HCG acquires Vizag-based Mahatma Gandhi Cancer Hospital and Research Institute for Rs 414 crore

Vizag: HealthCare Global Enterprises Limited (HCG), one of the largest cancer care networks in India, has announced the acquisition of Mahatma Gandhi Cancer Hospital and Research Institute (MGCHRI) in Vizag, Andhra Pradesh, for an Enterprise Value of INR 4,140 Mn. 

HCG will have initial 51% stake in MGCHRI, with plans to complete the acquisition of the additional 34% stake over the next 18 months. This strategic move entails leadership in a highly attractive micro-market with high quality primary catchment supported by large draining secondary catchment from neighbouring states.

Established in 1986, Mahatma Gandhi Cancer Hospital & Research Institute has emerged as the leading provider of comprehensive cancer care in Vizag with the highest market share. This acquisition is poised to significantly bolster HCG’s annual EBITDA by INR 3 per share and gain a leadership position with a dominant share in Vizag Region.

Also Read:HCG launches First Private Comprehensive Cancer Centre in Central India

The hospital boasts 196 operational beds and features advanced medical infrastructure, including 2 LINAC machines, 1 PET CT scanner, 1 Robotics Surgery System, and a dedicated Bone Marrow Transplant (BMT) unit. Its clinical team comprises 31 doctors, including 12 Surgical, 6 Radiation, and 4 Medical oncologists.

Commenting on the acquisition, Dr B.S. Ajaikumar, Executive Chairman, HealthCare Global Enterprises Ltd. Said, Dr B.S. Ajaikumar, Executive Chairman of HealthCare Global Enterprises Ltd., announced the acquisition of Mahatma Gandhi Cancer Hospital & Research Institute in Vizag, promoted by Dr Murali K V, a prominent Oncology Surgeon in Andhra Pradesh.

He highlighted that this acquisition is a significant milestone for HCG, emphasizing Vizag’s strategic importance in their growth journey. This expansion strengthens HCG’s presence in the region, enhancing their capabilities and reinforcing their commitment to providing high-quality treatment and support for cancer patients. Dr Ajaikumar noted that the combined market leadership of HCG and MGCHRI would enable better utilization of doctor bandwidth and medical technology consolidation.

Additionally, HCG aims to augment tech capabilities to further improve the quality of cancer care in the region. He expressed enthusiasm for continuing their mission to expand cancer care services and integrate innovative solutions to ensure exceptional, patient-tailored care”.

Mr. Raj Gore, CEO HealthCare Global Enterprises Ltd., added, “We are proud to join hands with the leading institute like Mahatma Gandhi Cancer Hospital & Research Institute and its team of experts, boosting our dominance in that region with top-tier medical talent. This partnership enhances our ability to provide cutting-edge care in Vizag’s competitive healthcare landscape. With its state-of-the-art facility, advanced technology and comprehensive medical program, MGCHRI aligns perfectly with our commitment to delivering high-quality healthcare services.

Leveraging our existing presence and deep understanding of the local market, we are poised to maximize synergies across our facilities. This strategic integration will not only strengthen operational efficiencies but also enable us to offer comprehensive, patient-centered care solutions. Our collective expertise and shared resources will drive innovation and foster new standards of excellence in healthcare delivery. We are excited about the opportunities ahead and remain focused on advancing healthcare outcomes for our patients while creating sustained value for our stakeholders”.

Dr Murali Krishna Vonna, Managing Director & Chief Surgical Oncologist, Mahatma Gandhi Cancer Hospital & Research Institute said, ‘‘Today marks a significant milestone for Mahatma Gandhi Cancer Hospital & Research Institute as we join forces with HCG, a leader in oncology care. This union represents our shared vision to provide the highest quality cancer treatment and care to our patients in Vizag, a city that ranks among the top 10 cities by GDP. By combining our strengths, we are poised to enhance our medical expertise, expand our services, and continue our commitment to patient-centric care. I am excited about the opportunities this partnership brings and jointly remain dedicated to our mission of offering hope and healing to those affected by cancer.’

The partnership aims to address the significant demand-supply gap in radiation therapy equipment, which has a penetration rate of less than 0.6 per million in Andhra Pradesh and Orissa. Mahatma Gandhi Cancer Hospital & Research Institute, located in a robust primary catchment area, also benefits from substantial secondary demand from neighbouring states. Its clinical standards closely align with HCG’s rigorous cancer care protocols, ensuring seamless integration post-acquisition.

HCG aims to expand its multi-modality programs and enhance customer engagement strategies through this acquisition, leveraging operational synergies and scale advantages. The integration will utilize established technology platforms for digital marketing initiatives, strengthening EBITDA margin and enhancing EPS growth.

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From Rs 15k to Rs 1.25 lakh per month: NMC data reveals glaring stipend disparity

New Delhi: Despite the National Medical Commission’s directive to implement a uniform stipend, there is still a glaring disparity of stipend paid to resident doctors in a specific State/UT or all across the country. 

The existing disparity in the stipend amount came to light as the NMC released the data regarding the students admitted through the National Eligibility-and-Entrance Test Postgraduate (NEET-PG) examination 2023, which is available on the official website of the Commission.

As per the data, the disparity in the amount of stipend paid to Junior Resident Doctors across the institutes in a State and also across the country still exists. 

While the workload for the resident doctors is almost similar across all the medical institutes in India, they are paid any amount ranging from Rs 15,000 (Karnataka) per month to Rs Rs 125000 (Delhi) per month as their stipend.

