Entries by aaron

MR Study sheds light on anti-inflammatory effects of SGLT-2 inhibitors and their beneficial impact in reducing HF risk

China: A two-sample Mendelian randomization (MR) study provides genetic evidence supporting the anti-inflammatory effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and their beneficial impact in reducing heart failure (HF) risk. CXCL10 emerged as a potential mediator, offering a novel intervention pathway for the treatment of heart failure. The findings were published online in Cardiovascular Diabetology […]

Adjuvant HBOT is beneficial in treating patients with pyoderma gangrenosum: Study

Brazil: A recent study has revealed that adjuvant hyperbaric oxygen therapy (HBOT) may provide some benefits in treating pyoderma gangrenosum patients, particularly those with multiple comorbidities precluding them from receiving more traditional treatments. The study findings were published online in the Journal of the European Academy of Dermatology and Venereology on March 20, 2024 “After […]

Experimental drug Olezarsen may reduce hypertriglyceridemia in high-risk patients: NEJM

Hypertriglyceridemia, or high levels of lipids (fats) in the blood, increases the risk of heart attack, stroke and acute pancreatitis. Currently available medications, including statins, ezetimibe, fibrates and prescription omega 3 fatty acids, typically lower triglyceride levels by anywhere from below 10% to up to 40%. These therapies help, but they are not enough to […]

Liver transplantation: Normothermic regional perfusion tied to better DCD liver allograft outcome, study reveals

USA: A recent study published in JAMA Surgery reports US liver transplant outcomes after normothermic regional perfusion (NRP) versus standard super rapid recovery. The findings suggest that NRP improves controlled donation after circulatory death (DCD) liver allograft outcomes and holds the potential to increase DCD organ use. “The multicenter cohort study comprisng136 livers recovered with […]

MRI imaging in prostate cancer screening reduces number of unnecessary prostate biopsies: JAMA

Austria: Findings from a recent meta-analysis published in JAMA Oncology support the integration of prostate magnetic resonance imaging (MRI) in prostate cancer (PCa) screening to improve the balance of patient harms and benefits. The systematic review and meta-analysis of 80 114 screened men from 12 studies revealed that MRI-based screening is associated with a reduced […]

Cannabis use during pregnancy may increase risk of ADHD, autism and intellectual disability in children: Study

A new study presented at the European Psychiatric Association Congress 2024 reveals a significant association between prenatal cannabis use disorder (CUD) and an increased risk of neurodevelopmental disorders in offspring, including attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID). Cannabis remains by far the most consumed illicit drug in Europe. […]

Pilocarpine may prevent radiation-induced xerostomia in head and neck cancer patients: Study

Pilocarpine may prevent radiation-induced xerostomia in head and neck cancer patients suggests a study published in the Oral Diseases. To assess long-term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation-induced xerostomia (RIX). Retrospective observational study was conducted. Eligibility criteria included irradiated […]