SR Post Vacancies: Walk In Interview At GB Pant Hospital Delhi In Various Specialties, View Details Here

New Delhi: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER) has notified vacancies for the Senior Resident post on an ad hoc basis in this medical institute.

The Institution has a unique recognition by the Medical Council of India and the University Grants Commission as an independent post-graduate College affiliated with Delhi University. the Foundation stone of Govind Ballabh Pant Hospital was laid in October 1961 and was commissioned by the then Prime Minister late Pt. Jawaharlal Nehru on 30th April 1964. From a very humble beginning with 229 beds, it has expanded to currently over 700 beds (714 beds). Today it is an internationally recognized tertiary care institution for Heart, Brain Gastrointestinal, and Psychiatric disorders. It offers super specialty treatment to about 3 lac patients in the OPD and almost 15,000 patients in General and Private wards yearly.

GIPMER Vacancy Details:

Total no of vacancies: 34

The vacancies are in the Departments of Neurology, Biochemistry, and Anaesthesiology.

The Walk-In-Interview date is 29th December 2023.

For more details about Qualifications, Age, Pay Allowance, and much more, click on the given link:
https://medicaljob.in/jobs.php?post_type=&job_tags=GB+Pant+Hospital&location=&job_sector=all

How to Apply For Eligible Candidates:-

1. Appointment will be subject to Medical fitness and verification of Certificate(s) of educational qualification/age/caste/DMC registration.

2. The vacancies are likely to vary and may be filled in phases.

3. Panel of wait listed candidates will be prepared separately.

4. No TA/DA will be paid for appearing in the aforesaid interview.

5. The appointment and services of selected SR’s will be governed under the Residency Scheme.

6. In case, interview cannot be completed on the scheduled date/duration the same shall be conducted on the following working day.

7. No correspondence or personal inquiries shall be entertained.

8. Bring all original documents along with their self-attested photocopies on the scheduled date of Interview & on the date of joining to the post.

9. The Candidates are advised to check the Institute website regularly for any/further updation in the matter.

10. FEES PAYABLE:- Rs. 300/-(Non-Refundable) in the form of a Cash/Demand Draft issued by a nationalized bank in favor of MEDICAL SUPERINTENDENT, G.B. PA VT HOSPITAL, PAYABLE At New Delhi, The eligible candidate can deposit the fee(in Cash) to the Cashier at Accounts Branch of this Institute, GIPMER.

JURISDICTION OF DISPUTE: In case of any Legal dispute, the jurisdiction of the Court will the Delhi/New Delhi only.

• Note: – The application form is available at the Institute’s website gbpant.delhigovt.nic.in.

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Lupin bags USFDA nod for Loteprednol Etabonate Ophthalmic Suspension

Mumbai: Global pharma major Lupin Limited has announced
that the Company has received approval from the United States Food and Drug Administration (U.S. FDA) for its
Abbreviated New Drug Application for Loteprednol Etabonate Ophthalmic Suspension, 0.2%, to market
a generic equivalent to the reference listed drug (RLD) Alrex Ophthalmic Suspension, 0.2%, of Bausch
& Lomb Inc.

The product will be manufactured at Lupin’s Pithampur facility in India.


Loteprednol Etabonate Ophthalmic Suspension, 0.2%, is indicated for the temporary relief of the signs
and symptoms of seasonal allergic conjunctivitis.

Loteprednol Etabonate Ophthalmic Suspension, 0.2% (RLD Alrex), had estimated annual sales of USD
29.1 million in the U.S. (IQVIA MAT October 2023).

Read also: Lupin to buy established products portfolio in Europe, Canada from Sanofi for Rs 91 crore

Lupin is an innovation-led transnational pharmaceutical company headquartered in Mumbai, India. The
Company develops and commercializes a wide range of branded and generic formulations, biotechnology
products, and APIs in over 100 markets in the U.S., India, South Africa, and across the Asia Pacific (APAC), Latin
America (LATAM), Europe, and Middle East regions.
The Company specializes in the cardiovascular, anti-diabetic, and respiratory segments and has
a significant presence in the anti-infective, gastro-intestinal (GI), central nervous system (CNS), and women’s
health areas. The company
invested 7.9% of its revenue in research and development in FY23.
Lupin has 15 manufacturing sites, 7 research centers.

