Recent research paper investigates the association between Sequential Organ Failure Assessment (qSOFA) and 28-day mortality in intensive care unit (ICU) patients admitted for sepsis, focusing on different income settings. The study included 4980 patients from 343 ICUs and 22 countries, analyzing the association of qSOFA with early (3-day), medium (28-day), and late (90-day) mortality in […]
USA: A recent study published in Menopause has revealed a joint association of migraines and persistent vasomotor symptoms (VMS) with a greater risk of stroke and cardiovascular diseases, although the risk attenuates with adjustment for traditional CVD risk factors. Catherine Kim, Departments of Medicine, Obstetrics and Gynecology, and Epidemiology, University of Michigan, Ann Arbor, MI, […]
Researchers have found that intravenous tirofiban, administered within 24 hours of stroke onset, decreases the risk of early neurological deterioration in patients with acute noncardioembolic stroke compared to oral aspirin. The study’s findings suggest that tirofiban may be an effective alternative to traditional antiplatelet therapy without increasing the risk of symptomatic intracerebral hemorrhage. This study […]
Canada: A first-of-its-kind network meta-analysis (NMA) published in the Journal of Cosmetic Dermatology has shed light on the relative effect of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss (PHL). For both agents, the efficacy appeared to be considerably dose-dependent. “Our findings can improve clinical guidelines and help dermatologists manage female […]
Recent findings from the Appendicitis Acuta II (APPAC II) trial indicated that treating uncomplicated acute appendicitis with just oral antibiotics may not be inferior to a combined regimen of intravenous and oral antibiotics. This study published in the Journal of American Medical Association offers critical look at the potential of antibiotic monotherapy to replace more […]
USA: A recent study published in The Laryngoscope has shed light on the effect of hormone replacement therapy (HRT) on chronic rhinosinusitis (CRS) management. Analyzing data from over 65,000 women aged 55 or older, the study found that those undergoing HRT were significantly less likely to require endoscopic sinus surgery (ESS) for chronic rhinosinusitis treatment […]
A recent retrospective study published in the Journal of American Medical Association unveiled a concerning association between prenatal opioid exposure (POE) and the alterations in the fetal immune system that potentially affect the long-term health of exposed children. This study encompassing health records of a vast cohort of 401,462 children born between 2003 and 2018 […]
Researchers have found that a dose of 300 mg of secukinumab can significantly alleviate symptoms of psoriatic arthritis (PsA) compared to placebo, according to a new study published in Rheumatology and Therapy. The study demonstrates that secukinumab provides better clinical outcomes for patients with PsA. This study was condiucted by Alan J. Kivitz, MD, from […]
The US Food and Drug Administration (FDA) has granted Fast Track designation to invesigational gene therapy AB-1002 for treatment of congestive heart failure (CHF).AB-1002 is an investigational one-time gene therapy designed to inhibit the action of protein phosphatase 1, which has been linked to heart failure. Inhibiting the function of this protein, which is linked […]
Patients of autoimmune liver disease treated with immune suppressants have a lower prevalence of apical periodontitis suggests a study published in the Journal of Endodontics. Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated auto-aggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of apical […]