Prescription Opioids Linked to Increased Fall Risks among elderly, study finds

In a significant revelation, a recent population-based cohort
study conducted in New South Wales, Australia, has uncovered concerning
associations between prescription opioid analgesics and an elevated risk of
serious falls, particularly among older adults. The
study’s findings suggest that prescription opioids are associated with an
increased risk of serious fall events among adults of all ages, with the
greatest risk observed in individuals aged 85 or older. The
study, designed to explore the age-related risk of serious fall events
associated with opioid use, delves into the nuances of opioid exposure, time
from initiation, and daily dosage.


The study results were published in the journal JAMA Internal
Medicine.

The primary objective of the study was to unravel the intricate
web of associations between prescription opioids and serious fall events.
Researchers aimed to provide a comprehensive perspective by analyzing these
associations across various age groups, shedding light on temporal patterns and
dosage-dependent risks associated with the use of prescription opioids.

Harnessing data that linked national pharmaceutical claims to
diverse datasets encompassing sociodemographic information, clinical
characteristics, medication use, healthcare utilization, and mortality records,
the study included adults aged 18 and older who initiated prescription opioid
treatment between 2005 and 2018.


Revealing Findings:

  • The cohort, consisting of 3,212,369 individuals, witnessed a
    total of 506,573 serious fall events, including 5,210 fatal falls.

  • Strikingly, the study illuminated that the risk of serious fall
    events was heightened across all age groups during exposure to opioids.

  • Notably, individuals aged 85 or older faced the highest risk,
    with an adjusted incident rate ratio of 6.35 in comparison to those aged 18 to
    44.


  • Temporal analysis revealed a critical period within the first 28
    days following opioid initiation, marked by an increased risk of serious falls.
  • This risk, the study found, escalated with age.

  • Additionally,
    for individuals aged 18 to 84, there was a discernible correlation between
    higher daily opioid doses and the occurrence of serious fall events.

  • The study’s findings prompt a reconsideration of opioid
    prescription practices, emphasizing the imperative need for healthcare
    providers to carefully weigh the risks and benefits of prescribing opioids,
    particularly in older populations.

The critical window of the initial month
following opioid initiation emerged as a pivotal period, urging targeted fall
prevention efforts during this timeframe.

The study advocates for a holistic approach to patient care,
prioritizing safety, especially among vulnerable populations.

As prescription opioids continue to be a mainstay in pain
management, this study addresses a pressing public health concern, urging a
reevaluation of opioid prescription practices and advocating for a proactive
stance on falls prevention in tandem with opioid therapy. The research marks a
significant step toward safeguarding the well-being of patients and fostering a
more nuanced understanding of the risks associated with prescription opioids
across diverse age groups.

Further reading: Age-Related Risk of Serious Fall Events and Opioid Analgesic Use. doi:10.1001/jamainternmed.2023.8154

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Deep learning-accelerated MRI improves detection of acute ischemic stroke: Study

Germany: Deep learning (DL)-accelerated brain MRI is four times faster, offers better image quality and diagnostic confidence and hence improves the detection of acute ischemic lesions compared to conventional MRI, a recent study published in Radiology has shown.

The researchers assert that the technique could translate to better patient care in that it could cut healthcare costs and improve imaging workflow.

Implementing this technique may be of great value, considering the increasing demand for medical examinations and increasing financial constraints placed on healthcare systems, the study stated.

DL-accelerated MRI can substantially reduce examination times. However, there is a lack of studies prospectively evaluating the diagnostic performance of DL-accelerated MRI reconstructions in acute suspected stroke. Therefore, Sebastian Altmann, University Medical Center Mainz, Germany, and colleagues investigated the interchangeability of DL-accelerated MRI with conventional MRI in patients with suspected acute ischemic stroke at 1.5 T.

For this purpose, they conducted a prospective study comprising 211 participants with suspected acute stroke who underwent clinically indicated MRI at 1.5 T between 2022 and 2023.