The NMC data revealed that the resident doctors who are being paid the least (Rs 25,000 or less) are pursuing their PG medical education in States like Karnataka, Punjab, Uttar Pradesh, and Rajasthan.

Karnataka-based Dr BR Ambedkar Medical College (Bangalore) pays the lowest stipend across the country to its resident doctors. Doctors who are enrolled at the institute for their PG medical courses and are pursuing MD/MS in Anaesthesiology, Dermatology, Venereology & Leprosy, General Medicine, Ophthalmology, Paediatrics, Pathology, Radiology, Community Medicine, ENT, General Surgery, Obstetrics and Gynaecology are getting a monthly stipend of Rs 15,000 per month.

Apart from this, the lowest amount is paid to the resident doctors in Punjab’s Bhatinda-based Adesh Institute of Medical Sciences & Research, where the residents are getting Rs 15,600 per month as stipend.

Karnataka’s Bangalore-based East Point College of Medical Sciences & Research and Centre and Rajasthan’s Bedwas-based American International Institute of Medical Sciences, Bedwas are paying Rs 20,000 as the monthly stipend to its residents. A similar amount is being paid to the residents at Lucknow-based Prasad Institute of Medical Sciences.

Further, the resident doctors at Varanasi-based Heritage Institute of Medical Sciences are getting Rs 21,000 as their monthly stipend, while the residents pursuing their postgraduation at Ananta Institute of Medical Sciences & Research Centre are being paid Rs 25,000 as their monthly stipend. In the case of Telangana’s Vinayaka Missions Kirupananda Variyar Medical College, only the students pursuing MD Pathology are getting Rs 25,000 as their monthly stipend.

Also Read: Rs 14,000 to Rs 1,20,000 Stipend: Glaring disparities in stipend paid to PG medicos In India

In terms of the highest amount of stipend, Delhi-based Army Hospital Research & Referral pays its resident doctors the most among the medical institutes across the country. PG medical students pursuing MD Microbiology are paid Rs 125000 per month as a stipend. MD Anaesthesiology residents get Rs 1,20,000 per month, MD/MS Ophthalmology, MD Paediatrics, and MS ENT residents get Rs 1,23,994 per month, revealed the NMC data.

Apart from this institute, several other medical colleges based in Delhi pay a huge stipend to their resident doctors. Delhi-based Atal Bihari Vajpayee Institute of Medical Sciences pays Rs 120965 to its resident doctors. The resident doctors at ESI-PGIMSR, ESI-Hospital, Basaidarapur, New Delhi get Rs 123000 as their monthly stipend. 

Further, the residents at G.B. Pant Institute of Postgraduate Medical Education, Kasturba Hospital, Hindu Rao Hospital Delhi, Institute of Human Behaviour and Allied Sciences, Delhi, University College of Medical Sciences & GTB Hospital, New Delhi get Rs 120965, Rs 123946, Rs 123946, and Rs 127384 respectively. VP Chest Institute of Medical Sciences pays its resident doctors a monthly stipend ranging from Rs 1,08,799 to Rs 123946. 

Stipend Disparity for Clinical Specialities: 

Speciality-wise, there is a huge disparity in the amount of stipend paid to resident doctors pursuing clinical branches such as MD-General Medicine, MS- Obstetrics & Gynaecology, MS-General Surgery, MD Paediatrics, MS-Orthopaedics and non-clinical branches such as MD-Pathology, MD Microbiology etc.

MD-General Medicine: 

When MD-General Medicine students are considered, they are paid most in Delhi, where they can be paid an amount ranging between Rs 56,100 to Rs 1,27,384 per month depending on the institute. 

In States like Andhra Pradesh, the resident doctors may receive a monthly stipend of Rs 30,000 per month in institutes like Alluri Sitaram Raju Academy of Medical Sciences or they may get a huge amount such as Rs 80,904 at Tirupati-based Sri Venkateswara Institute of Medical Sciences.

The data revealed a stark contrast in the stipend amount paid to the MD General Medicine students in Punjab as well. While Bhatinda-based Adesh Institute of Medical Sciences & Research pays Rs 15600 to the MD General Medicine students, the residents studying the same speciality can get as much as Rs 67,968 in medical colleges like Government Medical College Patiala or Guru Govind Singh Medical College, Faridkot.

In the case of Rajasthan, the amount of stipend for MD General Medicine Students can vary from Rs 20,000/Rs 25,000 per month to Rs 78,384 per month. In Tamil Nadu, the MD General Medicine residents can be paid a monthly stipend ranging from Rs 35,000 to Rs 1,05,000 depending on the institute. 

There is a huge disparity in the amount of stipend paid to the MD General Medicine students in Uttar Pradesh also, where they can get any amount ranging from Rs 20,000/Rs 21,000 per month to Rs 115916 per month.

MS-Obstetrics & Gynaecology: 

Similar to MD General Medicine, the MS Obstetrics & Gynaecology students are also paid the most in Delhi. They can be paid as high as Rs 127384 at the University College of Medical Sciences, or Rs 123946 in Kasturba Hospital, Rs 123000 at ESI PGIMSR, ESI Hospital, Basaidarapur, or Rs 120965 at Atal Bihari Vajpayee Institute of Medical Sciences. However, Delhi-based Lady Hardinge Medical College pays 56100 to its MS-Ob-Gyn residents.

Students pursuing MS Obstetrics & Gynaecology face huge stipend disparity in Karnataka, where they can be paid as low as Rs 15,000/Rs 20,000/Rs 24,000 per month or a huge amount of Rs 105818 per month, depending on the institute.

