No proposal to set up AIIMS in Ballia: MoS Health informs Lok Sabha

Uttar Pradesh: The Minister of State for Health, Shri Prataprao Jadhav, recently informed the Lok Sabha that there are no current plans to set up an AIIMS in the Ballia district of Uttar Pradesh under the Pradhan Mantri Swasthya Suraksha Yojana (PMSSY).

Under the PMSSY initiative, two AIIMS have already been established in Uttar Pradesh, one in Raebareli and the other in Gorakhpur. Both institutions are currently functional and are playing a key role in expanding tertiary healthcare services to the people of Uttar Pradesh.

Furthermore, the Ministry has approved several upgrade projects for medical colleges and healthcare institutes across the state. Currently, 11 projects have been sanctioned under the PMSSY. These initiatives are expected to significantly enhance the quality of medical education, healthcare infrastructure, and the availability of specialized medical services in the state.

Also Read: Bonds for PG medical admissions- Not NMC, Only States can provide in-service reservation: MoS Health in Parliament

The minister was responding to the questions raised by Shri Sanatan Pandey regarding whether the Government has any plan for setting up an AIIMS Hospital in Ballia district, if so, the details thereof; whether any survey has been conducted in this regard, if so, the details thereof;

He seeks to know whether the Government has any proposal to acquire land in this regard; and if so, the details thereof and if not, the reasons therefor.

Also Read: MoS Health Apprises Lok Sabha on Initiatives to Expand Hospital Network Under AB PMJAY

In response to these questions, MoS Health informed that under Pradhan Mantri Swasthya Suraksha Yojana (PMSSY), the setting up of 22 All India Institutes of Medical Sciences (AIIMS) has been approved including 2 AIIMS in the State of Uttar Pradesh: one AIIMS at Raebareli and other at Gorakhpur which are functional.

Further, for expansion and strengthening of tertiary healthcare facilities in Uttar Pradesh, under another component of PMSSY following eleven(11) upgradation projects of Government Medical Colleges/ Institutes have been approved on a Centre-State cost-sharing basis: (i) SGPGIMS, Lucknow (ii) Trauma Centre in IMS, BHU, Varanasi (iii) Jawaharlal Nehru Medical College of Aligarh Muslim University, Aligarh (iv) MLB Govt. Medical College, Jhansi (v) BRD Medical College, Gorakhpur (vi) MLN Medical College, Allahabad (vii) LLRM Medical College, Meerut (viii) SN Medical College, Agra (ix) GSVM Medical College, Kanpur (x) SSB at Institute of Medical Sciences (IMS), BHU, Varanasi and (xi) RIO at IMS, BHU Varanasi. In current phase of PMSSY, there is no proposal for establishment of AIIMS in Ballia district in Uttar Pradesh, added the Minister.

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DMER Maharashtra Issues Notice on bond service allotment to MDS degree holders Summer 2024 batch, check details

Maharashtra : Thorugh a recent notice, DMER Maharashtra has released the process for Central Round Allotment of Bonded Service to MDS Postgraduate Degree Holders Summer 2024 batch.

As per the Government Resolution, the Central Committee has been constituted.Accordingly, the Process of central round for allotment of the services to MDS bonded Postgraduate degree candidates will be carried out by filling the online application form and by online allotment as per the following schedule.

The concerned should note available vacant posts as – Assistant Professor, Dental Surgeon in Government Dental Colleges and Senior Resident in Dentistry Department of Govt. Medical Colleges in Maharashtra.

Schedule for MDS Post-Graduate Degree Holder (Candidates passed MDS Post-Graduate Degree Examination in Summer-2024)

Date Time Activity
16.12.2024 – 21.12.2024 From 10:00 AM to 5:00 PM Filling of online application form and preferences
23.12.2024 Up to 5:00 PM Declaration of allotment and issue of recommendation letters through login ID in the online bond portal

Instructions to the candidates

A) General Instructions:

1. Candidates will be allotted seats as per preference for posts of Assistant Professor, Dental Surgeon and Senior Resident on the basis of marks obtained In Post Graduate degree examination.

2. As per Government Resolution No.PWEN11011/C.R.352/11/Edu-2, dated 4 April, 2012 all posts will be allotted on merit basis as Open Category.

3. If any candidate does not fill online application form, then it will be considered that he/she is not interested to get allotment of bond service. Hence for such candidate the process of recovery of bond penalty amount will be initiated.

