Bomb threat at Chacha Nehru Hospital turns out to be hoax

New Delhi: The state-run Chacha Nehru Hospital in Shahdara received an email containing a bomb threat on Tuesday morning. Following this, officials confirmed that no suspicious items had been found on the hospital premises.

One of the Chacha Nehru hospital staff alerted the authorities upon receiving the bomb-threat email around 10 am.

Responding swiftly, a comprehensive team including the Bomb Detection Team, Bomb Disposal Squad, personnel from the Delhi Fire Service, and local law enforcement swiftly reached the children’s hospital. A thorough search operation commenced immediately, police officials confirmed.

Also Read:53-year-old dentist under scanner for hoax bomb threat at Noida hospital

As a precautionary measure, patients were evacuated from the hospital, while security personnel conducted thorough checks lasting for one and a half hours. 

According to a PTI report, The premises were evacuated and searches are underway. However, nothing has been recovered so far, they added.

“The hospital was packed with patients, so we had to ask them to vacate. The dog squad reached the hospital and a thorough search was conducted,” an officer said, adding that they were trying to identify the sender, reports TOI.

Also Read:Bomb scare at Arogya Hospital after owner receives threat on WhatsApp

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Manipal Hospitals to acquire 87% stake in Medica Synergie for Rs 1.4K crore

Delhi: Manipal Hospitals, the second-largest hospital chain in India announced the signing of a binding agreement to acquire 87% stake in Kolkata-based hospital chain Medica Synergie. 

Post a few customary processes, the transaction is expected to be consummated shortly. This acquisition is in line with Manipal Hospitals’ strategy of expanding its footprint and presence in Eastern India as the leading hospital chain in the region.

By leveraging the clinical expertise and infrastructure of Medica Synergie, along with the combined operations of its extensive network, Manipal Hospitals will be well-positioned to meet the increasing demand for high quality tertiary and quaternary healthcare services in Eastern India.

Also Read:Manipal Hospital unveils Advanced Robotic Technology for Orthopedics Surgeries

Commenting on the transaction, Dilip Jose, MD & CEO said, “We are delighted to welcome Medica Synergie with its highly talented team of professionals into the Manipal family. With this acquisition Manipal Hospitals builds on its strong presence in Eastern India, enabling us to expand our reach and meet the healthcare needs of this under-served region. We will integrate Medica Synergie into our portfolio and rebrand it.

Together, we are poised to deliver enhanced, exceptional quality healthcare to our patients across Eastern India, including the cities of Kolkata, Siliguri, and Ranchi.”

With the acquisition of Medica, Manipal Hospitals treats 7 million patients annually across 37 hospitals spanning 19 cities in 14 states. The addition of Medica has pushed the current hospital bed count from over 9,500 to over 10,500. With a talented pool of 5,600+ doctors, along with an employee strength exceeding 18,600, Manipal Hospitals is steadfast in its commitment to clinical excellence, patient-centric care, and ethical practices. Notably, in September 2023, Manipal Hospitals acquired an 84% stake in Emami Group’s AMRI Hospitals Ltd.

The advisors for Manipal Health Enterprise Pvt. Ltd. in this transaction were Allegro Capital Advisors, Khaitan and Co. and KPMG.

Also Read:Manipal Hospitals Launches New Autism Clinic

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No Association Between SARS-CoV-2 Vaccines and New-Onset Seizures, finds Comprehensive Review

Iran: A systematic review and meta-analysis of randomized clinical trials have found no association between SARS-CoV-2 vaccines and new-onset seizures. Amid concerns regarding the potential adverse effects of COVID-19 vaccines, particularly concerning neurological health, this comprehensive analysis provides reassurance regarding the safety profile of these vaccines.

“In the pooled analyses of more than 118,000 participants in randomized clinical trials (RCTs), the incidence proportion of new-onset seizures after SARS-CoV-2 vaccination was not statistically different between vaccine recipients and placebo recipients or unvaccinated participants,” the researchers reported in JAMA Neurology.

Seizures are an adverse effect of the SARS-CoV-2 vaccine. However, no study has answered whether there is any association between seizures in the general population and COVID-19 vaccination. Considering this, Ali Rafati, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, and colleagues aimed to evaluate the seizure incidence among SARS-CoV-2 vaccine recipients compared with those who received a placebo.

For this purpose, the researchers systematically searched online databases and the references of the included studies from 2019 to 2023. RCTs reporting seizure incidence with SARS-CoV-2 vaccination were included.

