Entries by aaron

Earlier anticoagulation reversal associated with better survival in patients with intracerebral haemorrhage: JAMA

USA: A cohort study including 9492 patients with anticoagulation-associated intracerebral haemorrhage (ICH) showed that a door-to-treatment time of 60 minutes or less is tied to lower mortality and hospice transfers. Stroke severity and White race were associated with faster administration of reversal interventions. The study, published in JAMA Neurology, highlights the importance of rapid treatment […]

Laryngopharyngeal reflux highly High prevalent among patients experiencing persistent hoarseness of voice, reveals study

India: A recent study published in the Indian Journal of Otolaryngology and Head & Neck Surgery suggests considering laryngopharyngeal reflux disease (LPRD) in patients presenting with voice hoarseness for more than three weeks. The study unveiled a notable association with gender (70.3% female), age (41–50 years), & severity of voice use, with hoarseness identified as […]

Antibody Combo Evusheld Fails to show Impressive results in COVID-19 Trial

In the Phase 3 DISCOVERY European trial, although there was a considerable rise in neutralizing antibodies against SARS-CoV-2 at days 3 and 8, Evusheld monoclonal antibody combination drug failed to exhibit significant improvements in the clinical status of hospitalized COVID-19 patients or accelerated viral clearance. The findings of this clinical trial were reported in a […]

Topology-optimized splints tied to better wrist functional outcomes than casting in treatment of distal end radius fractures: Study

Distal radius fractures (DRFs) are among the most common fracture injuries in emergency trauma departments. Treatments for DRFs comprise surgical and conservative approaches. The rise of 3-dimensional (3D) printing in orthopedics has led to bespoke splints with superior clinical efficacy, lightweight design, and better ventilation. These splints could reduce patient pain, lessen risks of joint […]

CDSCO Panel Approves AstraZeneca’s Protocol Amendment Proposal to Study Capivasertib Plus Abiraterone

New Delhi: The Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has approved the drug major AstraZeneca’s proposal for amendment of protocol for the clinical study ” A Phase III Double-Blind, Randomised, Placebo-Controlled Study Assessing the Efficacy and Safety of Capivasertib+Abiraterone Versus Placebo+Abiraterone as Treatment for Patients with DeNovo Metastatic […]

CDSCO Panel grants Sanofi’s Updated Prescribing Information for FDC Ibuprofen plus Paracetamol

New Delhi: The drug major Sanofi has got approval from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) to update prescribing information for the fixed-dose combination (FDC) Ibuprofen 100mg plus Paracetamol 162.5mg suspension and Ibuprofen 400mg plus Paracetamol 325mg tablet. This came after the firm presented the proposal for […]

CDSCO Panel Rejects Dr Reddy’s Proposal to Study FDC of Ketorolac plus Serratiopeptidase Capsules

New Delhi: Citing there is no rationality of the combination and significant benefits, the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has rejected the drug major Dr. Reddys Laboratories’ proposal to conduct a clinical trial of fixed-dose combination (FDC) Ketorolac Tromethamine 10mg plus Serratiopeptidase 15mg Capsules. This came after […]