Probiotics Show Benefits in Periodontitis Management, reveals meta-analysis

Probiotics supplementation has many beneficial impacts on periodontitis outcomes. This umbrella meta-analysis evaluated the effectiveness of probiotics in treating periodontitis, focusing on primary outcome measures, including reductions in probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), gingival index (GI), and PDD reduction in medium and deep pockets. All meta-analyses evaluating the impact of probiotics supplementation on periodontitis outcomes were considered eligible. A random-effects model was employed to estimate the pooled results. Subgroup and sensitivity analyses were conducted. The quality of the studies was evaluated using the AMSTAR2 tool. Overall, 19 meta-analyses with 67 data sets were included in this umbrella review. Our findings indicated that probiotics supplementation significantly decreased BOP (effect size [ES]: −8.20; 95% CI: −15.10 to −1.31; P = .02) and CAL after sensitivity analysis (ES: −0.52; 95% CI: −0.75 to −0.28; P < .05). No other significant effect was observed on PPD, PI, GI, or PDD reduction in medium and deep pockets. This umbrella meta-analysis found that, during their treatment process, probiotics supplementation may positively affect BOP and CAL in people with periodontitis.

Reference:

Junfeng Tan, Dan Zhang, Li Cheng, Ning Liu, Mehrdad Jamali, Helen Jamloo, Rosana Farjaminejad, Changjiang Lei, Ahmad Saedisomeolia, Abdolreza Jamilian, The Impacts of Probiotics Supplementation on the Treatment of Periodontitis: An Umbrella Meta-Analysis, Nutrition Reviews, 2025;, nuae190, https://doi.org/10.1093/nutrit/nuae190

Keywords:

Probiotics, Show, Benefits, Periodontitis, Management, reveals, meta-analysis, probiotics, periodontitis, oral flora, umbrella meta-analysis, Junfeng Tan, Dan Zhang, Li Cheng, Ning Liu, Mehrdad Jamali, Helen Jamloo, Rosana Farjaminejad, Changjiang Lei, Ahmad Saedisomeolia, Abdolreza Jamilian, Nutrition Reviews