Psoriasis Severity Linked to Apical Periodontitis but Not to Dental Caries: Study

Researchers have found in a new study that a significant association between psoriasis severity and apical periodontitis (AP), suggesting a possible role of psoriasis in AP pathogenesis. However, no significant correlation was observed between psoriasis and dental caries. Additionally, immune-modulating drugs from psoriasis patients did not appear to affect apical periodontitis prevalence.

A study evaluated the prevalence of apical periodontitis (AP) and caries in subjects with psoriasis vulgaris. In total, 152 patients with psoriasis vulgaris were included in the study. The severity and extent of psoriasis were assessed according to the Psoriasis Area Severity Index (PASI), the Body Surface Area (BSA) and the Physician’s Global Assessment Scale (PGA). Periapical status was assessed through dental examination and periapical radiographs. Data regarding the Periapical Index (PAI), caries experience expressed as the Decayed, Missing, Filled Teeth Index (DMFT) and psoriasis medications were recorded. A predictive logistic regression model for the presence of apical periodontitis and a linear regression model were then built to relate the severity and extent of apical periodontitis to the type of drug therapy taken for psoriasis and to the severity and extent of the skin disease. Results: Subjects with severe/moderate psoriasis showed a significantly higher prevalence of AP (p = .002) and a higher PAI score (p = .0035) than subjects with mild psoriasis. No significant correlation was found between apical periodontitis and caries experience (p = .76). The logistic regression model showed that moderate/severe psoriasis increased the odds of having apical periodontitis [odds ratio (OR) = 1.30 ± 1.088, 1.55]. A negative linear relationship between biological drug intake and PAI score value was observed (coefficient = −.54; p = .04). The degree of severity of psoriasis is significantly associated with apical periodontitis, suggesting that psoriasis may play a role in the pathogenesis of apical periodontitis. However, no significant correlation was observed for caries experience. Furthermore, the immune-modulating drugs taken by these patients did not seem to have different effects on the prevalence of apical periodontitis.

Reference:

Marruganti, C., Malvicini, G., Cinotti, E., Fuso, A., Trovato, E., Rubegni, P. et al. (2025) Association between apical periodontitis and psoriasis vulgaris: A cross-sectional study. International Endodontic Journal, 00, 1–14. Available from: https://doi.org/10.1111/iej.14222

Keywords:

Psoriasis, Severity, Linked, Apical, Periodontitis, Not, Dental, Caries, Study, Marruganti, C., Malvicini, G., Cinotti, E., Fuso, A., Trovato, E., Rubegni, P.

Powered by WPeMatico

Tune in to blood glucose for simpler early diabetes detection, recommends study

The highs and lows of blood glucose aren’t just an energy rollercoaster; they could be a key to detecting diabetes risk early and spare you a needle prick or two.

Researchers at the University of Tokyo have identified a simple, noninvasive method for assessing blood glucose regulation — an essential factor in diabetes risk. Their approach, based on continuous glucose monitoring (CGM) data, could improve early detection and risk assessment for diabetes without relying on blood samples and expensive or complex procedures.

The study is published in Communications Medicine.

Often called a “silent epidemic,” diabetes is an increasingly prevalent global health concern, with significant health and economic consequences. Early detection of impaired glucose regulation — an intermediate stage between normal blood glucose levels and diabetes — is essential for preventing or delaying the onset of Type 2 diabetes. Conventional diagnostic tools, however, often miss early signs because they rely on periodic blood samples rather than continuous monitoring.

“Traditional diabetes tests, while useful, do not capture the dynamic nature of glucose regulation under physiological conditions,” said Shinya Kuroda, a professor at the University of Tokyo’s Graduate School of Science and co-author of the current study.

To find a more practical alternative, the team turned to CGM, a wearable technology that continuously tracks glucose levels in real time, providing a clearer picture of blood glucose fluctuations in everyday life. Their goal was to identify a CGM-based method for estimating glucose handling capacity, which maintains stable levels, without invasive procedures.

The team analyzed 64 individuals without a prior diabetes diagnosis, using a CGM device, oral glucose tolerance tests (OGTT), and clamp tests that are used to assess insulin sensitivity and glucose metabolism. They then validated their findings with an independent dataset and mathematical simulations.

Their analysis showed that AC_Var, a measure of glucose-level fluctuations, strongly correlates with the disposition index, a well-established predictor of future diabetes risk. Moreover, the researchers’ model, which combines AC_Var with glucose standard deviation, outperformed traditional diabetes markers — such as fasting blood glucose, HbA1c and OGTT results — in predicting the disposition index.

“By analyzing CGM data with our new algorithm, we identified individuals with impaired glycemic control — even when standard diagnostic tests classified them as ‘normal,’” said Kuroda. “This means we can potentially detect issues much earlier, creating an opportunity for preventive interventions before diabetes is diagnosed.”

The team also showed that the method was more accurate than conventional diagnostic indicators in predicting diabetes complications such as coronary artery disease. To facilitate broader access to this approach, the research team has developed a web application that allows individuals and health care providers to easily calculate these CGM-based indices.

“Our ultimate goal is to provide a practical, accessible tool for widespread diabetes screening,” Kuroda said. “By enabling early detection of glucose regulation abnormalities, we hope to prevent or delay disease onset and reduce long-term complications.”