In the case of Manipur, the students can get as low as Rs 50,000 per month to a huge amount of Rs 102543 per month. As per the data, the stipend disparity for MS-Ob-Gyn students is huge in Punjab as well. In the State, the students can get an amount of monthly stipend ranging from Rs 15600 to Rs 67968. In Rajasthan, the stipend range for MS-Ob-Gyn students is between Rs 20,000/Rs 25000 per month to Rs 78384 per month.

The OB-GYN students in Tamil Nadu can get an amount ranging from Rs 35,000 per month to Rs 105000 per month. In Uttar Pradesh, the stipend amount ranges from Rs 21,000/Rs 22000 to Rs 115916. However, this disparity is comparatively lower in States like Maharashtra, where the amount of stipend for MS-Ob-Gyn can range from Rs 50,000 to Rs 79698 per month.

MS-General Surgery: 

MS-General Surgery medicos in Andhra Pradesh get any amount ranging from Rs 30,000 to Rs 80904 per month. In Assam, MS General Surgery students get Rs 48,000 per month. In the case of Bihar, the stipend amount ranges between Rs 60,000 per month to Rs 99,000 per month.

The amount varies from Rs 15000/24,000 per month to Rs 119800 in Karnataka and Rs 15600 per month to Rs 67968 in Punjab. There is a huge disparity in the stipend paid to MS-General Surgery in Rajasthan also, where students can get any amount ranging from Rs 20,000 to Rs 78384 per month.

In the case of Tamil Nadu, the students may get an amount ranging from Rs 35,000 per month to Rs 105000 per month and in Uttar Pradesh they can get a monthly stipend ranging from Rs 21000/Rs 22000 per month to Rs 115916 per month, depending on the institute.

MD Paediatrics: 

The stipend disparity is faced by the students pursuing MD Paediatrics courses as well. In Bihar, these students can get any amount ranging from Rs 68545 to Rs 99000 per month. In Delhi, the stipend amount ranges between Rs 56100 to Rs 127384 per month, depending on the institute. However, most of the colleges in Gujarat pay Rs 84,000-Rs 85,000 as a monthly stipend to the MD Paediatrics students.

In the case of Haryana, the amount of stipend ranges between Rs 44,000 per month to Rs 115853 per month. MD Paediatrics students in Karnataka can get any amount ranging from Rs 15,000/Rs 24,000 to Rs 105818 per month and in Punjab, the stipend amount varies from Rs 15600 per month to Rs 67968 per month.

MD Paediatrics students in Rajasthan can get any amount of stipend ranging between Rs 20,000 per month to Rs 78384 per month. In Uttar Pradesh, MD Pediatrics students may get the lowest stipend of Rs 21,000 at Heritage Institute of Medical Sciences, Varanasi and they may get a huge amount of Rs 115916 at King George Medical University, Lucknow.

MS- Orthopaedics: 

The PG medical students pursuing MS Orthopaedics can get a monthly stipend varying from Rs 35,000 per month to Rs 105000 per month in Tamil Nadu, depending on the institute. 

In Telangana, they may get a monthly stipend starting from Rs 44075 per month to Rs 120965 per month (ESIC Hyderabad). In Uttar Pradesh, they can get any amount ranging from Rs 21,000 per month to Rs 115916 per month, depending on the institute.

Also Read: Uniform Stipend for all PG Medicos in a particular State, UT: NMC

Non-Clinical Specialities:

Just like the clinical specialities, the stipend disparity is present in the case of non-clinical specialities as well. 

MD-Pathology: 

MD Pathology students in Andhra Pradesh may get any amount ranging from Rs 30,000 per month to Rs 80,904 per month, depending on the institute. This stipend range varies from Rs 15,000/Rs 24,000 per month to Rs 105818 per month (ESIC, Bangalore). 

In Uttar Pradesh, the amount of stipend for the MD Pathology students can be as low as Rs 21,000 per month at Heritage Institute of Medical Sciences, Varanasi or it can be Rs 115916 at KGMU, Lucknow.

MD Microbiology: 

MD Microbiology students can get a monthly stipend of Rs 67968 in Punjab. In Rajasthan, the amount of stipend for the MD Microbiology students may vary from Rs 55200 to Rs 78384, depending on the institute.

The MD Microbiology students in Tamil Nadu may get a monthly stipend varying from Rs 30,000 per month to Rs 105000 per month (ESIC, Chennai). UP-based institutes pay the microbiology students a monthly stipend ranging between Rs 10,000 per month ( T S Misra Medical College & Hospital, Amusi) to Rs 115916 per month (KGMU, Lucknow).

From the NMC data, it is clear that there still exists a stark contrast in the amount of stipend paid to the resident doctors in a particular State/UT or in the institutes across the country.

Meanwhile recently releasing the final Post-Graduate Medical Education Regulations, 2023 (PGMER 2023), which were published in the official Gazette on 29.12.2023, the National Medical Commission (NMC) introduced uniformity in the amount of stipend paid to the PG medicos in a particular State/UT.

The Commission specified that the PG medicos who are pursuing degree, diploma or super-speciality courses should be paid a stipend at par with the stipend being paid to the PG students of Government institutes, in that particular State/UT.

Medical Dialogues had been reporting about the complaints from MBBS interns and resident doctors alleging that they were not receiving stipends or receiving a meagre amount despite working in the hospitals round the clock. These complaints mainly come from medical students belonging to the private medical colleges.