For each participant, conventional MRI (including T1-weighted, T2-weighted, T2*-weighted, T2 fluid-attenuated inversion-recovery, and diffusion-weighted imaging; 14 minutes 18 seconds) and DL-accelerated MRI (same sequences; 3 minutes 4 seconds), were conducted.

The primary endpoint was the e interchangeability between conventional and deep learning-accelerated MRI for detecting acute ischemic infarction. Secondary endpoints included interchangeability regarding the impacted vascular territory and clinically relevant secondary findings (eg, neoplasm, microbleeds).

The overall occurrence of acute ischemic stroke, clinically relevant secondary findings, affected vascular territory, diagnostic confidence, and overall image quality were evaluated by three readers. For acute ischemic lesions, size and signal intensities were assessed.

The interchangeability margin was chosen as 5%. For interrater reliability analysis and interrater agreement analysis, intraclass correlation coefficient and multi-rater Fleiss κ, respectively, were determined.

The researchers reported the following findings:

  • The study sample comprised 211 participants (mean age, 65 years); 123 male and 88 female). Acute ischemic stroke was confirmed in 79 participants.
  • Interchangeability was demonstrated for all primary and secondary endpoints. No individual equivalence indexes (IEIs) exceeded the interchangeability margin of 5% (IEI, −0.002).
  • Almost perfect interrater agreement was observed.
  • DL-accelerated MRI provided higher overall image quality and diagnostic confidence.
  • The signal properties of acute ischemic infarctions were similar in both techniques and demonstrated good to excellent interrater reliability (intraclass correlation coefficient, ≥0.8).

“Despite being four times faster, DL-accelerated brain MRI was interchangeable with conventional MRI for detecting acute ischemic lesions,” the researchers concluded.

Reference:

Altmann S, Grauhan NF, Brockstedt L, Kondova M, Schmidtmann I, Paul R, Clifford B, Feiweier T, Hosseini Z, Uphaus T, Groppa S, Brockmann MA, Othman AE. Ultrafast Brain MRI with Deep Learning Reconstruction for Suspected Acute Ischemic Stroke. Radiology. 2024 Feb;310(2):e231938. doi: 10.1148/radiol.231938. PMID: 38376403.

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Consumer Court dismisses complaint against Gastrointestinal Surgeon, orders Religare health insurance company to compensate

Ludhiana: Holding that insurance companies are required to be more liberal in their approach without being too technical, the District Consumer Disputes Redressal Commission in Ludhiana has dismissed a complaint against Gastrointestinal Surgeon and directed Religare Health Insurance Company to consider and reimburse a patient’s medical claim in accordance with the policy terms and conditions.

The case concerned Kumar who purchased a health insurance policy for his family from Religare Health Insurance Company Ltd., valid from 18.11.2017 to 17.11.2018, renewed until 17.11.2019. The complaint stems from the hospitalization of his son, Uppal, at Satguru Partap Singh Hospital on 05.02.2019 for appendicitis surgery.

Uppal underwent surgery on 06.02.2019 and was discharged on 09.02.2019. The complainant initiated the insurance claim process through OP1 (hospital), OP2 (Religare Health Insurance Company Ltd.), and OP3 (Claims Department, Religare Health Insurance Company Ltd.). However, the hospital, company and the department took four days to decide the insurance claim, causing distress. On 09.02.2019, they rejected the pre-authorization claim, citing a pre-existing condition of ‘ASTHMA.’ The complainant disputed this, asserting his son had no history of asthma. The discharge summary, prepared by OP4 (Gastrointestinal Surgeon), inaccurately mentioned “Known case of Asthma,” leading to the denial of the insurance claim. The complainant, dissatisfied, approached the hospital and the surgeon to rectify the inaccurate remarks but was refused.

The complainant moved the Commission and accused the company and the surgeon of deficiency in service, resulting in mental agony. He requested compensation of Rs.1,00,000/- along with interest, litigation expenses of Rs.20,000/-, and the insurance claim amount of Rs.97,417/-.