The study is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, and the Mantel-Haenszel method was used. The risk of bias in the studies was evaluated using the Cochrane assessment tool for RCTs.

The outcome of interest was new-onset seizure incidence proportion compared among (1) SARS-CoV-2 vaccine recipients and (2) placebo recipients. The study included six RCTs.

The study led to the following findings:

  • Results of the pooled analysis comparing the incidence of new-onset seizure between the 63 521 vaccine and 54 919 placebo recipients in the 28-day follow-up after vaccine/placebo injection showed no statistically significant difference between the 2 groups (0.014% in vaccine and 0.002% in placebo recipients; odds ratio [OR], 2.70).
  • In the entire blinded-phase period after injection, with a median of more than 43 days, the researchers identified no significant difference between the vaccine and placebo groups regarding incident new-onset seizure (0.03% in vaccine and 0.012% in placebo recipients; OR, 2.31).

“According to this systematic review and meta-analysis, we found no statistically significant difference in the risk of new-onset seizure incidence between vaccinated individuals and placebo recipients,” the researchers wrote.

In conclusion, the systematic review and meta-analysis offer valuable insights into the safety profile of SARS-CoV-2 vaccines concerning new-onset seizures. With no evidence of an increased risk of seizures associated with vaccination, these findings provide important reassurance to healthcare providers and the general public. Moving forward, continued research and vigilance will be essential in ensuring the safety and effectiveness of COVID-19 vaccines as a cornerstone of global efforts to combat the pandemic.

Reference:

Rafati A, Jameie M, Amanollahi M, et al. Association of New-Onset Seizures With SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. JAMA Neurol. Published online April 29, 2024. doi:10.1001/jamaneurol.2024.0967

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Uttarakhand Health Department notifies guidelines for dengue and chikungunya management

Dehradun: The Uttarakhand health department has taken proactive measures to address the rising cases of dengue and chikungunya patients in the state by issuing comprehensive guidelines to all districts. Twenty key points have been communicated to District Magistrates and Chief Medical Officers (CMOs) to ensure effective prevention and treatment.

Dr R Rajesh Kumar, Secretary of Health, has been conducting regular review meetings to strategize the prevention of dengue and chikungunya. In consultation with health experts, the department has formulated guidelines aimed at the treatment and prevention of these diseases. 

The Health Secretary said that for the past few years, dengue and chikungunya disease have been reflected as a major public health problem in the state. The vector of dengue and chikungunya disease is the Aedes mosquito. The time from July to November is favourable for the infection of the dengue virus. Dengue and chikungunya disease is a mosquito-borne disease that is born in the water accumulated in coolers, flower vases, pots, open water tanks, old tyres, collected junk, etc. Public participation is very important for the prevention of dengue disease, reports news agency ANI.

Also Read:Spike in Dengue cases: Uttarakhand CM instructs officials for effective control

The Health Secretary said that all other departments also have an important role in the proper prevention and control of dengue and chikungunya disease. All the departments should carry out their activities for dengue prevention and control promptly. All the departments should continue to carry out all the activities to prevent the breeding of dengue mosquitoes so that the breeding of dengue mosquitoes can be prevented and the district health department should receive information about it continuously.  

Kumar said that for the prevention and control of dengue and chikungunya disease, ensure to prepare a block-wise micro plan and take action and the said microplan should be sent to the state NVBDCP unit. Swachhata Abhiyan should be run by municipal corporations so that the breeding of dengue mosquitoes can be prevented.

The Health Secretary said that all other departments also have an important role in the proper prevention and control of dengue and chikungunya disease. All the departments should carry out their activities for dengue prevention and control in a timely manner. 

Also Read:Uttarakhand Health Secretary urges for blood donation amid surge in dengue cases

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Evening Exercise May Offer Higher Health Benefits for Obese Adults: Study

A recent research published in the recent issue of Diabetes Care journal found that the timing of exercise plays a crucial role in reducing the risk of death and cardiovascular diseases in adults with obesity by including those with type 2 diabetes (T2D). The study utilized accelerometry data to monitor physical activity, suggests that performing aerobic moderate to vigorous physical activity (MVPA) in the evening could be particularly beneficial.

The study utilized data from the UK biobank and encompassed a large group of a total of 29,836 adults who were classified as obese with a body mass index (BMI) of 30 kg/m2 or higher. The participants were monitored over an average period of nearly eight years. During this time, the study recorded 1,425 deaths, 3,980 cardiovascular disease (CVD) events and 2,162 microvascular disease (MVD) events among the group.