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COVID JN.1 variant: Himachal health dept issues advisory to district units

Hamirpur: Following the detection of COVID-19 variant JN.1 in the country, Himachal Pradesh’s health department has issued an advisory to the chief medical officers in the state to test patients with COVID-like symptoms and take necessary precautions, officials said.

People with symptoms of cold, fever or cough are advised to take a COVID test, Una CMO Dr Sanjeev Kumar said on Tuesday. He also urged people to wear masks.

Also Read:COVID subvariant JN.1: AIIMS Delhi advises not to panic, need to remain alert

In cases of respiratory diseases like influensa, cough, cold, sore throat, runny nose, headache and fever, all patients should get an RT-PCR test done immediately, doctors said.

India has recorded 69 cases of COVID JN.1 variant, as per official sources.

Medical Dialogues team had earlier reported that after a surge in the cases of the new COVID subvariant JN.1, doctors from the All India Institute of Medical Sciences (AIIMS) have advised people to not panic but rather remain alert and vigilant. “People are getting infected by the new sub-variant of COVID-JN.1 in many states of the country. The symptoms of the patients are mild. Therefore, there is no need to panic but the need to remain alert,” Doctor Neeraj Nischal said.

Doctor Nischal, who is an Additional Professor in the Department of Medicine at AIIMS Delhi, said, “We have been saying this type of ripple will keep on happening. Even during the first and second waves, we predicted that this virus would mutate further and the stage would come where it would become more infectious but at the same time cause less mortality or morbidity.” “So this is, you can say, a fight between the viruses in human beings who are also trying to survive. People are becoming infected but at the same time, it’s not causing the problem that its predecessors, like the delta variant, caused,” said the doctor. 

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Doctors at KIMS Cuddles Hospital learn sign language to share infant’s progress with deaf-dumb parents

Hyderabad: Doctors and nurses at a private hospital in Hyderabad learnt sign language to share the new-born’s progress with her deaf and dumb parents. 

The medical team at KIMS Cuddles Hospital successfully treated and nurtured a premature baby born to a deaf-mute couple.

The baby’s survival and flourishing health were achieved through a challenging 80-day Neonatal Intensive Care Unit (NICU) stay, where the medical team went above and beyond to ensure effective communication with the parents.

Also Read:14-month-old brain-dead toddler’s kidneys transplanted in 58-year-old at KIMS Hospital

Marri Bhagyamma, 47, and Marri Rajasekhar, 55, a deaf-mute couple from Hyderabad, conceived twins through in vitro fertilization (IVF) at the age of 45.

Unfortunately, one of the twin boys faced pre-term complications and did not survive.

The surviving baby girl, born at an incredibly low weight of 540 grams, was admitted to KIMS Cuddles NICU.

The medical team, comprising seven doctors and nine support staff, faced the unique challenge of communicating with the deaf-mute parents.

Initially relying on written communication and the assistance of a young relative as a sign language interpreter, the team encountered a setback when the interpreter became unavailable.

Undeterred, the doctors and nurses undertook an impressive initiative, dedicating 10 days to learning sign language to communicate directly with the parents.

Dr Aparna Chandrasekharan, Clinical Director of Neonatology, Head of NICU, and Senior Consultant Neonatologist at KIMS Cuddles Hospital, noted the complexity of the case.

“The baby girl faced multiple complications, including respiratory challenges and the loss of her twin brother to necrotising enterocolitis. Throughout the 80-day NICU stay, our medical team ensured effective communication with the parents, using sign language to convey treatment details and progress.”

The baby girl’s journey involved various forms of respiratory support and meticulous care, leading to her discharge after 79 days with a weight of 1,642 grams. Importantly, she exhibited normal neurological examination, hearing, and vision.

Rajasekhar expressed their gratitude through sign language.