References: Hikaru Sugimoto, Ken-ichi Hironaka, Tomoaki Nakamura, Tomoko Yamada, Hiroshi Miura, Natsu Otowa-Suematsu, Masashi Fujii, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa & Shinya Kuroda Communications Medicine volume 5, Article number: 103 (2025)

Powered by WPeMatico

Drug Alert: 70 Drug Samples Fail To Clear CDSCO Test, 1 Declared spurious

New Delhi: With an aim to make stakeholders aware of the not-of-standard-quality (NSQ) batches identified in the market, in its latest drug alert, the apex drug regulatory body, the Central Drug Standard Control Organization (CDSCO), has flagged 70 medicine batches for failing to qualify for a random drug sample test and declared Telma 40 (Telmisartan tab 40mg) batch no. 5240226 as spurious for the month of March 2025.

This came as part of the continuous regulatory surveillance, where drug samples are picked from sales/distribution points, analyzed, and a list of spurious drugs is displayed on the CDSCO portal on a monthly basis. The purpose of displaying the spurious drugs list is to make stakeholders aware of the spurious drug batches identified in the market.

These include compound Amoxicillin Sodium and Clavulanate Potassium manufactured by Shandong New Time Pharmaceuticals, Pantoprazole Gastro- Resistant Tablets (Pantoshang-40) manufactured by Shangrila Industries, Pantoprazole tablets manufactured by Hindustan Antibiotics, Adrenaline Bitartrate Injection manufactured by Rathi Laboratories, Bupivacaine Hydrochloride In Dextrose Injection manufactured by Aishwarya Healthcare, Montelukast and Levocetirizine Tablet (Dumont-L ) manufactured by Hygeia Pharmaceuticals, Nitrazepam Tablets manufactured by Anglo-French Drugs and Industries, and others.

In addition, the apex drug regulatory body has released the list of spurious drugs for the month of March,2025, mentioning that Telma 40 (Telmisartan 40mg) with batch no. 5240226 failed critical quality tests and was declared as spurious. Manufactured in Feb 2024 with an expiry date of January 2027, this product does not conform to Indian Pharmacopoeia (IP).

As per the alert, the actual manufacturer (as per label claim) has informed that the impugned batch of the product has not been manufactured by them and that it is a spurious drug.

Furthermore, in accordance with the alert, a drug shall be deemed to be spurious;

a. If it is manufactured under a name which belongs to another drug; or

b. if it is an imitation of, or is a substitute for, another drug or resembles another drug in a manner likely to deceive or bears upon it or upon its label or container the name of another drug unless it is plainly and conspicuously marked so as to reveal its true character and its lack of identity with such other drug; or

c. If the label or container bears the name of an individual or company purporting to be the manufacturer of the drug, which individual or company is fictitious or does not exist; or

d. If it has been substituted wholly or in part by another drug or substance; or

e. If it purports to be the product of a manufacturer of whom it is not truly a product.

The term “Spurious Drug” has been defined under Section 17-B of the Drugs and Cosmetics Act, 1940.

List of Drugs, Medical Devices, Vaccine and Cosmetics declared as Spurious for the Month of March- 2025

S.No.	Name of Drugs/medical device/cosmetics	Batch No.	Date of Manufacture	Date of Expiry	Manufactured By	Reason for failure	Drawn By	Firm’s reply	Remarks
1.	Telma 40 (Telmisartan Tab I.P. 40mg)	5240226	Feb-24	Jan-27	Under Investigation	Does not Conform to I.P.	–	The actual manufacturer (as per label claim) has informed that the impugned batch of the product has not been manufactured by them and that it is a spurious drug.	The product is purported to be spurious, however, the same is subject to outcome of investigation.

Meanwhile, drugs that fail to meet the quality standards or specifications are known as Not of Standard Quality (NSQ) drugs. The term ‘standards of quality’ is defined under Section 16 (1) (a) of the Drugs and Cosmetics Act, 1940, as ‘standards of quality’ meaning that the drug complies with the standards set out in the Second Schedule of the said Act.

A few of the reasons why the drug samples tested failed were the failure of the assay, failure of the dissolution test, failure of pH, particulate matter, description, etc.

The samples collected were tested in six laboratories CDL Kolkata, RDTL Guwahati, CDTL Mumbai, and RDTL Chandigarh.

NOT OF STANDARD QUALITY (NSQ) ALERT FOR THE MONTH OF MARCH-2025 (CDSCO/Central Laboratories)

