NBE releases tentative exam calendar for forthcoming Exams

Through a recent notice, the National Board of Examinations (NBE), NBEMS has released the tentative exam calendar of its forthcoming examinations including NEET PG 2024, FMGE June 2024 along with GPAT, PDCET, DPEE, FNB exit, DNB and DrNB practical and theory exams.

According to the calendar, the National Eligibility-cum-Entrance Test for the postgraduate (NEET PG 2024) exam has been advanced to June 23 instead of July 7, 2024, in computer-based mode. Medical Dialogues had earlier reported about the preponement of the NEET PG 2024.

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Health Bulletin 06/ April/ 2024

Here are the top health stories for the day:

FMGE rescheduled; NBEMS revises exam calendar for NEET PG, other medical tests

Through a recent notice, the National Board of Examinations (NBE), NBEMS has released the tentative exam calendar of its forthcoming examinations including NEET PG 2024, FMGE June 2024 along with GPAT, PDCET, DPEE, FNB exit, DNB and DrNB practical and theory exams.

According to the calendar, the National Eligibility-cum-Entrance Test for the postgraduate (NEET PG 2024) exam has been advanced to June 23 instead of July 7, 2024, in computer-based mode. Medical Dialogues had earlier reported about the preponement of the NEET PG 2024.

For more information, click on the link below :


Assistant Professors with MBBS degree as essential qualification entitled to NPA: Delhi HC

Granting relief to a group of doctors employed at Jawaharlal Nehru University (JNU), the Delhi High Court bench recently held that an individual holding the post of Assistant Professor in a Central University, requiring an MBBS degree as an essential qualification, would also be entitled to a Non-Practicing Allowance (NPA).

“The rationale behind grant of NPA appears to be in the form of an incentive to Medical Doctors in lieu of their private practice. This rationale apparently is predicated on the individual possessing a MBBS degree recognized by the Indian Medical Council Act, 1956 or the Dentists Act, 1948 as an essential qualification alone without anything further. Thus, an individual holding the post of Assistant Professor in Central University requiring MBBS degree as an essential qualification would also be entitled to NPA,” observed the HC bench comprising Justice Tushar Rao Gedela.

For more information, click on the link below :

54 medicines will see only 1 paisa hike: Health Ministry

Responding to several media reports about the price rise of essential medicines from April 1, 2024, the Ministry of Health and Family Welfare has come out with a statement calling many reports claiming medicine prices to witness a significant hike by up to 12% from April, 2024 as false, misleading and malicious.

The ministry has clarified that of the 923 formulations which fall under the ceiling price, 728 will see no change in prices while 54 will see a price rise of merely one paisa.

For more information, click on the link below:


Apollo Hospitals’ health of Nation Report 2024: Revealing burden of non-communicable Diseases

As Apollo Hospitals unveils the fourth edition of its flagship Health of Nation Report on World Health Day 2024, the findings shed light on a sobering reality: India is facing an unprecedented surge in non-communicable diseases (NCDs). Among these, cancer stands out as a particularly concerning issue, with India experiencing the fastest rise in cancer cases globally. The report also highlights alarming statistics: one in three Indians are prediabetic, two in three are pre-hypertensive, and one in ten suffer from depression.
The emergence of the Nudge Effect marks a pivotal strategy in India’s battle against NCDs, emphasizing the importance of preventive measures and early interventions. With the prevalence of obesity on the rise and becoming a common risk factor for chronic NCDs, proactive steps are imperative to address this health crisis.

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USFDA issues 2 observations for Strides Pharma Science subsidiary Chennai facility

Bengaluru: Strides Pharma Science Limited has informed in a BSE filing that the United States Food and Drug Administration (USFDA) has issued two observations after a routine current Good Manufacturing Practices (cGMP) inspection at the Formulations Facility of Strides Alathur Private Limited, a wholly-owned subsidiary of the Company, at Alathur, Chennai.

USFDA inspected the facility during the week of April 1, 2024 to April 5, 2024.

“Company will respond to these observations
comprehensively to FDA within the stipulated time,” Strides added.

