Muscular strength and good physical fitness linked to lower risk of death in people with cancer: Study

Muscular strength and good physical fitness are linked to a significantly lower risk of death from any cause in people with cancer, finds a pooled data analysis of the available evidence, published online in the British Journal of Sports Medicine.

Tailored exercise to boost muscle strength and cardiorespiratory fitness in patients with cancer may help boost their chances of survival, suggest the researchers.

In 2022 alone, 20 million people were diagnosed with cancer worldwide, and nearly 10 million died from their disease-trends that are projected to increase in the coming decades, note the researchers.

And despite notable advances in cancer prevention, diagnosis, and treatment, the side effects of treatment, including those on the heart and muscles, can take their toll on survival, they add.

To inform potential options for extending survival in people diagnosed with cancer, the researchers set out to see if muscular strength and cardiorespiratory fitness might be associated with lower risks of death in these patients, and whether cancer type and stage might be influential.

They searched for relevant studies published in English up to August 2023 and included 42 in their pooled data analysis, involving nearly 47,000 patients (average age 64) with various types and stages of cancer.

Low muscle strength, using handgrip strength, was classified as either less than 13 kg to less than 25 kg in women, and from less than around 20 kg to less than 40 kg in men.

Cardiorespiratory fitness was assessed using either cardiopulmonary exercise testing (CPET) or the 6 minute walk test (MWT).

The pooled data analysis of the study results showed that both muscular strength and cardiorespiratory fitness were significantly associated with the risk of death from any cause and specifically from cancer.

Compared with those with poor muscle strength and low levels of cardiorespiratory fitness, those at the other end of the spectrum were 31%-46% less likely to die from any cause.

And this risk fell by a further 11% with each unit increase in muscular strength.

What’s more, this combination of strength and fitness was associated with an 8%-46% lower risk of death from any cause in patients with advanced cancer (stages 3 and 4), and a 19%-41% lower risk of death from any cause among those with lung or digestive cancers.

And each unit increase in fitness level was associated with an 18% lower risk of death from cancer itself.

“Our findings highlight that muscle strength could potentially be used in clinical practice to determine mortality risk in cancer patients in advanced stages and, therefore, muscle strengthening activities could be employed to increase life expectancy,” suggest the researchers.

Reference:

Bettariga F, Galvao D, Taaffe D, et alAssociation of muscle strength and cardiorespiratory fitness with all-cause and cancer-specific mortality in patients diagnosed with cancer: a systematic review with meta-analysisBritish Journal of Sports Medicine Published Online First: 21 January 2025. doi: 10.1136/bjsports-2024-108671

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Chronic Stress May Drive Lymph Node Metastasis in Postmenopausal Endometrial Cancer, Study Finds

South Korea: A study published on November 18 in Scientific Reports suggests that brain activity linked to chronic stress may influence the aggressiveness of tumors in women with endometrial cancer. Using PET imaging, researchers analyzed 161 women and found that high amygdala activity (AmygA) was associated with lymph node (LN) metastasis in postmenopausal patients but not in premenopausal patients.

Lead authors Ki-Jin Ryu, MD, PhD, and Sungeun Kim, MD, PhD, from the Korea University College of Medicine in Seoul, highlighted that the study provides new insights into the connection between chronic stress, as indicated by AmygA, and LN metastasis in endometrial cancer patients, particularly in postmenopausal women.

While numerous studies have shown that chronic stress can increase the risk and aggressiveness of tumors in cancers like stomach, lung, and skin cancer, the connection between chronic stress and endometrial cancer remains unclear. To further explore connections, the researchers aimed to investigate the relationship between AmygA and lymph node metastasis in patients with endometrial cancer.

For this purpose, the researchers recruited a total of 161 patients with newly diagnosed endometrial cancer who underwent preoperative 18F-FDG PET/CT scans. AmygA was calculated by dividing the maximum standardized uptake value (SUVmax) of the amygdala by the mean standardized uptake value (SUVmean) of the temporal lobe.