S.No	Product/Drug Name	Batch No.	Manufacturing Date	Expiry Date	Manufactured By	NSQ Result	Reported by CDSCO Laboratory
1.	Amoxicillin Sodium and Clavulanate Potassium (Sterile) 5:1	4032409004	09/2024	08/2028	M/s. Shandong New Time Pharmaceuticals Co. Ltd., No.1, North Outer Ring Road, Feixian Country, Shandong Province, China	Particulate Matter	CDL, Kolkata
2.	Pantoprazole Gastro- Resistant Tablets IP (Pantoshang-40)	SP240165	06/2024	05/2026	M/s. Shangrila Industries (P) Ltd., (Pharma Division) Mining Rangpo East Sikkim-737132	Dissolution (Buffer Stage)	CDL, Kolkata
3.	Pantoprazole tablets IP 40 mg	0081	05/2024	04/2026	M/s. Hindustan Antibiotics Ltd., Pimpri, Pune-411018, INDIA	Dissolution (Buffer Stage)	CDL, Kolkata
4.	Adrenaline Bitartrate Injection IP (Reoline Injection)	AD-204	11/2024	04/2026	M/s. Rathi Laboratories (Hindustan) Pvt. Ltd., Industrial Area, Patna-800013 Bihar	Appearance of solution, Particulate matter and Description	CDL, Kolkata
5.	Bupivacaine Hydrochloride In Dextrose Injection USP	AA4009	03/2024	02/2026	M/s. Aishwarya Healthcare, Samardung, Kower Kabrey Block, South Sikkim-737137	Particulate matter (visible) and Description	CDL, Kolkata
6.	Montelukast and Levocetirizine Tablet (Dumont-L )	DML 062	12/2024	11/2027	M/s.Hygeia Pharmaceuticals Mfg (P) Ltd., 608, Dwarir Road, Dhamaitala, P.O.- Dakshin Jagaddal, Dist-24 Pgs(S), Pin-700151, W.B.	Dissolution of Levocetirizine Hydrochloride and Montelukast	CDL, Kolkata
7.	Nitrazepam Tablets I.P. 10 mg. (Nitravet-10)	AXI23003P	09/2023	02/2028	M/s. Anglo-French Drugs & Industries Limited, Plot No-4, Phase-II, Peenya Industrial Area, Peenya, Bengaluru-560 058	Spurious Identification and Assay of Nitrazepam	CDL, Kolkata
8.	Vitamin B1, Vitamin B2, Nicotinamide, Vitamin B6, Vitamin B12 & Calcium D-Pantothenate Syrup (B-Complex Syrup)	BOB-2440	06/2024	11/2025	M/s. Apple formulations Pvt. Ltd., Plot no. 208, Kishanpur, Roorkee-247667 (U.K.)	Assay of Vitamin B12	CDL, Kolkata
9.	Vitamin B1, Vitamin B2, Nicotinamide, Vitamin B6, Vitamin B12 &	BOB-2451	06/2024	11/2025	M/s. Apple Formulations Pvt. Ltd., Plot no. 208, Kishanpur, Roorkee-247667 (U.K.)	Total aerobic viable count	CDL, Kolkata

	Calcium D-Pantothenate Syrup (B-Complex Syrup)					under Microbial limit test
10.	Vitamin C, Vitamin B12, Folic Acid and Niacinamide Injection (Curevit-12 (Combi Pack ))	CP-937	12/2024	05/2026	M/s. Pharma Cure Laboratories, Garha Jalandhar 144022 Punjab	Particulate Matter and Description	CDL, Kolkata
11.	Ceftriaxone and Salbactam for Injection 1.5 g (TriaxS 1.5 g)	DC40117	09/2024	08/2027	M/s. Captab Biotec, Unit-II, Plot No. 125, E.P.I.P. Road, Mauja, Jharmajri, Baddi, Dist. Solan (H.P.)-173205	Particulate Matter and Description	CDL, Kolkata
12.	Ceftriaxone & Sulbactam for Injection IP (Cefamed-S)	B4CT05E	10/2024	09/2026	M/s. Lenus Lifecare Pvt. Ltd., Plot No. 1, Industrial Area, Chambaghat, Solan (H.P.)-173 213(India)	Clarity of Solution, Particulate matter and Description	CDL, Kolkata
13.	Pantoprazole Gastro- Resistant and Domperidone Prolonged-release Capsules IP (Pantoryl- DSR )	MC-24229	04/2024	03/2026	M/s. Matins Healthcare Pvt. Ltd., Plot No.-10, Sector-5, I.I.E., SIDCUL, HARIDWAR- 249403 (U.K.)	Dissolution of Pantoprazole Sodium in Buffer stage	CDL, Kolkata
14.	Chlorhexidine Gluconate & Ethyle Alcohol Baed Hand and Skin Disinfectant (Safiser Hand Rub)	IJWX/074	09/2023	09/2025	M/s. SS Enterprises F-76,, Sector-8, Noida, G.B. Nagar (U.P.), India 201301	Assay of Ethyl alcohol, Chlorhexidine Gluconate	CDL, Kolkata
15.	Dexamethasone Sodium Phosphate Injection IP (Dexagain Injection )	VHI274001	12/2024	11/2026	M/s.Vidit Healthcare, Village Kishanpura, Paonta Sahib, Distt-Sirmour, H.P.-173025	Assay of Dexamethasone Sodium Phosphate calculated as Dexamethasone Phosphate	CDL, Kolkata
16.	Itraconazole Capsules BP 100 mg (Fungis-100)	C4050	06/2024	05/2026	M/s. Merril Pharma Pvt. Ltd., Unit- II Plot No.24,25,31,32 Somnath Industrial Park, Kerala GIDC, Near Bavla, Ahmedabad -382220, Gujarat, India	Dissolution	CDL, Kolkata
17.	Gentamicin Sulphate Injection IP (GENTAMICIN )	GN-37	09/2024	08/2026	M/s. Amba research Laboratories, Road No.-21, Rajiv Nagar, Patna-24	Sterility, Particulate Matter and Description	CDL, Kolkata
18.	Methylcobalamin, Thiamine HCl, Pyridoxine HCl, D-	UGA-24436E	08/2024	01/2026	M/s. Ultra Drugs Pvt. Ltd., Plot No. 1315-1318, Manpura,	Particulate Matter and Assay of Methylcobalamin	CDL, Kolkata