Strides, a global pharmaceutical company headquartered in Bengaluru, India, is listed on the BSE Limited and National Stock Exchange of India Limited (STAR). The Company mainly operates in the regulated markets and has an “in Africa for Africa” strategy and an institutional business to service donor‐ funded markets. The Company’s global manufacturing sites are located in India (Chennai, Puducherry, and two locations in Bengaluru), Italy (Milan), Kenya (Nairobi), and the United States (New York). The Company focuses on “difficult to manufacture” products sold in over 100 countries.

Read also: Strides Pharma Science Singapore arm gets USFDA okay for fibromyalgia drug Pregabalin

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Bengaluru Orthopaedician Dr Banarji B H gets patent for Arthroscopic Carpal Tunnel Release

Bengaluru: Dr Banarji B H, Senior Consultant Orthopedics and Specialist Shoulder Surgeon from Sakra World Hospital, Bengaluru, has been awarded a patent for an invention titled ‘Device and Apparatus for Arthroscopic Carpal Tunnel Release’. 

This patented device marks a significant advancement in orthopedic surgery, offering a revolutionary approach to treating carpal tunnel syndrome (CTS). This revolutionary tool is set to transform the procedure, providing patients with a minimally invasive alternative to traditional open surgery.

CTS is the prevailing type of focal mononeuropathy, constituting a substantial proportion of neuropathic instances. It arises from the compression of the median nerve within the wrist’s carpal tunnel, eliciting sensations such as numbness, tingling, and weakness in the thumb and fingers.

Also Read:Sakra World Hospital to set up 500-bed hospital in Bengaluru for Rs 1000 crore

Multiple factors, including repetitive strain injuries, arthritis, sprains, wrist fractures, and ganglion cysts, can precipitate its onset by inducing inflammation or irritation in the wrist, thereby exacerbating pressure on the median nerve.

The new device enables surgeons to conduct the procedure arthroscopically, using a small incision and specialized equipment to access and release the constricted ligament without requiring a large incision in the hand and palm.

Hence, this device differs from traditional open surgery by avoiding lengthy incisions in the palmar skin and wrist. Its minimally invasive nature contributes to faster healing, shorter hospital stays, and reduced treatment costs. Additionally, the smaller incision results in a more aesthetically pleasing outcome, allowing patients to return to work sooner.

Dr. Banarji B H, the Senior Consultant Orthopedics and Specialist Shoulder Surgeon at Sakra World Hospital in Bengaluru and the lead developer of the device, elaborated, “While carpal tunnel syndrome isn’t life-threatening, it can greatly diminish an individual’s quality of life. The experience of pain, numbness, or weakness in the hands and wrists can exhaust individuals mentally, emotionally, and physically.

The significance of this innovative device in advancing orthopedic surgery is that it offers a minimally invasive alternative to traditional open surgery, intending to enhance patient outcomes and reduce post-operative discomfort and recovery time.”

The device operates by being inserted beneath the tight ligament, creating space for an arthroscope or thin camera to visualize the area. Surgeons then use a specially designed tool to release the ligament. This technique allows for the effective decompression of the median nerve while avoiding the development of a painful scar in the hand and palm. It can be used in any set of people such as sportsmen, working professionals, young adults, or the elderly.

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Tomotherapy with AI: A Boon to Cancer Treatment – Dr Abhishek Purkayastha

Cancer is a disease that everybody fears. The moment anybody is detected with cancer, the eminent death comes into the patient’s mind. Today, medical science has developed many newer treatment modalities that can take care of cancer.

There has been huge progress in the last decade in the management of cancer. Often, many patients require all modalities which include surgery, chemotherapy, and radiation therapy. There are situations when the disease spreads very near to critical organs, making it extremely difficult to treat. But the Tomotherapy radiation machine has come as a boon in all such situations.

Tomotherapy with synchrony play an important role in treating such complex tumours with normal tissue toxicity and give successful results.

Successful management of the patient of Arteriovenous Malformation (AVM) via Tomotherapy:

“A 61-year-old female patient presented with complaints of headache, nausea, vomiting and reduced vision both eyes associated with two episodes of seizure since last 4 months. MRI Brain showed soft tissue mass lesion measuring 3.3 x 3.5 left fronto temporal region, with radiological diagnosis of Arterio Venous Malformation (AVM) confirmed by Cerebral Angiography. Brain AVMs are extremely rare and occur at an incidence of 1.12-1.42 per 100,000 person-years,” said Dr. Abhishek Purkayastha, Radiation Oncologist.