4. Recommendation /Selection list will be’displayed on DMER website on 23/12/2024 after 05.00 pm

5. Recommendation letter can be downloaded on Bond service Portal through login ID

6. Candidates should take print out of recommendation letter and report to concerned allotted institute with requisite documents within 7 days from the date of allotment.

7. Helpline Number – 022 22652193, Time 10.00 am to 05.45 pm. strictly.

B) The candidate must submit attested photo copy of requisite documents at respective institute where they will be allotted post as per the list given below:

a) SSC Passing Certificate / valid passpor: as proof of age).

b) First, Second, Third & fourth BDS mark-sheets

c) Mark sheet / Grade Certificate of MD5

d) Attempt certificate of all BDS examinatio is from the head of the institution.

e) BDS degree / Passing certificate.

f) MDS Degree /Passing Certificate.

g) Registration certificate of Maharashtra Dental Council or uiner State beiltd1Courn_ii5 in India/DC’ with renewal.

h) Online recommendation letter of allotrr Pnt of bond service. (will be mailed to the candidates on their registered email id)

C) Rule of TIE- BREAKER:

Selection of candidate for the vacant post shall be as per the procedure of preparation of merit list as given below.

First Level:- The Candidate having Highest Mark in postgraduate examination (MDS)will be preferred,if tie persists then –

Second Level: – The Candidate having Highest aggregate Mark in final BDS (part I +II) will be preferred, if tie persists then –

Third Level: – The Candidate having Highest Mark in 3rdBDS will be preferred, if tie persists then –

Fourth Level: – The older candidate will be preferred.

To view the official Notice, Click here : https://medicaldialogues.in/pdf_upload/mds2024notification1-264880.pdf

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Dr VP Pandey appointed as Interim Dean of MGM Medical College Indore

Indore: The Indore bench of the Madhya Pradesh High Court, has directed the appointment of Dr VP Pandey as the new acting Dean of Mahatma Gandhi Memorial Medical College (MGMMC) on Friday.

Dr VP Pandey, M.D. FRCP
(Edin), currently serves as the Professor and Head of the Department of Internal Medicine at Mahatma Gandhi Memorial Medical College, Indore. He has also held the positions of President of the Indian Rheumatology Association – MP Chapter and the Association of Physicians of India – Indore Chapter.

The move follows the
retirement of the previous dean, Dr Sanjay Dixit, on November 30. In its directive on Thursday, the court has appointed Dr Pandey, considering his seniority in the institute. The bench comprising Justice Vijay Kumar Shukla stated during the hearing that he would hold the position until the state government makes a direct or regular appointment, reports Free Press Journal.

This ruling addresses a year-old controversy in which the government appointed deans of 18 medical colleges through a direct recruitment process, allegedly at the expense of more
experienced candidates and favouring junior doctors. The most senior professor,
Dr Pandey, had previously gone to court to overturn this decision.

After Dr Dixit’s
retirement, a formal replacement of the college became necessary. Hence, MY
Hospital Superintendent Dr Ashok Yadav took over temporarily, but his appointment did not
get the court’s approval. Concerns were raised about the appropriateness of a
junior doctor overseeing the confidential records of senior faculty members. The
High Court’s order has made it clear that while Dr Pandey will serve as
interim dean, the state government retains the authority to appoint a permanent
replacement at its discretion, reports the Daily.

Medical Dialogues had earlier reported that Dr Ashok Yadav has taken over as the Dean of MGM Medical College after Dr Dixit’s retirement. Dr Ashok Yadav was the Professor and Head of the Department of Transfusion Medicine (I.H.B.T) and Director of the State-of-the-Art Model Blood Bank at M.G.M Medical College and
Associated Hospitals.

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Fact Check: Can honey and onion boost immunity by up to 200%?

A viral Instagram reel claims that honey and onion can boost immunity by up to 200%. This claim is False.

Claim

In an Instagram reel, it is claimed that honey and onion can boost immunity by up to 200%. The reel by the user besthealthsutras is captioned “Some remedies.” The user makes multiple health claims in the video which include, “Do you know honey and onion can boost immunity up to 200%? Carrots and lemon can flatten and clean your stomach, Ginger and honey clean your lungs, and Turmeric and orange can protect you from chronic diseases”

The viral video has racked up 67.3 million views, 1.6 million likes, 2,793 comments, and 2.5 million shares. The reel can be accessed here

Fact Check

The claims in the video are False. Honey and onion may support immunity but there is no scientific proof to that claim that it can boost immunity by 200%

What is Immunity?