	Panthenol and Nicotinamide Injection (Nuropat)				Nalagarh Road, Distt. Solan (H.P.) 174101
19.	Chloramphenirol Eye Ointment I.P. 1% W/W (EXPHENICOL)	1624-366	01/07/2024	30/06/2026	M/s. Zee Laboratories Ltd., Behind 47, Industrial Area, Paonta Sahib-173025	Assay of Chloramphenicol	CDL, Kolkata
20.	Calcium& Vitamin D3 Tablets IP	QT23144	11/2024	10/2026	M/s.Quest Laboratories Limited, Plot No.-45, Sector-III, Pithampur, Dist-Dhar-454775 (M. P.)	Description, Dissolution (for Calcium) and Assay of Elemental Calcium	CDL, Kolkata
21.	Rabeprazole Sodium Injection I.P.	MD23H29	08/2023	07/2025	M/s. Martin and Brown Bio- sciences, K.No.-918/419, Malkumajra, Nalagarh Road, Baddi, Distt.-Solan (H.P.) – 173205	Particulate matter, Related Substances, Clarity of solution, pH, Assay of Rabeprazole Sodium and Description	CDL, Kolkata
22.	Rabeprazole Sodium Injection I.P.	MD23H27	08/2023	07/2025	M/s. Martin and Brown Bio- sciences, K.No.-918/419, Malkumajra, Nalagarh Road, Baddi, Distt.-Solan (H.P.) – 173205	Clarity of solution, Particulate matter, Related Substances, pH, Assay of Rabeprazole Sodium and Description	CDL, Kolkata
23.	Iron Sucrose Injection USP	MA24G46	07/2024	06/2026	M/s. Martin and Brown Bio- sciences Pvt. Ltd., K.No.- 918/419, Malkumajra, Nalagarh Road, Baddi, Distt.- Solan (H.P.) -173205	pH	CDL, Kolkata
24.	Cholecalciferol (Vitamin D3) 60000 IU/gm Granule Sachet	TPD24015	07/2024	06/2026	M/s. Affy Parenterals, Vill. Gullarwala, P.O. Baddi, Distt. Solan -173205 (HP)	Assay/content of Cholecalciferol (Vitamin D3)	CDL, Kolkata
25.	Calcium Carbonate 500 mg + VIT. D3 250 IU TABLETS IP (CALXIA 500 )	GTL1258	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat.	Dissolution (for Calcium)	CDL, Kolkata
26.	Calcium Carbonate 500 mg + VIT. D3 250 IU TABLETS IP (CALXIA 500 )	GTL1296	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat.	Dissolution (for Calcium)	CDL, Kolkata

27.	Omeprazole for Injection (Lyophilized) 40 mg (Fexona )	324-609	05/2024	04/2027	M/s. Zee Laboratories Ltd., Behind 47, Industrial Area, Paonta Sahib-173025	Sterility of Water for Injection	CDL, Kolkata
28.	Omeprazole for Injection (Lyophilized) 40 mg (Fexona )	324-608	05/2024	04/2027	M/s. Zee Laboratories Ltd., Behind 47, Industrial Area, Paonta Sahib-173025	Sterility of Water for Injection	CDL, Kolkata
29.	Cholecalciferol (Vitamin D3) 60000 IU/gm Granule Sachet	TPD24020	07/2024	06/2026	M/s. Affy Parenterals, (WHO- CGMP/ISO 9001:2015 Certified Co.) Vill-Gullerwala, PO-Baddi, Dist-Solan-173205 (H.P.)	Assay/content of Cholecalciferol (Vitamin D3)	CDL, Kolkata
30.	Cholecalciferol (Vitamin D3 ) 60000 IU/gm Granule Sachet	TPD24019	07/2024	06/2026	M/s. Affy Parenterals, (WHO- CGMP/ISO 9001:2015 Certified Co.) Vill-Gullerwala, PO-Baddi, Dist-Solan-173205 (H.P.)	Assay/content of Cholecalciferol (Vitamin D3)	CDL, Kolkata
31.	Cholecalciferol (Vitamin D3 ) 60000 IU/gm Granule Sachet	TPD24018	07/2024	06/2026	M/s. Affy Parenterals, (WHO- CGMP/ISO 9001:2015 Certified Co.) Vill-Gullerwala, PO-Baddi, Dist-Solan-173205 (H.P.)	Assay/content of Cholecalciferol (Vitamin D3)	CDL, Kolkata
32.	Calcium Carbonate 500 mg + VIT. D3 250 IU TABLETS IP (CALXIA 500 )	GTL1288	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No. 611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
33.	Cefuroxime Axetil Tablets I.P. 500 mg (BREXETIL-500 )	ST-25345	10/2024	09/2026	M/s. Sunvij Drugs Private Limited, 511, GIDC, Waghodia, Baroda-391760, Gujarat	Dissolution	CDL, Kolkata
34.	Aceclofenac & Paracetamol Tablets (ALDIGESIC P )	BHT23229M B	09/2023	08/2025	M/s. Sri Ram Healthcare Pvt. Ltd., Plot No.-81-C/2, EPIP, Phase-1, Jharmajri, Baddi, Dist-Solan (H.P.)-174103	Description	CDL, Kolkata
35.	Ambroxol Hydrochloride and N-Acetyl L-Cysteine Tablets (Kufril-NT )	INT 115	07/2024	06/2026	M/s. Med Manor Organics Pvt Ltd., Unit-II, Kh.No-143 M/7, Village-Raipur, Pargana- Bhagwanpur, Tehsil-Roorkee, Dist. Haridwar, Uttarakhand- 247661	Description	CDL, Kolkata
36.	Calcium Gluconate Injection I.P. 10 ml	MV24B35	02/2024	01/2026	M/s. Martin and Brown Bio- sciences Pvt. Ltd., K.No.- 918/419, Malkumajra, Nalagarh Road, Baddi, Distt.- Solan (H.P.) -173205	Extractable Volume, Particulate matter and Description	CDL, Kolkata

