An avocado a day may improve overall diet quality, researchers report

Eating one avocado per day may improve overall diet quality, according to a team led by researchers in Penn State’s Department of Nutritional Sciences. Poor diet quality is a risk factor for many diseases, including heart disease, and many American adults have poor diet quality and do not meet key dietary recommendations provided by the Dietary Guidelines for Americans.

This study was led by Kristina Petersen, associate professor of nutritional sciences, and Penny Kris-Etherton, retired Evan Pugh University Professor of Nutritional Sciences, and recently published in the journal Current Developments in Nutrition.  The researchers examined how a food-based intervention-one avocado per day-impacts overall diet quality.

“Avocados are a nutrient-dense food, containing a lot of fiber and other important nutrients. We wanted to see if regular intake of this food would lead to an increase in diet quality,” Petersen said. “Previous observational research suggests avocado consumers have higher diet quality than non-consumers. So, we developed this study to determine if there is a causational link between avocado consumption and overall diet quality.” 

Petersen stated that because only 2% of American adults are regular avocado consumers, the researchers wanted to determine if including avocados in an individual’s daily diet could significantly increase their diet quality.

Researchers conducted phone interviews with participants before the study began and at a few points throughout to determine what their dietary intake was like in the previous 24 hours and evaluated their diets using the Healthy Eating Index to determine how well they adhered to the Dietary Guidelines for Americans. Adherence to the guidelines was used as a measure of overall diet quality.

The study consisted of 1,008 participants who were split into two groups. One group continued their usual diet and limited their avocado intake during the 26-week study, while the other group incorporated one avocado per day into their diet.

“We found that the participants who had an avocado per day significantly increased their adherence to dietary guidelines,” Petersen said. “This suggests that strategies, like eating one avocado per day, can help people follow dietary guidelines and improve the quality of their diets.”

Although researchers said they were not surprised to see that eating avocados daily improved diet quality, they had not predicted how participants were able to achieve it.

“We determined that participants were using avocados as a substitute for some foods higher in refined grains and sodium,” Petersen said. “In our study, we classified avocados as a vegetable and did see an increase in vegetable consumption attributed to the avocado intake, but also participants used the avocados to replace some unhealthier options.”

According to Petersen, having poor diet quality substantially increases the risk for conditions like heart disease, type 2 diabetes, kidney disease and many other preventable diseases.

“By improving people’s adherence to dietary guidelines, we can help to reduce their risk of developing these chronic conditions and prolong healthy life expectancy,” Petersen said.

Petersen has also conducted similar studies investigating the impact of food-based interventions, including the relationship between pistachios and diet quality, but said that more research is needed to determine what other food-based strategies can be used to improve people’s adherence to dietary guidelines. 

“In studies like this one, we are able to determine food-based ways to improve diet quality, but behavioral strategies are also needed to help people adhere to dietary guidelines and reduce their risk of chronic disease,” Petersen said.

Reference:

Kristina S Petersen, Sydney Smith, Alice H Lichtenstein, Gina Segovia-Siapco, David M Reboussin, Penny M Kris-Etherton, One Avocado per Day as Part of Usual Intake Improves Diet Quality: Exploratory Results from a Randomized Controlled Trial, Current Developments in Nutrition, https://doi.org/10.1016/j.cdnut.2024.102079.

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Patient death due to Post Partum Hemorrhage: Nursing Home, Doctor slapped Rs 43 lakh compensation for negligence

Hyderabad: The State Consumer Disputes Redressal Commission (SCDRC) Telangana recently directed a nursing home and its doctor to pay Rs 43 lakh compensation to the husband and child of a patient, who died while delivering the baby from Post Partum Hemorrhage (PPH).

It was observed by the consumer court that the treating facility and the doctor were not properly equipped despite PPH being an anticipated emergency. 