The study led to the following findings:

  • Postmenopausal patients with positive LN metastasis showed elevated AmygA levels and increased systemic inflammation markers, such as spleen and bone marrow SUVmax, compared to those without LN metastasis.
  • AmygA was independently associated with LN metastasis in postmenopausal patients but not in premenopausal patients.
  • The correlation between AmygA and systemic inflammation markers was more pronounced in postmenopausal patients.

“The lack of a significant link between AmygA and LN metastasis in premenopausal women suggests that menopausal status may influence how stress-related neural activity affects cancer progression,” the researchers noted.

While further studies are needed to understand the underlying mechanisms, the findings emphasize the importance of considering menopausal status when assessing stress’s impact on cancer progression.

The researchers also suggested that AmygA could be a useful imaging biomarker for identifying patients at higher risk of LN metastasis, particularly in postmenopausal women.

This study has several limitations, including its single-center design, small sample size, and cross-sectional nature, which may introduce bias. The unbalanced lymph node metastasis in premenopausal patients could affect results. The limited resolution of 18F-FDG PET/CT restricted the assessment of stress-related brain regions, and a whole-body scan protocol prevented a more detailed amygdala analysis. Additionally, the researchers couldn’t directly evaluate markers of the HPA axis and sympathetic nervous system activity.

Reference:

Ryu, K., Kim, S., Joung, C., Lee, S., Park, H., Song, J. Y., Pahk, K. J., & Pahk, K. (2024). Association between chronic stress-related amygdala metabolic activity and lymph node metastasis in endometrial cancer. Scientific Reports, 14(1), 1-11. https://doi.org/10.1038/s41598-024-79987-8

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Point-of-care ultrasound enhances early pregnancy care, cuts emergency visits by 81%, finds study

Published in Annals of Family Medicine, a University of Minnesota Medical School research team found that implementing point-of-care ultrasounds (POCUS) to assess the viability and gestational age of pregnancies in the first trimester enhanced care for pregnant patients and cut emergency visits by 81% for non-miscarrying patients.

Previously, early pregnancy care was provided through separate appointments for ultrasound, risk assessment and patient education. This new integrated approach allows patients who are under 14 weeks pregnant to receive comprehensive care during a single visit. This includes ultrasound-based pregnancy dating, immediate assessment of pregnancy viability, risk evaluation and on-site counseling-all based on real-time ultrasound results.

“Our study demonstrates that the use of point-of-care ultrasound provides meaningful benefit to the patients we serve by addressing early pregnancy problems at the time they are identified,” said Allison Newman, MD, an assistant professor at the U of M Medical School and family medicine physician with M Health Fairview. “POCUS in early pregnancy helps clinicians more efficiently and accurately diagnose problems without compromising the quality of needed first trimester assessments-saving time, money and stress for patients.”

The research team introduced this integrated approach at M Health Fairview Clinic – Bethesda in fall 2022, allowing the clinic to quickly identify high-risk cases and offer timely intervention for issues such as miscarriage or abnormal pregnancies. They found:

  • The clinic saw an 81% reduction in emergency visits, urgent clinic appointments and first-trimester phone inquiries for non-miscarrying patients.
  • Clinic implementation led to more timely diagnosis of abnormal pregnancies and improved education and support for all patients, including those who experience miscarriage.
  • For miscarriage cases, the time from initial concern to diagnosis decreased from an average of 5.8 days to 1.7 days.

Reference:

Allison Newman and Mark Berg, Enhancing First Trimester Obstetrical Care: The Addition of Point-of-Care Ultrasound, The Annals of Family Medicine, DOI: https://doi.org/10.1370/afm.3180.

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Prone Position More Effective for Treating Proximal Ureteral Stones with Shock Wave Lithotripsy, finds study

A recent multi-center study revealed that the prone position is significantly more effective than the supine position for treating proximal ureteral stones using ultrasound-guided shock wave lithotripsy (SWL). This study published in the World Journal of Urology was conducted between June 2020 and December 2023 to determine the optimal patient position for maximizing treatment outcomes. 

The prospective study involved a total of 1,187 patients with proximal ureteral stones, divided nearly equally between those treated in the prone (50.5%) and supine (49.5%) positions. This research assessed the stone-free rate (SFR) as the primary outcome, while secondary outcomes included the complete SFR, the number of SWL sessions required, and complication rates. A propensity score-matched (PSM) analysis was performed to ensure fair comparisons between the two groups.