37.	Tranexamic Acid Injection I.P. (Tranexacure Injection )	TC-038	12/2024	11/2026	M/s. Pharma Cure Laboratories, Garha Jalandhar 144022 Punjab	Particulate Matter and Description	CDL, Kolkata
38.	Domperidone Suspension IP	DPS3-24- 225	08/2024	07/2026	M/s. Ornate Labs Pvt. Ltd., Bela Industrial Estate, Muzaffarpur-842005	Total aerobic viable count under Microbial contamination test and Assay/content of Domperidone	CDL, Kolkata
39.	Calcium Carbonate 500 mg + VIT.D3 250 IU TABLETS IP (CALXIA- 500 )	GTL1307	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
40.	Calcium CarbonateE 500 mg + VIT. D3 250 IU TABLETS IP (CALXIA-500 )	GTL1312	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
41.	Calcium Carbonate 500 mg + VIT. D3 250 IU TABLETS IP (CALXIA- 500 )	GTL1313	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
42.	Calcium Carbonate 500 mg.+VIT. D3 250IU TABLETS IP (CALXIA- 500 )	GTL1314	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
43.	Calcium Carbonate 500 mg.+VIT. D3 250 IU TABLETS IP (CALXIA- 500 )	GTL1315	12/2024	11/2026	M/s. Gidsha Pharmaceuticals, Plot No.-611 612, Mega GIDC, Kharedi, Dahod-389151, Gujarat	Dissolution (for Calcium)	CDL, Kolkata
44.	Iron Sucrose Injection USP 100 mg/5ml	24RS13	10/2024	09/2026	M/s. SAI Parenterals Limited, D1 &D4, Survey No. 280, Phase-V, IDA, Jeedimetla, Hyderabad-500055, TS	Alkalinity and pH	CDL, Kolkata
45.	Iron Sucrose Injection USP 20 mg/ml (I-PIC)	A24105K	06/2024	05/2026	M/s. Pace Biotech Village Surajpur, Paonta Sahib, Dist. Sirmour (H.P.)-173001	Particulate matter in Injections	CDL, Kolkata
46.	Gentamicin Sulphate Injection I.P. 30 ml (Gentalab )	OGNI-037	07/2024	06/2026	M/s. Laborate Pharmaceuticals India Ltd., #31, Rajban Road, Nariwala Paonta Sahib, (H.P.)	Particulate matter and Description	CDL, Kolkata
47.	Alprazolam Tablets I.P. 0.50 mg (Calmpik-05)	AT24266	07/2024	06/2027	M/s. Aarpik Pharmaceuticals Pvt.Ltd., C1/306/5,Kerala G. I.D.C,Kerala Bavla Road,Dist. Ahmedabad	Dissolution	RDTL, Guwahati

48.	Calcium 500 mg with Vitamin D3 250 IU Tablets IP	LMT240449	04/2024	03/2026	M/s. Life Max Cancer Laboratories, Plot No. 106 & 106 A, Sector6A, IIE, SIDCUL, Haridwar249403 (U.K)	Dissolution (Calcium) and Assay of Vitamin D3	RDTL, Guwahati
49.	Calcium And Vitamin D3 Tablets IP	07493	01/2024	12/2025	M/s. Healthy Life Pharma Pvt. Ltd., Factory: N-31/1, M.I.D.C., Tarapur, Boisar – 401 506, Dist. Palghar. Maharashtra	Assay/Content of Vitamin D3	RDTL, Guwahati
50.	Pantoprazole Gastro- Resistant Tablets IP 40 mg (Pantojack-40)	T-1261	04/2024	03/2026	M/s. Jackson Laboratories Pvt.Ltd, 22-24, Majitha Road, Bye Pass, Amritsar-143 001(India)	Description and Dissolution	RDTL, Guwahati
51.	Telmisartan Tablets I.P. (DV-TELMI-40)	GTE2206	08/2024	07/2026	M/s. Digital Vision, 176, Mauza Ogli, Nahan Road, Kala-Amb, Distt. Sirmour (H.P.) – 173 030	Dissolution	RDTL, Guwahati
52.	Telmisartan Tablets IP 40mg	251TTF014	08/2024	07/2026	M/s. Swiss Garnier Life Sciences, No. 21-23, Industrial Area, Mehatpur, Dist. Una, Himachal Pradesh-174 315. INDIA	Dissolution	RDTL, Guwahati
53.	Dexamethasone Oral Solution USP 0.5mg per 5ml	LG24-29	07/2024	06/2026	M/s. Om Biomedic Pvt. Ltd..,, Plot No. 68, 69, 82 & 83, Sector – 6A, IIE, SIDCUL, Haridwar-249 403 (U.K.)	Assay	RDTL, Guwahati
54.	Amoxycillin & Potassium Clavulanate Injection IP.	AB193049A	05/2023	04/2025	M/s. ANG Lifesciences India Ltd., Village: Kishanpura, Nalagarh Road, Tehsil: Baddi, Distt.: Solan, HP-174101	Assay (Content of Clavulanic Acid)	RDTL, Guwahati
55.	Insulin Syringe (U-40 Insulin 1ml Syringe) (Mr. INJECT)	0123338	12/2023	11/2028	M/s Biomed Healthcare Products Pvt. Ltd.,, Unit-II, Plot No. 62-65, Sector-6A, Sidcul, Haridwar 249403, Uttarakhand, India	Sterility	RDTL, Guwahati
56.	Infusion Set (BMD)	BIV-020	08/2024	07/2027	M/s.Bhagwati Medicare devices, 8, Maruti Industrial Estate, Nr. Sindhvai Mata Temple, C.T.M.- Ramol Road, Amraiwadi, Ahmedabad- 380026. Gujarat (India)	Sterility	RDTL, Guwahati
57.	Amoxycillin & Potasium Clavulanate Tablets I.P. (IPHA CLAV-375)	NCP-151	01/2024	06/2025	M/s. Park Pharmaceuticals, Vill. Kalujhanda, Near Nanakpur, Teh. Baddi, Distt. Solan (H.P.)- 174103	Assay of Clavulanic Acid	RDTL, Guwahati
58.	Lactulose Solution U.S.P. (Apelact), 200 ml	AFL-121	08/2024	07/2026	M/s.Apex Formulations Pvt. Ltd., 1276, Raipur, Highway, Dist. Mehsana, Gujarat	“Organic impurities” and	CDTL-Mumbai