Recently, the NMC asked the medical colleges to submit the details of the stipend paid to their UG Interns, Post-Graduate Residents, and Senior Residents or PGs in Super Specialty for the financial year 2023-24 by 23rd April 2024. NMC asked the medical colleges to submit the details of their name and address, the amount of stipend paid by the State Government, and the month-wise details of the stipend paid to the MBBS interns, 1st/2nd/3rd-year Post-Graduate Residents, and 1st/2nd/3rd-year Senior Residents or PGs in Super Specialty for the academic year 2023-2024.

Also Read: Doctors laud NMC move seeking stipend details from medical colleges

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Eating more soy foods could improve thinking and attention in kids, suggests study

Chicago: A new study found that school-aged children who consumed more isoflavones from soy foods exhibited better thinking abilities and attention.

These findings pave the way for future research aimed at unraveling how soy foods can positively impact children’s cognitive abilities.

Isoflavones are naturally occurring compounds found in various plants, particularly soybeans and soy products. Although previous research in adults has suggested that soy isoflavones can improve memory, the benefits haven’t been studied well in children.

“Soy foods are often not a regular part of children’s diets in the United States,” said Ajla Bristina, a neuroscience doctoral student at the University of Illinois Urbana-Champaign. “Our study adds evidence of the importance of nutrients found in soy foods for childhood cognition.”

Bristina will present the findings at NUTRITION 2024, the flagship annual meeting of the American Society for Nutrition held June 29–July 2 in Chicago.

To examine the potential benefits of soy isoflavones, the researchers examined previously available data from a cross-sectional study that included 128 children ages 7 to 13. They used information from 7-day diet records to calculate each child’s average dietary intake, including the amounts of macronutrients, micronutrients, vitamins and isoflavones consumed. To assess the children’s general intellectual ability, the researchers used a set of pencil and paper tests adjusted for grade level. They also measured attentional abilities using a computerized task known as the flanker task while electroencephalographic (EEG) activity was recorded and used to measure information processing speed and attention.

“No other studies have examined the association between soy isoflavones and attentional abilities using EEG or similar measures to record electrical activity generated by the brain,” said Bristina.

Overall, the analysis revealed that the children in the study tended to consume low amounts of isoflavone-containing soy foods. However, those who did consume more soy foods showed faster responses during the attentional tasks and exhibited faster processing speed. No association was observed between soy isoflavone intake and general intellectual ability.

“The children in our study consumed an average of 1.33 mg of isoflavones per day, which while relatively low, aligns with previously reported values for the United States,” said Bristina. “Soy consumption for individual participants ranged from 0 to 35 mg/day. To put this into perspective, an 8 fl. oz serving of soy milk provides about 28 mg of isoflavones, a serving of tofu provides about 35 mg and half a cup of steamed edamame provides about 18 mg of isoflavones.”

Bristina says that snacks like roasted edamame, soynuts or soymilk are a good way to incorporate more soy into the diet. Tofu, tempeh or soy-based nuggets are also good options for meals.

“Correlational studies like this are only the first step,” said Bristina. “To better understand the effects of eating soy foods on children’s cognitive abilities and the precise amount of isoflavone intake necessary to elicit faster response times will require intervention approaches.” To find out more, the research team recently began a clinical trial examining the effects of soy foods on thinking abilities, sex hormones, metabolic health and gut health.

References: Eating more soy foods could improve thinking and attention in kids AMERICAN SOCIETY FOR NUTRITION MEETING NUTRITION 2024

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Chronic loneliness may increase stroke risk among older adults: Study

Chronic loneliness may significantly raise older adults risk of stroke, according to a new study led by Harvard T.H. Chan School of Public Health.

“Loneliness is increasingly considered a major public health issue. Our findings further highlight why that is,” said lead author Yenee Soh, research associate in the Department of Social and Behavioral Sciences. “Especially when experienced chronically, our study suggests loneliness may play an important role in stroke incidence, which is already one of the leading causes of long-term disability and mortality worldwide.”

The study will be published in eClinicalMedicine.

While previous research has linked loneliness to higher risk of developing cardiovascular diseases, few have examined the impact on stroke risk specifically. This study is one of the first to examine the association between loneliness changes and stroke risk over time.

Using 2006-2018 data from the Health and Retirement Study (HRS), the researchers assessed the association between changes in loneliness and stroke incidence over time. During 2006-2008, 12,161 participants-all adults ages 50 and above who never had a stroke-responded to questions on the Revised UCLA Loneliness Scale, from which the researchers created summary loneliness scores. Four years later (2010-2012), 8,936 participants who remained in the study responded to the same questions again. The researchers then placed the participants into one of four groups according to their loneliness scores across the two time points: “consistently low” (those who scored low on the loneliness scale at both baseline and follow-up); “remitting” (those who scored high at baseline and low at follow-up); “recent onset” (those who scored low at baseline and high at follow-up); and “consistently high” (those who scored high at both baseline and follow-up).

Among the participants whose loneliness was measured at baseline only, 1,237 strokes occurred during the follow-up period (2006-2018). Among the participants who provided two assessments of loneliness over time, 601 strokes occurred during the follow-up period (2010-2018). The researchers analyzed each group’s risk of stroke over the follow-up period in the context of their experiences with loneliness, controlling for other health and behavioral risk factors. These included social isolation and depressive symptoms, which are closely related but distinct from loneliness.

