Entries by aaron

Digitoxin Reduces Mortality and Hospitalizations in Heart Failure with Reduced Ejection Fraction: NEJM

Heart failure with reduced ejection fraction (HFrEF) remains a leading cause of morbidity and mortality worldwide, despite advances in guideline-directed medical therapy. Novel or adjunctive pharmacologic interventions are continuously explored to improve clinical outcomes, including reductions in hospitalizations and mortality. Digitoxin, a cardiac glycoside, has long been used for heart failure and atrial arrhythmias, but […]

Ensuring Medication Safety for Pediatric Patients in Resource-Limited Settings ,study finds

Medication errors and adverse drug events pose a significant risk for pediatric patients undergoing anesthesia, especially in lower middle-income countries (LMICs) where healthcare systems face resource constraints. A recent study examined the frequency and types of medication errors reported over a 20-year period in the anesthesia department of a tertiary care teaching hospital in an […]

Perfusion Index may Predict for SAIH in Orthopedic Surgery, Less Effective in Elderly: Study

A new study published in the journal of BMC Surgery showed that Perfusion Index (PI) is a non-invasive tool for predicting spinal anesthesia-induced hypotension in lower extremity orthopedic surgery patients (cut-off value = 2.25), but shows reduced accuracy in elderly individuals. The most frequent side effect of spinal anesthetic is hypotension, which is becoming more […]

HEPA Filters Lower Blood Pressure in High-Pollution Areas: Study

Researchers have found in a new randomized trial that using high-efficiency particulate arrestance (HEPA) filters in homes significantly reduced elevated blood pressure in individuals exposed to air pollution near major highways. However, no benefit was observed in people with normal systolic blood pressure (≤120 mm Hg). Researchers recommend targeting HEPA filtration for vulnerable populations residing […]

Keto diet linked to reduced depression symptoms in college students: Study

 A new study shows an association between at least 10 weeks of following a well-formulated ketogenic diet and a roughly 70% decrease in depression symptoms among a small group of college students. Beyond the reduction in self-reported and clinician rated depression, the students’ global well-being increased nearly three-fold and their performance improved on several cognitive […]

Age-related Eye Diseases Increase Risk of Comorbid CHD and Depression, reveals study

Researchers have discovered in a new study that patients with age-related eye diseases (AREDs) have a significantly increased risk of simultaneously developing coronary heart disease (CHD) and depression as compared to either of the conditions alone. The research established that patients with AREDs, such as age-related macular degeneration, glaucoma, cataract, and diabetes-related eye diseases (DRED), […]

Tirzepatide and Thiazide Use in CKD Linked to Risk of Severe Hypercalcemia, Reveals Case Report

USA: Researchers have reported a potential risk of severe hypercalcemia when tirzepatide, a dual GIP and GLP-1 receptor agonist, is used in combination with chronic thiazide diuretics—particularly hydrochlorothiazide (HCTZ)—in patients with pre-existing chronic kidney disease (CKD).   The finding comes from a new case report published in Endocrinology, Diabetes & Metabolism Case Reports, highlighting a previously unrecognized […]

Vancomycin Linked to Higher AKI Risk in ICU Patients: Study

A recent target trial emulation study found that vancomycin use in ICU patients is associated with a higher risk of acute kidney injury compared to alternatives such as clindamycin and linezolid, highlighting the importance of following established prevention strategies. The study was published in Pharmacoepidemiology & Drug Safety journal by Izak A. and colleagues. The […]