Dr. Abhishek Purkayastha further highlighted, “If untreated they rupture and cause brain haemorrhage resulting in morbidity and sometimes mortality. The relatives were very anxious and patient was unwilling for surgery. The patient was counselled and was assured of a curative treatment.

She was treated with Stereotactic radiosurgery (SRS) to a dose of 18 Gy in single fraction. Patient reviewed after 2 weeks with significant improvement in her symptoms. Her relatives were also happy with her improvement. She was kept on close follow-up, and her MRI Brain 3 months after SRS showed 40% reduction in the size of the AVM.

Next, serial MRI also showed reduction in the size of AVM. Now over a year post SRS, the patient comes for regular reviews, and she is able to lead a normal life with improvement in her vision and other symptoms. SRS directs many highly targeted radiation beams at the AVM to damage the blood vessels and cause scarring.

SRS have shown excellent treatment outcomes for patients with small- to moderated sized AVM which can be achieved in 80-90 % complete obliteration rate with a 2–3 years latency period. SRS is widely accepted as an alternative to microsurgery.”

Why Tomotherapy is a Game-Changer for Patients?

1. It is one of the revolutionary radiotherapy delivery systems, which is the latest and newest way to deliver radiation in a helical fashion. It has several revolutionary technologies like “Artificial Intelligence” based “Auto contouring Adaptive Radiotherapy, Re-irradiation module, Precise imaging system along with ultrafast delivery which helps to deliver radiation at all sites including difficult ones like, TMI, very long targets, complex tumours in proximity to a critical structure multiple targets at time, second-time radiation, moving targets, changing targets, etc. which were very difficult to deliver on conventional LINACs.

2. Tomotherapy gives highly conformal radiotherapy and can treat high-risk tumours safely even when the target is near to critical structure with minimal side effects.

Disclaimer: The views expressed in this article are of the author and not of Medical Dialogues. The Editorial/Content team of Medical Dialogues has not contributed to the writing/editing/packaging of this article.

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What’s wrong with Delhi’s Health infrastructure? Status report in High Court

New Delhi: Describing the current status of the health infrastructure in the National Capital and what’s plaguing it, a committee constituted by the Delhi High Court has filed a comprehensive interim report with recommendations to improve the medical services in Delhi.

The 267-page interim report has been drafted by the six-member committee headed by Dr SK Sarin, Director, Institute of Liver and Biliary Sciences (ILBS), Delhi and submitted to the Delhi High Court for observation.

The report deals with various aspects of medical services at the clinical establishments run by the State Government and Municipal Corporation of Delhi, further identifying its deficiencies and actionable measures on how to counter them.

It presents detailed data on the number of sanctioned posts vs vacancies in the hospitals for specialists, General Duty Medical Officers (GDMOs), Senior Resident Doctors, Junior Residents, Nursing and Paramedical staff, as well as the availability of manpower, ICUs, OTs and equipment status.

In its report, the panel has listed major deficiencies which need urgent remedial actions by the government including huge vacancies of medical professionals, shortage of critical faculty, lack of adequate ICUs and high-dependency beds and structured critical care services, inability to run emergency and trauma services along with no structured referral system for citizens and non-availability of medicines and surgical consumables.

Delving into these, the committee addressed the issue of ‘efficient emergency health care services’ as its top priority and laid down salient action points enlisting immediate, short-term and long-term measures to resolve the priority health issues in a time-bound manner. Immediate measures need to be implemented within 30 days, subject to model code of conduct, Short-term within 31-90 days, Intermediate within 91-365 days and Long-term within 1-2 years.

Following are the reported issues and the measures recommended by the panel:

Optimization of Existing Resources (Manpower and Equipment)

Immediate Measures

  • Redistribution/ posting of consultants
  • Shifting the unused equipment’s to the facilities where expertise are available
  • Non-functional Equipment should be made functional & ensure they are functional round the clock

Short term Measures

  • Computerization of OPD registration and drug distribution counters

ICU and HDU beds Control Room establishment for real-time bed vacancy & ancillary facilities

Immediate Measures

  • Additional 1024 ICU beds to be added
  • Centralized dashboard manned by Medical professionals and trained executives for smooth execution of same (functional NIC dashboard to be upgraded in the control room).
  • Referral coordinator to be tasked from each hospital for feeding real time data information.

