Biocon receives over Rs 3 crore penalty over GST related issues

New Delhi: Biocon Ltd has said it has been imposed a penalty of over Rs 3 crore over GST-related issues. The company has received an order of adjudication imposing a penalty of Rs 3,03,78,465 dated February 22, 2024, from the office of Deputy Commissioner of Commercial Taxes, Divisional GST Office, Bangalore, Biocon Ltd said in a regulatory filing.

The demand is related to input tax credit reporting error in GST monthly returns, denial of input tax credit on sales and promotional expenditures, valuation issue GST under corporate guarantee, and denial of exemption on export of services, it added. Biocon further said it is “in the process of taking appropriate actions, including but not limited to, filing of the necessary appeal with the appellate authority in this regard”.

There is no material impact on the financials, operations or other activities of the company, the filing said.

Read also: Biocon Biologics, Sandoz Australia ink pact for biosimilars Trastuzumab, Bevacizumab

Biocon Limited, publicly listed in 2004, is an innovation-led global biopharmaceuticals company. It has developed and commercialized novel biologics, biosimilars, and complex small molecule APIs in India and several key global markets as well as Generic Formulations in the US, Europe & key emerging markets. It also has a pipeline of promising novel assets in immunotherapy under development.

Read also: Biocon registers consolidated revenue of Rs 4519 crore in Q3

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HC Relief: MBBS Admissions to Radha Devi Jageshwari Memorial Medical College held legally valid

Patna: Granting relief to the medical students who were admitted at Radha Devi Jageshwari Memorial Medical College in Muzaffarpur back in 2021-2022, the Patna High Court recently put an end to an ongoing litigation in this regard.

While dismissing a batch of intra-court appeals filed by the National Medical Commission (NMC) and others, a Division bench of the HC comprising Chief Justice K Vinod Chandran and Justice Harish Kumar opined that the admissions of the students, made through the counselling by the State’s board, were legally valid.

After granting permission to the medical college for MBBS admission first time for the academic year 2021-2022, the National Medical Commission (NMC) later withdrew the same. Consequently, the medical college and the society managing it, challenged the cancellation of permission to start the MBBS course.

Meanwhile, the students sought to be shifted to government medical colleges as they would be deprived of continuing their studies because of the cancellation of permission.

Issuing an order, a Single Judge bench stayed the cancellation of the permission and this, in turn, enabled the students to continue in the same college. After considering the matter, the bench set aside the order of cancellation dated 18.04.2022 issued by NMC. This order was issued by the bench while considering the petitions filed by the medical college and the society managing the college. Similarly, the prayer of the students for shifting them to government medical colleges was also negated.

Challenging this order, the National Medical Commission (NMC) filed appeals before the Division bench after a considerable delay. Though notices were not issued, the parties were represented by their Counsel and the matter was heard on consent of all parties, especially considering the fact that the students admitted to the academic year 2021-2022, had been continuing based on the interim order and the final judgment passed by the Single Judge bench.

The counsel for NMC challenged the single judge order contending that the bench erred in presuming that since the permission was granted for the academic year 2022-2023, finding adequate facilities in the college, in the previous year too there would have been adequate facilities.

Further, the NMC counsel argued that the Single Judge also erred in finding the Medical Assessment and Rating Board (MARB) of NMC as not empowered to cancel a recognition. He also contended that the justifications offered by the medical college for having lesser number of faculties and inpatients were not acceptable.

The counsel for the Commission relied on the records to show that even though permission was granted to the medical college, a surprise inspection was conducted when gross deficiencies were detected. Consequently, MARB reported the same to NMC after conducting the physical inspection and issued an order specifically directing that no admissions were to be carried out for the academic year 2021-2022. Therefore, the NMC counsel argued that the admissions were carried out in violation of this restriction. Ultimately, based on the inspection report, NMC withdrew its Letter of Permission on 18.04.2022.