The findings showed a link between loneliness and higher risk of stroke and found that chronic loneliness heightened risk the most. When loneliness was assessed at baseline only, the participants considered lonely had a 25% higher risk of stroke than those not considered lonely. Among the participants who reported loneliness at two time points, those in the “consistently high” group had a 56% higher risk of stroke than those in the “consistently low” group, even after accounting for a broad range of other known risk factors. While the baseline analyses suggest loneliness at one time point was associated with higher risk, those who experienced remitting or recent onset loneliness did not show a clear pattern of increased risk of stroke—suggesting that loneliness’ impact on stroke risk occurs over the longer term.

“Repeat assessments of loneliness may help identify those who are chronically lonely and are therefore at a higher risk for stroke. If we fail to address their feelings of loneliness, on a micro and macro scale, there could be profound health consequences,” said Soh. “Importantly, these interventions must specifically target loneliness, which is a subjective perception and should not be conflated with social isolation.”

The authors noted that further research examining both nuanced changes in loneliness over the short-term, as well as loneliness patterns over a longer period of time, may help shed additional light on the loneliness-stroke association. They also noted that more research is needed to understand the potential underlying mechanisms, and that the study findings were limited to middle-aged and older adults and may not be generalizable to younger individuals.

Reference:

Yenee Soh, Ichiro Kawachi, Laura D. Kubzansky, Lisa F. Berkman, Henning Tiemeier, Chronic loneliness and the risk of incident stroke in middle and late adulthood: a longitudinal cohort study of U.S. older adults, EClinicalMedicine, https://doi.org/10.1016/j.eclinm.2024.102639

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Cannabidiol Oil Reduces Seizures in Some Drug-Resistant Epilepsy Patients, unravels study

Researchers in a recent study have found that cannabidiol-enriched oil (CBDO) can significantly reduce seizure frequency in a subset of adults with drug-resistant epilepsy (DRE). This study was published in the journal Epilepsia which was conducted by Sigal Glatt and colleagues at Neurological Institute, Tel Aviv Medical Center, Israel. The study aimed to assess the broader effects of CBDO on various health metrics, suggesting that while CBDO can be beneficial for some, it may not be effective for all patients.

Cannabidiol-enriched oil (CBDO) is increasingly used as an adjunct treatment for adults with drug-resistant epilepsy (DRE). Despite its rising popularity, there is a lack of large-scale studies supporting its efficacy in this patient population. This study aimed to evaluate the impact of add-on CBDO on seizure frequency, gait, cognitive function, affective state, and sleep quality. The study explored electrophysiological changes in responders and non-responders to CBDO treatment.

In this prospective study, 19 adult DRE patients were recruited, and 16 completed both pre- and post-CBDO assessments. Patients were given a daily maintenance dose of approximately 260 mg of CBD and 12 mg of Δ9-tetrahydrocannabinol (THC) for four weeks. The outcomes measured included seizure frequency, gait testing, Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), and sleep-quality questionnaires. Electroencephalography (EEG) recordings during rest and event-related potentials (ERPs) during a visual Go/NoGo task, both sitting and walking, were also analyzed.

The study findings were as follows:

  • Among the 16 patients, seven (43.75%) were classified as responders, showing an average seizure reduction of 82.4%.

  • Nine patients (56.25%) were non-responders, experiencing an average seizure increase of 30.1%.

  • Responders showed better performance in dual-task walking post-treatment (p = .015).

  • A significant correlation was found between an increase in MoCA scores and seizure reduction (r = .810, p = .027).

  • Post-CBDO P300 amplitude was lower during No/Go-sitting in non-responders (p = .028) and during No/Go-walking in responders (p = .068).

The study highlights that CBDO can be an effective treatment for reducing seizures in a significant subset of patients with DRE. However, the treatment may not be beneficial for all, as some patients experienced an increase in seizure frequency. The findings suggest that there are no specific baseline clinical or electrophysiological characteristics that can predict response to CBDO treatment. CBDO shows promise in reducing seizure frequency in some patients with drug-resistant epilepsy, although it may not be effective for all.

Reference:

Glatt, S., Shohat, S., Yam, M., Goldstein, L., Maidan, I., & Fahoum, F. (2024). Cannabidiol‐enriched oil for adult patients with drug‐resistant epilepsy: Prospective clinical and electrophysiological study. Epilepsia. https://doi.org/10.1111/epi.18025

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Study Compares Sevoflurane and Propofol for Squint Surgery in Children

Children who undergo strabismus surgery are at a high risk of experiencing postoperative vomiting. Recent study compared the incidence of postoperative vomiting (POV) in children undergoing strabismus surgery under balanced anesthesia with sevoflurane versus intravenous anesthesia with propofol. Seventy ASA I-II children aged 1-12 years were randomized to receive sevoflurane-based anesthesia (Group S) or propofol-based anesthesia (Group P) for maintenance. Surgical details, intraoperative hemodynamic parameters, recovery characteristics, and emergence delirium were recorded. The incidence of POV in the 0-2 hours, 2-6 hours, and 6-24 hours period was noted, and any rescue antiemetic administration was also recorded. The study found that the average duration of surgery was 118.2 ± 41.88 min in Group S and 137.32 ± 39.09 min in Group P, with no statistically significant difference in POV incidence in the first 24 hours between the two groups. The median time to discharge from the post anesthesia care unit (PACU) was significantly less in the propofol group (50 min) than in the sevoflurane group (60 min).

