and cardiovascular and all-cause mortality.

The interaction tests revealed no positive relationships. With corresponding AUC values of 0.611 for all-cause mortality and 0.609 for cardiovascular mortality, PAR demonstrated greater predictive value for death when compared to other inflammatory markers. The inclusion of PAR in the baseline model produced a moderate but substantial increase in outcome prediction, as indicated by the C-statistic, continuous NRI, and IDI. Overall, this study showed that in patients receiving PD, elevated blood PAR was strongly linked to an increased risk of death from all causes and from CVD.

Reference:

Ma, H., Chen, J., Zhan, X., Ao, S., Deng, J., Tang, R., Peng, F., Tian, N., Wen, Y., Wang, X., Feng, X., Su, N., Tang, X., Wu, X., Zhou, Q., & Xu, Q. (2024). Platelet-to-albumin ratio: a potential biomarker for predicting all-cause and cardiovascular mortality in patients undergoing peritoneal dialysis. In BMC Nephrology (Vol. 25, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12882-024-03792-8

Chennai- In an unfortunate incident, a medical student in Chennai allegedly committed suicide in his hostel room near Porur in Chennai.

The medico has been identified as Rishikesh, a resident of Kumarapalayam in Namakkal district. He was a medical student studying in a private medical college in Chennai. It is believed that he took the drastic step after feeling dejected over his relationship issues.

After the incident took place, the police were informed and a preliminary investigation was conducted. The preliminary police investigation revealed that the student was depressed due to ‘love failure’. His body has been recovered and sent to Kilpauk Medical College Hospital for post-mortem, reports DTNext.

Currently, the police filed a case under the relevant section of IPC. Further investigation in this regard is underway.

A few days back 23-year-old student, also a trainee doctor of Meenakshi Medical College in Kanchipuram allegedly committed suicide by jumping from the fifth floor of her hostel building.

Medical Dialogues team had previously also reported about a 2nd-year MBBS student of Pondicherry Institute of Medical Sciences (PIMS) who allegedly committed suicide by hanging himself in a lodge near Thideer Nagar in Madurai. The 20-year-old student was struggling with stress regarding his studies and left the house on July 8. His family after being unable to find him filed a missing complaint at the police station.

His death came to light when a room boy knocked on the door of the student’s room but he did not answer. After receiving no response from him, the boy called the police who broke open the door and found the student hanging from the ceiling. 

Hyderabad: CuraTeQ Biologics Private Limited, a wholly owned subsidiary of Aurobindo Pharma Limited, has received a
GMP certificate of compliance for its biosimilars manufacturing facility from the EMA. The GMP inspection,
conducted by EMA representatives from April 8th to April 12th, 2024, assessed mammalian and microbial drug
substance manufacturing facility sections, prefilled syringes and vials filling, packaging, and QC testing and
release laboratories

Dr. Satakarni Makkapati, Director of Aurobindo Pharma Limited and CEO of Biologics, Vaccines, and Peptides,
stated, “The EU GMP certification marks a significant milestone in CuraTeQ’s commitment to manufacturing
high-quality biosimilars for patients worldwide. This inspection outcome paves way for securing approvals for
our three biosimilars in Europe, currently under review by the Agency, within the next two to five months.”

K. Nithyananda Reddy, Vice-Chairman and Managing Director of Aurobindo Pharma Limited, added, “Our
portfolio comprises fourteen biosimilars in development across oncology and immunology segments. We are
dedicated to building a sustainable biosimilars portfolio and bringing these essential therapies to patients.”

Read also: Aurobindo Pharma arm announces successful Phase 1 clinical study outcome of their BP11 product

Read also: Aurobindo Pharma unit partners with MSD to foray into contract manufacturing operations