Immunity is the body’s natural defense system against infectious diseases, comprising three types: innate, adaptive, and passive. Innate immunity serves as the first line of defense, relying on physical barriers like skin and mucous membranes to block harmful substances from entering the body. Adaptive immunity develops when the body encounters a microorganism through infection or vaccination, producing a specific immune response that can provide lifelong protection. Passive immunity, on the other hand, involves receiving antibodies from an external source, offering immediate but temporary protection that lasts only a few weeks or months. Together, these mechanisms protect the body from illness and maintain health.

Dr Aman Rathore, DNB, Critical Care Medicine, Max Super Speciality Hospital said “Immunity is the body’s complex defense system that protects us from harmful pathogens like bacteria, viruses, and other foreign invaders. It’s an intricate network involving white blood cells, antibodies, and various organs and tissues that work together to identify and neutralize threats. The immune system has two main components: innate immunity, which offers general protection, and adaptive immunity, which targets specific pathogens the body has encountered before. Maintaining a strong immune system is vital for overall health and can be supported through balanced nutrition, regular exercise, and adequate sleep.”

What are the health benefits of Honey?

Honey is derived from flower nectar by honeybees Apis mellifera and has been revered for its nutritional, medicinal, and industrial uses. Ancient civilizations like the Greeks, Egyptians, and Chinese used honey for both sustenance and healing, a practice that continues today. With its high fructose content, making it 25% sweeter than sugar, honey is a natural sweetener increasingly popular in beverages. Its stability, with a water activity of 0.56–0.62 and a pH of around 3.9, allows for long-term storage without refrigeration. Beyond its culinary applications, honey exhibits antioxidant, anti-inflammatory and antibacterial along with protective benefits for respiratory, gastrointestinal, cardiovascular, and nervous systems. 

Why are onions considered beneficial for health?

Onions add abundant flavor to a wide variety of food, yet are low in calories. With only 45 calories per serving, onions are naturally fat and cholesterol-free. They are a source of dietary fiber, vitamin C, vitamin B6, potassium, and other key nutrients including folate, calcium and iron. Onions contain a variety of other naturally occurring chemicals known as organosulfur compounds linked to lowering blood pressure and cholesterol levels. Among some of their best-known benefits, onions contain the flavonoid quercetin which acts as an anti-inflammatory in the body, inhibits low-density lipoprotein oxidation (an important reaction in atherosclerosis and coronary heart disease), protects and regenerates vitamin E (a powerful antioxidant), and protects from many forms of cancer.

Can honey and onion boost immunity by up to 200%?

Honey and onion are known for their health benefits and potential immune-supporting properties, but there is no scientific evidence or medical consensus to support the claim that honey and onion can boost immunity by up to 200%.

Onions, rich in bioactive compounds, have been shown to offer significant health benefits. The study by Narges Marefati et al. highlighted the potential effects of onions and their constituents in addressing oxidative stress, inflammation, and immune dysregulation. The findings suggest that onions may have significant value in the treatment of certain diseases associated with oxidative stress, inflammation, and immune dysregulation.

Another study published in Food Bioscience highlights quercetin in onions as a significant phytochemical with the potential to manage inflammatory responses and strengthen immunity against viral infections. It also emphasizes onion dehydration as an effective method to extend shelf life, minimize wastage, and improve accessibility worldwide.

Honey, a natural substance with numerous health benefits. A study published in Pharmacognosy Research found that honey stimulates leukocytes to release cytokines, initiating the tissue repair process. Additionally, honey activates the immune response to infections and promotes other immune activities, including the proliferation of B- and T-lymphocytes and the enhancement of phagocytic activity.

Similarly, a review by Razan J Masad et. al. highlights honey’s potential as an immunomodulatory agent in cancer, altering the tumor microenvironment, reducing angiogenesis, and reprogramming immune cells to inhibit cancer growth. Flavonoids in honey were found to block IL-6R and STAT3 activation, revealing a novel anti-tumor mechanism. 

Honey and onion may support overall health and immunity, but their effects cannot be precisely quantified, making the claim that that honey and onion can boost immunity by up to 200% false.

Pooja Shah Bhave, Consultant Dietician and Certified Diabetes Educator, Mumbai in a conversation with the Medical Dialogues Fact Check Team said, “Yes, the combination does enhance immunity to some extent. But saying that it makes immunity two hundred percent stronger is just blowing out of proportion. It is not so easy to multiply immunity. Immunity increases by mild to moderate levels by including super foods and herbs like onion, turmeric, neem, tulsi, giloy, aamla, garlic, ginger, spices etc. But it is not easy to quantify as to how much exactly the immunity increases and it requires more definite research.