Therefore, the counsel argued that there can be no admissions made to the academic year 2021-2022 and the permission granted for admission to the academic year 2022-2023, cannot relate back to the earlier year. So, the students admitted have to be shifted to other medical colleges, argued the counsel.

It was argued by the counsel for one of the students that admissions were made in violation of MARB recommendations and the government agency carrying out the admissions ought not to have allotted students in the respondent college. Therefore, the counsel argued that the appellants, who had been admitted to the college, whose letter of Permission was withdrawn, should be accommodated in government medical colleges. It was further submitted that the management of the college had been fleecing them with demands for exorbitant fees, more than that stipulated by the regulatory body, students are harassed and even prohibited from appearing in exams etc.

Meanwhile, the college management argued that even though a surprise inspection is permissible, before inspecting team left the premises, the faculty attending the funeral had returned. However, the inspecting team refused to acknowledge the presence of such faculty members.

The college submitted that it obtained the LOP for the first time in the academic year 2021-2022 and the admissions were delayed because of COVID pandemic and the admissions were made only after the commencement of the academic year 2022-2023. After the surprise inspection, MARB and NMC slept over the matter and meanwhile, the admissions were carried out based on the allotment made by Bihar Combined Entrance Competitibe Examination Board. By the time the admissions were made, the academic year was over and in the academic year 2022-2023, the college received a Letter of Permission. 

Therefore, it was the contention of the medical college that though the admissions of 2021-2022 would have been in their second academic year in 2022-2023, their first year of academics was commenced only in the year 2022-2023.

While considering the matter and the allegations of the students regarding exorbitant fees, the Court observed, “At the outset, we have to notice that the contention of the students regarding the harassment meted out to them and the demand for higher fees by the management are not the subject of consideration in the above appeals. There are other forums to agitate the cause and the students would be entitled so to do before the regulatory authority or such other appropriate forum. In the appeals, we are concerned only with the sustainability of the cancellation of the Letter of Permission.”

“Having noticed the earlier permission granted and its withdrawal, the fact that the students admitted in the previous year were continuing, was also recorded. The assessors had specifically found that deficiency earlier noticed in faculty, residents, and bed occupancy were rectified except for the mild deficiencies of out-patient attendance on the day of inspection. The type of assessment at Sl. No. 3 was stated to be for ‘first renewal’. Hence, it has to be deemed to be a renewal and not a fresh permission granted for the academic year 2022-2023,” it further noted.

It was observed by the Court that even though the permission was granted for the academic year 2021-2022, that too the first academic year, no students were admitted to the college. The Letter of Permission was granted after an inspection by the MARB. Even then, there were no admissions made since the pandemic had stalled the entire process. It was not disputed that the admissions were commenced, for the year 2021-22 only by 15.01.2022.

It was further observed by the Court that MARB conducted the surprise inspection on 27.11.2021, when there were no admissions made to the college and there was no possibility of any admissions made in the near future.

“Hence, when the report was drawn up it was incumbent upon the MARB to have given some time for the rectification of defects. This would have caused no prejudice to the standards of medical education since, at that point, there were no students admitted to the college,” noted the bench.

“In any event, there was no measure taken on the recommendation till the Board came out with Annexure-P/7 on 15.01.2022 to admit students. The show-cause notice at Annexure-8 was issued on 15.02.2022, simultaneous to the admission commenced by the State Board. As has been rightly pointed out by the learned counsel for the NMC, it was specifically directed that the admissions for the academic year 2021-22, shall not be carried out. The fact remains that such admissions were carried out and the students were continued after the withdrawal; on interim orders of this Court. In the next academic year, in which the course of the earlier year also commenced, there was an assessment carried out and after noticing the earlier permission granted and its withdrawal, the assessors had specifically found that the deficiency noticed in faculty, residents, and bed occupancy were rectified except for the mild deficiencies of out-patient attendance on the day of inspection. The type of assessment at Sl. No. 3 was stated to be first renewal. Hence, it has to be deemed to be a renewal and not a fresh permission granted for the academic year 2022-2023,” it further observed.

