Entries by aaron

Conduct bioequivalence study: CDSCO Panel tells Zydus Healthcare on Glycopyrrolate, Indacaterol Metered dose inhalation

New Delhi: Rejecting the clinical trial waiver proposal, the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has opined the drug major Zydus Healthcare to conduct a bioequivalence study (BE) of Glycopyrrolate plus Indacaterol Maleate Metered dose inhalation. This came after Zydus Healthcare presented a proposal along with BE protocol […]

Merck gets European Commission nod for two new indications for Keytruda in gastrointestinal cancers

Rahway: Merck, known as MSD outside of the United States and Canada, has announced the European Commission (EC) has approved two new indications for KEYTRUDA, Merck’s anti-PD-1 therapy, in gastrointestinal cancers: KEYTRUDA in combination with fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative […]

JIPMER General Surgery faculty, residents excel at ASICON 2023

Visakhapatnam: In a resounding display of excellence, the faculty and residents of the Department of Surgery of Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) garnered accolades at the 82nd Annual Conference of the Association of Surgeons of India (ASICON 2023), held in Visakhapatnam from 13th-16th December 2023. The prestigious ASICON event served as a […]

Use of Eplerenone potential strategy to reduce arterial inflammation among persons with HIV: JAMA

USA: Eplerenone was shown to significantly reduce arterial inflammation in a 12-month, placebo-controlled, randomized clinical trial of 26 well-treated persons with HIV (PWH) without known cardiovascular diseases (CVD). The researchers observed an even greater effect in the most diseased segment of the index vessel. “Mineralocorticoid receptor antagonism by Eplerenone may be a potential strategy to […]

Benidipine calcium channel blocker may reduce cigarette smoke-induced senescent cells and improves emphysema

France: In a recent study published in Aging, the researchers performed a chemical screen, using an FDA-approved drug library, to identify compounds selectively promoting the death of CS-induced senescent lung cells.  In the study, researchers Alberta Palazzo, and colleagues from France revealed that benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and […]

Antioxidants after post-space irrigation increase bond strength favouring glass fiber post-cementation: Study

Brazil: A recent study published in the Journal of Esthetic and Restorative Dentistry has shed light on the effect of antioxidants after post-space irrigation on the adhesive interface of glass fibre post-cementation. The researchers revealed that the antioxidants (10% sodium ascorbate and 20% alpha-tocopherol) used after post-space irrigation with sodium hypochlorite appear to increase the […]

Inflow control may safely reduce blood loss in laparoscopic subsegmentectomy of liver

A recent study scrutinized various inflow control methods used during laparoscopic subsegmentectomy in liver resections to determine their impact on patient outcomes. This study was published in BMC Surgery by Wang and colleagues. The study offers clinicians substantial evidence that both the half-Pringle and Pringle maneuvers are safe and effective methods for inflow control during […]