Well onion itself is considered a super food for its immune enhancing properties and antioxidant properties. The sulphur containing compounds in onion have anti-bacterial and anti-viral properties which help fight against bacterial and viral infections especially cold and cough. Honey is a great natural expectorant that helps to relieve cough. So onion and honey combined is one of the home remedy to relieve bacterial or viral cold and cough.

Main virtue of onion is that it has ‘Quercetin’, a flavonoid that is an excellent antioxidant that fights and eliminates damage causing toxic free radicals from the body. It thus helps to prevent clogging of arteries, heart diseases, cancer and overall cell damage caused by these free radicals. It also helps to lower bad cholesterol.”

Dr Aman Rathore, DNB, Critical Care Medicine, Max Super Speciality Hospital responded to the viral claim and said, “While onions and honey have beneficial properties, claiming they can make your immune system ‘200% stronger’ is an exaggeration. This is a False claim. Onions contain antioxidants and compounds, which can support immune health, while honey has antimicrobial and soothing properties. Together, they may contribute to general well-being and help reduce inflammation. However, no single food or combination can drastically boost immunity alone. A well-rounded diet rich in fruits, vegetables, whole grains, and lean proteins, along with a healthy lifestyle, is key to maintaining and supporting the immune system effectively.”

Medical Dialogues Final Take

Consuming honey and onion may offer health benefits due to their natural properties, such as antioxidants and antimicrobial effects, which can support overall immunity. However, claims like boosting immunity by 200% are highly exaggerated and there is no scientific evidence or medical consensus to back the claim by the user that honey and onion can boost immunity by up to 200%. Immunity cannot be quantified or enhanced by such specific percentages through dietary means alone.

Hence, the claim by the user is False.

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AIIMS Releases Datesheet For 2nd MBBS Professional Exams, Details

New Delhi: Through a recent notice, the All India Institute of Medical Sciences (AIIMS) has released the datasheet of the Second MBBS Professional Examination scheduled to be held in January 2025.

All the concerned students are advised to take note of the following details:

SCHEDULE OF SECOND M.B.B.S. PROFESSIONAL EXAMINATIONS TO BE HELD IN JANUARY 2025 

I. THEORY EXAMINATIONS
Date Day Subject Paper
No.
Venue of Theory Time
of Theory
06.01.2025 Monday Microbiology I Examination
Section First Floor Convergence Block
AIIMS New Delhi
02:00 PM to 05:00 PM
07.01.2025 Tuesday -do- II
09.01.2025 Thursday Pathology I
10.01.2025 Friday -do- II
13.01.2025 Monday Pharmacology I
14.01.2025 Tuesday -do- II
16.01.2025 Thursday Forensic Medicine I
II. PRACTICAL EXAMINATIONS (Please check
time and venue from the respective departments)
Date Day Subject Roll No. Subject Roll No.
20.01.2025 Monday Microbiology 3887-3898, 3900-3913 3915-3926, 3928-3934 Pathology 3935 – 3979
21.01.2025 Tuesday -do- 3935 – 3979 -do- 3980-3989, 3991-4015 4017,4018,3339,3397
3702,3788,3884
22.01.2025 Wednesday -do- 3980-3989, 3991-4015
4017,4018,3339,3397 3702,3788,3884
-do- 3887-3898,
3900-3913 3915-3926, 3928-3934
23.01.2025 Thursday Pharmacology 3887-3898,
3900-3913 3915-3926, 3928-3934
Forensic Medicine 3935 –
3979
24.01.2025 Friday -do- 3935 – 3979 -do- 3980-3989, 3991-4015
4017,4018,3702,3788,3884
25.01.2025 Saturday -do- 3980-3989, 3991-4015 4017,4018,3339,3397,
3526, 3702,3751,3788, 3884
-do- 3887-3898, 3900-3913 3915-3926,
3928-3934

The students must note that rules of examination (Regular/Supplementary) will be applicable as mentioned in the admit card in which student is appearing.

All candidates are advised to submit their Examination Fees before the last date of Registration (to be announced later) and take a print out of Admit Card from the website.

 No candidate will be permitted to enter the examination hall without Admit Card and Identity Card.

 No candidate will be allowed to enter the Examination Hall after the closing time mentioned in the Admit Card. All latest information will only be available at Examination Section website in “STUDENT TAB”. Please visit the website regularly. 