“The doctors and other staff of the hospital have told us the entire treatment procedure. We had regular counseling about our baby’s condition. They gave every minute of information,” she said

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Syphilitic Uveitis Hospitalizations on the rise, reveals JAMA study

A recent retrospective study by Tahreem Mir and team brought out findings that indicate a significant increase in syphilitic uveitis-related hospitalizations in the United States. The key findings of this study were published in Journal of American Medical Association – Ophthalmology.

This study was conducted by utilizing data from the the Nationwide Inpatient Sample. The research team analyzed data from a total of 444,674 patients from 2010 to 2019. There were an estimated 5,581 syphilitic uveitis-related hospitalizations during this period. The median age of individuals diagnosed was 45 years, with a significant majority (78.9%) being male. Importantly, syphilitic uveitis disproportionately affected African American individuals which constituted 32% of the total cases despite comprising only 13.6% of the population.

Moreover, the individuals belonging to the lowest median household income quartile were significantly impacted which made up 38.8% of the total cases. The national incidence reached 0.15 per 100,000 population which displayed a worrying upward trend. Yearly analysis revealed the lowest incidence in 2011 (0.08 per 100,000) and the highest in 2019 (0.23 per 100,000). The regional breakdowns mirrored this trend with all four US geographical regions experiencing an notable increase in incidence.

The study also identified 23.2% of patients with comorbid AIDS which emphasizes the complexity and severity of cases. Amidst this concerning increase, it is imperative to observe that the study primarily captured inpatient diagnoses.

The increase in syphilitic uveitis-related hospitalizations demands urgent attention from clinicians and public health officials. Also, this spike which is occurring concomitantly with a nation wide shortage of injectable penicillin G suggests a critical scenario for patients in need of treatment. The study highlights the importance of maintaining a high index of suspicion for syphilis when assessing patients with intraocular inflammation.

Source:

Mir, T. A., Kim, S. J., Fang, W., Harvey, J., & Hinkle, D. M. (2023). Rising incidence of syphilitic uveitis–related hospitalizations in the US. JAMA Ophthalmology. https://doi.org/10.1001/jamaophthalmol.2023.5386

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Ultrasound-guided ESWL may be first treatment choice for distal ureteral stones

Ultrasound-guided ESWL may be first treatment choice for distal ureteral stones suggests a new study published in the Urolithiasis.

The study aimed to analyze the factors influencing the efficacy of ultrasound-guided extracorporeal shockwave lithotripsy (ESWL) in the treatment of ureteral stones. The clinical data of 8102 patients (6083 men and 2019 women) who presented with ureteral stones were retrospectively analyzed. All the patients were treated with ultrasound-guided ESWL.

The stone-free rate (SFR) was calculated to evaluate the effect of ESWL. The characteristics of the patients and their stones, and the ESWL parameters applied were compared to identify the factors affecting the treatment outcomes. The SFR and that following one ESWL session were 94.6% (7663/8102) and 75.4% (6107/8102), respectively. Multivariate analysis showed that stone location (OR 0.656, p < 0.001), stone size (OR 1.103, p < 0.001), and degree of hydronephrosis (OR 1.952, p < 0.001) independently affected SFR; and age (OR 1.005, p = 0.022), stone location (OR 0.729, p < 0.001), stone size (OR 1.103, p < 0.001), degree of hydronephrosis (OR 1.387, p = 0.001), maximum energy level(OR 0.691, p < 0.001) independently affected SFR following one session. Ultrasound-guided ESWL is effective in all levels of ureteral stones.

Large stone size and moderate hydronephrosis are correlated with treatment failure. Ultrasound-guided ESWL may be the first choice for distal ureteral stones.