The participants were divided into categories based on the timing of their exercise routines which were at morning, afternoon and evening. The reference group consisted of the individuals who averaged less than one bout of aerobic MVPA per day. The data revealed that engaging in exercise during the evening was associated with the lowest risk of all-cause mortality with a hazard ratio (HR) of 0.39. Morning and afternoon activities also showed beneficial effects but were less pronounced when compared to evening exercises.

The risk of developing cardiovascular and microvascular diseases were significantly lower among the evening exercisers. The findings showed that evening activity was associated with a 36% lower risk of CVD and a 24% reduction in MVD risk. The benefits extended to the individuals with obesity and T2D that suggests a potentially vital strategy for managing both conditions.

The study adjusted for a variety of potential confounders by ensuring that the results robustly support the conclusion that not just the quantity, but the timing of physical activity is critical for health outcomes in obese adults. These findings could be transformative for the management strategies of obesity and type 2 diabetes that emphasizes the importance of regular physical activity and also its timing. Further research may explore the physiological mechanisms that support why evening exercise offers these health benefits.

Reference:

Sabag, A., Ahmadi, M. N., Francois, M. E., Postnova, S., Cistulli, P. A., Fontana, L., & Stamatakis, E. (2024). Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity. In Diabetes Care (Vol. 47, Issue 5, pp. 890–897). American Diabetes Association. https://doi.org/10.2337/dc23-2448

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Moderate Alcohol Consumption May Reduce Risk of Peripheral Artery Disease, finds study

A recent research published in the European Journal of Preventive Cardiology unveiled a potentially significant relationship between alcohol consumption and the risk of developing peripheral artery disease (PAD), where narrowed arteries reduce blood flow to the limbs. The study combined new cohort data with a meta-analysis of existing research and suggests that light to moderate drinking could be associated with a reduced risk of PAD which is contrasting strongly with risks associated with high levels of alcohol consumption.

The comprehensive study involved data analysis from two large groups that consisted of 70,116 Swedish and 405,406 British adults who were coupled with results from previous studies. According to the findings of this study, a U-shaped association was observed which indicated that both abstention and high alcohol intake might increase the PAD risk with moderate consumption showing potential protective effects.

The key findings suggest that individuals who consume alcohol lightly (≤2 drinks per week) appear to have the reduced risk of developing PAD, with a relative risk reduction at 17% when compared to non-drinkers. This risk becomes significantly pronounced with higher levels of alcohol consumption for the individuals who consume 10 or more drinks per week.

The meta-analysis included additional observational studies that confirmed the U-shaped curve with a significant statistical nonlinearity (P < 0.001)  by indicating that the relationship between alcohol consumption and PAD risk is not straightforward but varies with the amount of alcohol consumed.

The results could redefine the existing guidelines for alcohol consumption in relation to vascular health for the individuals at risk of or managing PAD. While light to moderate alcohol intake could potentially be advised as part of lifestyle modifications for at-risk populations, the clear risks associated with higher levels of drinking are also poorly underlined.

These findings pertain specifically to PAD and may not necessarily apply to other health conditions or the overall health impact of alcohol that can be detrimental in various other respects. Also, the outcomes emphasized the continuity of these links across different types of observational studies which supports the robustness of the results despite potential limitations in this observational research. Overall, the study adds an crucial dimension to our understanding of the complex interactions between lifestyle factors like alcohol intake and specific health outcomes such as PAD.

Source:

Yuan, S., Wu, J., Chen, J., Sun, Y., Burgess, S., Li, X., Åkesson, A., & Larsson, S. C. (2024). Association between alcohol consumption and peripheral artery disease: two de novo prospective cohorts and a systematic review with meta-analysis. In European Journal of Preventive Cardiology. Oxford University Press (OUP). https://doi.org/10.1093/eurjpc/zwae142

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Flank Position Safe and Effective for Kidney Stone Removal Surgery among obese and high risk patients: Study

A recent comprehensive meta-analysis focused on the safety and efficacy of the flank position during percutaneous nephrolithotomy (PCNL) for the removal of kidney stones and suggests that this surgical position may offer distinct advantages for certain high-risk patient groups.

The study systematically reviewed data from multiple databases including PubMed, Embase, SCOPUS, the Cochrane database libraries and the Chinese Biomedical Literature Database. This research included 7 randomized controlled trials which encompassed a total of 587 patients. By employing rigorous inclusion criteria and analytical methods using RevMan 5.4 software, the team led by Changjian Zheng aimed to provide a clear comparative analysis between the flank and the more traditional prone positions used during PCNL.