To view the official Notice, Click here : https://medicaldialogues.in/pdf_upload/date-sheet-second-mbbs-january-2025-website-264754.pdf

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Faculty Post At ESIC Medical College And Hospital Kalaburagi: View All Details Here

Bengaluru: The Employees State Insurance Corporation Medical College and Hospital (ESIC Medical College and Hospital Kalaburagi) has announced vacancies for the Faculty Post on a Contract Basis. The final selection will be based on performance in the personal interview.

ESIC is a statutory body constituted under an Act of Parliament (ESI Act, 1948) and works under the administrative control of the Ministry of Labour and Employment, Government of India.

ESIC Vacancy Details:

Total no. of vacancies- 31

Professor:- 05

The Vacancies are in the Department of Biochemistry, Forensic Medicine, Radio Diagnosis, Psychiatry, and Physical Medicine & Rehabilitation.

Associate Professor:- 15

The Vacancies are in the Department of Biochemistry, Paediatrics,, Psychiatry, General Surgery, Orthopaedics, ENT, Anaesthesiology, Radio Diagnosis, Emergency Medicine, and Physical Medicine & Rehabilitation.

Assistant Professor- 11

The Vacancies are in the Department of Anatomy, Physiology,, Biochemistry, Microbiology, General Medicine, Paediatrics, General Surgery, Radio Diagnosis, and Physical Medicine & Rehabilitation.

Registration and Document Verification timings 16th December 2024 9:00 AM to 10:30 AM
Personal interview 17th December 2024 9:30 AM onwards

Venue: Office of the Dean, ESIC Medical College, Kalaburagi, Karnataka.

For more details about Qualifications, Age, Pay Allowance, and much more, click on the given link:
https://medicaljob.in/jobs.php?post_type=&job_tags=ESIC+Kalaburagi&location=&job_sector=all

What are the General Conditions for Eligible Candidates?

a) Candidate can walk in and register for interview from 09:00AM to 10:30 AM on 16.12.2024. No candidate will be entertained after 10:30 AM.

b) Application form is enclosed with the advertisement.

c) All eligible candidates should apply through the application form enclosed with the advertisement and must fill the application form before registration process.

d) Candidates should produce all the original documents in respect of all the parameters filled in the form during scrutiny on the day of Walk in Interview.

e) Candidates are requested to report by 9 AM at the venue on scheduled dates.

f) Please bring all following relevant Original certificates and their self attested photocopies (1 set), 2 copies of passport size photographs and the relevant certificates issued by the competent authority in the form prescribed by Government of India, Department of Personnel & Training for consideration of reservation to the reserved candidates, failing which they will not be allowed for interview.

“No photocopies will be arranged/ provided by the office under any circumstances.”

List of Documents to be produced at the time of Interview :

• SSC/10th Standard Certificate as proof of age.

• M.B.B.S Certificate

• PG Degree Certificate

• Registration with Karnataka State Medical Council(KMC)/NMC

• Caste Certificate issued by the Competent Authority, if applicable

• Experience Certificate

• Relieving Certificate from Previous institution

• Proof of ID (Aadhar Card and PAN Card)

• Passport size 02 photograph

• Other documents /Publications as per NMC criteria for faculty appointment.

Also Read:Applications Open for PGIMS Rohtak Vacancies: 153 Post For Senior, Junior House Surgeons

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Diabetic kidney damage linked to ratio of non-HDL-C to HDL-C: Study

A new study published in the PLOS ONE journal found that diabetic kidney disease (DKD) is linked to the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (HDL-C). Diabetes is a common endocrine condition marked by high blood glucose levels. It is mostly caused by beta-cell failure in the pancreas and the ensuing lack of insulin. Diabetic kidney disease, a serious consequence that affects 30% to 40% of people with diabetes, has increased in tandem with the growth in the prevalence of diabetes.

DKD presents a serious global threat to public health as it is linked to increased mortality and is a major cause of end-stage renal disease (ESRD). The urine albumin to creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) are now the main indicators for diagnosing DKD in renal structure and function. Because it lowers oxidative stress and promotes anti-apoptotic effects, high-density lipoprotein cholesterol (HDL-C) is well known for its preventive function in cardiovascular diseases (CVD).

This study makes the assumption that lipid metabolism abnormalities affect the progression of DKD, which leads to a link between Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) and DKD. This study attempts to offer a fresh viewpoint for the sophisticated identification and diagnosis of DKD using NHANES data from 1999 to 2020.

The strict inclusion and exclusion criteria were used to choose the participants. To look into the connection between NHHR and DKD, this research utilized smooth curve fitting, multivariate logistic regression, and single-factor analysis. A total of 8,329 diabetic participants were enrolled in this study who were divided into groups with and without renal impairment.