Therefore, the bench dismissed the plea to shift the students to other government colleges noting that admissions to the government and private medical colleges are made in order of merit, and if a college to which admissions are made is found to have a valid claim to continue the course, there is no question of any shifting of students from that college to other colleges.

Further reiterating the fact that even though the admissions were for the academic year 2021-2022, the admissions were made after the conclusion of the academic year on 31.02.2022, the bench highlighted that

“The students admitted on 18.04.2022 in the first year, carried out their first year course in the academic year 2022-23, for which year the college had a valid permission issued by the NMC. We are told that even the admissions of the academic year 2022-23, was commenced only in the year 2023. Hence, though the admissions were of the academic year 2021-22, they have carried out the course only in the year 2022-23, when the college had a valid Letter of Permission. We find absolutely no reason to interfere with the directions of the learned Single Judge.”

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/patna-hc-232980.pdf

Also Read: Delay in Bond-Service Posting: 500 PG Medical Graduates from Bihar to seek relief from High Court

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Health Bulletin 24/February/2024

Here are the top health stories for the day:

PM Modi will inaugurate Kakinada’s ESI Hospital, costing Rs 114 crore

Kakinada: Prime Minister Narendra Modi will inaugurate the ESI hospital constructed at a cost of Rs. 114 crores in the Sambamurtynagar area here on February 25 in virtual mode.

Kakinada MP Vanga Geeta Viswanath told media persons at the hospital here on Thursday that the construction of the hospital was started in 2020 and completed on schedule despite the COVID epidemic and heavy rains lashing the area.

For the full story, check out the link given below:

PM Modi To Inaugurate Rs 114 Crore ESI Hospital At Kakinada On February 25

Fraudsters posing as investors swindle a doctor of Rs 56 lakh for hospital construction

A Nellore-based doctor has been duped of Rs 56 lakh under the pretext of constructing a hospital. The Delhi Police’s Crime Branch has initiated an investigation into a doctor’s complaint who informed the police about his plan to establish a dental hospital in his hometown.

According to the doctor, a family friend promised to facilitate a government grant for a 100-bed multispecialty hospital. However, the friend insisted on a payment of Rs 60 lakh to government officials to secure the grant.

For the full story, check out the link given below:

Doctor Duped Of Rs 56 Lakh Under Pretext Of Building Hospital


Consumer court awards Rs 10 lakh for newborn’s skin peeling from hot water mishap

Holding a Hubballi-based private hospital and its doctors guilty of medical negligence while taking care of a newborn baby, the District Consumer Disputes Redressal Commission, Dharwad has directed them to pay Rs 10 lakh as compensation to the victim’s family.

It was alleged by the complainants that the newborn suffered severe burns as the attendant dipped the baby in hot water while giving a sponge bath.

For the full story, check out the link given below:

Newborn’s Skin Peels After Being Dipped In Hot Water: Consumer Court Holds Medical Negligence, Slaps Rs 10 Lakh Compensation

Lt Gen Ashok Kumar Jindal appointed as the new Executive Director and CEO of AIIMS Raipur

Lt Gen Ashok Kumar Jindal, former Director and Commandant of Army Hospital (Research & Referral), New Delhi on Monday joined India’s premier medical and research institute- All India Institute of Medical Sciences (AIIMS) Raipur as Executive Director and CEO.

An army doctor who recently retired from the position of director of the army hospital possesses over 40 years of experience with leadership experience across multiple hospitals.

For the full story, check out the link given below:

Lt Gen Ashok Kumar Jindal Appointed As New Executive Director And CEO Of AIIMS Raipur

High Court Ruling: Delhi Government granted authority to take over UCMS from Delhi University

New Delhi: Vacating an Interim Order dating back to 2016, the Delhi High Court has now paved the way for the Delhi Government to take over the University College of Medical Sciences Block and Guru Teg Bahadur Hospital Complex (UCMSB-GTBH).

