UK: Researchers have found in a new study that sleep-disordered breathing (SDB) is highly prevalent in hypertrophic cardiomyopathy (HCM) patients and is linked to adverse myocardial remodeling, greater diastolic dysfunction, and elevated troponin-T levels, indicating subclinical myocardial injury. The findings support further trials on treating SDB to improve outcomes in HCM. The study, published in […]
China: A new study has found that metabolic syndrome (MS) independently contributes to more severe and unfavorable coronary artery plaque characteristics in patients with type 2 diabetes mellitus (T2DM). These include higher rates of mixed, noncalcified, and nonobstructive plaques, as well as spotty calcification and extensive plaque burden. The findings […]
China: A new cardiac MRI-based workflow has shown promise in improving the prediction of sudden cardiac death (SCD) among individuals with nonischemic dilated cardiomyopathy (DCM), offering clinicians refined tools for risk stratification and personalized treatment strategies. By establishing specific cutoff values for late gadolinium enhancement (LGE) and extracellular volume fraction (ECV), the study demonstrates a […]
USA: Researchers have found in a new cost-effectiveness analysis that vasectomy is a more cost-effective permanent contraceptive option. While salpingectomy prevented more unintended pregnancies and reduced ovarian cancer risk, it only became the more cost-effective option at higher willingness-to-pay levels. The investigation, published in Obstetrics & Gynecology by Jill Brown, MD, MPH, of the Department […]
Shimla: The Himachal Pradesh High Court has upheld the conviction of a chemist under the Drugs and Cosmetics Act, 1940, for stocking allopathic medicines without a valid licence, stressing that such offences affect public health and must be dealt with strictly. Justice Rakesh Kainthla rejected Sanjay K. Maanav’s challenge and affirmed the trial court’s 2007 […]
The U.S. FDA has approved Johnson & Johnson’s INLEXZO™ (gemcitabine intravesical system) for adults with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS), with or without papillary tumors. This new therapy offers an alternative for patients who decline or are ineligible for bladder removal surgery (radical cystectomy). Gemcitabine intravesical system is co-packaged […]
A new study has investigated the impact of biologic therapies on cancer risk among patients with psoriasis and found that these treatments may offer protective benefits compared to traditional topical therapies. Psoriasis is a chronic immune-mediated condition that often requires long-term management, and concerns about the potential for systemic therapies to influence malignancy risk have […]
Netherlands: Wearing a valgus knee brace can meaningfully reduce walking-related pain in patients with medial compartment knee osteoarthritis (OA), according to a randomized controlled trial published in PLOS One. After six months of use, patients reported both statistically significant and clinically important improvements in pain intensity during walking, along with a reduced reliance on pain […]
USA: A prospective trial in gastrointestinal cancer patients found that preemptive DPYD/UGT1A1 genetic testing before chemotherapy was feasible, enabled timely results in over half of cases, and showed potential to lower treatment-related side effects and modifications. The research, led by Dr. Sony Tuteja from the Perelman School of Medicine at the University of Pennsylvania […]
A newly published retrospective cohort study (APeX‑P trial) in Journal of Allergy and Clinical Immunology: In Practice found that oral berotralstat—a once‑daily plasma kallikrein inhibitor—was well tolerated and highly effective in reducing hereditary angioedema (HAE) attack rates in children aged 2–11 years. Among the 29 pediatric participants (median age 8), berotralstat led to early and […]