The FDA has approved inclisiran (Leqvio) for first-line use in lowering LDL cholesterol, even without combining it with statins, according to Novartis. The FDA proactively requested the label update based on the robust LDL-C lowering data for PCSK9-targeting therapies. “This first-line label update reinforces Leqvio’s proven ability to effectively lower LDL-C, a critical risk factor […]
Although metformin has been the go-to medication to manage type 2 diabetes for more than 60 years, researchers still do not have a complete picture of how it works. Scientists at Baylor College of Medicine and international collaborators have discovered a previously unrecognized new player mediating clinically relevant effects of metformin: the brain. By uncovering […]
A new study published in the Journal of American Heart Association revealed that clusters of cardiovascular risk factors during pregnancy markedly increased the probability of stillbirth. It is often acknowledged that stillbirth, which is the intrauterine death of a fetus that usually happens between 20 and 28 weeks of gestation, is a crucial sign of […]
New Delhi: With an aim to demonstrate the safety and efficacy on lower back pain, the Subject Expert Committee (SEC) functioning under the Central Drugs Standard Control Organisation (CDSCO) has opined that Elevate Scientific should conduct the clinical investigation of Radiopaque Gelified Ethanol (Absolute Gel) on the Indian population. In addition, the expert panel suggested […]
New Delhi: Dr. Reddy’s Laboratories Limited has received approval from the Subject Expert Committee (SEC) under CDSCO to conduct a Phase III clinical trial of its investigational dermatological product Tapinarof Cream 1%, aimed at treating plaque psoriasis. The decision was made during the SEC’s 7th meeting held on 23rd July 2025 at CDSCO headquarters, New […]
Twin reversed arterial perfusion (TRAP) sequence is a rare and serious complication primarily observed in monochorionic monoamniotic (MCMA) twins, manifesting with acute impacts on both twins involved. With a historically low incidence of approximately 1%, the advent of advanced ultrasonography and assisted reproductive technologies may increase the observed frequency, potentially up to 1 in 40 […]
A new study published in BMC Nephrology has found that elevated levels of high-sensitivity C-reactive protein (hs-CRP) are significantly associated with an increased risk of diabetic nephropathy (DN), a serious microvascular complication of diabetes. Researchers analyzed data across multiple studies and concluded that hs-CRP—an inflammatory biomarker—may serve as a useful tool for identifying high-risk individuals […]
A two-drug combination for treating advanced kidney cancer had sustained and durable clinical benefit in more than five years of follow-up, according to a study published in Nature Medicine. The study reports final clinical data and biomarker analyses from the Phase 3 KEYNOTE-426 trial, which compared the drug combination pembrolizumab plus axitinib versus the single […]
A new study published in the Journal of Cosmetic Dermatology has found that vitiligo has a direct causal relationship with a number of autoimmune diseases, most notably rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), and alopecia areata (AA). Applying novel genetic analysis, this research provides strong evidence of a bidirectional causal relationship between vitiligo […]
Researchers have found in a new randomized clinical trial that modified open anterior mesh repair repair is a suitable option for groin hernia repair in women, especially in low-resource settings. Femoral hernias were highly prevalent, and exposing the femoral canal was crucial for their accurate detection. The study was published in JAMA Network by Alphonsus […]