While analyzing the efficacy of ultrasound-guided ESWL for ureteral stones, researchers identified stone location, size, and the degree of hydronephrosis as independent factors influencing overall stone-free rates (SFR). Age, stone location, size, degree of hydronephrosis, and maximum energy level affected SFR after one ESWL session. Distal ureteral stones showed positive outcomes across all levels

Reference:

Liang, J., Xie, L., Gao, H. et al. Factors influencing the efficacy of ultrasound-guided extracorporeal shockwave lithotripsy in the treatment of ureteral stones: a retrospective study. Urolithiasis 52, 15 (2024). https://doi.org/10.1007/s00240-023-01512-9

Keywords:

Ultrasound-guided, ESWL, may be, first, treatment, choice, for, distal, ureteral stones,Liang, J., Xie, L., Gao, H

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Bariatric surgery may offer beneficial cardiac effects in non-HFpEF patients with obesity

Recently, there has been mounting clinical evidence supporting the metabolic and weight-loss benefits of bariatric surgery for obese patients, which leads to improved cardiac structure. However, its effectiveness in enhancing the cardiac function of heart failure patients remains controversial.

A recent study published in Obesity Surgery found bariatric surgery to have beneficial cardiac effects on non-HFpEF (heart failure and preserved ejection fraction) obese patients. However, it did not substantially improve the pooled analysis of cardiac parameters. The extent of improvement may be influenced by factors such as the patient’s baseline age and BMI and BMI loss extent. Shi-jing Lu et al. led the study.

This meta-analysis assessed BS’s effect on cardiac function by examining LVEF (left ventricular ejection fraction) and NYHA  (New York Heart Association) changes in non-HFpEF patients post-surgery.

Articles were sourced from PubMed and Embase, starting from their inception to December 9, 2022, using the Minors scale to evaluate their quality. The study included patients with non-HFpEF and severe obesity, requiring pre-operative and post-operative values of LVEF or NYHA to be reported.

Important points of consideration from the study include:

· Nine studies (146 patients) were included, with a final result showing improved cardiac functional parameters in non-HFpEF patients.

· Following the mean follow-up time of 15.8 months, the mean NYHA decreased by 0.59, and the mean LVEF increased by 7.49%.

In conclusion, bariatric surgery is associated with improved cardiac parameters in patients with non-HFpEF (heart failure and preserved ejection fraction). The extent of BS on cardiac functional improvement may relate to baseline BMI, age, and extent of BMI loss.

Bariatric surgery positively influences the cardiac function of non-HFpEF patients with obesity, they said.

PhD research initiation program of Liaoning Province, 2022-BS-358, funded the study.

Reference:

Lu, Sj et al. Evidence of Bariatric Surgery Benefits Cardiac Function in Non-HFpEF Patients with Obesity: a Meta-Analysis. OBES SURG 33, 3353–3361 (2023). https://doi.org/10.1007/s11695-023-06670-8

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Unbound bilirubin, a robust predictor of acute bilirubin encephalopathy in infants

India: Findings of the association between unbound bilirubin (UB) and acute bilirubin encephalopathy (ABE) indicate that bilirubin-induced neurological dysfunction (BIND) scoring with UB measurement may be useful for evaluating ABE in ≥ 34 weeks GA infants.

The study, published in The Journal of Pediatrics, emphasizes the importance of incorporating UB measurement into BIND scoring for a more accurate evaluation in this patient cohort.

Sanjiv B Amin, Department of Pediatrics, Sir Ganga Ram Hospital, Delhi, India, and colleagues conducted the study to compare the association of unbound bilirubin, total serum bilirubin (TSB), and bilirubin: albumin molar ratio (BAMR) with acute bilirubin encephalopathy as assessed by BIND score, in infants with significant hyperbilirubinemia (TSB ≥ 20 mg/dL or underwent exchange transfusion).

The prospective cohort study involved infants ≥ 34 weeks gestational age (GA) with significant hyperbilirubinemia during the first two postnatal weeks. Those with chromosomal disorders, craniofacial malformations, surgery, TORCH infections, or a family history of congenital deafness were excluded. Serum albumin, total serum bilirubin, and unbound bilirubin were measured at hospital admission using the bromocresol green, colorimetric, and modified peroxidase method, respectively.

