Hallmarks of precancer: Researchers investigate the principles governing the biology of early, precancerous lesions

Every oncologist and cancer researcher is familiar with the hallmarks of cancer, a series of functional capabilities that human cells acquire as they transition from a normal state to a neoplastic state (a state of excessive and abnormal growth). These hallmarks have been used (and updated) during the last quarter of a century as a “conceptual scaffold” to help “rationalize the complex phenotypes of diverse human tumor types and variants in terms of a common set of underlying cellular parameters.”

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