Several PILs had been filed before the HC bench by associations consisting of teaching and non-teaching staff of UCMS, who challenged various orders passed by the Central and Delhi Government and also the Delhi University to implement the Union Cabinet’s decision dated August 25, 2005.

For the full story, check out the link given below:

HC Allows Delhi Govt To Take Over UCMS From DU

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AIIMS Rishikesh Notifies On Spot Counselling For MD, MS, MDS, DM, MCh seats, all details here

Rishikesh: All India Institute of Medical Sciences (AIIMS Rishikesh) has notified on Institute level spot counselling for DM/MCh. and MD/MS/MDS/MCH (6Years) January, 2024 session seats.

The spot counselling at AIIMS Rishikesh will be held in the institute on per following dates, Subject to the availability of vacant seats:

DM/M.Ch.: 27.02.2024

MD/MS/MDS/M.Ch. (06 Years) : 28.02.2024

Eligibility Criteria:

a) All those Candidates who have been declared qualified vide result notification No. 218/2023 dated 22 November 2023 (AIIMS Merit List (AML) for DM/MCH/MD Hospital Administration Courses for January 2024 Session at AIIMS New Delhi & Nine Other AIIMS) will be eligible to participate irrespective of their rank in Entrance Examination.

b) Candidates who wish to participate in spot counselling have to register by filling form in prescribed format with cleared scanned copy of all following documents & send via email to sra.assessment@aiimsrishikesh.edu.in by 05:00 PM, 25.02.2024.

c) Under no circumstances, candidate registration will be entertained after 05:00 PM, 25.02.2024.

d) Candidate need to report 09:30 AM to 12:00 noon on 27.02.2024. Candidates reporting after 12:00 noon will not be entertained for spot counselling. Only those candidates will be entertained on 27.02.2024 who will send their registration form on or before 05:00 PM, 25.02.2024.

e) Candidates who wish to participate in spot counselling must bring all original documents as prescribed below (1 to 14).

f) No Authorized representative will be allowed to attend spot counselling.

g) Candidate who have joined DM/M.Ch. course or have opted DM/M.Ch. seat elsewhere are not eligible for Spot Counseling.

h) Produce printout of mail to attend spot Counseling along with all original certificates and one set of selfattested Photocopy & 04 Photograph of certificates.

i) Candidates will not be allowed to attend spot Counseling without production of print out of email sent to sra.assessment@aiimsrishikesh.edu.in

j) The candidate selected in Institute Level Spot Counselling on 27.02.2024 has to join the department after completing all the formalities on or before 28.02.2024 by 5:00 pm.

k) The candidate appearing for institute level spot counseling are advised to come prepared with all original documents & baggage so that they can join the course/institute within the stipulated date & time.

l) Any candidate submits any document which is not valid as per prospectus and any notice published will be treated as providing false information. For example

a) Submitting a document which is not issued between dates as prescribed in the prospectus and submitted by a candidate to obtain eligibility despite knowing the fact that certification is not valid as not issued as prescribed in prospectus.

b) Applying in anticipating of obtaining desired qualification and not obtained on the date as required.

c) False reporting on caste, age, gender, date of acquiring eligibility, date of completion of internship.

d) Any other information which is not true as required in prospectus/ notice and submitted in order to dispute at later stage.

m) If it is established, at any time during the process of Seat allocation of INI-SS January 2024 or later, that applicant has deliberately furnished incorrect information for the purpose of falsification, it shall be treated as an attempt to cheat and the candidature shall be annulled and further legal and disciplinary actions will be taken.

n) For other details please visit AIIMS, Rishikesh website, Original Documents to be mail & deposited at AIIMS, Rishikesh

