Entries by aaron

Merck announces Phase 3 trial initiations for 4 investigational candidates from its hematology, oncology pipeline

Rahway: Merck, known as MSD outside of the United States and Canada, has announced the initiation of pivotal Phase 3 trials for four of its investigational candidates from its diverse pipeline in hematologic malignancies and solid tumors. Global Phase 3 studies have been initiated and are actively enrolling for the following investigational candidates: Bomedemstat, an investigational […]

Final PGMER 2023 Regulations released in Gazette

Around four months after the Draft was released, the final Post-Graduate Medical Education Regulations, 2023 (PGMER 2023) have now been published. These Regulations, which have come into force from the date of their publication in the official gazette i.e. 29.12.2023, lay down the rules and regulations regarding admission, counselling, and other details related to the […]

Medtronic gets CE Mark for next generation Micra leadless pacing systems

Dublin: Medtronic plc has announced it has received CE (Conformité Européenne) Mark for its Micra AV2 and Micra VR2, the next generation of its miniature, leadless pacemakers. Micra AV2 and Micra VR2, the world’s smallest pacemakers, provide longer battery life and easier programming than prior Micra pacemakers, while still delivering the many benefits of leadless pacing […]

Faricimab outperforms anti-VEGF Drugs in DME and AMD Treatment by improving central subfoveal thickness

In the industrialized world, Neovascular age-related macular degeneration (AMD) and diabetic macular edema (DME) cause blindness. Faricimab, launched in the US in January 2022, treats diabetic macular edema and wet age-related macular degeneration. Based on evidence from Systematic reviews, anti-VEGF agents’ are advantageous in AMD and DME compared to other therapies. In a study published […]

Higher AMH levels lower ovulation chances during induction with clomiphene and metformin in PCOS patients

USA: A recent study published in Fertility and Sterility has shown reduced odds of ovulation with ovulation induction (OI) with clomiphene, metformin, and clomiphene+metformin with a higher Anti-Müllerian hormone (AMH) concentration in women with polycystic ovary syndrome (PCOS) and infertility. “Higher baseline AMH concentrations were associated with a 10% reduction in the odds of ovulation […]

Doxofylline Shows Promise as Steroid-Sparing Treatment for Pediatric Asthma

A recent pilot study conducted in Mexican children with asthma suggests that doxofylline, when used in conjunction with inhaled corticosteroids (ICS), may offer a potential steroid-sparing effect. This study was published in the Journal Of Asthma by Sandra Diaz. and colleagues. The study, a 10-week open-label crossover trial, aimed to evaluate the efficacy of doxofylline […]

ChatGPT has low diagnostic accuracy in pediatric cases, finds JAMA study

USA: A recent study published in JAMA Pediatrics has shed light on the diagnostic accuracy of a large language model (LLM) in pediatric case studies. The researchers found that a LLM-based chatbot gave the wrong diagnosis for the majority of pediatric cases. They showed that the ChatGPT version 3.5 reached an incorrect diagnosis in 83 […]

Elevated liver enzyme levels tied to risk of incident type 2 diabetes in obese patients

Among obese individuals, elevated liver enzyme levels tied to risk for incident type 2 diabetes suggests a new study published in the Acta Diabetologic The role of liver steatosis and increased liver enzymes (ALT) in increasing incident type 2 diabetes mellitus (T2DM) is debated, because of their differential effects on different ethnicities and populations. The […]