The matter goes back to 2013 when the complainant’s wife was admitted to Taraporewalla Nursing Home, Secunderabad for the delivery of her child and Dr. Taraporewalla attended the patient. The patient delivered a female baby by normal delivery. However, after the delivery, she developed a bleeding problem i.e. Post Partum Hemorrhage (PPH).

Allegedly, the treating doctor assured that the bleeding was minor and informed that a hysterectomy may be needed as a last resort. The complainant accepted this. As per the instruction by the doctor, the Complainant arranged blood but by the time he reached the hospital, he was informed by the doctor that the pulse rate of the patient was very low due to excess bleeding, her condition was serious and there was no chance of recovery. The blood brought by the complainant was not even transfused and the patient was declared dead on the same day.

The complainant alleged that the premature death of his wife occurred only due to a lack of necessary care and skill exhibited by the nursing home and the doctor. It was submitted that even though as per the Antenatal Record, the expected date of delivery was 25.08.2013, the patient was admitted on 10.08.2013 as per the advice of the doctor. 

Further, the complainant alleged that the facility was not properly equipped with the necessary infrastructure to meet the emergency and complicated cases and the doctor failed to properly visualize the situation of the patient after the development of PPH and was negligent in not even conducting the grouping of the blood which was routine. Therefore there was a delay in summoning the blood immediately after the development of the PPH. 

It was also alleged that the doctor did not shift the patient to any other corporate hospital even though the complainant had informed them that he was capable of bearing the necessary expenditure apart from the reimbursement facility.

Therefore, alleging deficiency in service on the part of the treating doctor and nursing home, the complainants filed the case seeking direction to them to pay Rs 99 lakh as compensation and Rs 50,000 as legal cost.

On the other hand, the nursing home and the doctor claimed that the complainant was not present at the time of delivery and blood was not made available despite requesting blood and the sample being made available to the attendants by 9:30 a.m. 

It was also clarified that the patient was not in a condition to be shifted to any other super speciality hospital until and unless she was stabilized. Referring to the Antenatal Card of the patient, they claimed that blood grouping was done many months before the patient’s admission for delivery and the blood group was mentioned to be O+ in the card.

They further informed the Commission that they admitted the patient a few days before the expected date of delivery since the liver function test of the patient done on 27.07.2013 showed alkaline phosphatase with itching all over the body. She was diagnosed as having cholestatic jaundice and started on Actamarin Forte 1 b.d. (ursodeoxycholic acid) and in such a situation, the delivery is to be done at 38 weeks i.e. 15 days prior to expected date of delivery.

The nursing home and the doctor clarified that their facility was fully equipped for obstetric emergencies with cardiac monitors/ defibrillators/central O2/pulse oximeters etc. It was also claimed that the doctor properly visualized the patient’s situation after the development of PPH and initiated all the proper treatment measures immediately without any delay.

It was further stated on their part that complete step-by-step treatment of PPH was done with all possible injections and uterine massage etc. but the patient suffered uncontrolled Catastrophic Postpartum Hemorrhage which is a known risk factor in delivery. Therefore, they submitted that there was no negligence on their part and prayed for the dismissal of the complaint.

Referring to the medical records, the Commission noted that the child was born at 8.58 a.m., at 9.50 a.m. other doctors were informed of the hysterectomy and the BP was 70/100. At 10.34 am the record mentions pulse absent, ECG leads attached, and activity after cardiac massage is seen. Thereafter, the patient was declared dead at 11.45 a.m.

“At 10.34 itself it is stated that “pulse absent”. In this document, there is a complete absence of having asked the patient’s attendants to procure the required blood for transfusion,” the consumer court noted at this outset.

“It is necessary to emphasize that if a patient has no attender then what is the duty of the nursing home/hospital to assist the patient to procure blood from a blood bank. Does no attender mean that treatment will be halted? or blood will not be immediately procured?” questioned the Commission.