Intermediate and Long-term measures

  • Hospital to have 5% ICU and larger, 20% ICU beds

Human Resource

Immediate Measures

  • To fill up 15% of the vacancies immediately by hiring faculty/consultants by respective Head of Institutions
  • Salary and perks should be at par with regular employees.
  • Empanelment of private visiting consultants in radiology, anaesthesia, critical care, orthopaedics, neurosurgery, etc.

Short term Measures

  • 50% of the remaining vacant positions to be filled. 
  • Regular selection through UPSC etc. should be streamlined and expedited

Intermediate and Long-term measures

  • New posts should be created based on the projections given.
  • Creation of additional cadres in level 3 and level 4 hospitals
  • Creation of post of Manager at level 2 and above hospitals

Human Resources (Nursing and Para Medics)

Immediate Measures

  • Hiring from empanelled private agencies.

Equipment

Immediate Measures

  • Should opt for PPP model for ultrasound, CT Scan, MRI scan, etc. 
  • On lease from a private vendor

Short term Measures

  • Rate contract of any other govt. hospital could be utilized for immediate procurement
  • Financial powers up to 5 crore to respective heads

Maintenance of High-End Equipment

Immediate Measures

  • Every equipment’s should be purchased with 5-year warranty and additional S year of paid CMC 
  • Penalty clause should be included in the Rate Contract to compensate for downtime of equipment with provision of replacement equipment.

Suggestions for reducing stress on referral hospitals

Immediate Measures

  • 15% of the equipment requirement should be procured
  • Small and district hospital should be strengthened to provide round-the-clock emergency services.

Short term measures

  • Availability of medicines and consumables should be ensured at all hospitals by providing financial power to the respective MSs

Intermediate and Long-term measures

  • SRs from larger hospitals should be rotated to small hospitals
  • Academic and non-academic SRs posts from smaller hospitals to be pooled in the larger hospital posts and recruitment to be carried out in larger hospitals attached with medical colleges.

Medicine and consumables

Immediate measures

  • CPA should be strengthened
  • Hospital should maintain minimum 20% inventory
  • Financial powers to the MS and Directors to purchase medicines and consumables on daily basis
  • Empaneling Local chemist and Jan Aushadhi kendra within a radius of 5 km for local purchase.

Short-term measures

  • Space for Pharmacy and storage of consumable should be made available in all hospitals.
  • Implementation of a system to maintain 3- month inventory of medicines and consumables for uninterrupted medical services.

Intermediate and Long term measures

  • Central and storage of Procurement Agency (CPA) to be strengthened. and made accountable. All processes should be through e-file system.

Other Recommendations for Improving Medical Services in Delhi

Immedidate measures

  • Introduction of Emergency (E)-OAK service.
  • Allowing residents of Delhi to use Adhar Card in all private hospitals and get cashless facilities at CGHS rate. 
  • Teaching faculty to provide tele consultation to the district hospitals 
  • Full time MS/Director for all hospital

Short-term measures

  • Starting TeleMedicine service.
  • Delhi Health Authority should be set up.

Further recommendations include the creation of the Delhi State Health Authority, the completion of ongoing hospital projects, establishment of new medical colleges along with reliance on the private sector.

“The committee has reasons to believe that the recommendations of this report are doable, if enough budgetary provisions are made. In fact, the honorable High Court order has also stated that huge investments with structural reforms in the functioning of government hospitals is necessary to bring about a change,” the panel said.

In February this year, the Delhi High Court expressed serious apprehensions about the inadequate health infrastructure in Delhi hospitals and reprimanded the government for its failure to ensure the operational status of facilities.

“Where are things going wrong? Is proper infrastructure not there? Why are beds not available, what has happened in recent years? Just imagine, in four hospitals, a person does not get admission,” Justice Manmohan had said, adding “infrastructure was not keeping pace with the demand of the growing population of the city.” With this note, the High Court directed the State to constitute a committee of doctors to examine the hospitals run by the city government and come up with a solution. Based on the HC directive, the committee now filed its report.

Read Also: Improvement of health infrastructure at Delhi Govt, MCD Hospitals: HC sets up 6-member committee

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Pay Rs 1.5 Lakh for 4 hrs, Rs 4 Lakh for 12 hrs to Visiting Consultants: Panel Recommends measures to tackle huge vacancies of Specialists in Delhi

New Delhi: Taking note of around 50% vacancies of specialists in the Delhi-based hospitals, a committee constituted by the Delhi High Court has suggested paying remuneration based on working hours to the visiting consultants to deal with the shortage of specialists.

