Researchers have found in phase IIIa REDEFINE 1 trial that Addition of investigational cagrilintide to GLP-1 agonist semaglutide led to 20.4% body weight loss in adults with obesity with or without type 2 diabete . The findings of the trial were presented at the American Diabetes Association annual meeting. Semaglutide at a dose of 2.4 […]
Researchers have found in a phase IIb study that investigational antifungal olorofim demonstrated efficacy in 29% of patients with invasive fungal disease lacking other treatment options. When including stable disease in the success definition, 75% achieved a global response. The drug was well-tolerated, with elevated liver enzymes being the most common side effect. Only a […]
A new meta-analysis published in the Journal of American Medical Association found an early invasive strategy did not reduce all-cause mortality compared to conservative treatment in acute coronary syndrome (ACS). However, it did lower the risk of recurrent myocardial infarction (MI) and need for repeated coronary revascularization, though it also increased the risk of major bleeding. […]
The FDA has approved a 200 mg/mL autoinjector of belimumab (Benlysta) for at-home subcutaneous use in children aged 5 years and older with active lupus nephritis receiving standard therapy-marking the first treatment of its kind for pediatric patients. Lupus nephritis is one of the most serious complications of lupus and occurs when the immune system […]
China: A new study published on April 21 in the Journal of Radiation Research and Applied Sciences has shown that combining clinical parameters with ultrasound imaging significantly improves the detection of endometrial malignancy in postmenopausal women. The research, led by Dr. Xiu Yun Dong and her team at the Jinan Maternal and Child Health Hospital […]
USA: Researchers have found in a new study that even in the absence of anemia, iron deficiency (ID) during adolescence is associated with changes in brain development. Early screening for ID in at-risk adolescents may help improve neuropsychiatric outcomes. The study, conducted by Dr. Dimitri Fiani and colleagues from Baylor College of Medicine in Houston, […]
Researchers have discovered in a new study that both maternal smoking and secondhand smoke (SHS) exposure were independently and jointly associated with a higher risk of stroke. Therefore there was an urgent need for stronger tobacco control policies to reduce these harmful exposures and their public health consequences. A study was done to evaluate the […]
The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) published the new Clinical Practice Guideline (CPG): Surgical Management of Chronic Rhinosinusitis today in Otolaryngology-Head and Neck Surgery. Chronic rhinosinusitis (CRS) affects 11.6% of adults and prompts 4.1 million annual ambulatory visits. “Chronic rhinosinusitis doesn’t just affect the nose—it can influence a person’s general life. […]
Researchers have found in a Phase III Trial that patients with schizophrenia who were treated with the investigational long-acting oral weekly risperidone formulation (LYN 005) remained clinically stable without any unexpected safety issues. The findings of the trial have been published in Lancet Psychiatry. The new drug formulation may assist in solving one of schizophrenia […]
Most indirect pulp capping Materials, except for Kerr Life, do not compromise the peripheral seal to dentin in very deep cavity areas. Further, hydraulic cements can be used without negatively affecting the dentin seal. The aim of this in-vitro study was to evaluate the effect of different indirect pulp capping (IPC) materials on bond strength […]