The patients treated in the prone position showed a superior SFR of 85.7% when compared to 77.4% in the supine position (P = 0.001). Also, the complete SFR, which measures the total elimination of stones, was higher in the prone group at 83.3%, versus 75.0% in the supine group (P = 0.001). Both groups required a similar number of SWL sessions (prone: 1.27, supine: 1.20; P = 0.092), and the complication rates were statistically insignificant across the groups, demonstrating that the prone position does not compromise safety.

The prone position was associated with a shorter skin-to-stone distance (SSD), an important metric for SWL success. The patients in the prone group had an SSD of 50 mm when compared to 101 mm in the supine group (P < 0.001), likely contributing to the improved SFR in the prone position.

The study concludes that the prone position offers better outcomes for patients with proximal ureteral stones undergoing SWL without increasing complications. The shorter SSD in this position may explain the improved effectiveness. The findings advocate prioritizing the prone position for eligible patients, particularly when treatment feasibility allows.

Overall, the findings of this study provide valuable insights for medical practitioners by enabling them to tailor treatment protocols for better patient outcomes. While both positions remain viable, the evidence strongly supports the prone position as the preferred option for managing proximal ureteral stones through SWL.

Source:

Shan, L., Liu, G., Ge, C., Guo, H., Song, S., Wu, F., & Bai, S. (2024). The effectiveness and safety between prone position and supine position for ultrasound guided shock wave lithotripsy in proximal ureteral stones: a multi-center prospective propensity score-matching study. In World Journal of Urology (Vol. 43, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1007/s00345-024-05383-6

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Snoring in adolescents linked to problem behaviors but not cognitive deficits, reveals JAMA study.

Snoring in adolescents linked to problem behaviors but not cognitive deficits, reveals JAMA study.

Snoring is central to sleep-disordered breathing (SDB), which arises from nocturnal upper airway resistance. Habitual snoring is associated with cognitive and behavioral problems in young children, but less is known about these associations in adolescents. A study was done to assess the longitudinal associations of snoring with cognition and problem behaviors among adolescents. This cohort study was a secondary analysis of the Adolescent Brain Cognitive Development (ABCD) Study dataset (release 5.0), which enrolled 11 875 children and a parent or caregiver from June 1, 2016, to October 15, 2018, at 21 participating US research institutions and followed-up for 5 years. The analysis was performed between December 2023 and April 2024. Cognition was assessed using 5 measures from the National Institutes of Health Toolbox (NIH-TB), and caregiver-reported problem behaviors were assessed using the Child Behavior Checklist (CBCL), including Total Problems, Internalizing Problems, and Externalizing Problems. Longitudinal associations of snoring with these assessment measures were analyzed using linear mixed-effects models stratified by obesity. Model fits were assessed after including the fixed-effects of age, sex at birth, race, family income, follow-up time, visit type, and the random-effects of site and identification number. Results: The study included data from 11 862 children at year 1 (mean age, 119.0 months [95% CI, 118.8 to 119.1 months]; 6164 male [52.2%]) and 11 198, 10 870, 10 064, and 4668 children at years 2 to 5, respectively. The proportion of habitual snorers decreased from 811 participants (6.8%) in year 1 to 150 participants (3.2%) in year 5. Snoring was not associated with any of the NIH-TB scores. A statistically significant association of snoring was identified with all CBCL scales. The largest-magnitude association was of snoring with the CBCL Total Problems scale among adolescents with obesity (β = 3.18; 95% CI, 2.59-3.77). In this cohort study analyzing associations of snoring with cognitive test scores and problem behaviors based on the ABCD dataset, the prevalence of snoring declined over time; snoring in adolescents was associated with problem behaviors but not cognitive deficits. These findings may aid shared decision-making regarding treatment options such as adenotonsillectomy for adolescents with SDB.