Upon notice, the company and the claim department appeared and filed a joint written statement, raising preliminary objections and challenging the complaint’s maintainability, alleging it was misleading and premature. They clarified that the complainant had only submitted a cashless request claim and had not filed any reimbursement claim with them. They pointed out that the complainant held a policy named “Care Floater”, covering him and his family members from 18.11.2017 to 17.11.2018 for a sum insured of Rs.5,00,000/-. The policy was subsequently renewed from 18.11.2018 to 17.11.2019.

The sequence of events unfolded when the insurance company and the department received a cashless request from Satguru Pratap Singh Hospital, Ludhiana, on 05.02.2019, for the admission of the insured, Uppal. The provisional diagnosis was Acute Appendicitis. In response, the Company sent a Query Letter dated 06.02.2019, requesting specific documents, including the exact duration and past history of the present ailment with the first consultation paper and all past treatment records, as well as pre-hospitalization OPD treatment records.

Upon receiving the hospital’s reply to the query, the Company issued an Authorization Letter on 06.02.2019. Subsequently, on 09.02.2019, a Deficiency Letter was sent, asking for complete indoor case papers, admission notes, history sheet, doctor’s notes, nursing notes, vital chart, and further details regarding the exact duration and past history of the present ailment, including the first consultation paper for asthma.

The joint response from the company and the claim department highlighted the communication and document exchange between the hospital and the insurance company, outlining the steps taken in processing the cashless request and addressing deficiencies. The complaint appeared to hinge on the rejection of the claim and the alleged pre-existing condition of asthma, a matter contested by the complainant.

The insurance company, after receiving documents from the hospital regarding a cashless claim, issued a Query Letter on 09.02.2019, requesting specific details, including the exact duration and past history of the present ailment with the first consultation paper and all past treatment records. Additionally, they sought the PAC Note related to pre-anesthesia checkup and treatment records regarding a lower respiratory tract infection (LRTI) from one year back.

Upon reviewing the documents and information gathered during the investigation, the insurance company emphasized that the insured was mentioned as a known case of Asthma in the Discharge Summary and Doctor’s progress notes, with a history of LRTI. Despite multiple Query Letters sent to the hospital, the company claimed not to have received adequate replies. Consequently, on 09.02.2019, the company rejected the complainant’s claim through a Claim Denial Letter, stating the non-submission of required necessary documents for past treatment details, which led to the inability to rule out the pre-existing nature of the ailment. The complainant was advised to file for reimbursement with all supportive documents.

On the merits of the case, the company and the department reiterated their earlier objections, denying any deficiency in service and urging the dismissal of the complaint.

In a separate written statement, the surgeon raised preliminary objections challenging the maintainability of the complaint. The doctor argued against the mis-joinder of necessary parties, asserting that the complaint was misconceived and an abuse of the process of law. Furthermore, he claimed that the complainant lacked the locus standi to file the complaint.

The surgeon emphasized that he had fulfilled his duties diligently and prudently in treating the patient with the utmost care. The patient, Uppal, was admitted to Satguru Partap Singh Hospital on 05.02.2019, diagnosed with acute appendicitis, and subsequently treated with Laparoscopic Appendectomy by OP4 on 06.02.2019. Throughout the treatment, the patient was clinically evaluated, thoroughly investigated, and post-operatively managed with antibiotics, analgesics, antacids, and other supportive measures. The patient’s condition improved, and he was discharged in a satisfactory condition on 09.02.2019.

The doctor further clarified that during the admission procedure, the complainant provided a history of the patient’s past ailment, specifically mentioning asthma. This information was duly recorded in the hospital’s records and reflected in the discharge summary provided to the complainant. The doctor asserted that the complainant did not object to this information at the time of discharge.

In response to queries raised by the company and the claim department regarding the patient’s treatment, the doctor provided a detailed written response on 09.02.2019, which was sent to both of them. The surgeon then claimed that neither the complainant nor the company and the department contacted him thereafter, and there was no reason for them to do so. The doctor insisted that neither OP1 (Satguru Partap Singh Hospital) nor he had any role or concern in the alleged claim refusal.