Study Conclusions

The study concludes that propofol-based anesthesia did not offer advantages over sevoflurane in reducing POV after squint surgery when dual prophylaxis with dexamethasone and ondansetron was administered. However, it did reduce the duration of stay in the PACU. The study also highlighted that all children fell into a high-risk category for POV, and the low POV incidence may be attributed to factors such as adequate hydration, avoidance of nitrous oxide, and satisfactory pain relief. The propofol group exhibited higher mean arterial pressure (MAP) than the sevoflurane group throughout the surgery, postinduction of anesthesia. No difference in the incidence of oculocardiac reflex (OCR) was identified between the propofol and sevoflurane groups in the study.

Overall Study Implications

Overall, the study indicates that propofol-based anesthesia may not offer a significant advantage over sevoflurane anesthesia in terms of reducing POV after squint surgery when dual prophylaxis with dexamethasone and ondansetron is administered. However, it may be beneficial in reducing the duration of stay in the PACU. The study also discusses the importance of using multimodal antiemetic agents and the role of procedural factors, anesthesia, and patient-related factors in influencing POV incidence in pediatric squint surgery.

Key Points

– The study concludes that propofol-based anesthesia did not offer advantages over sevoflurane in reducing POV after squint surgery when dual prophylaxis with dexamethasone and ondansetron was administered. However, it did reduce the duration of stay in the PACU. The study also highlighted that all children fell into a high-risk category for POV, and the low POV incidence may be attributed to factors such as adequate hydration, avoidance of nitrous oxide, and satisfactory pain relief. The propofol group exhibited higher mean arterial pressure (MAP) than the sevoflurane group throughout the surgery, postinduction of anesthesia. No difference in the incidence of oculocardiac reflex (OCR) was identified between the propofol and sevoflurane groups in the study.

– Overall, the study indicates that propofol-based anesthesia may not offer a significant advantage over sevoflurane anesthesia in terms of reducing POV after squint surgery when dual prophylaxis with dexamethasone and ondansetron is administered. However, it may be beneficial in reducing the duration of stay in the PACU. The study also discusses the importance of using multimodal antiemetic agents and the role of procedural factors, anesthesia, and patient-related factors in influencing POV incidence in pediatric squint surgery.

Reference –

Subramanian S, Shetty D, Shivanna P, Das P, Phadke M. Post‑operative vomiting after pediatric strabismus surgery: A comparison of propofol versus sevoflurane anaesthesia. J Anaesthesiol Clin Pharmacol 2024;40:305‑11

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Late amniocentesis safe and highly diagnostic for pregnancies complicated by multiple congenital anomalies: Study

Late amniocentesis is safe and highly diagnostic for pregnancies complicated by multiple congenital anomalies suggests a study published in the American Journal of Obstetrics and Gynecology.

Amniocentesis for genetic diagnosis is most commonly done between 15 and 22 weeks of gestation but can be performed at later gestational ages. The safety and genetic diagnostic accuracy of amniocentesis have been well-established through numerous large-scale, multicenter studies for procedures before 24 weeks, but comprehensive data on late amniocentesis remains sparse. A study was done to evaluate the indications, diagnostic yield, safety, and maternal and fetal outcomes associated with amniocentesis performed at or beyond 24 weeks of gestation. They conducted an international, multicenter retrospective cohort study examining pregnant individuals who underwent amniocentesis for prenatal diagnostic testing at gestational ages between 24w0d and 36w6d. The study, spanning from 2011 to 2022, involved nine referral centers. We included singleton or twin pregnancies with documented outcomes, excluding cases where other invasive procedures were performed during pregnancy or if amniocentesis was conducted for obstetric indications. We analyzed indications for late amniocentesis, types of genetic tests performed, their results, and the diagnostic yield, along with pregnancy outcomes and post-procedure complications. Results: Of the 752 pregnant individuals included in our study, late amniocentesis was primarily performed for the prenatal diagnosis of structural anomalies (91.6%), followed by suspected fetal infection (2.3%) and high-risk findings from cell-free DNA screening (1.9%). The median gestational age at the time of the procedure was 28w5d, and 98.3% of pregnant individuals received results of genetic testing before birth or pregnancy termination. The diagnostic yield was 22.9%, and a diagnosis was made 2.4 times more often for fetuses with anomalies in multiple organ systems (36.4%) compared to those with anomalies in a single organ system (15.3%). Additionally, the diagnostic yield varied depending on the specific organ system involved, with the highest yield for musculoskeletal anomalies (36.7%) and hydrops fetalis (36.4%) when a single organ system or entity was affected. The most prevalent genetic diagnoses were aneuploidies (46.8%), followed by copy number variants (26.3%) and monogenic disorders (22.2%). The median gestational age at delivery was 38w3d, with an average of 59 days between the procedure and delivery date. The overall complication rate within two weeks post-procedure was 1.2%. We found no significant difference in the rate of preterm delivery between pregnant individuals undergoing amniocentesis between 24-28 weeks and those between 28-32 weeks, reinforcing the procedure’s safety across these gestational periods. Late amniocentesis, at or after 24 weeks gestation, especially for pregnancies complicated by multiple congenital anomalies, has a high diagnostic yield and a low complication rate, underscoring its clinical utility. It provides pregnant individuals and their providers with a comprehensive diagnostic evaluation and results before delivery, enabling informed counseling and optimized perinatal and neonatal care planning.