						“Assay of Lactulose”
59.	Lactulose Solution U.S.P. (Reevac), 100 ml	R23K015	11/2023	10/2025	M/s.Rhombus Pharma Private Limited., 816/1, Rakanpur, Kalol- 382721 (Gujarat)	“Organic impurities”	CDTL-Mumbai
60.	Albendazole Tablets I.P. (DV-BEND 400)	GTE1974	07/2024	06/2026	M/s Digital Vision, 176, Mauza Ogli, Nahan Road, Kala-Amb, Dist. Sirmour (H.P.)- 173 030.	“Dissolution”	CDTL-Mumbai
61.	Atorvastatin Tablets IP (GATOVAS- 20)	CT24250423	06/2024	05/2026	M/s.CMG Biotech Pvt. Ltd., (Unit-II), Plot No.58, Phase-III, Industrial Area, Sansarpur Terrace, HP- 176501. Mkt By : Same as manufacturer	“Related substances”	CDTL-Mumbai
62.	Atorvastatin Tablets IP 10 mg	00 57	09/2024	08/2026	M/s.Hindustan Antibiotics Ltd., Pimpri, Pune- 411 018, India.	“Related substances”	CDTL-Mumbai
63.	Sodium Bicarbonate Tablets U.S.P. 1000 mg	T-2401309	01/2024	12/2025	M/s.Rivpra Formulation Pvt. Ltd., Plot No.8, Sector-6A, I.I.E., SIDCUL, Haridwar- 249 403 (U.K.). Manufatured for : Pharmaceuticals and Medical Devices Bureau of India (PMBI), 8th Floor, Videocon Tower, Block E-1, Jhandewalan Extension, New Delhi-110 055.	“Description”	CDTL-Mumbai
64.	Pantoprazole Sodium Gastro-Resistant & Domperidone Prolonged-Release Capsules IP (Pengin- DSR Capsules)	NHD24057D	01/2024	12/2025	M/s.Nest Healthcare Private Limited., Plot No. 300, G.I.D.C., Odhav, Ahmedabad- 382415 (Guj.). India. Mkt By : Megan healthcar, C-403, 4th Floor, Abhishek Complex 1, Opp. Haripura Bus Stop, Babupura, Asarwa, Ahmedabad, Gujarat.	“Dissolution for Domperidone”	CDTL-Mumbai
65.	Sacubitril and Valsartan Tablets 50 mg (SVJAJ 50)	SVA04H24C	08/2024	07/2026	M/s.Bajaj Healthcare Ltd., R.S. No. 1818, Manjusar- Savli Road, At & Post- Manjusar, Tal. Savli Dist. Vadodra – 391775, Gujarat, India.	“Assay”/ content of “Sacubitril” and “Valsartan”	CDTL-Mumbai
66.	Sodium Chloride Injection I.P. 0.45 % W/V (0.45 NS)	1266688H	06/2024	05/2027	M/s.Shree KrishnaKeshav Laboratories Ltd., Amraiwadi Road, Ahmedabad- 380 008, India	Misbranded	CDTL-Mumbai
67.	Hydro Cellular Foam with ART Principle Antibacterial PU top	10241283L	10/2024	09/2027	M/s Datt Mediproducts Pvt. Ltd., 52-54 & 63-64,Roz-ka-	Sterility	RDTL, Chandigarh

	Layer with Silicone Gel (Veflfix-S Border (Sacrum))				Meo Ind. Area, Nuh.Mewat- 122103, Haryana, India
68.	Chlorpheniramine Maleate Dextromethorphan Hydrobromide & Phenylephrine HCl Syrup (DXCP)	ML-012	08/2024	07/2026	M/s Maha Avtar, Health Care Pvt. Ltd., D-22, Sector-17, Kavi Nagar Indl.Area, GZB-201002.	Identification and Assay of Dextromethorpha n Hydrobromide	RDTL, Chandigarh
69.	Povidone-Iodine Ointment USP	OI4004A	09/2024	08/2026	M/s. Navkar Lifesciences, Plot No. 76, Lodhi Majra, Industrial Area, Baddi, Distt. Solan (H.P.)	Assay of Povidone Iodine calculated as available Iodine	RDTL, Chandigarh
70.	Omega-3 Fatty Acid, Green Tea Extract, Ginkgo Biloba, Ginseng Extract, Grape Seed Extract, Multimineral, Multivitamin with Antioxidants and Trace Elements Softgel Capsules (VRICH-24 CAPSULES)	RHSD-3149F	02/2024	01/2026	M/s.Ramom Healthcare Pvt.Ltd. (An ISO & GMP Certified Company), Plot No.58, Sector-5, Parwanoo (HP)	Assay of Magnesium Oxide calculated as elemental Magnesium, Vitamin D3, Ferrous Fumarate, Zinc Oxide calculated as elemental Zinc, Copper Sulphate Pentahydrate calculated as elemental Copper, Manganese Sulphate calculated as elemental Manganese, Calcium Ascorbate, Citrus Bioflavonoids, Vitamin B6, Folic acid	RDTL, Chandigarh