On the merits of the case, the surgeon reiterated the objections, denying any deficiency in service and requesting the dismissal of the complaint.

After considering the arguments from the parties, examining the complaint, affidavits, annexed documents, and written statements, the Commission noted that the complainant, covered by a cashless health insurance policy, had his son, Uppal, admitted to Satguru Partap Singh Hospital for appendicitis surgery. The surgery took place on 06.02.2019, and the discharge occurred on 09.02.2019, within the policy period.

During the hospitalization, a pre-authorization for a cashless claim was initiated on 06.02.2019, but the company and the claim department raised queries through Deficiency Letters. The cashless facility was ultimately declined on 09.02.2019 due to non-receipt of required documents, as stated in the Denial Letter. The complainant was advised to file a reimbursement claim with necessary documents.

In the Deficiency Letter dated 09.02.2019, the company and the department requested specific documents related to the ailment and medical history, particularly mentioning the possibility of asthma. Despite multiple requests and Deficiency Letters, the complainant did not file the claim with the company, leading to the rejection of the claim on 09.02.2019.

The complainant asserted a claim of Rs.1,73,087/- based on bills submitted as evidence. The Commission emphasized the need for insurance companies to adopt a more liberal approach in settling claims, citing the lack of significant assistance rendered to policyholders during claim settlements. The Commission suggested that insurance companies should be more considerate and less technical in their approach to claims. It noted;

“The Insurance companies do depute their officers/agent for procurement of business at the doorsteps of person(s) to be insured but at the time of settling the claims, the company’s officials or TPAs render little assistance to the policy holder. The insurance companies are required to be more liberal in their approach without being too technical.”

The Commission cited a 2022 Supreme Court judgment (Gurmel Singh Vs Branch Manager National Insurance Company Ltd.) emphasizing that insurance companies should not act too technically or arbitrarily while settling claims. The judgment stressed that insurers must not reject claims based on flimsy or technical reasons, especially when the insured faces challenges in providing certain documents. In light of this, the Commission directed the complainant to submit the required documents mentioned in Deficiency Letters to the company and the claim department. Following this, they were instructed to consider and reimburse the complainant’s claim in accordance with the policy’s terms and conditions after receiving the documents.

The complainant raised concerns against OP4, Dr. Singh, a Gastrointestinal Surgeon at Satguru Partap Singh Hospital, alleging that he incorrectly stated in the discharge summary that the patient was a “Known Case of Asthma,” leading to the rejection of the insurance claim by the company and the claim department. However, the doctor provided a certificate clarifying that the mention of asthma was based on the history provided by a distant relative, and the doctor had no role in processing the reimbursement claim. The certificate emphasized that the current illness (acute appendicitis) was unrelated to the past history of asthma. Consequently, the Commission deemed the complaint against the doctor as not maintainable and recommended its dismissal.

The complaint was partially allowed with a directive for the complainant to submit necessary documents, as per the Deficiency Letters, to the company and the claim department after receiving the order. Subsequently, they were instructed to consider and reimburse the complainant’s claim in accordance with the policy terms and conditions. No costswere  awarded. The complaint against the doctor was dismissed.

To view the original order, click on the link below:

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Hearing relaxing words in your sleep slows your heart down

A discovery by researchers from the GIGA – Center of Research Cyclotron at University of Liège reveals that the sleeping body also reacts to the external world during sleep, explaining how some information from the sensory environment can affect sleep quality.

Researchers at ULiège have collaborated with the University of Fribourg in Switzerland to investigate whether the body is truly disconnected from the external world during sleep. To do so, they focused on how heartbeat changes when we hear different words during sleep. They found that relaxing words slowed down cardiac activity as a reflection of deeper sleep and in comparison to neutral words that did not have such a slowing effect. This discovery is presented in Journal of Sleep Research and sheds new light on brain-heart interactions during sleep.