Reference:

Zemet R, Ali Maktabi M, Tinfow A, Giordano JL, Heisler TM, Yan Q, Plaschkes R, Stokes J, Walsh JM, Corcoran S, Schindewolf E, Miller K, Talati AN, Miller KA, Blakemore K, Swanson K, Ramm J, Bedei I, Sparks TN, Jelin AC, Vora NL, Gebb JS, Crosby DA, Berkenstadt M, Weisz B, Wapner RJ, VAN DEN Veyver IB. Amniocentesis in pregnancies at or beyond 24 weeks: An international multicenter study. Am J Obstet Gynecol. 2024 Jun 22:S0002-9378(24)00693-8. doi: 10.1016/j.ajog.2024.06.025. Epub ahead of print. PMID: 38914189.

Keywords:

Late, amniocentesis, safe, highly, diagnostic, pregnancies, complicated, multiple, congenital, anomalies, study, American Journal of Obstetrics and Gynecology, Zemet R, Ali Maktabi M, Tinfow A, Giordano JL, Heisler TM, Yan Q, Plaschkes R, Stokes J, Walsh JM, Corcoran S, Schindewolf E, Miller K, Talati AN, Miller KA, Blakemore K, Swanson K, Ramm J, Bedei I, Sparks TN, Jelin AC, Vora NL, Gebb JS, Crosby DA, Berkenstadt M, Weisz B, Wapner RJ, VAN DEN Veyver IB, Chromosomal microarray analysis; exome sequencing; fetal anomalies; genetic testing; late amniocentesis; next-generation sequencing panel; prenatal diagnosis; preterm birth; third trimester amniocentesis.

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Revolutionizing infant dermatology: Weekly pulsed dye laser treatments erase birthmarks safely and swiftly, study finds

New York: In a groundbreaking development for pediatric dermatology, weekly pulsed dye laser treatments yield promising results in managing infants’ port-wine birthmarks. Port-wine birthmarks, characterized by reddish-purple discolorations on the skin, affect approximately 3 in every 1,000 infants worldwide. These marks, caused by abnormal blood vessels near the skin’s surface, often pose cosmetic concerns and potential health risks as they can thicken and become nodular over time.

The findings suggest that during the first few months of life, once-weekly pulsed dye laser (PDL) treatments for port-wine birthmark (PWB), which were well tolerated due to the absence of posttreatment-related purpura in this age group, are associated with shorter overall treatment duration and improved therapeutic outcomes.

“In the case series of 10 patients, seven patients achieved either PWB’s near-total or total clearance two months after treatment initiation. The other three patients achieved near-total clearance with additional treatments,” the researchers reported in JAMA Dermatology. 

The conventional approach to treating port-wine birthmarks involves pulsed dye laser therapy, which targets the blood vessels responsible for the discoloration. However, the frequency of treatments, especially in infants, has been challenging due to concerns about skin sensitivity and optimal therapeutic intervals.

Early PWB treatment can be life-altering and is often tied to improved outcomes and quality of life. There is growing evidence that shorter treatment intervals may lead to a more rapid PWB clearance; however, optimal treatment intervals have not been established. Considering this, Shirin Bajaj, Laser & Skin Surgery Center of New York, New York, and colleagues describe the outcomes of once-weekly pulsed dye laser treatments for PWB in infants.

The case series analyzed the medical records of PWB patients who received once-weekly PDL treatments at the Laser & Skin Surgery Center of New York. The patients were younger than six months. Before-and-after treatment photographs were independently evaluated and graded 2 months after treatment initiation.

The primary outcome was the percentage PWB improvement, graded using the following scale: 96% to 100% (total clearance), 76% to 95% (near-total clearance), 51% to 75% (marked improvement), 26% to 50% (moderate improvement), 1% to 25% (mild improvement), and 0% (no improvement).

The following were the key findings of the study:

  • Of the 10 patients (60% males; median age at first treatment, 4 weeks) included, 70% had experienced either near-total clearance (76%-95%) or total clearance (96%-100%) of their PWB with once-weekly PDL treatments after 2 months.
  • The other 3 patients all saw marked improvement (51%-75%) and subsequently achieved near-total clearance with additional treatments.
  • The median duration of treatment and number of treatments to achieve near-total or total clearance in all patients were 2 months and 8 treatments, respectively.
  • There were no adverse events.

In conclusion, the case series revealed that weekly pulsed dye laser treatments administered during the first few months of life led to near-total or complete clearance of PWB without any documented adverse events. These findings suggest that adopting a shorter treatment duration could potentially yield improved outcomes. Further investigation into this innovative treatment interval of one week is warranted to validate its efficacy and safety profile.

Reference:

Bajaj S, Tao J, Hashemi DA, Geronemus RG. Weekly Pulsed Dye Laser Treatments for Port-Wine Birthmarks in Infants. JAMA Dermatol. 2024;160(6):606–611. doi:10.1001/jamadermatol.2024.0293

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Prediabetes and poorly controlled type-diabetes may increase risk of peri-implant diseases, States meta-analysis

Prediabetes and poorly controlled type diabetes may increase the risk of peri-implant diseases, states meta-analysis suggests published in the Journal of Dentistry.