The key findings from the study revealed a statistically significant lower reduction in hemoglobin levels in the patients who were operated in the flank position when compared to the individuals in the prone position. The mean difference in hemoglobin reduction was −0.15 with a 95% confidence interval from −0.22 to −0.08 that indicates lesser blood loss during the surgery which is a crucial factor for patient safety.

Also, the analysis showed no significant differences in several other critical outcomes such as the stone-free rate, operative time, length of hospital stay and postoperative complications categorized under Clavien grades I, II and III. These results suggest that the flank position does not compromise the effectiveness or the safety of the surgery when compared to the prone position.

The flank position that involves the patient lying on their side was considered particularly advantageous for obese patients or the individuals with reduced cardiopulmonary function, as this can potentially reduce the stress on the heart and lungs during the operation.

Despite these positive results, the study advocate for more extensive trials to further validate their findings. While the results are encouraging, confirming these benefits across a broader demographic and with larger sample sizes is crucial for universal recommendation.

The findings have significant benefits on clinical practice in the treatment of nephrolithiasis, which affects millions worldwide and often requires surgical intervention. The flank position could become a preferred method in PCNL procedures by potentially offering a safer alternative for high-risk patients. This also helps in ensuring better patient outcomes and potentially reduces the risks associated with this common surgery.

Reference:

Zheng, C., Yang, H., Lv, Y., & Yang, L. (2024). Flank versus prone position in percutaneous nephrolithotomy: a meta-analysis of randomized controlled studies. In Urolithiasis (Vol. 52, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1007/s00240-024-01557-4

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Fibrin sealant may reduce hospitalization and operative time among patients undergoing thyroidectomy: Study

Fibrin sealant may reduce length of hospitalization and operative time among patients undergoing thyroidectomy suggests a study published in the BMC Surgery.

Various studies have focused on the application of fibrin sealants (FS) in thyroid surgery. Utilizing a meta-analysis, this systematic review analyzed the findings of recent randomized controlled trials on the safety and efficacy of FS in patients who underwent thyroidectomy. The Cochrane Library, Web of Science, Embase, PubMed, and Medline databases were searched for relevant studies, without any language restrictions. Seven randomized controlled trials were included in the originally identified 69 studies. Overall, 652 patients received FS during thyroid surgery; their outcomes were compared with those of conventionally treated patients. The primary outcomes were total volume of wound drainage, length of hospitalization, and operative time. Significant differences were observed in the total volume of wound drainage (mean deviation (MD): -29.75, 95% confidence interval (CI): -55.39 to -4.11, P = 0.02), length of hospitalization (MD: -0.84, 95% CI: -1.02 to -0.66, P < 0.00001), and surgery duration (MD: -7.60, 95% CI: -14.75 to -0.45, P = 0.04). Secondary outcomes were seroma and hypoparathyroidism development. The risk of hypoparathyroidism did not differ between the FS and conventional groups (I = 0%, relative risk = 1.31, P = 0.38). Analysis of “seroma formation that required invasive treatment” indicated that FS showed some benefit (I2 = 8%, relative risk 0.44, P = 0.15). Heterogeneity among the different trials limited their conclusions. The meta-analysis showed that although FS use did not significantly reduce seroma or hypoparathyroidism incidence in patients after thyroidectomy, it significantly reduced the total drainage volume, length of hospitalization, and duration of surgery.

Reference:

Zheng, X., Wang, F., Su, Y.C. et al. Efficacy and safety of fibrin sealant application in patients undergoing thyroidectomy: a systematic review and meta-analysis. BMC Surg 24, 122 (2024). https://doi.org/10.1186/s12893-024-02414-2

Keywords:

Fibrin sealant, reduce, length, hospitalization, operative time, among, patients, undergoing, thyroidectomy, study, Zheng, X., Wang, F., Su, Y.C, BMC Surgery, Thyroid surgery, Fibrin sealants, Wound drainage, Length of hospitalization, Meta-analysis

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Home OCT device useful tool for self-monitoring of neovascular age-related macular degeneration: Study

Home OCT device useful tool for self-monitoring of neovascular age-related macular degeneration suggests a study published in the Ophthalmology Retina.

