A new study found that Monosodium urate (MSU) crystal deposits, detectable with dual-energy CT (DECT), diminish rapidly during pegloticase treatment, particularly when co-administered with methotrexate (MTX) for uncontrolled gout. The volume of MSU crystals also slowed or stopped even when SU was maintained at <6mg/dL with oral ULT. The study findings were published in the […]
The US Food and Drug Administration has approved injectable drug ceftobiprole medocaril sodium (Zevtera) for treatment of Staphylococcus aureus bacteremia (SAB) among adults. Ceftobiprole, a pyrrolidinone cephalosporin antibiotic, is active moiety of the prodrug ceftobiprole medocaril. It is indicated for people with right-sided infective endocarditis, acute bacterial skin and skin structure infections (ABSSSI), and community-acquired […]
USA: Using an electronic health record (EHR)-based algorithm plus practice facilitators embedded in primary care clinics did not reduce hospitalization at one year, according to a pragmatic trial involving patients with the triad of chronic kidney disease, hypertension, and type 2 diabetes. “The hospitalization rate of patients in the intervention group at one year was […]
Bariatric surgery may result in significant cardiometabolic improvements, particularly among younger, female, or white people and those without comorbidities, according to new research published in the Journal of the Endocrine Society. The United States has the highest obesity rates globally. In 2017-2018, about 40% of U.S. adults had obesity and 9% had severe obesity. The […]
Neonatal hypoglycemia, a condition marked by low blood sugar levels in newborns, poses significant risks and can be particularly concerning for infants with perinatal stress or fetal growth restriction. Understanding the underlying mechanisms of this condition is crucial for effective management and prevention. Perinatal stress and fetal growth restriction are known risk factors for neonatal […]
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke. The new research, published today in Neurology®, the medical journal of the […]
A woman’s cardiovascular risk can rise sharply after she goes through menopause, quickly catching up to men of a similar age and health profile, according to new findings presented at the American College of Cardiology’s Annual Scientific Session. Researchers said the study underscores the importance of recognizing and addressing early warning signs of heart disease […]
Exposure to high altitudes presents physiological challenges such as arterial hypoxemia, electrolyte imbalances, and periodic breathing, which can increase vulnerability to cardiac arrhythmias. Cardiac arrhythmias, including tachyarrhythmias and bradyarrhythmias, pose serious health risks, particularly in challenging environments such as high altitudes. However, the incidence and characteristics of arrhythmias in individuals undertaking extreme altitude climbs like […]
USA: A prospective cohort study has revealed an association between lower insulin sensitivity and albuminuria development, suggesting a role for insulin signaling in the pathogenesis of proteinuria. The findings, published in Diabetes, Obesity and Metabolism on February 28, 2024, highlight the potential of improving insulin signaling as a therapeutic strategy. The study implies that maintaining […]
Denmark: Findings from a randomized clinical trial have suggested potential adverse health effects from n–3 (ω–3) long-chain polyunsaturated fatty acid (n–3 LCPUFA) supplementation during pregnancy. The study was published online in The American Journal of Clinical Nutrition in its April 2024 issue. The researchers revealed that children of mothers receiving n–3 LCPUFA supplementation had an […]