Entries by aaron

Daily aspirin can significantly reduce liver fat content in metabolic dysfunction-associated steatotic liver disease: Study

USA: A recent clinical trial revealed that six months of daily low-dose aspirin significantly reduced hepatic fat quantity compared with placebo in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).  The most common chronic liver disease is metabolic dysfunction-associated steatotic liver disease characterized by an increased buildup of fat in the liver due to factors such […]

Adding ribociclib to hormone therapy reduces the risk of breast cancer recurrence: NEJM

A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators. The team found adding ribociclib, […]

Statins could help calm gum disease by altering behavior of macrophages: Study

USA: A recent study has suggested that statins could improve gum health and reduce the risk of heart disease.  Could taking statins benefit your mouth in addition to your arteries? The study conducted in cell cultures showed that cholesterol-lowering drugs help to dampen the inflammation associated with periodontal disease by altering the behavior of macrophages, […]

Low exposure to antibiotics in newborns may not increase risk of early-onset sepsis: JAMA

In a nationwide study conducted in Sweden, researchers have discovered that administering antibiotics to newborns during their first week of life does not substantially heighten the risk of early-onset sepsis (EOS) or associated mortality. This finding comes as a significant reassurance to healthcare providers and parents, amid growing concerns regarding the overuse of antibiotics and […]

Intravascular Imaging Increases Cost-Effectiveness of Coronary Artery Procedures: AHA

A recent study unveiled the cost-effectiveness of intravascular imaging-guided percutaneous coronary intervention (PCI) compared to conventional angiography-guided procedures. The findings were published in Circulation: Cardiovascular Quality and Outcomes reveal significant benefits for patients with complex coronary artery lesions. The RENOVATE-COMPLEX-PCI trial was conducted in Korea from May 2018 to May 2021 and examined the clinical […]

Invasive Angiography Adds Nothing to CCTA Alone for risk stratification of patients with stable CAD: ISCHEMIA

Canada: An analysis of the ISCHEMIA trial revealed that both invasive coronary angiography and coronary CT angiography (CCTA) add incremental information over baseline characteristics for predicting risk in stable coronary artery disease (CAD) patients. The findings, published in JACC: Cardiovascular Imaging, also show that invasive angiography addition on top of CCTA does not provide any […]

Switching to integrase inhibitor may accelerate weight gain during menopause inHIV patients: Study

Integrase strand transfer inhibitors (INSTIs) are associated with more significant weight gain in women with HIV (WWH) compared to men with HIV. Menopausal transition leads to changes in body composition. A finding published in CROI, Conference on Retroviruses and Opportunistic Infections, mentioned that switching to INSTIs during the late peri- and postmenopausal phase is associated […]

No advatage of Laparoscopic surgery over open surgery in reducing risk of bowel obstruction in complicated appendicitis: Study

No advantage of Laparoscopic surgery over open surgery in reducing the risk of bowel obstruction in complicated appendicitis suggests a new study published in the Journal of Pediatric Surgery. Complicated appendicitis is associated with a higher risk of postoperative complications, including adhesive bowel obstruction. This meta-analysis aims to investigate the difference in rates of postoperative […]