Matthieu Koroma (Fund for Scientific Research-FNRS postdoctoral researcher), Christina Schmidt and Athena Demertzi (both Fund for Scientific Research -FNRS Research Associate) from the GIGA Cyclotron Research Center at ULiège teamed up with colleagues from University of Fribourg led a previous study analyzing brain data (electroencephalogram) showing that relaxing words increased deep sleep duration and sleep quality, showing that we can positively influence sleep using meaningful words. By that time, the authors hypothesized that the brain also remains able to interpret sensory information in a way that makes our body more relaxed after hearing relaxing words during sleep. In this new study, the authors had the opportunity to analyze cardiac activity (electrocardiogram) to test this hypothesis and found that the heart slows down its activity only after the presentation of relaxing, but not control words.

Markers of both cardiac and brain activity were then compared to disentangle how much they contributed to the modulation of sleep by auditory information. Cardiac activity has been indeed proposed to directly contribute to the way we perceive the world, but such evidence was so far obtained in wakefulness. With these results, the ULiège researchers showed that it was also true in sleep, offering a new perspective on the essential role of bodily reactions beyond brain data for our understanding of sleep.

“Most of sleep research focuses on the brain and rarely investigates bodily activity”, says Dr. Schmidt.

“We nevertheless hypothesize that the brain and the body are connected even when we cannot fully communicate, including sleep. Both brain and body information need then to be taken into account for a full understanding of how we think and react to our environment”, explains Dr. Demertzi.

“We shared freely our methodology following the principles of Open Science hoping that the tools that helped to make this discovery will inspire other researchers to study the role played by the heart in other sleep functions”, Dr.Koroma advocates.

This work offers a more comprehensive approach about the modulation of sleep functions by sensory information. By looking into the cardiac responses to sounds, we may, for example, study in the future the role of the body in the way sounds influence emotional processing of memories during sleep.

Reference:

Matthieu Koroma, Jonas Beck, Christina Schmidt, Björn Rasch, Athena Demertz, Probing the embodiment of sleep functions: Insights from cardiac responses to word-induced relaxation during sleep, Journal of Sleep Research, https://doi.org/10.1111/jsr.14160.

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AAOS: sports-related orthopedic injuries in seniors projected to grow 123 percent by 2040

Sports-related injuries among older adults are expected to increase 123 percent between 2021 and 2040, according to a study presented at the 2024 Annual Meeting of the American Academy of Orthopaedic Surgeons, held from Feb. 12 to 16 in San Francisco.

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Why bans on smartphones or social media for teenagers could do more harm than good

There are growing calls for young people under the age of 16 to be banned from having smartphones or access to social media. The Smartphone Free Childhood WhatsApp group aims to normalize young people not having smartphones until “at least” 14 years old. Esther Ghey, mother of the murdered teenager Brianna Ghey, is campaigning for a ban on social media apps for under-16s.

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New cell-based immunotherapy offered for melanoma

Siteman Cancer Center, based at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, is one of the first centers nationwide to offer a newly approved cell-based immunotherapy that targets melanoma.

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Research examines 700 plant-based foods to see how healthy they really are

If you’re thinking about buying plant-based foods, a trip to the supermarket can leave you bewildered.

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PGIMER issues notice on spot counselling for MD, MS admissions January 2024 Session, Details

Chandigarh- Regarding spot counselling and admission in MD and MS courses for the January 2024 session, the Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh has issued a notice.

The Spot counselling and admission process for MD and MS courses at PGIMER for the January 2024 session will take place on 29 February 2024 at the Bhargava Auditorium of the institute. The eligible and interested candidates are requested to sit in the auditorium on 29th February 2024 at 09:30 AM.

Spot counselling is being conducted for those candidates who have qualified for INI-CET January 2024 conducted by AIIMS, New Delhi and have not joined or held any seat in INIs for the January- 2024 session.