1. Printout of Spot counseling registration mail.

2. Score Card/Rank Letter by AIIMS New Delhi.

3. Final Registration Slip

4. Admit Card issued by AIIMS New Delhi

5. Mark Sheets of MBBS/BDS 1st, 2nd and 3rd Professional Examinations

6. MBBS/BDS Degree Certificate

7. Internship Completion Certificate.

8. MD/MS Degree/Provisional Pass Certificate

9. Tenure & Course Completion till 31.01.2024

10. Permanent/Provisional Registration Certificate issued by NMC /State Medical Council

11. High School/Higher Secondary Certificate/Birth Certificate as proof of date of birth

12. Category Certificate in specified format given in Prospectus (SC/ST/ EWS/PWBD)/(OBC (NCL) – Certificate (OBC (NCL)- 10/10/2022 to 11/10/2023 (both dates inclusive) /EWS- 01/04/2023 to11/10/2023 (both dates inclusive)/SC/ST/Ex-Serviceman/PWBD- Certificate should be issued before 11.10.2023.) (if applicable)

13. Sponsorship Certificate (if applicable)

14. Relieving Letter/Study Leave Letter (if applicable)

15. 4 Photograph

16. One Set Xerox of above documents, Self-attested. 

According to the seat matrix released on the official website, a total of 11 MD and MS seats, 1 MCh 6 years, and 11 DM, MCh seats are available for the spot round.

To view the official Notice, Click here : https://medicaldialogues.in/pdf_upload/notice-md-ms-mds-mch-6-years-spot-counselling1-232920.pdf

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Centre working proactively for transformation of health sector: Shri J P Nadda

Bilaspur: A slew of new healthcare facilities including Radiation Oncology, 128 Slice CT Scanner and a Liquid Medical Oxygen (LMO) plant was yesterday inaugurated at AIIMS Bilaspur, Himachal Pradesh by the Chief Guest, Shri Jagat Prakash Nadda, Member of Parliament, Rajya Sabha in the presence of Dr Mansukh Mandaviya, Union Minister of Health and Family Welfare & Chemical and Fertilizers and Shri Anurag Thakur, Union Minister of Information and Broadcasting & Youth Affairs and Sports.

Shri Jai Ram Thakur, Leader of Opposition and Former Chief Minister, Himachal Pradesh was also present on the occasion. He also laid the foundation stone for a Vishram Sadan (night shelter) at AIIMS Bilaspur. The addition of these services will significantly enhance the healthcare infrastructure in the Himalayan state and will immensely benefit the people of neighbouring states as well, marking a new era in patient care.

Also Read:AIIMS Bilaspur, IIM Sirmour to establish new incubation centres

Addressing the gathering, Shri J P Nadda said, “The Union Government has been proactively working for the transformation of the health sector which can not only be witnessed in the expansion of the AIIMS network but also in other areas of the Health sector like the doubling of medical colleges, increase in MBBS and PG seats, creation of nursing colleges, Ayushman Arogya Mandirs and many other similar policies.”

Shri Nadda said, “Today our health policy embraces a holistic approach, emphasizing on preventive measures to avoid diseases in the first place. Our focus extends beyond prevention to include curative, palliative, and rehabilitative healthcare.” He highlighted that because of the launch of Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB-PMJAY), the world’s largest healthcare coverage scheme in India, all eligible people in Himachal Pradesh are completely insured today.

He also informed about other achievements in the health sector in the last 10 years which include 64% increase in TB notifications and more than 80% success in treatment of TB cases, reduction in prices of stents and medicines and facilitating their wider reach across the nation through the expansion of Jan Aushadhi Kendras, promoting holistic healthcare through the creation of AYUSH blocks in medical institutes like AIIMS, creation of bulk drug parks etc.

Underlining the importance of an effective leadership in bringing about transformational impact in society, Shri Nadda stated that, “until a few years back, it was unimaginable to believe that an AIIMS-like institute could come up in a region like Bilaspur. This was made possible only due to the sincere efforts of the Union Government towards bringing healthcare services to the last mile”. “Similarly, a lot of fear and apprehension were created during the Covid-19 pandemic which was a once in a century pandemic. However, the Hon’ble Prime Minister was successful in bringing the whole country together in containing the spread without the need for use of force or other violent measures that were witnessed across the world”, he further stated.