The study answers the PECO question: “In adults with dental implants (P), do subjects suffering from type-2 diabetes or prediabetes (E) have worse peri-implant conditions (O) than subjects without type-2 diabetes and prediabetes (C)?”. Prediabetes (5.7–6.4 % HbA1c), and the different qualities of glycemic control in type-2 diabetes; well-controlled (>8 % HbA1c), and poorly controlled (>8 % HbA1c) individuals; were classified according to the recommendations of the American Diabetes Association. An electronic search in the MEDLINE, Embase, and Cochrane libraries were conducted without any filters or language restrictions. Additionally, manual search of the reference lists were carried out to identify all relevant articles. Eligibility criteria were cohort, case-control and cross-sectional studies that answerd our PECO question with at least 1 year of follow-up. From a total of 2660 records, 35 articles (1761 individuals) were included in the analysis. Meta-analytic difference in means for crestal bone loss was 1.2 mm [95 % CI=0.4; 2.1] in patients with prediabetes, 1.8 mm [CI=1.0; 2.7] in poorly controlled patients, whereas 0.4 mm [CI=-0.3; 1.1] in well-controlled individuals. Meta-regression showed that 1 % increase in HbA1c increased crestal bone loss by 0.24 mm. Within the limitations of the study, patients with poorly controlled type-2 diabetes or prediabetes may have worse peri-implant conditions compared to patients without diabetes and well-controlled type-2 diabetes. Well-controlled type-2 diabetes is not a risk indicator for peri-implant diseases. Clinicians should measure blood HbA1c levels when planning implant-supported restorations, thus patients with undiagnosed or poorly controlled type-2 diabetes can be identified, that allows for glycemic level adjustment prior to dental implant surgery, ensuring peri-implant health.

Reference:

Bulcsú Bencze, Bianca Golzio Navarro Cavalcante, Mario Romandini, Virág Róna, Szilárd Váncsa, Gábor Varga, Márton Kivovics, Bence Szabó, Gergely Agócs, Zoltán Géczi, Péter Hermann, Péter Hegyi, Dániel Végh. Prediabetes and poorly controlled type-2 diabetes as risk indicators for peri-implant diseases:A systematic review and meta-analysis,

Journal of Dentistry. Volume 146, 2024, 105094, ISSN 0300-5712,. https://doi.org/10.1016/j.jdent.2024.105094.

(https://www.sciencedirect.com/science/article/pii/S030057122400263X)

Keywords:

Prediabetes, poorly, controlled, type-diabetes, increase , risk, peri-implant diseases, States meta-analysis, Journal of Dentistry, Diabetes mellitus; Glycemic control; HbA1c; Dental implants; Crestal bone loss; Peri-implant diseases, Bulcsú Bencze, Bianca Golzio Navarro Cavalcante, Mario Romandini, Virág Róna, Szilárd Váncsa, Gábor Varga, Márton Kivovics, Bence Szabó, Gergely Agócs, Zoltán Géczi, Péter Hermann, Péter Hegyi, Dániel Végh

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MAKO Robot-Assisted TKA Shows Superior Early Outcomes Over Conventional Methods: Study

Researchers have found that MAKO robot-assisted total knee arthroplasty (MA-TKA) provides better short-term clinical efficacy and alignment planning compared to conventional manual total knee arthroplasty (CM-TKA) for patients with end-stage knee osteoarthritis (KOA). A study was recently published in the International Orthopedics journal by Nanshan Ma and colleagues. This retrospective study analyzed the efficacy and safety of these two surgical techniques during the early postoperative period.

Total knee arthroplasty (TKA) is a common and effective procedure for alleviating pain and improving function in patients with KOA. With advancements in technology, robot-assisted TKA has been introduced, promising more precise surgical outcomes. This study aimed to compare the early postoperative results of MAKO robot-assisted TKA with conventional manual TKA.

From April 2023 to July 2023, a total of 48 patients with KOA were retrospectively analyzed. Among them, 22 patients underwent MAKO robot-assisted TKA (MA-TKA) and 26 patients underwent conventional manual TKA (CM-TKA). Various parameters were recorded and compared, including hip-knee-ankle angle (HKA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), American Knee Society Score (AKSS), Forgotten Joint Score-12 (FJS-12), visual analogue scale (VAS), and postoperative complications.

Both surgical groups successfully completed the procedures without major intraoperative complications. Key findings include:

Radiographic Parameters:

  • Postoperative LDFA and HKA were significantly lower in the MA-TKA group compared to the CM-TKA group (P < 0.05).

  • At the one-month follow-up, 86.4% of patients in the MA-TKA group had an HKA less than 3°, compared to 76.9% in the CM-TKA group.

Clinical Outcomes:

  • VAS scores at 24 hours, 48 hours, and 72 hours postoperatively were lower in the MA-TKA group both at rest and during activity.

  • AKSS Function Scores and FJS-12 scores at one month and three months postoperatively were significantly higher in the MA-TKA group compared to the CM-TKA group (P < 0.05).

Postoperative Complications:

  • No complications were reported in the MA-TKA group.

  • One patient in the CM-TKA group experienced postoperative knee stiffness, which resolved after physical therapy.

The findings suggest that MAKO robot-assisted TKA offers superior early postoperative outcomes compared to conventional manual TKA. The improved radiographic parameters and higher functional scores indicate better alignment and overall clinical efficacy with the robot-assisted technique. The absence of complications in the MA-TKA group further supports the safety of this advanced surgical method.

This study concludes that MAKO robot-assisted TKA demonstrates better short-term clinical efficacy, improved alignment planning, and maintains good safety compared to conventional manual TKA. These results may encourage the adoption of robotic assistance in TKA procedures, potentially leading to better patient outcomes.

Reference:

Ma, N., Sun, P., Xin, P., Zhong, S., Xie, J., & Xiao, L. (2024). Comparison of the efficacy and safety of MAKO robot-assisted total knee arthroplasty versus conventional manual total knee arthroplasty in uncomplicated unilateral total knee arthroplasty a single-centre retrospective analysis. International Orthopaedics. https://doi.org/10.1007/s00264-024-06234-0

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