A new study has determined that increased concentrations of methylglyoxal (MGO), a potent reactive byproduct of glucose metabolism, can independently cause the onset of liver fibrosis among obese individuals. The finding is consistent with mounting evidence indicating that MGO and similar compounds not only initiate inflammation and produce deleterious advanced glycation end products (AGEs), but […]
A study published in Annals of Internal Medicine has revealed that menopausal women with larger waist circumference faced a higher risk of death across all body mass index (BMI) categories. Researchers emphasized that waist circumference is a simple and cost-effective measure for assessing health risks. The study was conducted by Aaron K. and fellow researchers. […]
For most children, influenza (flu) usually means unpleasant symptoms like a fever, sore throat, and achy muscles. But for a small subset of kids, the flu can trigger a rare but serious complication called influenza-associated acute necrotizing encephalopathy (ANE). This form of brain inflammation typically occurs in response to a virus — such as those […]
A new study published in The New England Journal of Medicine showed that daily dapagliflozin dramatically reduced the risk of death or deteriorating illness among patients with heart failure (HF) at one year following transcatheter aortic valve implantation (TAVI). Since patients with valvular heart disease have been mostly excluded from randomized studies of the medicine, […]
A new study published in the Nature Scientific Reports showed that compared to kidney recipients who got preemptive transplants, individuals who experienced dialysis prior to transplantation are at a higher risk of developing long-term visual problems, including dry eye and diabetic retinopathy. For individuals with end-stage renal disease, kidney transplantation is the only proven therapy […]
Surgical removal of enlarged tonsils and adenoids in children with mild sleep-disordered breathing (SDB) appears to significantly reduce the frequency of medical office visits and prescription medicine use in this group, according to a clinical study supported by the National Institutes of Health (NIH). The findings, published in JAMA Pediatrics, show that the surgery, called […]
In a recent study investigating the effects of prostaglandin E1 (PGE1) on reducing inspired oxygen concentration during one-lung ventilation (OLV), several key findings and outcomes were identified. The study included 120 patients undergoing thoracic surgery, randomly assigned to four groups receiving different FiO2 levels and PGE1 nebulization. The primary outcome was oxygenation during OLV, with […]
USA: A recent research letter published in JAMA Ophthalmology has identified a potential link between certain glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and an elevated risk of nonarteritic anterior ischemic optic neuropathy (NAION) in older adults with type 2 diabetes. The study, led by Kin Wah Fung from the Lister Hill National Center for Biomedical […]
SetPoint Medical’s vagus nerve stimulator has received FDA approval for treating moderate-to-severe rheumatoid arthritis (RA) in patients who do not respond to or cannot tolerate biologics or Janus kinase inhibitors. This marks the first electrical therapy approved for RA. The SetPoint System is a first-of-its-kind neuroimmune modulation device for the treatment of adults living with […]
Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality globally, particularly affecting women with gestational hypertension due to their vulnerability to blood volume reduction. A recent retrospective cohort study analyzed the impact of epidural labor analgesia on blood loss within two hours post-delivery in this specific population, a critical period where up to 80% […]