The Consumer court observed that the Medical Literature filed by the complainant’s counsel highlighted the factors of prevention and management of Post postpartum haemorrhage. “PPH occurs in women with no risk factor. So Physicians must be prepared to manage this condition at every delivery. Physical examination will suggest the diagnosis, and the etiology of hemorrhage determines the proper management. Hysterectomy should ultimately control hemorrhage. This is certainly within the knowledge and the capacity of the opposite parties but they did not treat the hazard as severe and give it the immediate medical attention,” the Commission observed.

Taking note of the reliance placed by the nursing home and doctor on the 25th Edition of ‘Williams Obstetrics’, the consumer court noted, “When these measures have been emphasized upon, the opposite party failed to mobilize the emergent care and urgent help from Anaesthesia team. Recognition of Obstetrical Hemorrhage severity is crucial to its management. It is also further referred in the literature provided by the opposite parties that in most institutions today whole blood is rarely available , thus most women with obstetrical hemorrhage and on going blood loss are given packed red cells and crysteloids. There is no explanation provided by the opposite parties as to why these measures which have been enunciated in the literature provided vide ‘Williams OBSTETRICS’ were not followed for the management of postpartum hemorrhage.”

SCDRC observed that the main defence by the nursing home and the doctor was that PPH is an uncontrollable catastrophic haemorrhage and cannot be imputed or linked as medical negligence. On the other hand, they also stated that PPH accounts for 60% of maternal deaths. “That being the case, should the opposite parties not be more cautious and alert in expecting complications during delivery?” questioned the consumer court.

The State Commission opined that the protocol to manage postpartum bleeding is surely specified and Nursing Homes dealing in this area of specialty should be equipped to respond faster and more skillfully. It further observed that the failure on the part of the nursing home and the doctor is “very visible” and not having a skilled surgeon has been “a very heavy price to pay, by the complainant”.

“The opposite parties blame the attendants in wasting valuable time to procure the required blood for transfusion. Instead, the opposite party hospital could have been better equipped. When this is an anticipated emergency, a nursing home should have the necessary facility to manage the eventuality instead of blaming the attendants of wasting 35 minutes,” the Commission noted.

“In the absence of timely and appropriate action, the young patient died because of PPH . In the developed world PPH is a largely preventable and manageable condition. It is pertinent to mention that the deceased was not suffering from any complications during her pregnancy. No such negative reference is made,” it further observed.

While the consumer court agreed that the tragic death of the young mother can never be quantified monetarily and the loss of the mother’s love for her child can never be replaced, the Commission took into account several factors such as loss of companionship by the complainant, the earnings of the deceased, and the legal precedence set by the Supreme Court in the case of Sarala Verma case, “for the injustice suffered on account of the opposite parties’ negligence”.

Therefore, the Consumer Court directed the nursing home and doctor to pay the complainants a sum of Rs 43,57,000 with interest and place half of the amount in F.D. in the name of the young child in any Nationalized Bank till she attains majority.

“In the result, complaint is allowed in part directing the opposite parties to pay to the complainants a sum of Rs.43,57,000/- with interest @ 7% p.a. from the date of complaint till the date of realization. We further direct that half of this amount must be placed in F.D. in the name of the young child i.e. complainant no.2 in any Nationalized Bank till she attains majority. The balance of the awarded amount is to be withdrawn by the complainant no.1,” ordered the Consumer Court.

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/telangana-scdrc-234972.pdf

Also Read: Vision Loss Due to Undiagnosed Malignancy in Optic Nerve, NCDRC slaps Rs 20 lakh compensation for negligence

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Trial Reveals Long-Term Success of First-Line Rituximab Treatment for Pemphigus Patients

In a revolutionary development for pemphigus treatment, a 7-year follow-up study of the Ritux 3 trial has unveiled the remarkable long-term efficacy and safety of a first-line treatment approach utilizing rituximab.  The findings of this trial, conducted across 25 dermatology departments in France, offer a promising breakthrough supporting the efficacy and safety of the Ritux 3 treatment regimen for pemphigus, particularly when used as a first-line therapy.for patients grappling with this challenging condition.

The Trial results were published in the journal JAMA Dermatology. 

