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The study evaluated patients treated between February 2012 and January 2024 who received a dexamethasone (Dex) implant in addition to standard ablative therapy, with a follow-up duration exceeding 12 months. Out of 15 enrolled patients, the analysis included 11 patients. The cohort primarily consisted of males (90.9%) with unilateral disease, while the only female participant presented with bilateral involvement. The mean age at diagnosis was 14.8 years, spanning a wide age range from 2 to 60 years, highlighting the diverse presentation of the disease.

The following were the notable findings of the study:

• At baseline, 58.3% of the eyes were classified as stage 3a1, 25% as stage 3a2, and 16.7% as stage 2b.
• Over an average follow-up of nearly 66 months, visual acuity remained stable in 50% of the treated eyes.
• One-third of the eyes showed measurable improvement of at least one Snellen line.
• Two eyes demonstrated a two-line gain, while the other two eyes achieved a single-line gain in visual acuity.
• Vision deteriorated in both eyes during the study period.
• Transient intraocular pressure (IOP) elevation was observed in 66.7% of treated eyes.
• Cataract progression occurred in 58.3% of eyes, with one-third requiring cataract surgery.
• One eye developed a secondary vasoproliferative tumor, necessitating CyberKnife therapy and vitrectomy.
• No severe implant-related complications were reported, indicating a favorable safety profile for the treatment.

The findings suggest that intravitreal dexamethasone implants may serve as a useful adjunctive option, particularly in pediatric patients, to reduce the need for repeated general anesthesia and in adults with extensive macular exudation, where conventional ablative therapy alone may be insufficient. While the outcomes are promising, the authors acknowledge key limitations, including the retrospective design, small sample size, absence of a control group, and the study’s setting in a tertiary referral center, which may have resulted in a higher proportion of advanced cases.

Despite these limitations, the research highlights the value of dexamethasone implants in achieving anatomical and functional stabilization in Coats’ disease. With half of the treated eyes maintaining stable vision and one-third showing improvement, the study adds evidence supporting the integration of steroid implants into multimodal treatment strategies,” the authors wrote.

They recommend further studies to validate these findings and better define patient subgroups that may benefit most from this adjunctive approach.

Reference:

Ural Fatihoglu, O., Ayhan, Z., Ozturk, T. et al. Place of dexamethasone implant as an adjunctive treatment in Coats’ disease: a retrospective single-center study. BMC Ophthalmol 25, 435 (2025). https://doi.org/10.1186/s12886-025-04279-2

As per the prospectus, a total of 125 seats for Indian nationals are available for admission to the MBBS course. The reservation matrix would be as per the Medical Counselling Committee (MCC) directives. AIIMS Kalyani has an MBBS course divided into three professional divisions, i.e. First, Second and Third Professional MBBS are of one, one and a half and two years duration respectively.

Admitted candidates must attend the Orientation Program and join classes on the stipulated date. The admission of the candidates, who fail to join the Course by the date stipulated in the letter of intimation, shall automatically be cancelled and such seats shall then be offered to the candidates on the waiting list in order of merit in the same category

The candidates selected for admission to the MBBS course at the AIIMS Kalyani, after verification of their eligibility and being offered admission, should bring the following original certificates/ testimonials/documents at the time of admission-

1 Certificate of having passed the 10+2 or equivalent Examinations, showing the subject offered by him/her in the Examination.

2 Certificate from the Board from which he/she passed the High School/Higher Secondary Examination, showing his/her date of birth.

3 Certificate/Mark sheet from the Board from which he/she passed the 10+2 or equivalent Examination showing that he/she has secured 60% or more marks (50% in case of SC/ST/Persons with Benchmark Disability) in aggregate in English, Physics, Chemistry and Biology.

4 Migration Certificate from the University/Board last attended by him/her.

COMPULSORY ROTATORY INTERNSHIP TRAINING

After passing the Final MBBS Examination, all the candidates will be required to do a compulsory internship for a period of one calendar year (12 months) in the hospital and rural health centres recognised by the AIIMS. During the internship period, the interns are allowed a total of 15 days leave in the full term of one year. The degree of MBBS shall be awarded after satisfactory completion of one year’s internship.

FEES & OTHER PAYMENTS

The dues are to be paid in cash immediately, after the candidates have been declared medically fit in the Medical Board of the Institute, as per details given below-

To view the prospectus, click the link below

https://medicaldialogues.in/pdf_upload/aiims-kalyani-mbbs-2025-125-seats-offered-know-complete-admission-rules-fee-structure-297700.pdf