Entries by aaron

Aficamten improved outcomes for patients with obstructive hypertrophic cardiomyopathy: Phase 3 SEQUOIA-HCM trial

USA: The pivotal Phase 3 clinical trial (SEQUOIA-HCM) of aficamten in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) has yielded positive results, as announced by drugmaker Cytokinetics. The top-line results from the SEQUOIA-HCM trial showed that aficamten, a novel cardiac myosin inhibitor, improved outcomes for patients with symptomatic obstructive HCM. The full results from SEQUOIA-HCM […]

Nirsevimab effective in preventing hospitalization for RSV associated lower RTI in infants

Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infection in young children and infants, leading to hospitalization. According to a study published in the New England Journal of Medicine, Nirsevimab protected infants against hospitalization for RSV-related lower respiratory infections in conditions that approximated real-world settings. The aim of the study was […]

Submit safety, efficacy data of Indian Patients: CDSCO Panel Tells AstraZeneca on additional indication of Enhertu 100mg

New Delhi: In response to the drug major AstraZeneca’s proposal for the additional indication of Trastuzumab Deruxtecan Powder Concentrate Solution for Infusion (Enhertu 100mg) to treat adult patients with unresectable or metastatic Non-small cell lung cancer (NSCLC) whose tumors have activated HER2 (ERBB2) mutations and who have received prior systemic therapy, the Subject Expert Committee […]

Metoclopramide may decrease need for second look Endoscopic Visualization in Active Upper GI Bleeding

In a recent breakthrough study conducted between April 2021 and October 2022, researchers delved into the effectiveness of metoclopramide in improving gastric visualization for patients experiencing active upper gastrointestinal bleeding (UGIB). They found that Metoclopramide did not significantly enhance endoscopic visualization overall but notably reduced the need for a second-look esophagogastroduodenoscopy (EGD) in patients with […]

Delhi Vigilance Dept calls for CBI probe into suspected spurious drugs

The Delhi government’s Directorate of Vigilance has sent the matter of suspected spurious drugs to the Union Home Ministry, urging a thorough investigation by the Central Bureau of Investigation (CBI). The Directorate of Vigilance, in a formal letter to the Union Home Ministry on Thursday, said, “Assigning the matter if reported supply of not of […]

WBCERC has no authority to adjudicate Medical Negligence Cases: Calcutta High Court

Kolkata: In a major decision, the Calcutta High Court bench has clearly iterated that matters concerning the issues of medical negligence cannot be adjudicated by the West Bengal Clinical Establishment Regulatory Commission (WBCERC). Clarifying its stand in this regard, the HC bench comprising Justice Arijit Banerjee and Justice Apurba Sinha Ray noted, “The negligence in […]

Bayer Pharma gets CDSCO Panel nod to study Asundexian 50mg tablets

New Delhi: Bayer Pharmaceutical has got approval from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) to conduct the phase III clinical trial of Asundexian (BAY 2433334) tablets. However, this approval is subject to the condition that clarity on PFO (patent foramen ovale) and arterial episode findings in Echo […]

Delhi reports first Covid JN.1 case

Following the identification of the first case of the Covid-19 sub-variant JN.1 in the national capital, the All India Institute of Medical Sciences (AIIMS) in Delhi has released guidelines for managing suspected or positive Covid patients in hospitals. In response to a meeting with department heads, the AIIMS Delhi Director has directed the establishment of […]