Pemphigus, a rare autoimmune blistering disorder, has long posed challenges in achieving sustained remission without the drawbacks of prolonged corticosteroid use.The original Ritux 3 trial had already demonstrated the short-term success of rituximab compared to standard corticosteroid regimens. However, the lack of data on the long-term outcomes left a critical gap in understanding the sustained benefits of this innovative treatment. The current 7-year follow-up study bridges this gap, shedding light on the enduring success of the Ritux 3 regimen.

A total of 90 patients from the Ritux 3 trial were included in this extended analysis, conducted from January 1, 2010, to December 31, 2015. Patients were initially randomized into two groups: one receiving rituximab plus prednisone, and the other receiving prednisone alone. The results at the end of the follow-up period, with a median follow-up of 87.3 months, paint a compelling picture of the advantages of the rituximab-based approach.

Findings: 

One of the key findings revolves around disease-free survival (DFS) without corticosteroids.

Patients who received rituximab as a first-line treatment showcased significantly longer 5- and 7-year DFS compared to those in the prednisone-alone group.

Impressively, 93% of patients in the rituximab group achieved complete remission without corticosteroids at some point during the follow-up.

Moreover, the rituximab group exhibited a remarkable reduction in relapse rates, experiencing about half the relapses compared to the prednisone-alone group. This not only emphasizes the sustained effectiveness of rituximab but also underscores its potential in preventing disease recurrence over the long term.

Safety considerations also favored the rituximab plus prednisone regimen. The incidence of severe adverse events (SAEs) was significantly lower in this group, pointing to a more favorable safety profile compared to the prednisone-alone approach.

Exploring the predictive value of antidesmoglein (Dsg) antibody levels, the study found promising correlations. Specific antibody values demonstrated potential as indicators for long-term relapse, providing clinicians with valuable insights for personalized treatment strategies.

The study’s lead investigator highlighted the impact of treatment initiation, noting that patients who received rituximab as a first-line option exhibited longer DFS than those who received it as a second-line treatment. This underscores the importance of early intervention with rituximab for optimal long-term outcomes.

In conclusion, the Ritux 3 regimen emerges as a game-changer in pemphigus treatment, offering not only short-term efficacy but also sustained remission without the burden of prolonged corticosteroid therapy. The study’s findings mark a significant advancement in the field, providing hope for improved quality of life for pemphigus patients worldwide.

Further reading: Tedbirt B, Maho-Vaillant M, Houivet E, et al. Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial. JAMA Dermatol. Published online January 24, 2024. doi:10.1001/jamadermatol.2023.5679

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U-shaped Kirschner wire internal fixation safe and effective treatment for Skier’s thumb: Study

U-shaped Kirschner wire internal fixation safe and effective treatment for Skier’s Thumb suggests a new study published in the BMC Surgery.

Skier’s thumb is a type of injury to the ulnar collateral ligament of the metacarpophalangeal joint of the thumb, which can result in bone fragmentation and joint instability. The objective of this study was to compare the traditional Kirschner wire fixation method with the U-shaped Kirschner wire method for treating small bone fragments with displacement, rotation, or instability in skier’s fractures. A retrospective study was conducted on 30 patients with skier’s thumb who were treated at Tianjin Hospital from January 2019 to December 2021. Patients were divided into two groups: Group A received traditional Kirschner wire fixation, while Group B received U-shaped Kirschner wire fixation. Functional assessments and complications during the perioperative period were evaluated. Results: Both surgical methods significantly reduced postoperative pain and increased joint range of motion. Group B had a lower incidence of pain during follow-up and showed significant functional improvement in Tip-pinch and Grip tests compared to Group A. U-shaped Kirschner wire fixation significantly reduced complications during the perioperative period. The U-shaped Kirschner wire internal fixation is a safe and effective treatment for the thumb proximal phalanx base ulnar side avulsion fracture.