There was a notable variation in NHHR across these groups. The study discovered a favorable correlation between NHHR and the prevalence of DKD after controlling for possible variables. In particular, the prevalence of DKD increased by 6% with every unit increase in NHHR, and this relationship held true for all stratified NHHR levels.

According to threshold effect analysis, there was an inflection point at an NHHR of 1.75. Where the prevalence of DKD increased by 7% for every unit rise in NHHR, beyond this. Subgroup analysis validated that these results were robust. Overall, the results show that the prevalence of DKD and NHHR are positively correlated. To clarify the causal association and offer further proof for the early diagnosis and prediction of DKD, future randomized controlled studies are crucial.

Reference:

Zhang, L., Fan, D., Zhu, T., Geng, L., Gan, L., Ou, S., & Yin, D. (2024). The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol is associated with diabetic kidney disease: A cross-sectional study. In M. Khorasani (Ed.), PLOS ONE (Vol. 19, Issue 11, p. e0311620). Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0311620

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Prophylactic Antibiotics Show Limited Impact on Mortality in ICU Patients with Acute Brain Injury: Meta-Analysis

Australia: Ventilator-associated pneumonia is a frequent complication in patients with acute brain injuries, potentially leading to adverse outcomes in this vulnerable population. While a previous analysis of two studies suggested that prophylactic antibiotics might offer better outcomes, the current study’s authors conclude that these antibiotics do not significantly enhance outcomes. However, they note that the available evidence is of low or very low certainty.

“There is ongoing uncertainty about the use of prophylactic antibiotics in adults with acute brain injuries invasively ventilated in intensive care units (ICUs). Although this practice is common, conclusive evidence supporting its ability to significantly lower mortality rates in these critically ill patients is lacking,” the researchers wrote in the CHEST Journal.

Invasive mechanical ventilation, often required for patients with acute brain injuries, carries a high risk of ventilator-associated infections. Prophylactic antibiotics are sometimes administered as a preventative measure to mitigate this. However, the benefits of this approach remain unclear, with studies yielding mixed results regarding its impact on patient outcomes.

To fill this knowledge gap, Anthony P. Delaney, Critical Care Program, The George Institute for Global Health and UNSW, Barangaroo, NSW, Australia, and colleagues aimed to investigate whether administering prophylactic parenteral antibiotics, compared to placebo or usual care, is associated with reduced mortality in adults with acute brain injury receiving invasive mechanical ventilation in an ICU.

For this purpose, the researchers conducted a systematic review and meta-analysis by searching electronic databases and unpublished trials for randomized clinical trials (RCTs).

The primary outcome assessed was hospital mortality, while secondary outcomes included the incidence of ventilator-associated pneumonia, ICU length of stay, and duration of mechanical ventilation. A random effects model was applied to estimate the pooled risk ratio (RR) with 95% confidence intervals (CI) for binary outcomes and the mean difference (MD) with 95% CI for continuous outcomes. The certainty of evidence was evaluated using the Grading of Recommendations Assessment Development and Evaluation (GRADE) methods.

The following were the key findings of the study:

  • One thousand seven hundred twenty-eight study reports were screened, with seven randomized clinical trials (RCTs) involving 835 participants included.
  • None of the trials were considered to have a high risk of bias.
  • The pooled estimated risk ratio (RR) for mortality with prophylactic antibiotics was 0.91, indicating low certainty.
  • The pooled RR for ventilator-associated pneumonia was 0.56, with low certainty.
  • The mean difference (MD) in the duration of mechanical ventilation between prophylactic antibiotics and control groups was –2.0 days, with very low certainty.
  • The MD admission duration in ICU was –2.2 days, with very low certainty.

“Current evidence from randomized clinical trials does not conclusively establish the impact of prophylactic antibiotics on mortality in patients undergoing invasive mechanical ventilation in the ICU,” the researchers concluded.

Reference:

Hadley-Brown K, Hailstone L, Devane R, Chan T, Devaux A, Davis JS, Hammond N, Li Q, Litton E, Myburgh J, Poole A, Santos J, Seppelt I, Tong SYC, Udy A, Venkatesh B, Young PJ, Delaney AP. Prophylactic Antibiotics in Adults With Acute Brain Injury Who Are Invasively Ventilated in the ICU: A Systematic Review and Meta-Analysis. Chest. 2024 Oct 28:S0012-3692(24)05420-5. doi: 10.1016/j.chest.2024.10.031. Epub ahead of print. PMID: 39490972.