Reference:

Isaiah A, Uddin S, Ernst T, Cloak C, Li D, Chang L. Cognitive and Behavioral Outcomes of Snoring Among Adolescents. JAMA Netw Open. 2024;7(11):e2444057. doi:10.1001/jamanetworkopen.2024.44057

Keywords:

Snoring, adolescents, linked, problem, behaviors, cognitive, deficits, reveals, JAMA, study, Isaiah A, Uddin S, Ernst T, Cloak C, Li D, Chang L

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Ultraviolet-induced fluorescence trichoscopy effectively differentiates non-scarring alopecias from scarring alopecias, finds study

Ultraviolet-induced fluorescence trichoscopy effectively differentiates non-scarring alopecias from scarring alopecias, finds study published in the Dermatologic Therapy.

Dermatologic TherapyUltraviolet-induced fluorescence dermoscopy (UVFD) is increasingly utilized in dermatooncology and general dermatology. The objective of the study was to characterize the ultraviolet-induced fluorescence trichoscopy (UVFT) findings in a wide range of hair and scalp conditions. Consecutive patients with non-scarring alopecias (alopecia areata, AA, n = 40; androgenetic alopecia, AGA, n = 40), scarring alopecias (frontal fibrosing alopecia, FFA, n = 20; lichen planopilaris, LPP, n = 20; folliculitis decalvans, FD, n = 14; discoid lupus erythematosus, DLE, n = 23), and inflammatory scalp conditions (psoriasis, n = 30; seborrheic dermatitis, n = 14) were included. Examinations were performed using polarized trichoscopy and UVFT. Results: The following features were observed under UVFT: white-blue perifollicular fluorescence, white-blue interfollicular fluorescence, irregular confluent dark areas, dark follicular dots, dark perifollicular areas, regular/irregular pink-red follicular fluorescence, regular/irregular green follicular fluorescence, short white hair, black dots, exclamation mark hair, double/triple white follicular dots, pink-red fluorescence of the scales, pink-red fluorescence of the background. Non-scarring alopecias showed more frequently pink-red or green follicular fluorescence (p < 0.001), dark follicular dots (p < 0.001), short white hair (p < 0.001), and double/triple white follicular dots (p < 0.001). In scarring alopecias, white-blue perifollicular fluorescence (p < 0.001), dark perifollicular areas (p < 0.001), and dark confluent areas (p < 0.001) were more commonly observed. Psoriasis showed more frequently pink-red fluorescence of the scales than seborrheic dermatitis (p = 0.019). UVFT supports the differentiation between scarring and non-scarring alopecia, as well as between psoriasis and seborrheic dermatitis. UVFT may hypothetically facilitate the biopsy site selection by highlighting the subclinical perifollicular and interfollicular inflammation.

Reference:

Kołcz K, Reich A, Żychowska M. Application of Ultraviolet-Induced Fluorescence Trichoscopy (UVFT) in Hair and Scalp Diseases. Dermatol Ther (Heidelb). 2025 Jan 3. doi: 10.1007/s13555-024-01335-5. Epub ahead of print. PMID: 39754002.

Keywords:

Ultraviolet-induced, fluorescence, trichoscopy, effectively, differentiates, non-scarring, alopecias, from, scarring, alopecias, finds, study, Alopecia; Dermoscopy; Trichoscopy; Ultraviolet-induced fluorescence dermoscopy; Ultraviolet-induced fluorescence trichoscopy, Kołcz K, Reich A, Żychowska M.

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Elevated Total Alkaline Phosphatase Levels linked to increased risk of Osteoporosis and Mortality: Study

Elevated levels of serum total alkaline phosphatase (T-ALP) have been linked with decreased bone mineral density (BMD), higher prevalence of osteoporosis, and higher mortality rate in patients with osteoporosis. This was concluded in a recent study published in the journal Osteoporosis International conducted by Ran Chen and colleagues.

Data were analyzed from 13,724 adults aged 18 to 85 years who had participated in National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Mortality data were obtained from the National Death Index through December 31, 2019. Serum T-ALP levels were correlated with BMD at the femoral neck and lumbar spine using linear regression models, subgroup analysis, and weighted logistic regression. Of participants diagnosed with osteoporosis (n = 944), survival analysis, including Kaplan-Meier curves and Cox proportional hazards models, was applied to examine how serum T-ALP could predict mortality.