In its Interim Report, the panel suggested that visiting consultants from the private sector can be hired for 4 hours, 8 hours, 12 hours and for night calls every day. 

Opining that such doctors should be paid remuneration plus incentives based on how many hours they work, such visiting consultants should be paid Rs 1.5 lakh plus incentives for 4 hours, Rs 3 lakh plus incentives for 8 hours, Rs 4 lakh plus incentives for 12 hours and Rs 2 lakh plus incentives or on-call basis for night calls, the committee suggested in its report.

As a long-time measure to tackle the scarcity of specialists in Delhi government hospitals, the committee has suggested creating a panel of consultants comprising private practitioners who can cater to government hospitals on a part-time basis. However, the committee recommended ensuring that such specialists were receiving at least 1.5 times more salary or fees than that of a regular employee on weekdays and double on holidays and weekends.

Medical Dialogues had previously reported that earlier this year, expressing displeasure over the “misleading” information provided to it on the functioning of medical equipment in GTB hospital, the Delhi High Court had advised the State to constitute a committee of doctors to examine the hospitals run by the city government to come up with a solution. These directions were issued by the Court while considering a PIL initiated by it on its own in 2017 concerning the issue of the non-availability of ICU beds and ventilator facilities in government hospitals in Delhi.

Also Read:Set up committee to examine state-run hospitals: Delhi HC tells Govt

Consequently, the Delhi HC on February 13 formed a six-member committee of experts to evaluate and improve the medical facilities run by the State Government and Municipal Corporation of Delhi.

The Committee recently submitted its Interim Report and as per the report, there are 1700 sanctioned posts of specialists in 38 hospitals in Delhi. Among these 882 posts are filled and the rest of the 818 posts are still lying vacant.

Reasons for Vacancies of Specialists (Teaching and non-Teaching): 

As per the Committee, the reasons why around 50% posts of specialists are lying vacant in Delhi hospitals are as follows:

(i) Delayed recruitment by UPSC and preferential posting at Central Government Hospitals.

(ii) Proposal of creation of additional posts is rejected on the ground that the existing vacancies are not filled up.

(iii) If any new facility is planned, the new posts are not allowed by administrative reforms department which considers all doctors in one category (JR/SR/Faculty) and also irrespective of specialization. In addition, the requirement of staff is calculated on the basis of bed ratio.

(iv) Due to lack of modern equipment/facilities/OT time, specialists prefer to work in private hospitals to gain experience.

(v) Posting at areas far away from their residence.

Measures Recommended by the Delhi HC Committee: 

In order to tackle the scarcity of specialists in Delhi hospitals, the committee has recommended both immediate measures to implement them within 30 days and also long term measures as a solution to the problem.

Immediate Measures (30 days): 

1. The committee has recommended to utilise the services of consultants from the private sector on a contractual basis. Visiting consultants such as Anesthetist, Gynecologist, Pediatrician, Orthopaedician, General Surgeon, Neurosurgeon, any other specialist as per the need of a given hospital can be hired through contracts, suggested the panel.

“The consultants can be hired/ empanelled in 4 categories, as per their seniority, and as per the prevalent practices in the private sector,” the panel recommended in its interim report.

The committee also suggested that the visiting consultants can be hired for 4 hours, 8 hours, 12 hours and for night calls every day and further mentioned that they should be paid Rs 1.5 lakh plus incentives for 4 hours, Rs 3 lakh plus incentives for 8 hours, Rs 4 lakh plus incentives for 12 hours, and Rs 2 lakh plus incentive or on-call basis for Night Call.

“Another alternative is to have a panel of consultants in different specialties available at every hospital, drawn from the vicinity. A roster can be prepared to attend to the patients between them and the payment should be on per- patient or per-procedure-basis. The honorarium to be calculated in accordance with the above recommendation,” the panel mentioned in its report.

“The consultants should be empaneled on the basis of their qualification and requisite experience as defined by the NMC, the quality of service provided should be at par with the standard of care prescribed,” it further added.