The details of vacant seats for admission to the MD and MS courses along with the counselling procedure are below

S.NO

Name of the MD/MS course

Total

UR

SC

1

BIOCHEMISTRY

1

1

2

RADIOTHERAPY AND CLINICAL ONCOLOGY

1

1

Total

2

1

1

For Foreign Nationals and Bhutanese Nationals

S.NO

Name of the MD/MS course

FN

BHUTANI

1

BIOCHEMISTRY

1

2

PSYCHIATRY

1

3

MEDICINE

1

4

PHARMACOLOGY

1

Total

3

1

COUNSELLING PROCEDURE

Date

Time

Event/Proceedings

Venue

29.02.2024

09:30 AM to 11:00 AM

Reporting and submission of self-attested copies of INI-CET (January-2024) Scorecard/Rank letter, Final Registration Slip, copy of Admit Card and undertaking for not holding any seat in any INIs for the January 2024 session.

Bhargava
Auditorium,

PGIMER,
Chandigarh

12:00 PM

Counselling of eligible candidates

It is to be noted that no candidate will be allowed spot counselling after 11:00 am on 29th February 2024.

Further, the Candidates willing to participate in spot counselling are instructed to bring all their original documents with them. Also, candidates who will opt for the seat during counselling will have to join immediately on the same day and also submit the original documents at the time of counselling. On this, no request for an extension of joining will be considered. The original documents should be submitted along with one set of self-attested photocopies.

DOCUMENTS

1. INI-CET (January 2024) Scorecard.

2. Final Registration Slip.

2. Admit Card issued by AIIMS New Delhi.

3. Mark Sheets of MBBS/ 1st, 2nd and 3rd Professional Examinations.

4. MBBS Degree Certificate.

5. Internship Completion Certificate/Certificate from the Head of the Institution or College that the candidate will be completing the internship by 31st January 2024.

6. Permanent/Provisional Registration Certificate issued by NMC/State Medical Council. 7. High School/Higher Secondary Certificate/Birth Certificate as proof of date of birth (Matriculation).

8 The Candidate should also bring the valid category certificate (SC/ST/OBC) in Original issued by the competent authority, if applicable.

PAYMENT

Selected candidates will have to deposit a course fee or security deposit of Rs. 4470/- for provisional confirmation of their seat on the spot through a debit card.

IMPORTANT POINTS

1 All provisional eligible candidates, who are not holding any seat by allocation, are eligible to participate in spot counselling and spot admission.

2 All those candidates who have been allotted a seat in any previous round of seat allocation and have joined/reported on the allotted seat as per the procedure of joining/reporting and seat holding, are not eligible for the stray round/Spot counselling and spot admission

3 The candidates with minimum percentile in INI-CET January-2024 as mentioned below against each category and not joined or held any seat in INIs for the January 2024 session are eligible to attend the Spot Counseling.

a. For seats under Unreserved (UR), the 50th percentile will be for foreign nationals including Overseas Citizens of India (OCI).

b. The seats for OBC, SC, ST, PWBD and Bhutanese nationals will be 45th percentile.

4 Seats of Foreign Nationals/Bhutanese Nationals will not be converted to any other category.

5 No Foreign National/Bhutanese National candidate will be allowed to join the MD/MS course without registration with the National Commission of India.

6 Any seats accumulated till the date of counselling will be filled and this will change the position of available seats shown in this notice. Therefore, the above seats are provisional and subject to change.

Lastly, it is directed that if any applicant deliberately gives false information during the process of seat allotment of INI-CET January then it will be considered as a cheat and the candidature will be cancelled and Legal And disciplinary action will also be taken further.

False information such as

1 Submitting a document which is not issued between dates as prescribed in the prospectus and submitted by a candidate to obtain eligibility despite knowing the fact that certification is not valid as not issued as prescribed in the prospectus.

2 Applying in anticipation of obtaining the desired qualification and not obtaining it on the date as required.

3 False reporting on caste, age, gender, date of acquiring eligibility and date of completion of internship.

4 Any other information which is not true as required in the prospectus/ notice and submitted to dispute at a later stage.

To view the official notice, click the link below

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Electric bike injuries, hospitalizations increased significantly in recent years

The incidence of electric bicycle (e-bicycle)-related injuries, particularly head injuries, has surged in the United States since 2017, according to a research letter published online Feb. 21 in JAMA Surgery.

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