A study was done to assess the feasibility of daily Home OCT imaging among patients with neovascular age-related macular degeneration (nAMD). Participants meeting the ocular eligibility criteria were considered for enrollment; those who provided consent received a Notal Vision Home OCT device. Participants were instructed to scan both eyes daily. Retina specialists managed treatment according to their standard practice, without access to the Home OCT data. The presence of fluid detected by a reading center (RC) from in-office OCT scans was compared with fluid volumes measured by the Notal OCT Analyzer (NOA) on Home OCT images.Proportion of participants meeting ocular eligibility criteria who participated in daily scanning, frequency and duration of scanning, proportion of scans eligible for fluid quantification, participant experience with the device, agreement between the RC and NOA fluid determinations, and characteristics of fluid dynamics.

Results: Among 40 participants meeting ocular eligibility criteria, 14 (35%) initiated self-scanning. Planned travel (n = 7, 17.5%) and patient-reported inadequate cell reception for the upload of images (n = 5, 12.5%) were the most frequent reasons for not participating. Considering scans of the study eye only, the mean (standard deviation) was 6.3 (0.6) for weekly scanning frequency and 47 (17) seconds for scan duration per eye. Among 2304 scans, 86.5% were eligible for fluid quantification. All participants agreed that scanning became easier over time, and only 1 did not want to continue daily scanning. For 35 scan pairs judged as having fluid by in-office OCT, the NOA detected fluid on 31 scans (89%). For 14 scan pairs judged as having no fluid on in-office OCT, the NOA did not detect fluid on 10 scans (71%). Daily fluid patterns after treatment initiation varied considerably between patients. For patients with nAMD who initiated home scanning, frequency and quality of scanning and accuracy of fluid detection were sufficient to assess the monitoring of fluid at home. Accommodations for travel and Wi-Fi connectivity could improve uptake of the Home OCT device.

Reference:

Kevin J. Blinder, Claire Calhoun, Maureen G. Maguire, Adam R. Glassman, Calvin E. Mein, Darrell E. Baskin, Gabriela Vieyra, Lee M. Jampol, Moises A. Chica, Jennifer K. Sun, Daniel F. Martin, Adam R. Glassman, Roy W. Beck, Alyssa Baptista, Wesley T. Beaulieu, Claire T. Calhoun, Sharon R. Constantine, Brian B. Dale, Simone S. Dupre, Crystal A. Franklin, Sandra Galusic, Meagan Huggins, Brenda L. Hunter, Paula A. Johnson, Kristin Josic, Brittany Kelly, Danni Liu, Maureen G. Maguire, Britney Meadows, Michele Melia, Carin M. Preston, Cynthia R. Stockdale, Alice Zokruah, Jennifer K. Sun, Daniel F. Martin, Sangeeta Bhargava, Andrew J. Barkmeier, Darrell Baskin, Roy W. Beck, Barbra Blodi, Emily Chew, Frederick L. Ferris, Glenn J. Jaffe, Lee M. Jampol, Chirag D. Jhaveri, Mathew MacCumber, Daniel F. Martin, Raj K. Maturi, Sharon D. Solomon, Cynthia R. Stockdale, Andrew N. Antoszyk, Brandon Lujan, Chirag D. Jhaveri, Emily Chew, Raj K. Maturi, Frederick L. Ferris, Lee M. Jampol, Daniel F. Martin, Hani Slahi-Had, Cynthia R. Stockdale, Andrew J. Barkmeier, Richard Gary Lane, Lydia Adams, Rachel R. Rivera, Brenda Nakoski, Rhonda F. Weeks, Allan L. Braverman, Lauren McDonald-Mueller, Maria A. Stuart, Brook G. Pulliam, Lynda K. Boyd, Jarrod Wehmeier, Steve A. Schremp, Joseph M. Googe, Kristina Oliver, Justin Walsh, Julie Asher, Katie Milstead, Jeff Wheeler, Hodge A. Griffone,

Home OCT Imaging for Newly Diagnosed Neovascular Age-Related Macular Degeneration: A Feasibility Study,

Ophthalmology Retina,

Volume 8, Issue 4,

2024,

Pages 376-387,

ISSN 2468-6530,

https://doi.org/10.1016/j.oret.2023.10.012.