2. Another immediate measure suggested by the committee is to give autonomy to the respective hospitals to fill up the vacant posts on adhoc/contractual basis. The Committee suggested that to attract doctors on adhoc/contractual basis, the emoluments and other benefits for the contractual employees should be at par with the regular appointments.

“Filling these posts will be easier if the salary is 25% more than that of a regular employee,” suggested the HC Committee.

3. Considering the vacancy of specialists, the panel also suggested offering Telemedicine services by specialists from a teaching hospital to cater to patients. It has recommended establishing a system of telemedicine for consultation and mentorship, to strengthen the quality of service and infuse confidence in smaller hospitals.

Long Term Measures: 

Among the long-term measures to tackle the huge shortage of specialists in the Delhi Government hospitals, the HC Committee has suggested the following measures:

1. The panel recommended creating the Delhi Health Authority to create a panel of consultants comprising of private practitioners who can provide their services in Delhi Govt. Hospitals on a part-time basis. It suggested commencing this practice by identifying consultants from the specialists including Radiology, Anaesthesia, Neurosurgery, and Intensive Care.

The salary or fees to these specialists should be fixed at a rate which is equivalent to at least 1.5 times that of a regular employee on weekdays and double on holidays and weekends. For example, if a regular Professor’s salary is Rs. 10000/ day (i.e. Rs. 1250/ hour considering 8 hours duty per day}, the visiting consultant should be paid approximately Rs. 1900/hour or equivalent thereof for a surgery I procedure. The details can be worked out,” the HC committee suggested in its interim report.

2. Among other measures, the committee recommended setting up Telemedicine facilities, especially in the field of Radiology (teleradiology), where the specialist can provide services to multiple facilities, without having to visit them physically. For this, the committee opined that additional posts will required to be created at the tertiary care centres.

3. The panel recommended that the administrative reforms department to be more receptive regarding organizational hierarchy in the Medical Profession.

4. It also suggested to provide for a place of posting near the residence, as much as possible. According to the committee, posting near the residence will improve patient care as doctors need to visit hospitals frequently in odd hours.

5. Further, the committee has suggested providing Incentives as per the criteria for the quantity/quality of services provided. 

6. It also recommended to modernize the infrastructure or equipment.

7. Finally, it recommended strictly complying with the referral system for tertiary care hospitals. 

Also Read: Improvement of health infrastructure at Delhi Govt, MCD Hospitals: HC sets up 6-member committee

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Medical Bulletin 06/ April/ 2024

Here are the top medical news for the day:

Study finds prebiotics and probiotics effect on depression and obesity

A recent study published in the journal Nutrients discovered the interactions between depression and nutrition, coupled with exercise.
Obesity and depression frequently co-occur, along with anxiety disorders, sharing a bidirectional relationship. Depression often leads to comfort eating and inactivity, increasing the risk of obesity by 40% during emotional stress. Conversely, obesity can heighten the likelihood of anxiety or depression due to negative self-image and societal stigma. While antidepressants effectively treat depression, they may contribute to weight gain.
In this study, researchers explored the potential of gut microbes in treating both obesity and depression, focusing on the role of probiotics and prebiotics. They found that dietary patterns influence around 57% of gut microbiota composition. Probiotics enhance the gut barrier and immune system, improving depressive symptoms. Additionally, supplementation with fatty acids and vitamins E and D, along with specific diets like the Mediterranean or DASH diets, may help counter severe depression and reduce neuroinflammation.
The findings suggested that depression and obesity risk could be reduced with both the DASH and the MD. High-quality vegetarian diets were protective against depression, underlining the pivotal role of diet quality. Furthermore, some clinical trials in humans suggested a positive effect of probiotics on depressive disorders as well as on obesity and related metabolic conditions like insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD).
Reference: Klaudia Sochacka,Agata Kotowska and Sabina Lachowicz-Wiśniewska; The Role of Gut Microbiota, Nutrition, and Physical Activity in Depression and Obesity—Interdependent Mechanisms/Co-Occurrence; Journal: Nutrients; https://doi.org/10.3390/nu16071039
Do newly diagnosed type 2 diabetics succeed in weight management?
A register-based study from Finland identified three distinct BMI trajectory groups among patients with newly diagnosed type 2 diabetes.
The study was carried out by researchers at the University of Eastern Finland, and was published in the journal Clinical Epidemiology.
Most type 2 diabetes (T2D) patients live with obesity, and weight loss is one of the therapeutic objectives in T2D management. Clinical trials have demonstrated that modest weight loss, i.e, 5‒10%, in T2D patients with high BMI improves the risk factors of diabetes complications, such as hyperglycaemia, hyperlipidaemia, and hypertension. Complications of type 2 diabetes (T2D) can be classified into microvascular (retinopathy, neuropathy, nephropathy) and macrovascular (cardiovascular disease, cerebrovascular disease, peripheral vascular disease) categories. Observational studies exploring the association between BMI and these complications have yielded mixed results, with some showing positive, inverse, or no associations.
In this cohort study, electronic health records from public primary and specialized healthcare services were utilized and included a total of 889 adults with newly diagnosed T2D between 2011 or 2012 (mean age at baseline 62.0 years). Individual BMI trajectories from the T2D diagnosis until 2014 were estimated. Data was collected on patients’ birth year, sex, measurements of BMI, fasting plasma glucose (FPG), glycated haemoglobin (HbA1c) and low-density lipoprotein (LDL), diagnosis codes and dates for T2D and complications, as well as the date of death.
The results revealed that in a four-year follow-up, most patients followed a stable trajectory without much weight change. Only 10% of patients lost weight, whereas 3% gained weight. Mean BMI exceeded the threshold of obesity in all groups at baseline. Patients belonging to each trajectory group were followed up for another eight years for diabetes complications. During the follow-up, 13% of all patients developed microvascular complications, 21% developed macrovascular complications and 20% of patients deceased. The risk of microvascular complications was 2.9 times higher and the risk of macrovascular complications 2.5 times higher among patients with an increasing BMI compared to those with a stable BMI.
“These results underscore the significance of continuous BMI monitoring and weight management in patients with type 2 diabetes. Tailored treatments and support with lifestyle changes are crucial for efficiently preventing weight gain and reducing the risk of diabetes complications,” said Doctoral Researcher Zhiting Wang of the University of Eastern Finland.
Reference: Zhiting Wang, Piia Lavikainen, Katja Wikström, Tiina Laatikainen; Trajectories of Body Mass Index and Risk for Diabetes Complications and All-Cause Mortality in Finnish Type 2 Diabetes Patients; Journal: Clinical Epidemiology; https://doi.org/10.2147/CLEP.S450455
Do soy products lower the risk of cancer?
In a recent review published in the journal Nutrients, researchers discussed the possible associations between the consumption of soy products and the risk of developing cancer.
Soy products are rich in compounds like isoflavones, phytosterols, and dietary fibre, all of which may mitigate cancer risk. However, research has suggested these effects vary with soy products and cancer types. Cancer rates continue to rise globally, with breast, lung, colorectal, prostate, and stomach cancers leading in terms of both new cases and deaths. Researchers have observed variations in cancer prevalence, which may be attributed to different dietary habits, particularly soy product consumption.
The study analyzed 28 studies involving 24,090 cases and 5,53,282 participants to examine the link between soy product consumption and cancer risk. High soy intake was associated with a 31% reduced risk of cancer, particularly in case-control studies, showing a 24% reduction in women but not men. Additionally, analyzing 7 cohort and 19 case-control studies with 18,729 cases and 3,12,770 participants revealed that high tofu consumption was found to significantly reduce cancer risk by 22% in both males and females.
The results observed a notable risk reduction in gynaecological cancers, including ovarian cancers, as well as cancers affecting the gastrointestinal and upper aerodigestive tract, prostate, and lungs. The dose-response analysis indicated non-linear relationships, with increased soy consumption and tofu associated with a reduced cancer risk.
The findings revealed that higher consumption of total soy foods, tofu was associated with a reduced risk of cancer, particularly gastrointestinal and gynaecological cancers. However, evidence regarding other soy products is insufficient, thus necessitating the need for additional well-designed prospective cohort studies.
Reference: Chenting Wang, Keqing Ding, Xuanzhen Xie, Jinyue Zhou,Pengju Liu,Shuang Wang, Ting Fang,Guozhang Xu, Chunlan Tang, Hang Hong; Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies; Journal: Nutrients; https://doi.org/10.3390/nu16070986

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Sanofi new polio vaccine gets nod in India

New Delhi: Drug giant Sanofi has received a nod for an alternative injectable vaccine, IMOVAX-Polio, to replace the widely used Inactivated Polio Vaccine (IPV) ShanIP in the India.