The study had a number of important findings:

  • High serum T-ALP levels were correlated strongly with low BMD both at the femoral neck and the lumbar spine. In fact, this correlation was apparent across all subgroups which include age, sex, race, and BMI

Osteoporosis Prevalence :

  • The prevalence of osteoporosis in each 1 SD increase for T-ALP values was increased by 0.5% [Odds Ratio (OR) : 1.005; 95% CI : 1.005–1.005 ; p < 0.001].

  • Participants with serum T-ALP levels at the highest tertile (>79 IU/L) had a risk of 29.2% to develop osteoporosis than those in the lowest tertile (<53 IU/L) [OR: 1.292; 95% CI: 1.021–1.636; p = 0.033].

All-Cause Mortality of Osteoporosis

  • In subjects with osteoporosis, with every increase in 1 SD in the T-ALP values, there was an increase of 0.4% in all-cause mortality [HR: 1.004; 95% CI: 1.002–1.006; p < 0.001].

  • The highest T-ALP category was associated with a 23.2% higher mortality risk than the lowest category [HR: 1.232; 95% CI: 1.041–1.459; p = 0.015].

The current study emphasizes the fact that serum T-ALP levels significantly correlate with low BMD, a higher prevalence of osteoporosis, and all-cause mortality in patients suffering from osteoporosis. Regular assessment of T-ALP levels in clinical practice could provide valuable information for assessing risk and enhancing outcomes in such patients.

Reference:

Chen R, Gong K, Chen W, Chen Z, Hua X, Tan J, Tian Y, Liu D, Zhang L, Tang Y, Li Y, Zhou S. Association of serum alkaline phosphatase levels with bone mineral density, osteoporosis prevalence, and mortality in US adults with osteoporosis: evidence from NHANES 2005-2018. Osteoporos Int. 2024 Nov 29. doi: 10.1007/s00198-024-07324-w. Epub ahead of print. PMID: 39611944.

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Prenatal Exposure to Butylparaben Increased Risk of Childhood Asthma: Study

A new study from the Japan Environment and Children’s Study (JECS) identified potential links between prenatal exposure to certain phenols and an increased risk of asthma in children. The findings highlighted the role of maternal exposure to specific chemicals, particularly butylparaben, during early pregnancy and its association with asthma development by age 4.

This nationwide birth cohort study analyzed data from a total of 3,513 mother-child pairs. Urine samples collected during the first trimester of pregnancy were tested for 24 types of phenols, including nitrophenol, parabens, bisphenol, octylphenol, and nonylphenol. This research found that phenol concentrations varied widely across participants.

The study found that the high maternal exposure to butylparaben was associated with a 54% higher risk of asthma in children, as indicated by an odds ratio of 1.54 (95% confidence interval: 1.11–2.15). Methylparaben was detected in nearly all participants at consistently high levels, but no direct link to asthma was established.

The effects of 4-Nonylphenol differed significantly by gender. For male children, low maternal exposure was associated with more than double the risk of asthma (odds ratio: 2.09, 95% confidence interval: 1.20–3.65). Also, female children showed no significant risk associated with 4-nonylphenol exposure (odds ratio: 0.65, 95% confidence interval: 0.25–1.70).

The study illuminates the importance of understanding prenatal exposure to everyday chemicals found in cosmetics, cleaning products, and household items. While previous research has highlighted phenols like nonylphenol as endocrine disruptors, this study looks deep into the specific effects of maternal exposure on asthma development in children by emphasizing potential gender-specific vulnerabilities. This study emphasized that these findings could guide future public health recommendations, particularly regarding the use of butylparaben-containing products during pregnancy. 

Overall, high exposure to butylparaben during pregnancy may significantly increase the risk of asthma in children, with notable gender differences observed for exposure to 4-nonylphenol. For expectant mothers, the findings reinforce the importance of minimizing exposure to potentially harmful chemicals during pregnancy. The study also highlighted the need for further investigation into the gender-specific effects of phenol exposure.

