Germany: In adults with a BMI of 27 kg/m2 or greater without diabetes, once-weekly survodutide produced significant reductions in body weight versus placebo from baseline to week 46, findings from a recent phase 2 trial have revealed. Survodutide’s tolerability profile was in line with what would be expected based on its mechanism of action; participants […]
USA: A phase III study showed that an investigational oral drug sebetralstat provided on-demand relief during tissue swelling attacks from hereditary angioedema (HAE). KONFIDENT is the first phase 3 trial for oral on-demand treatment in hereditary angioedema, evaluating a representative population. Safety and efficacy results were presented at the American Academy of Allergy, Asthma & […]
Previous studies have suggested that intravascular imaging-guided percutaneous coronary intervention (PCI) may reduce adverse events compared to angiography guidance alone. However, these studies lacked power to assess specific outcomes like all-cause death and myocardial infarction, and primarily used intravascular ultrasound rather than optical coherence tomography (OCT). A recent systematic review and meta-analysis aimed to evaluate […]
Zirconia-based single-tooth restorations are reliable alternative materials to metal-based restorations with favorable outcomes suggests a new study published in the Journal of Evidence-Based Dental Practice. The primary aim was to investigate the survival rate of zirconia versus metal abutments, and the secondary aim was the clinical outcomes of all-ceramic versus metal-ceramic crowns on single-tooth implants. […]
A recent study published in the Journal of American Medical Association uncovered alarming connections between posttraumatic epilepsy (PTE) and long-term dementia risk. While both head injuries and epilepsy have long been associated with cognitive impairments, this study looked into the specific risk posed by PTE on dementia development over extended periods. The study was conducted […]
Non-alcoholic fatty liver disease (NAFLD) has emerged as a prevalent chronic liver disorder with its severe manifestation which is often linked to oxidative stress. A recent study published in the Nature Scientific Reports uncovered promising evidence of the protective potential of Vitamin E against NAFLD. This study utilized data from the National Health and Nutrition […]
USA: The cohort study of 5,279 children found that exposure to PM2.5 or NO2 air pollution during early childhood may lead to the development of childhood asthma. A higher risk was reported among minoritized families living in densely populated communities characterized by fewer resources and opportunities and multiple environmental coexposures. “Mean nitrogen dioxide (NO2) and […]
A recent study highlights the persistent risk of long-term health consequences following SARS-CoV-2 infection and the protective effects of COVID-19 vaccination. The findings were published in the recent edition of the Nature Communications journal that provide crucial insights into the ongoing pandemic. This retrospective cohort study was conducted in Hong Kong analyzed data from a […]
Heart disease researchers have identified a group of patients in whom international guidelines on aspirin use for heart health may not apply. In a study published in the renowned medical journal Circulation, the findings of a review of data from three clinical trials challenge current best practice for use of the drug for primary prevention […]
Collagen patch cover applied to anastomotic site after laparoscopic colectomy may facilitate recovery of bowel function suggests a new study published in the BMC Surgery. Numerous factors can influence bowel movement recovery and anastomotic healing in colorectal surgery, and poor healing can lead to severe complications and increased medical expenses. Collagen patch cover (CPC) is […]