IMOVAX-Polio shares the same composition and formulation as ShanIPV. It has been employed in over 100 countries for more than 40 years. 

“We wish to assure all stakeholders that there will be no shortage of IPV vaccines in India on our account, towards safeguarding the nation’s status of remaining polio-free. We remain fully committed to fulfilling our public health mission in India,” a Sanofi India spokesperson told PTI.

To ensure the adequate availability of the IPV vaccines, the Company has already received approvals for IMOVAX-Polio.

“…Sanofi has had to adapt its strategy and portfolio to these (emerging) trends. Accordingly, Sanofi Healthcare India Pvt Ltd (SHIPL) announced that by the end of 2023, it will discontinue ShanIPV, which was only filled and packaged at our factory in Hyderabad, India,” the spokesperson added.

ShanIPV, a trivalent inactivated injectable vaccine was launched in 2015 in India. It was administered in two stages- at six weeks and 14 weeks of age under the government’s immunization programme.

Sanofi, along with Serum Institute of India, has been at the forefront of supplying IPV vaccines in the country.

Read also: AstraZeneca-Sanofi Beyfortus approved in Japan for prevention of RSV disease in infants

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Dr Reddy’s Labs, Bayer collaborate to market, distribute second brand of heart failure drug Vericiguat in India

Hyderabad: Dr
Reddy’s Laboratories Ltd. and Bayer announced that both
companies have entered into a partnership to market and distribute a second
brand of Vericiguat in India.

Under the terms of this agreement, Bayer has
granted non-exclusive rights to Dr. Reddy’s under the brand name Gantra.

Vericiguat,
a soluble guanylate cyclase (sGC) stimulator, in India, is indicated, along
with guideline-based medical therapy, in adults with symptomatic chronic heart
failure with reduced ejection fraction (less than 45%), following a recent
event of worsening heart failure which required hospitalization or outpatient
intravenous (IV) diuretics. Vericiguat works on a
pathway not currently targeted by existing heart failure treatments and can
reduce the combined risk of cardiovascular death and heart failure
hospitalization in such patient. India has between
8-10 million people with heart failure, making it one of the largest populations
with this condition. 

Shweta
Rai, Managing Director, Bayer Zydus Pharma and Country Division Head (CDH) for
Bayer’s Pharmaceuticals Business in South Asia said, “Despite therapy,
chronic heart failure patients can experience disease progression that disrupts
their lives and leads to worsening heart failure events. Vericiguat can help
slow down disease progression, reduce hospital admissions and improve their chances of survival. The introduction of
a second brand of vericiguat in India, through our partnership with Dr. Reddy’s
is a reaffirmation of our commitment to making innovative healthcare solutions
accessible to as many patients as possible. We are excited about the possibilities this
partnership with Dr. Reddy’s presents in improving health outcomes for patients
with chronic HF, following a recent event of worsening heart failure.”

M.V. Ramana, Chief
Executive Officer, Branded Markets (India and Emerging Markets), Dr Reddy’s
said, “Strengthening our chronic therapy portfolio in India continues to be
a focus area for us. Vericiguat is a first-in-class sGC stimulator indicated
for adults with symptomatic, chronic HF and ejection fraction less than 45%
following worsening heart failure. The addition of Vericiguat bolsters our
heart failure management portfolio that includes Cidmus, Daplo and beta
blockers. The partnership with Bayer is part of Dr. Reddy’s continuous efforts
to make innovative medicines available to patients in India through strategic
collaborations. We will use our strengths in marketing and distribution to
widen access to this novel treatment in metros and beyond into tier-I and
tier-II towns in India.”

Heart
failure is a major public health issue affecting more than 8-10 million people
in India. The average age of an Indian heart failure patient is a decade
younger than their Western counterparts being 55 – 60 yrs. Despite the substantially
younger age of patients with HF in India, the 5-year mortality rate is 60%. In patients with
chronic heart failure, with reduced ejection fraction (less than 45%) an event
of worsening heart failure can happen at any stage. 90% of patients who suffer
from worsening heart failure are not in the advanced stage of chronic heart
failure.
HF remains the commonest cardiac cause of hospitalization in India with
worsening heart failure events being one of the most important causes of death
in heart failure patients.

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