Source:

Kuraoka, S., Oda, M., Ohba, T., Mitsubuchi, H., Nakamura, K., Katoh, T., Kamijima, M., Yamazaki, S., Ohya, Y., Kishi, R., Yaegashi, N., Hashimoto, K., Mori, C., Ito, S., Yamagata, Z., Inadera, H., Nakayama, T., Sobue, T., Shima, M., … Katoh, T. (2024). Association of phenol exposure during pregnancy and asthma development in children: The Japan Environment and Children’s study. In Environmental Pollution (Vol. 361, p. 124801). Elsevier BV. https://doi.org/10.1016/j.envpol.2024.124801

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External cephalic version safe and effective option for women with previous cesarean section, reveals research

Non-cephalic presentations are observed in 3% of pregnancies at term. Affected pregnant women may be presented with the choices of an elective cesarean section (CS), a vaginal breech delivery, or an external cephalic version (ECV). Recent research paper thoroughly investigates the success rate and complications associated with external cephalic version (ECV) in pregnant women who have previously undergone a cesarean section. Conducted as a retrospective cohort study at the “Virgen de la Arrixaca” Clinic University Hospital in Murcia, Spain, the study analyzed data from January 2014 to December 2023, including 911 women who were offered ECV, with 42 of them having a history of cesarean delivery.

Success Rates and Complications

The success rate of ECV in the group with prior cesarean sections was found to be 78.6%, with no significant difference compared to the 72.3% success rate in women without a previous cesarean (P = 0.371). The study calculated an adjusted odds ratio (aOR) of 1.18 for women with a previous cesarean, indicating no significant disadvantage when compared to those without. Additionally, the study highlights that multiparity, amniotic fluid volume, and transverse fetal lie were significant factors positively correlated with ECV success rates. The overall complication rate for ECV was relatively low at 9.5% among women with prior cesarean deliveries, with complications including non-reassuring fetal heart rates (7.1%) and major vaginal bleeding (2.4%). The findings reinforce the safety of ECV procedures even for women who have experienced a cesarean section. It emphasizes that the presence of a uterine scar should not deter healthcare providers from offering ECV to eligible patients with breech presentations at term. The complications related to ECV were comparable between those with and without previous cesarean sections, suggesting ECV is a viable option for women seeking vaginal delivery.

Limitations and Future Directions

The authors note that while the results are promising, limitations include the small sample size of women with prior cesarean sections and the retrospective nature of the study. The paper calls for more prospective studies to further validate these findings and establish protocols surrounding ECV in women with prior cesarean deliveries. Overall, this study contributes significant evidence supporting ECV as a safe practice for women with previous cesarean histories, aiding in the decision-making process for those desiring a vaginal birth after cesarean.

Key Points

– The study is a retrospective cohort analysis conducted at a Spanish hospital, examining the outcomes of external cephalic version (ECV) in 911 pregnant women, of whom 42 had previously undergone cesarean sections, over a period from January 2014 to December 2023.

– The success rate of ECV for the women with prior cesarean deliveries was 78.6%, comparable to the 72.3% success rate in those without a cesarean history, indicating that a previous cesarean does not significantly hinder ECV efficacy (P = 0.371).

– An adjusted odds ratio (aOR) of 1.18 was calculated for the ECV success among women with prior cesarean sections, further underscoring that these women do not face significant disadvantages compared to those who have not had a cesarean.

– Key factors influencing positive ECV outcomes included multiparity, amniotic fluid volume, and transverse fetal lie, all contributing to higher success rates in the procedure.

– The overall complication rate associated with ECV in women with prior cesarean was low at 9.5%, with reported complications including non-reassuring fetal heart rates (7.1%) and major vaginal bleeding (2.4%).

– Despite the positive findings, the study acknowledges limitations such as a small sample size of women with prior cesareans and its retrospective design, advocating for further prospective research to validate results and enhance clinical guidelines for ECV in this demographic.

Reference –

J. SáNchez-Romero et al. (2024). External Cephalic Version Following Prior Cesarean Delivery: A Comparative Cohort Analysis.. *International Journal Of Gynaecology And Obstetrics: The Official Organ Of The International Federation Of Gynaecology And Obstetrics*. https://doi.org/10.1002/ijgo.15738

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AIIMS New Delhi Invites Applications for PhD Programme January 2025 Session, check all admission details

New Delhi- All India Institute of Medical Sciences (AIIMS) New Delhi is inviting online applications from candidates willing to take admission to PhD Programme for the January 2025 session. The online registration process has already started, therefore candidates willing to take admission to PhD Programme January 2025 session can fill out the online application through the official website of AIIMS till 06 February 2025, 05:00 PM.