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Heart-related side effects of cancer treatment must be addressed as early as possible, warns study

The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasise that heart and cardiovascular health must be included as early as possible in the patient’s cancer treatment plan to ensure the best possible outcomes.

Due to an ageing population, and a growing number of cancer diagnoses there is also an increasing number of patients with cardiovascular side effects of cancer treatment. To tackle this growing problem, the ESC is launching a new conference on cardio-oncology to specifically target this increasingly important area that overlaps cancer treatment and its associated cardiovascular disease (CVD) side effects. ESC Cardio-Oncology 2025 will take place in Florence, Italy, from Friday, 20 June – Saturday, 21 June 2025.

Previous research from prospective registries published in the European Heart Journal estimate that approximately one-third (32%) of patients experience mild toxicities that could potentially progress in severity without adequate monitoring, while 3% develop moderate toxicity and a further 3% the most severe toxicity.

“The main goal of this emerging specialty of cardio-oncology is to reduce the burden of CVD in cancer patients allowing them to receive the best anticancer therapy (chemotherapy, targeted molecular therapies, hormone therapy, immunotherapy or radiotherapy) with the lowest rate of side effects and treatment interruptions,” explains Dr Teresa López-Fernandez, University Hospital La Paz – Madrid, Spain and co-Chair of the ESC Cardio-Oncology Guidelines Task Force.

“We could soon be facing cardio-oncology ‘epidemic’ due to either the growing population of cancer survivors, the increasing number of patients aged over 65 who need chronic cancer therapy, and the high frequency of cancer therapy induced CVDs in these populations,” says Dr Alexander Lyon, Royal Brompton Hospital, London, UK, and also co-Chair of the ESC Cardio-Oncology Guidelines Task Force.

Concerns about the increasing prevalence of cardiotoxicity caused by cancer therapies led to the ESC establishing, in 2018, the Council of Cardio-Oncology as a multidisciplinary constituent body which encourages the prevention, early diagnosis and management of cancer therapy-related CVD. Today, the council brings together over 2,000 members worldwide and a team of volunteers part of the Council of Cardio-Oncology Board.

In 2022, the Guidelines Taskforce, led by Drs López-Fernandez and Lyon, published the first ever ESC Clinical Practice Guidelines on cardio-oncology . These guidelines include advice on how to conduct an assessment of cardiovascular toxicity risk, in collaboration with the cardio-oncology team, using specific risk scores; the implementation of preventive strategies in high-risk patients; and analysis of methods to monitor cancer treatments with advanced cardiac imaging techniques (including MRI and strain) and biomarkers.

They also include techniques of early management of potential cardiac toxicities, aiming to maintain cancer treatment whenever cardiac toxicity is manageable, and the patient remains stable; and also, advice on carrying out long-term follow-up of cancer survivors who have received treatments with potential late cardiovascular effects.

“Cardio-oncology teams design effective ‘shields’ to protect the hearts of oncology patients,” says Dr López-Fernandez. “The teamwork between cardiologists and cancer specialists promotes the prevention of cardiovascular diseases in cancer survivors.”

The Guidelines provide highly detailed explanations of cancer therapy-related CV toxicity (CTR-CVT), and various examples of this including cardiac dysfunction, arrhythmias, hypertension (arterial and pulmonary), thrombosis. If cardiac dysfunction is detected, cardiology and oncology teams are strongly recommended to discuss the pros and cons of continuing versus stopping cancer treatment. Dr Lyon comments: “Our mission is always to ensure that cancer patients have the best and most effective cancer treatment safely, and to prevent interruptions in their cancer treatment due to cardiovascular problems which could have been prevented.”

Populations needing special considerations, including children and adolescents and pregnant women with cancer, are also all addressed in the Guidelines. “As the global population grows older, we will see more and more people with cancer and thus more and more with toxic CVD side-effects of cancer treatment,” says Dr López-Fernandez. Dr Lyon adds: “This specialised area of medicine is one that is only going to grow, and as such we and other experts at the European Society of Cardiology believe the time has come to have a global forum, in the form of our first ever ESC Cardio-Oncology conference, to gather global experts to ensure better outcomes for this growing patient group.”