Shri J P Nadda concluded his address by congratulating the healthcare workers at AIIMS Bilaspur and encouraging them to provide the best services in the region in keeping with the spirit of the “AIIMS culture”.

Speaking on the occasion, Dr Mansukh Mandaviya said “It is a moment of celebration that 12 new facilities in AIIMS Bilaspur have been inaugurated or foundation stone laid today, the cumulative cost of which is more than Rs 400 crore.”

Highlighting how the government has converted challenges into opportunities, the Union Health Minister pointed out that “despite the enormous challenges brought forward by the Covid-19 pandemic which disrupted healthcare services around the world, including in some developed countries, the healthcare system in India not only withstood the pressure but is today more prepared than ever in addressing such challenges”. “Most of the healthcare infrastructure that have been created in the last 10 years like LMO plants, installation of advanced medical equipment and cutting-edge machinery in AIIMS and other medical institutions is to ensure preparedness of the health sector especially in dealing with health emergencies”, he stated.

Dr Mandaviya said that the Union Government is working to bring healthcare services to the last mile and in pursuit of that endeavour, many new medical colleges, nursing colleges and AIIMS have been opened across the nation. He said the purpose is to ensure that people don’t have to move to metro cities for availing quality medical treatment.

Shri Anurag Thakur said that AIIMS Bilaspur took only 3 years from foundation stone laying to completion, marking another milestone in the Union Government’s effort towards bringing timely and quality health infrastructure to the last mile. He also said that once the construction of the Vishram Sadan is completed, it will give much needed relief to the people coming from the far-flung areas of the hilly region.

The dignitaries also visited Cardiac Cath Lab, Coronary Care Unit (CCU), Central Sterile Supply Department (CSSD) and Laundry in the main hospital building which were recently inaugurated by Union Health Minister, Dr Mansukh Mandaviya.

All India Institute of Medical Sciences (AIIMS), Bilaspur (Himachal Pradesh), an institute of National Importance with autonomous functioning under the Ministry of Health and Family Welfare was conceived under Phase V of the ‘Pradhan Mantri Swasthya Suraksha Yojana’ (PMSSY) with the objective of correcting imbalances in the availability of affordable/reliable tertiary level healthcare in the country.

The radiation oncology services have been started at AIIMS with the vision to provide state-of-the-art radiotherapy treatment to the cancer patients with the cutting-edge machinery costing approximately Rs. 30 crores. With the help of advanced technology, cancer patients can be treated through High Energy Linear Accelerator (HELA), HDR Brachytherapy and 4D CT Simulator which will help in planning of treatment with precision, effectively targeting tumours while preserving the integrity of surrounding healthy tissues.

The state-of-the-art 128-slice CT scanner is installed in emergency department, AIIMS at a cost of Rs. 7 crores with generous Corporate Social Responsibility (CSR) funding from POWERGRID. It will provide fast and precise imaging combined with exceptional clarity in shorter time, thereby reducing waiting time for patients. This is especially beneficial for patients presenting in emergency who are critically sick and need a quick accurate diagnosis. An MRI machine will also be provided by POWERGRID at an estimated cost of Rs. 16 crores under CSR fund in next few months.

Another generous support provided by POWERGRID under CRS is the Vishram Sadan at AIIMS Bilaspur. It will be constructed with a capacity of 250 people. It will give a comfortable stay to the waiting patients and their attendants and provide protection from biting cold, harsh summer and incessant rains during monsoon. It will be ready in approximately 18 months at an estimated cost of Rs. 26.75 crores.

The Liquid Medical Oxygen (LMO) plant will provide AIIMS Bilaspur with round the clock oxygen supply at the bedside of patients. There are two LMO tanks and each tank can hold up to 20 kilolitres (kL) of LMO.

Prof. Vir Singh Negi, Executive Director, AIIMS Bilaspur; senior officials from the Union Government and Government of Himachal Pradesh and representatives of AIIMS Bilaspur and POWERGRID were present on the occasion.

