Entries by aaron

Synthetic Glucocorticoids use tied to Neuropsychiatric Effects, depression and mania most common

A recent systematic review and meta-analysis shed light on the neuropsychiatric effects of synthetic glucocorticoids, commonly used in treating various diseases. Glucocorticoids, known for their efficacy, are associated with neuropsychiatric adverse effects, prompting researchers to delve into their prevalence and severity. This study was published in The Journal Of Clinical Endocrinology & Metabolism by Anne-Sophie […]

Use of diffusion optics technology spectacle lenses may prevent juvenile myopia progression

Researchers have found in a new study that Use of diffusion optics technology spectacle lenses may prevent juvenile myopia progression.  The findings of the new study have been published in the British Journal of Ophthalmology. Mutations in the L/M cone opsin gene array cause abnormally high perceived retinal contrast and the development of myopia. Environmental […]

Valproate Use Linked to Brain Volume Reduction in Epilepsy Patients

Recent study unveiled important findings about the impact of valproate (VPA) use on the brain volume of individuals with idiopathic generalized epilepsy. The crucial results of the extensive study were published in Epilepsia Journal. The study employed voxel-based morphometry on magnetic resonance imaging (MRI) and focused on 112 patients currently using VPA (VPA+ group), 81 […]

Point-of-care PCR may help guide antibiotic choice and improve pneumonia treatment

Community-acquired pneumonia (CAP) is a leading cause of hospitalization and death. Timely antibiotic treatment is crucial to prevent complications like bacteremia, sepsis, organ failure, and death. Initial treatment is often empiric, and an uncertain or delayed diagnosis can lead to broad-spectrum antibiotic use. This contributes to adverse effects, such as Clostridioides difficile infection and super-infections […]

Statin Initiation Linked to Reduced Mortality in Chronic Kidney Disease among Older Veterans

In a breakthrough study focusing on older veterans with chronic kidney disease (CKD), researchers have discovered a potential game-changer in the form of statin initiation. The study, employing a target trial emulation design, aimed to investigate the impact of statin use on all-cause mortality and major adverse cardiovascular events (MACE) in veterans aged over 65 […]

High resting heart rate may be risk factor for end-stage renal disease

High resting heart rate may independent risk factor for end-stage renal disease suggests a new study published in the Journal of the American Heart Association.  The relationship between resting heart rate (RHR) and the risk of end‐stage renal disease (ESRD) among those without cardiovascular disease remains unclear. We aim to establish temporal consistency and elucidate […]

Elagolix monotherapy Safe Against Heavy Menstrual Bleeding associated with Uterine Leiomyomas

A new phase 4 study published in The Journal of Obstetrics and Gynecology found elagolix 150 mg monotherapy taken once-daily to solve heavy menstrual bleeding associated with uterine leiomyomas were the safe and effective. This offers promise to premenopausal patients aged 18–51 years. This randomized, double-blind, placebo-controlled study assessed  a total of 82 patients, with […]

PFAS exposure tied to reduced bone health in adolescents and young adults

USA: Exposure to per- and polyfluoroalkyl substances (PFAS) is associated with lower bone mineral density (BMD) in adolescence and young adulthood, critical periods for bone development, which may have implications on future bone health and osteoporosis risk in adulthood, a recent study has found.  PFAS manufactured chemicals used in products such as food packaging and […]