Also Read:Drug Alert: CDSCO Flags 52 Formulations As Not Of Standard Quality

To view the official notice, click the link below:

https://medicaldialogues.in/pdf_upload/drugsafetyalertmarch122025-284187.pdf

https://medicaldialogues.in/pdf_upload/mdmar25-284188.pdf

Powered by WPeMatico

Police officers fire more shots than civilians in homicides, research shows

An analysis using data from the US National Violent Death Reporting System (NVDRS) has found that in homicides with police shooters, victims have been shot far more times than in homicides with civilians as shooters. The new study, appearing in the American Journal of Preventive Medicine, showed that individuals aged 25 to 44, Black people, and those living outside the Northeast region of the US tend to be disproportionately killed by police as well as sustain a higher number of bullet wounds.

Powered by WPeMatico

Federal COVID websites now promote lab leak theory

The Trump administration has replaced two major federal websites for COVID information with a new page that promotes the theory that the virus came from a lab in China.

Powered by WPeMatico

Safer opioid supply improves health outcomes among people at high risk of overdose

Research from ICES and Unity Health Toronto shows that safer opioid supply programs and methadone both reduce opioid overdoses, health care utilization, and costs.

Powered by WPeMatico

Pulmonary fibrosis has no cure. Could a cancer drug hold the answer?

Researchers at Tulane University have identified a potential new way to treat idiopathic pulmonary fibrosis (IPF), a deadly and currently incurable lung disease that affects more than 3 million people worldwide.

Powered by WPeMatico

WHO announces ‘significant’ layoffs amid US funding cuts

The World Health Organization chief said Tuesday that operations and jobs would be slashed as US funding cuts had left the UN agency with a budget hole of several hundred million dollars.

Powered by WPeMatico

Telangana Private Medical Colleges warned over stipend irregularities, ghost faculty

Hyderabad: Amid the concerns over ghost faculty and stipend irregularities at private medical colleges in Telangana, the Telangana Health Minister, Damodar Rajanarsimha, has warned the institutes. The medical colleges have now been told to regularly pay the stipends to the medical students

Apart from this, the Minister also stressed the implementation of the Clinical Establishment Act in all medical colleges and warned of taking strict action against those colleges that fail to comply with the quality standards of medical education. He also clarfied that the harassment of students for additional fees will also viewed strictly.

These directions were issued by the Minister while holding a review meeting with the management, dean and principals of the private medical colleges at the Secretariat on Monday i.e. April 21.

Also Read: Unpaid stipend, illicit means to show amount transactions: Telangana medicos allege stipend discrepancies

During the meeting, the Minister reviewed the quality standards of medical education, regulations introduced by the National Medical Commission (NMC), faculty, attendance, fees, and so on, Edex Live has reported.

Addressing the issue of quality of medical education, the Minister was quoted as saying by the Times of India, “If the quality standards in medical education decline, it will endanger the lives of the people. The govt will be very strict in this matter. We will take strict action against colleges that do not comply with the quality standards.”

TOI has reported that the Health Minister also warned to take serious action against ghost faculties in private medical colleges in the State. Noting that the doctors of Telangana have a good reputation globally, he stated that such actions would lead to the deterioration of the standards of medical education in the State.

Further, he said that the provisions of the Clinical Establishment Act must be followed in teaching hospitals affiliated with colleges and assured colleges to resolve the issues raised by them regarding the NMC regulations.

The Minister’s directions asking the private medical colleges to pay stipends to the medical students comes when allegations were raised in this regard by the MBBS interns and resident doctors at the private medical colleges of the State.

Medical Dialogues had earlier reported about the allegations made by the house surgeons and resident doctors at the private medical colleges in Telangana, who alleged that most of the institutes do not pay any stipends to them. There were also allegations stating that several colleges take stipend amounts from the students and show transfer of amounts to students using illicit means. The students claimed that either they do not receive stipends at all or get nominal amounts, such as Rs 10,000 for the resident doctors and Rs 2,000 for the MBBS interns.

Recently, a complaint was filed with the National Medical Commission‘s (NMC) Undergraduate Medical Education Board (UGMEB) seeking disciplinary action against Bhaskar Medical College (BMC), Moinabad, for allegedly underpaying stipend to the MBBS interns.

The college had also been accused of deliberately misrepresenting the government orders. Allegedly, despite multiple reminders from the NMC to the Telangana DME since February 2025 and even after a follow-up directive was issued on March 3, 2025, no corrective steps were taken.

