Entries by aaron

Balloon Dilation Safe and Effective for Bile Duct Stones, finds Study

Researchers have found in a new study that percutaneous papillary balloon dilation is safe and highly effective for the treatment of common bile duct stones (CBDS) and is a useful alternative in patients who are unable to undergo endoscopy or surgery. The study was published in BMC Gastroenterology journal by Yiran S. and colleagues. Common […]

SGLT2 Inhibitors Linked to Lower Risk of Kidney Stones in Patients With Type 2 Diabetes: Study Shows

Thailand: Use of sodium-glucose co-transporter-2 inhibitors (SGLT2is) may help reduce the risk of kidney stone formation in individuals with type 2 diabetes (T2D) without increasing the likelihood of urinary tract infections (UTIs), according to new research published in Diabetology & Metabolic Syndrome. The retrospective cohort study highlights potential renal benefits of SGLT2i beyond glucose control. […]

New trial finds diabetes drug and nasal insulin improve brain health in early Alzheimer’s disease

 A clinical trial from Wake Forest University School of Medicine shows that two widely available medications, the diabetes drug empagliflozin (Jardiance) and intranasal insulin, safely improve brain health in people with mild cognitive impairment and early Alzheimer’s disease. The study, published in Alzheimer’s & Dementia, the journal of the Alzheimer’s Association, marks the first time […]

Heart rate changes predict depression treatment success with magnetic brain stimulation: Study

Researchers led by Dr. Roberto Goya-Maldonado at the University Medical Center Göttingen have identified a rapid physiological marker that predicts which patients with major depression will respond to magnetic brain stimulation therapy. The peer-reviewed research article, published in Brain Medicine, found that patients whose heart rates slowed within 45 seconds of starting treatment showed significantly […]

New guideline provides treatment recommendations for central sleep apnea

A new clinical practice guideline developed by a task force of the American Academy of Sleep Medicine provides updated recommendations for the treatment of central sleep apnea. Available online as an accepted paper in the Journal of Clinical Sleep Medicine, the guideline updates the AASM’s previous practice parameters published in 2012 and 2016. Among other […]

Gene Therapy Restores Hearing in Children with OTOF-Related Congenital Deafness: NEJM

A recent phase I/II CHORD trial published in the New England Journal of Medicine has shown that a novel gene therapy targeting OTOF variants can restore hearing in children with congenital profound deafness. The therapy involves delivering a functional OTOF gene to the inner ear using a viral vector, aiming to correct the underlying genetic […]

FDA Approves Obinutuzumab for Active Lupus Nephritis

The FDA has approved Gazyva® (obinutuzumab) for treating adult patients with active lupus nephritis who are already on standard therapy. The approval is based on results from the phase 3 REGENCY trial (NCT04221477), which involved 271 patients with class 3 or 4 lupus nephritis (with or without class 5) receiving mycophenolate mofetil (MMF) and corticosteroids. […]

TyG-BMI Index Predicts Higher Mortality Risk in Osteoporosis Patients: Study

Researchers have found in a new study that elevated triglyceride-glucose body mass index (TyG-BMI) levels have a strong correlation with higher risks of all-cause and cardiovascular mortality in osteoporotic patients, suggesting that insulin resistance plays an important part in their long-term outcome. Osteoporosis, a systemic skeletal disease characterized by decreased bone mass and fragility, is […]