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Medical Bulletin 24/February/2024

Here are the top medical news highlights for the day:

New zinc discovery offers promise for cystic fibrosis patients

Researchers from the University of Queensland havediscovered a fault in the bacteria-killing function of immune cells in people with Cystic Fibrosis and a way to reduce infections in people living with it.

Cystic Fibrosis is a chronic disease in which defects in the CFTR (cystic fibrosis transmembrane conductance regulator) channel cause a build-up of mucus in the lungs, airways and digestive system, leading to recurring infections. In people with Cystic Fibrosis, immune cells called macrophages are defective in a zinc pathway that the body uses to kill bacteria.

“One way that macrophages destroy bacteria is by poisoning them with toxic levels of metals such as zinc,” said Professor Matt Sweet,Molecular Bioscience Professor at UQ. “We discovered that the CFTR ion channel is crucial to the zinc pathway and because it doesn’t work properly in people with CF, it may partly explain why they’re more susceptible to bacterial infections.”

Around 70,000 to 100,000 people worldwide are affected by cystic fibrosis, which can reduce life expectancy to an average of 47 years.

The researchers have now identified a zinc transport protein that can restore the macrophages’ ability to kill bacteria when the CFTR protein is not working.

Professor Peter Sly at UQ’s Child Health Research Centre, a paediatric respiratory physician and key collaborator on the project, suggested discovering more about how CF affects the immune system is key to patient care.

“People with CF have a hyper inflammatory state in their airways and are very susceptible to bacterial infections but frequent treatment with antibiotics can often lead to antibiotic-resistant infections,” Professor Sly said.“Current treatments can restore many aspects of CFTR function but they don’t resolve or prevent lung infections so there is a need to restore immune functions.”

“Our goal now is to deliver this zinc transport protein to macrophages in people with CF with the expectation that it would reactivate their immune response and reduce infections,” concluded Professor Sweet.

Reference: DOI: 10.1073/pnas.2315190121

New discovery links gene to incurable birth defect

Researchers from Melbourne-based medical research institute, WEHI, have discovered mutations in a gene can lead to an incurable neurodevelopmental disorder that causes abnormal brain development in newborns and infants.

The study published in Journal eLife reveals that a protein called Trabid helps control neuronal development, and that mutations to this protein can lead to microcephaly – a condition where a baby’s brain is smaller than expected.

Neurons are the fundamental building blocks of the nervous system, responsible for transmitting electrical and chemical signals that enable communication between different parts of the body and the brain.Microcephaly is a neurodevelopmental condition leading to an underdeveloped brain that adversely affects learning and behaviour

“Our understanding into how neurodevelopmental conditions, like microcephaly, develop continues to grow,” Assoc Prof Dewson, a Laboratory Head at WEHI, said. “While previous research has indicated there could be a link between defects in Trabid and microcephaly, our study is the first to provide evidence for the gene’s function in neuronal guidance –filling a vital knowledge gap.”

In 2015, UK researchers published a study that first suggested a possible connection between the gene encoding Trabid (ZRANB1) and microcephaly, after identifying two patients with the brain disorder who had mutations in this gene.

The researchers now suggest that the defects in Trabid, or the proteins that Trabid controls, could help identify babies who are at-risk of developing microcephaly – allowing for potential early interventions.

“Abnormalities in neuron migration and guidance can lead to neurodevelopmental disorders like microcephaly” said Dr HoanhTran.“Cells in the developing brain must migrate to the right location. If the address is missed, developmental defects can occur.Healthy neurons extend long processes called axons in a directional, ordered manner. In our study, we found the neurons from models with defective Trabid project axons that migrate with a wayward trajectory.These significant findings provide an understanding of Trabid/ZRANB1 as a new human microcephaly gene.”