While filling out the application form, candidates have to pay the application fee, where General/OBC category candidates have to pay Rs 2000/-, SC/ST/EWS category candidates have to pay Rs 1600/-, however, PwBD candidates are exempted from any fee. The application fee must be paid through debit, credit card or net banking.

Also Read: AIIMS Nagpur Invites Applications for Entrance Exam to PhD Programme July 2024 session, Details

Candidates willing to take admission to PhD Programme January 2025 session will have to appear for a written examination (CBT) which will be conducted online mode on Thursday, February 20, 2025. Upon this, the final determination of centres and allotment of roll number/admit card will be available on the website from Saturday, February 15, 2025. Meanwhile, the date of declaration of result is expected to be announced on Monday, March 03, 2025.

After this, the final results will be declared on Sunday, March 12, 2025, and the final results will be declared on Wednesday, March 19, 2025. After this is completed, the process of joining the PhD Program will start, the last date to join the programme is Tuesday, April 15, 2025.

For further details, AIIMS New Delhi has also released a prospectus which contains important details like exam pattern, eligibility, instructions to fill out the online application form, method of selection, documents etc. Below are some of the details-

DOCUMENTS TO BE ATTACHED TO THE REGISTRATION FORM

No document is required, except the following applicability-

i Sponsored Candidates and Foreign nationals-

a Sponsorship Certificate (in the case of a sponsored candidate) in the format prescribed in the Prospectus, duly completed and signed by the competent authority.

b NOC from the Ministry of Health & Family Welfare in the case of Foreign Nationals.

ii Proof of award of eligible fellowship for non-medical candidates applying in the category.

iii Candidates who qualify in Stages I and II and are called for Departmental Assessment must upload their self-attested/attested copies of certificates/documents in support of their educational qualifications, marks, date of birth, category, experience etc. as mentioned in Stage-I and II results on the website by logging in with their credentials. They must write their Candidate ID, Roll No. & concerned Department on the top of the first page of each certificate.

GENERAL ELIGIBILITY

Eligibility for Ph. D course (Open candidates)- A candidate seeking admission to the course of study leading to the award of a Degree of Doctor of Philosophy must possess at least one of the following qualifications-

A a) Medical qualification: MBBS/BDS with minimum 55% aggregate marks or MD/MS/MDS/DM/M.Ch. in the subject concerned or Diplomat of the National Board of Examination. Candidates who have obtained any of these degrees from medical colleges which are not recognized by the Medical Council of India shall not be eligible to apply.

b) Nursing Qualification: Candidates holding an MSc degree with a minimum 55% aggregate marks in Nursing Speciality will also be eligible for Ph. D admission in the College of Nursing.

B. Non-Medical – For non-medical candidates eligibility shall be a Master’s Degree (two-year’s course) awarded by Indian Universities as per the requirement of the project.M.Sc. Life Sciences is a specific degree and no other degree shall be considered equivalent to the same for eligibility for a particular seat where M.Sc. Life Sciences is mentioned for eligibility.

Candidates holding M.Sc. (Other than M.Sc. Nursing) M.Tech. degree, BAMS & BHMS will be eligible for the Non-Medical Qualification Category. Candidates having eligibility under the non-medical category should have at least 60% marks in the last eligibility examination qualified. However, candidates possessing a Master’s Degree through distance learning courses shall not be eligible.

(a) Special weightage for non-medical candidates-

(i) Candidates who have qualified the below listed National Entrance Tests leading to the award of a fellowship will be given special weightage in the entrance examination as detailed in the method of selection part of the guidelines. Such candidates should apply under the Own Fellowship (OF) category and upload proof of award of the qualifying fellowship in the online form.

i Joint CSIR-UGC NET for JRF.

ii ICMR – JRF.

iii DBT – JRF.

iv NBHM screening test.