Also Read: Bhaskar Medical College allegedly paying meagre Rs 2,000 stipend to MBBS interns- NMC action sought

Powered by WPeMatico

Enrollment in Government Health Schemes Mandatory: Maha Govt tells Charitable Hospitals

Mumbai: In the wake of the tragic incident at Deenanath Mangeshkar Hospital in Pune, where a mother of twin babies lost her life reportedly being denied admission, the Maharashtra government has made it mandatory for all charitable hospitals in the state to must enroll in government health schemes. These include the Mahatma Phule Jan Arogya Yojana (MPJAY), the Pradhan Mantri Jan Arogya Yojana (PMJAY), and the National Child Health Programme.

The decision came after a government-appointed committee found that Pune’s Deenanath Mangeshkar Hospital, a charitable hospital, had refused to admit a woman during childbirth and tragically, the woman died after giving birth on March 31.

Medical Dialogues had recently reported that a seven-month pregnant woman carrying twins died after allegedly being denied admission at the Deenanath Mangeshkar Hospital in Pune due to non-payment of an advance of Rs 10 lakh. The 30-year-old woman was reportedly facing severe pregnancy-related complications when she was rushed to the hospital, but was turned away for treatment.

The patient was the wife of BJP MLC Amit Gorkhe’s personal secretary. Allegedly, the gynaecologist who attended to the patient had demanded the deposit before admitting her and starting the treatment. The woman’s husband alleged that the hospital demanded a sum of Rs 10 lakh for treatment, even as he expressed his willingness to pay Rs 2.5 lakh upfront. He alleged that the hospital’s refusal to admit her or provide immediate medical care caused significant delays. As her condition deteriorated, the situation became increasingly critical. Left with no choice, the family rushed her to another hospital, but tragically, she passed away shortly after giving birth to her twin daughters.

In response to the incident, the state health department has formed a five-member panel to investigate the matter. The committee, constituted by the state health department, visited all three hospitals where the woman was taken by her family before and after delivery. After reviewing the circumstances surrounding her death, the committee concluded that Deenanath Mangeshkar Hospital failed to fulfill its responsibility by not admitting the patient when she sought care.

To prevent patients from facing such situations, a government resolution (GR) issued on Monday by the state’s law and judiciary department said that all charitable hospitals must register under the three health schemes from now on. Until now, joining these schemes was optional for private and charitable hospitals.

Also read- FIR against Gynaecologist in pregnant woman’s death case

“It has come to light that a woman was denied admission by Deenanath Mangeshkar Hospital, Pune, during her delivery. An inquiry committee was constituted under the relevant government resolution to investigate it. The matter of issuing instructions for necessary action in accordance with the recommendations of the panel is under consideration of state govt. The committee constituted under the chairmanship of the joint commissioner of charity, Pune, also submitted its report and recommendations to the govt. In accordance with it, the charity commissioner should instruct all the charity hospitals to effectively implement the Charity Hospital Scheme for patients belonging to the lower and weaker sections,” mentioned the GR.

According to a TOI news report, as of now, Maharashtra has a total of 2,031 hospitals empanelled under the govt health insurance schemes. The new GR mentioned that the updated information regarding the Indigent Patient Fund (IPF) account of charitable hospitals should be updated regularly on the charity commissioner’s website. All charitable hospitals must immediately treat a patient coming to the emergency ward, including pregnant women seeking medical attention.

The GR also stated that many charitable hospitals transferred a major source of their income to external sources like pharmacy and diagnostic tests (pathology, radiology or microbiology). As a result, the main hospital’s income appeared lower, and less money was going into the Indigent Patient Fund (IPF), which is meant to support poor patients. To fix this, the government has now said that even outsourced services must contribute 2% of their yearly income to the IPF. Under the charity scheme, a hospital has to reserve 2% of the annual gross bill for the IPF account.

Further, it stated “All charitable hospitals should take prior approval of the “Charity Hospital Emergency Room” at the Mantralaya through the online system to provide reserved beds to patients belonging to indigent and weaker sections, and for their scheduled treatment/surgery. Similarly, in case of emergency, charitable hospitals should urgently admit and treat patients concerned. The facilities should register them through the online system and send the proposal to the Charity Hospital Emergency Room of the ministry for approval within the next 48 hours for post-operative approval.

Restrictions have been imposed on charitable hospitals through the GR on demanding unreasonable money from patients. Hospitals have also been restricted from asking for additional documents from patients, apart from those prescribed by the high court or the govt. The facilities must ensure that no patient was denied treatment owing to lack of funds.”

Also read- Sassoon hospital panel to probe pregnant woman’s death

Powered by WPeMatico

Psoriasis Severity Linked to Apical Periodontitis but Not to Dental Caries: Study

Tune in to blood glucose for simpler early diabetes detection, recommends study

Drug Alert: 70 Drug Samples Fail To Clear CDSCO Test, 1 Declared spurious

Also Read:Drug Alert: CDSCO Flags 52 Formulations As Not Of Standard Quality

Police officers fire more shots than civilians in homicides, research shows

Federal COVID websites now promote lab leak theory

Safer opioid supply improves health outcomes among people at high risk of overdose

Pulmonary fibrosis has no cure. Could a cancer drug hold the answer?

WHO announces ‘significant’ layoffs amid US funding cuts

Telangana Private Medical Colleges warned over stipend irregularities, ghost faculty

Enrollment in Government Health Schemes Mandatory: Maha Govt tells Charitable Hospitals

Find us @ Facebook

Search Anything

Also Read:Drug Alert: CDSCO Flags 52 Formulations As Not Of Standard Quality

Find us @ Facebook

Find related topics

Search Anything