References: DOI: 10.7554/eLife.90796.3

Study suggests excess vitamin B3 could increase heart disease risk

The team, led by Stanley Hazen, M.D., Ph.D., from Cleveland Clinic have discovered a link between 4PY, a breakdown product from excess niacin, and heart disease.

The study, published in Nature Medicine, details genetic links between 4PY and vascular inflammation. The findings provide a foundation for potential new interventions and therapeutics to reduce or prevent that inflammation.

Niacin, also known as vitamin B-3, is one of the eight B vitamins essential for converting food into energy and maintaining healthy skin and nervous system function. Since the body cannot produce niacin on its own, it must be obtained from dietary sources or supplements. Tryptophan, found in animal products, is converted into niacin by the body. Any excess niacin not utilized by the body is eliminated through urine, as it is not stored.

Excessive niacin can lead to an increase in certain blood fats, which may contribute to heart disease risk. Additionally, high doses of niacin can cause flushing, which may worsen existing cardiovascular conditions.

For the study, Dr. Hazen and his team studied the fasting plasma from about 1,100 people with stable cardiac health. Upon analysis, researchers discovered that higher circulating levels of N1-methyl-4-pyridone-3-carboxamide, or 4PY, were strongly associated with the development of a heart attack, stroke, or other unhealthy cardiac events.

The findingssuggested that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.

“The compound 4PY was identified that is linked to future CVD events” said Dr. Hazen. “We then performed preclinical studies (animal model) and cell-based studies — all of which showed this compound contributes to vascular inflammation. 4PY, it turns out, is a breakdown product made from excess niacin.”

“Our studies found high levels of 4PY in the blood predict future cardiac disease. These new studies help identify a new pathway that contributes to heart disease,” concludedDr. Hazen.

Reference: Cleveland Clinic

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Eminent paediatrician Dr Vinky Rughwani takes charge as administrator of Maharashtra Medical Council

Mumbai: The President of the Thalassemia Society of Central India, Dr Vinky Rughwani has been appointed as the new administrator of the Maharashtra Medical Council (MMC) by the Maharashtra Medical Education Department on Friday.

Dr Rughwani is an eminent paediatrician from Nagpur who has been working on the prevention and welfare of Thalassaemia and Sickle Cell patients for the last 25 years and has worked as the Vice-President of the Maharashtra Medical Council for the last 5 years.  

Dr Rughwani has been assigned additional responsibilities for a period of one year or until the MMC elections take place. He will also carry out his duties as the administrator until a new council is established, following the disbandment of the 18-member MMC committee in 2022.

Also read- Dr Dilip Mhaisekar Appointed As New Administrator Of Maharashtra Medical Council

This appointment took place after Dr Dilip Mhaisekar’s term ended which allowed Dr Rughwani to serve as the new administrator of MMC.

Medical Dialogues team had earlier reported that Director of Medical Education and Research (DMER) Dr Dilip Mhaisekar was appointed as the Maharashtra Medical Council (MMC) administrator.  He was selected as the new administrator of MMC in place of J J hospital dean Pallavi Saple as her one-year tenure ended on October 9.

A notice issued by the Maharashtra government confirmed the appointment of Dr Vinky Rughwani as the new administrator to exercise all the powers and perform all the duties of the Council for the next year or till the time MMC elections are held.

He is the President of the Thalassemia Society of Central India (an Organisation working for the welfare of Thalassemia & Sickle Cell patients and the prevention of this Illness in Central India) and the Director of the Thalassemia and Sickle Cell Centre, Nagpur (a Centre providing free treatment to Thalassemia and Sickle Cell patients).

Speaking to HT, Dr Rughwani said, “My focus will be to provide fast-track registration services as an MMC administrator. Medical negligence cases will be decided in a time-bound manner in the near future. I will implement the “know your doctor” concept as a bogus doctor is a major challenge and an online continuous professional development platform will be strengthened to give the latest knowledge update training to doctors so that time doctors will be saved.”

Also read- JJ Hospital Dean Dr Pallavi Saple Appointed As New Administrator Of Maharashtra Medical Council

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