(ii) To be eligible for special weightage marks, ALL the following criteria must be fulfilled-

1 The result of the above-listed National Entrance Tests must have been declared between January 2023 and January 2025.

2 The award of the fellowship must be based on the result of the above-listed National Entrance Tests.

3 The fellowships should be tenable at AIIMS, New Delhi.

4 The letter of award of fellowship must be uploaded with the application form. Passing the listed National Entrance Tests alone is not acceptable as proof of award of fellowship.

C Eligibility for of seats- To be eligible for OF seats, candidates must fulfil ANY of the following criteria-

1 Candidates who have qualified the National Entrance Tests leading to the award of a fellowship tenable at AIIMS AND are eligible for the award of special weightage marks as provided in section B (a) above.

2 In-service or sponsored candidates who will receive their salary/stipend from the sponsoring/parent organization.

DURATION OF THE COURSE

1. The duration of the course shall be the period from registration to the submission of the thesis. The minimum period of registration in respect of all the candidates who are registered for PhD shall be three years. The maximum period of registration shall not exceed five years. Extension beyond the period of 5 years can be given for a maximum period of 6 months on the recommendation ofthe Dean Committee and final approval by the Dean/Director.

2 Further extensions beyond 5 years & 6 months can only be given by the Academic Committee for a maximum period of 6 months in highly exceptional circumstances (like medical exigencies, natural calamities, etc.) and such extensions may not be given retrospectively.

3 The Chief guide of Ph.D. A student shall give a clear reason for the delay to the Academic Committee and must present the case before the Academic Committee.

4 Failure to submit a thesis within the stipulated time of maximum 5yrs. with extension after approval upto 5½ years (6 years in exceptional circumstances by prior approval of Academic Committee) shall lead to cancellation of PhD registration of the candidate.

FEES

Each candidate selected for admission will have to pay the following Course Duration Fees and dues-

S.NO

PARTICULARS

FEES

DURATION

1

Registration Fee

Rs. 25/-

2

Tuition Fee

Rs. 720/-

3 Years

3

Laboratory Fee

Rs. 120/-

3 Years

4

Pot Money.

Rs. 720/-

3 Years

5

Hostel Rent.

Rs. 1080/-

3 Years

6

Electricity.

Rs. 240/-

3 Years

7

Gymkhana Fee.

Rs. 120/-

3 Years

8

Caution Money.

Rs. 100/-

3 Years

9

Hostel Security.

Rs. 1000/-

3 Years

SEATS AVAILABLE FOR PhD PROGRAM

S.NO

DEPARTMENT

TOTAL SEATS VACANT

1

Anatomy.

08

2

Biochemistry.

5

3

Biochemistry (NCI Jhajjar).

1

4

Biophysics.

4

5

Biotechnology.

2

6

Cardiac Biochemistry (CNC).

1

7

Cardiology.

1

8

Emergency Medicine JPNATC.

2

9

Gastroenterology & HNU

1

10

Hematology.

2

11

Laboratory Medicine.

2

12

Laboratory Oncology (Dr. BRA IRCH).

1

13

Medical Oncology (Dr. BRA IRCH).

2

14

Medical Physics (Dr. BRA IRCH).

1

15

Microbiology.

3

16

.National Drug Dependence Treatment Centre

(NDDTC)

2

17

Neurology.

2

18

Neuropathology, Neuroscience Centre.

2

19

Ocular Pharmacology (RPC).

2

20

Ophthalmology (RPC).

3

21

Paediatric Surgery(JPNATC).

1

22

Paediatrics

1

23

Pathology.

6

24

Pharmacology.

6

24

Physiology.

2

26

Preventive Oncology (Dr BRA IRCH)

1

27

Preventive Oncology (NCI Jhajjar).

4

28

Psychiatry.

5

29

Reproductive Biology.

3

30

Rheumatology.

2

31

Stem Cell.

3

32

Transplant Immunology & Immunogenetics (TII).

1

TOTAL

82

To view the prospectus, click the link below

https://medicaldialogues.in/pdf_upload/aiims-new-delhi-invites-applications-for-phd-programme-january-2025-session-apply-now-270923.pdf

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