Reference:

Ma, S., Zuo, J. & Hu, Y. U-shaped kirschner wire transfixation: effective treatment for Skier’s thumb. BMC Surg 24, 91 (2024). https://doi.org/10.1186/s12893-024-02382-7

Keywords:

U-shaped, Kirschner wire, internal fixation, safe and effective, treatment

Skier’s thumb, BMC Surgery, U-shaped Kirschner wire, Ulnar collateral ligament, Metacarpophalangeal joint, Bone fragmentation

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Canadian study finds physician work hours, especially for male doctors, have declined since 1987

Physicians in Canada, especially male physicians, are working fewer hours than they did three decades ago, and these long-term trends must be considered in workforce planning, according to new research in CMAJ (Canadian Medical Association Journal).

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A primer on recent measles outbreaks, transmission, symptoms and complications, including ‘immune amnesia’

Canada is seeing a resurgence of measles, with cases in the first quarter of 2024 already far surpassing the total for all of 2023. There were 12 cases last year, and more than three times that number so far in 2024, with 38 reported as of March 19.

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Bypassing oral immunotherapy buildup safe in children with food allergy

An initial phase of multifood sublingual immunotherapy (SLIT) that bypasses oral immunotherapy (OIT) buildup is safe and effective, according to a study published online Feb. 27 in the Journal of Allergy and Clinical Immunology: In Practice.

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Race is on to make Paris Olympics mosquito-free

France is scrambling to make sure that that virus-carrying tiger mosquitos, a growing menace in Europe, don’t spoil the Paris Olympics for athletes and fans, with millions of visitors due in the French capital for the summer Games.

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Mifepristone access is coming before the US Supreme Court. How safe is this abortion pill?

The U.S. Supreme Court will take up a case Tuesday that could impact how women get access to mifepristone, one of the two pills used in the most common type of abortion in the nation.

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AIIMS Announces Time Table for Final MBBS Supplementary Professional Exams, details

New Delhi- Through a recent notice, the All India Institute of Medical Sciences (AIIMS) has released the schedule of the final MBBS supplementary professional examinations which will take place in May 2024.

The theory examination will commence from 1st to 14th May 2024 between 02:00 PM and 05:00 PM at the Examination Section on the 1st Floor of the Convergence Block at AIIMS, New Delhi. Practical examinations, on the other hand, will be held from May 16th to May 21st, 2024. Candidates are advised to refer to their respective departments for the timing and venue of the practical exams.

THEORY SCHEDULE

Date

Day

Subject

Paper No.

Venue of Theory

Time of Theory

01.05.2024

Wednesday

Obstetrics & Gynecology

I

Examination Section First Floor

Convergence Block AIIMS, New Delhi

02:00 PM to 05:00 PM

03.05.2024

Friday

Paediatrics

I

06.05.2024

Monday

Community Medicine

I

07.05.2024

Tuesday

Community Medicine

II

09.05.2024

Thursday

Medicine

I

10.05.2024

Friday

Medicine (Medicine, Dermatology, Psychiatry)

II

13.05.2024

Monday

Surgery (Surgery, Orthopedics)

I

14.05.2024

Tuesday

Surgery (Surgery, Ophthalmology, ENT)

II

PRACTICAL SCHEDULE

16.05.2024

Thursday

Community Medicine

17.05.2024

Friday

Medicine

18.05.2024

Saturday

Obstetrics & Gynecology

20.05.2024

Monday

Paediatrics

21.05.2024

Tuesday

Surgery

Candidates must have their Admit Card and Identity Card to enter the examination hall. Students are urged to stay informed about the latest updates by checking the Examination Section’s official website under the “STUDENT TAB” as mentioned in the schedule. It is advised that candidates visit the website regularly, the notice stated.

All India Institute of Medical Sciences, also known as AIIMS Delhi, is a globally acclaimed public medical research university and hospital based in New Delhi, India. The AIIMS Act, of 1956 govern the institute and operates autonomously under the Ministry of Health and Family Welfare.

To view the official notice, click the link below

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