Reference:

José López-Sendón, Carlos Álvarez-Ortega, Pilar Zamora Auñon, Antonio Buño Soto, Alexander R Lyon, Dimitrios Farmakis, Daniela Cardinale, Miguel Canales Albendea, Jaime Feliu Batlle, Isabel Rodríguez Rodríguez, Olaia Rodríguez Fraga, Ainara Albaladejo, Guiomar Mediavilla, Jose Ramón González-Juanatey, Amparo Martínez Monzonis, Pilar Gómez Prieto, José González-Costello, J on behalf of the CARDIOTOX Registry Investigators, Classification, prevalence, and outcomes of anticancer therapy-induced cardiotoxicity: the CARDIOTOX registry, European Heart Journal, Volume 41, Issue 18, 7 May 2020, Pages 1720–1729, https://doi.org/10.1093/eurheartj/ehaa006

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Real-time feedback tied to improved compliance with pre-defined ventilation targets during CPR, reveals study

Ventilations play a vital role in cardiopulmonary resuscitation (CPR). However, there is inconsistent evidence regarding the best approach to ventilation in managing cardiac arrest. Recent findings indicate that, irrespective of the ideal ventilation technique, actual ventilations frequently do not adhere to guideline recommendations. Recent study examined the impact of real-time feedback on ventilation quality during out-of-hospital cardiac arrest resuscitation. It was a before-and-after study conducted across four paramedic services in Ontario, Canada. The study enrolled 412 adult out-of-hospital cardiac arrest patients, with 191 in the before phase (without feedback) and 221 in the after phase (with feedback). The study used the ZOLL AccuventÒ device to measure ventilation rate and volume during resuscitation. In the before phase, the AccuventÒ was used but providers were blinded to the real-time feedback. In the after phase, the feedback dashboard was activated and providers used the real-time feedback to guide their ventilations. All other aspects of resuscitation remained consistent.

Objectives and Analysis

The main objective was to compare the proportion of each case that was compliant with pre-defined ventilation targets (rate of 10 ± 2 breaths/min, volume of 450 ± 50 mL) with and without real-time feedback. The study also examined the impact of advanced airway use on ventilation quality and the association between ventilation parameters and return of spontaneous circulation (ROSC).

Key Results

The results showed significant improvements in both ventilation rate and volume compliance in the after phase (with real-time feedback) compared to the before phase (without real-time feedback). The proportion of ventilations compliant with targets for rate increased from 29% to 52%, and for volume increased from 21% to 28%. The proportion compliant with both rate and volume targets increased from 7% to 18%.

Ventilation Compliance Findings

The study did not find any differences in ventilation compliance with or without advanced airways, or during intra-arrest or post-cardiac arrest periods. The exploratory analysis also did not find any association between ventilation parameters and ROSC.

Conclusion

In conclusion, the use of real-time feedback was associated with improved compliance with pre-defined ventilation targets during cardiac arrest resuscitation. However, further work is required to optimize the use of real-time ventilation feedback and determine its impact on patient outcomes.

Key Points

1. The study examined the impact of real-time feedback on ventilation quality during out-of-hospital cardiac arrest resuscitation. It was a before-and-after study conducted across four paramedic services in Ontario, Canada, with 412 adult out-of-hospital cardiac arrest patients enrolled.

2. The study used the ZOLL AccuventÒ device to measure ventilation rate and volume during resuscitation. In the before phase, the AccuventÒ was used but providers were blinded to the real-time feedback, while in the after phase, the feedback dashboard was activated and providers used the real-time feedback to guide their ventilations.

3. The main objective was to compare the proportion of each case that was compliant with pre-defined ventilation targets (rate of 10 ± 2 breaths/min, volume of 450 ± 50 mL) with and without real-time feedback. The study also examined the impact of advanced airway use on ventilation quality and the association between ventilation parameters and return of spontaneous circulation (ROSC).

4. The results showed significant improvements in both ventilation rate and volume compliance in the after phase (with real-time feedback) compared to the before phase (without real-time feedback). The proportion of ventilations compliant with targets for rate increased from 29% to 52%, and for volume increased from 21% to 28%. The proportion compliant with both rate and volume targets increased from 7% to 18%.

5. The study did not find any differences in ventilation compliance with or without advanced airways, or during intra-arrest or post-cardiac arrest periods. The exploratory analysis also did not find any association between ventilation parameters and ROSC.

6. In conclusion, the use of real-time feedback was associated with improved compliance with pre-defined ventilation targets during cardiac arrest resuscitation. However, further work is required to optimize the use of real-time ventilation feedback and determine its impact on patient outcomes.

Reference –

I. Drennan et al. (2024). The Impact Of Real-Time Feedback On Ventilation Quality During Out-Of-Hospital Cardiac Arrest: A Before-And-After Study.. *Resuscitation*, 110381 . https://doi.org/10.1016/j.resuscitation.2024.110381.

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