(https://www.sciencedirect.com/science/article/pii/S2468653023005146)

Keywords:

Home, OCT device, useful, tool, self-monitoring, neovascular, age-related, macular degeneration, Study, Ophthalmology Retina, Home OCT; Neovascular age-related macular degeneration; OCT, Kevin J. Blinder, Claire Calhoun, Maureen G. Maguire, Adam R. Glassman, Calvin E. Mein, Darrell E. Baskin, Gabriela Vieyra, Lee M. Jampol, Moises A. Chica, Jennifer K. Sun, Daniel F. Martin, Adam R. Glassman, Roy W. Beck, Alyssa Baptista, Wesley T. Beaulieu, Claire T. Calhoun, Sharon R. Constantine, Brian B. Dale, Simone S. Dupre, Crystal A. Franklin, Sandra Galusic, Meagan Huggins, Brenda L. Hunter, Paula A. Johnson, Kristin Josic, Brittany Kelly, Danni Liu, Maureen G. Maguire, Britney Meadows, Michele Melia, Carin M. Preston, Cynthia R. Stockdale, Alice Zokruah, Jennifer K. Sun, Daniel F. Martin, Sangeeta Bhargava, Andrew J. Barkmeier, Darrell Baskin, Roy W. Beck, Barbra Blodi, Emily Chew, Frederick L. Ferris, Glenn J. Jaffe, Lee M. Jampol, Chirag D. Jhaveri, Mathew MacCumber, Daniel F. Martin, Raj K. Maturi, Sharon D. Solomon, Cynthia R. Stockdale, Andrew N. Antoszyk, Brandon Lujan, Chirag D. Jhaveri, Emily Chew, Raj K. Maturi, Frederick L. Ferris, Lee M. Jampol, Daniel F. Martin, Hani Slahi-Had, Cynthia R. Stockdale, Andrew J. Barkmeier, Richard Gary Lane, Lydia Adams, Rachel R. Rivera, Brenda Nakoski, Rhonda F. Weeks, Allan L. Braverman, Lauren McDonald-Mueller, Mari

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Discontinuation of nonindicated PPI therapy may cut morbidity and mortality in ICU patients: Study

Discontinuation of nonindicated PPI therapy in ICU may cut morbidity, rehospitalization rate, and mortality suggests a new study published in the Critical care Medicine.

Proton pump inhibitors (PPIs) are among the drugs most commonly used in critically ill patients. Although mainly applied temporarily for stress ulcer prophylaxis, their application is frequently not terminated. Potential adverse effects of PPI treatment could impact the outcome in case of unnecessary and, therefore, avoidable long-term continuation. We tested the hypotheses that nonindicated PPI therapy continued beyond hospital discharge is associated with increased morbidity, rehospitalization rate, and mortality. Nationwide retrospective cohort study considering critically ill patients treated on German ICUs between January, 2017, and December 2018 with a 2-year follow-up. A total of 591,207 patient datasets of a German healthcare insurer were screened. They identified 11,576 ICU patients who received PPI therapy for the first time during their index ICU stay without indicating its continuation. The cohort was stratified into two groups: 1) patients without further PPI therapy and 2) patients with continuation of PPI therapy beyond 8 weeks after hospital discharge. MEASUREMENTS AND MAIN RESULTS: Frequency of pre-described adverse events associated with PPI therapy, 1-year rehospitalization rate, and 2-year mortality were determined. The proportion of patients with continued PPI therapy without an objectifiable indication was 41.7%. These patients had a 27% greater risk of pneumonia and a 17% greater risk of cardiovascular events (OR 1.17; 95% CI, 1.08-1.26; p < 0.001). Continued PPI therapy was associated with a 34% greater risk of rehospitalization (OR 1.34; 95% CI, 1.23-1.47) and a nearly 20% greater 2-year mortality risk (hazard ratio 1.17; 95% CI, 1.08-1.27; p = 0.006). These data demonstrate that an unnecessary continuation of PPI therapy after hospital discharge may significantly impact morbidity and mortality. To avoid potentially harmful overuse of a PPIs, intensivists should ensure timely cessation of a temporarily indicated PPI therapy.

Reference:

Palmowski L, von Busch A, Unterberg M, Bergmann L, Schmitz S, Schlüter A, Peters J, Adamzik M, Rahmel T. Timely Cessation of Proton Pump Inhibitors in Critically Ill Patients Impacts Morbidity and Mortality: A Propensity Score-Matched Cohort Study. Crit Care Med. 2024 Feb 1;52(2):190-199. doi: 10.1097/CCM.0000000000006104. Epub 2024 Jan 19. PMID: 38240505; PMCID: PMC10793775.

Keywords:

Discontinuation, nonindicated PPI therapy, ICU, morbidity, rehospitalization rate, mortality, Respiratory Medicine, Palmowski L, von Busch A, Unterberg M, Bergmann L, Schmitz S, Schlüter A, Peters J, Adamzik M, Rahmel T, critical care medicine

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