Infants were assessed on admission for ABE using a standardized neurological examination. They were assigned a BIND score by trained physicians. Infants with a total BIND score of 0 were deemed normal and those with a score ≥ 1 were deemed to have ABE.

The study led to the following findings:

  • A total of 151 infants were studied, among whom 37 had ABE. Of these,
  • 19 had mild ABE [BIND score 1 to 3] and 18 had moderate to severe ABE [BIND score 4-9].
  • On logistic regression, UB, but not TSB or BAMR, was associated with ABE (adjusted OR:1.64).
  • On ordered logistic regression, UB, but not TSB or BAMR, was associated with the severity of ABE (adjusted OR:1.76).

“Unbound bilirubin levels, but not bilirubin: albumin molar ratio or total serum bilirubin, have emerged as a robust predictor of acute bilirubin encephalopathy occurrence and severity in infants ≥ 34 weeks GA,” the researchers wrote.

“This emphasizes the importance of UB measurement incorporation into bilirubin-induced neurological dysfunction scoring for a more accurate evaluation in this patient cohort,” they concluded.

Reference:

Amin SB, Saluja S, Kler N. Unbound Bilirubin and Acute Bilirubin Encephalopathy in Infants Born Late Preterm and Term with Significant Hyperbilirubinemia. J Pediatr. 2023 Dec 20:113880. doi: 10.1016/j.jpeds.2023.113880. Epub ahead of print. PMID: 38135027.

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Low to moderate-intensity exercise may prevent metabolic conditions and atherosclerosis in young people

USA: Compared to no exercise, exercising at low to moderate exercise intensity for 1 h sufficiently attenuated a fat meal-induced postprandial hypertriglyceridemia (PHTG), a recent study published in the Journal of Exercise Science & Fitness has shown. Moderate exercise intensity was also effective in mitigating insulin resistance.

“An acute bout of exercise at 40 %, 60 %, and 70 % VO2 max 12 h before intake of a fat-meal had similar effects on PHTG attenuation,” the researchers reported. “Also, there was an improvement in insulin sensitivity among all exercise trials, leading to decreased insulin response to fat-rich meal.”

The randomized controlled trial found that compared to no exercise, low-intensity exercise on a treadmill for 1 hour significantly lowered serum triglyceride levels following a fat-rich meal that was ingested 12 hours post-exercise

Cardiovascular disease (CVD) is the foremost cause of death worldwide. Postprandial hypertriglyceridemia is a condition characterized by elevated triglyceride levels after a meal. It is a common lipid abnormality linked to an increased CVD risk.

Previous studies showed that exercising at 40-70% intensities not only attenuates PHTG but also lowers insulin response among physically inactive people with metabolic syndrome. However, there is a need to elucidate the effects of different exercise intensities on insulin resistance and PHTG in healthy individuals (non-hyperlipidemic). Therefore, John Q. Zhang, Department of Kinesiology, The University of Texas at San Antonio, USA, and colleagues aimed to investigate the effects of different exercise intensities on insulin resistance and postprandial lipemia (PHTG) in healthy individuals.

The study included 10 adult males (age = 34 ± 2.8 y, fasting plasma TG = 1.36 ± 0.18 mmol/l, body mass = 72.9 ± 2.4 kg, VO2max = 43.7 ± 3.0 ml/kg/min, fasting Homeostatic Model Assessment for Insulin Resistance (HOMA2-IR) = 1.7 ± 0.3, and fasting glucose = 5.2 ± 0.2 mmol/l) with normal fasting triglyceride (TG) concentrations.

Each participant performed a control trial (Ctr, no exercise), and three exercise trials at 40 % (40%T), 60 % (60%T), and 70 % (70%T) of their VO2 max. In the exercise trials, participants jogged on a treadmill for one hour at a designated intensity. Each participant consumed a fat-rich meal 12 hours after exercise. Blood samples were taken at 0 h (before the meal), and 2 h, 4 h, 6 h, 8 h, and 24 h after the meal. After the meal, they analyzed the plasma TG, HOMA2-IR, and area score under the TG concentration curve over an 8 period (TG tAUC).

The study led to the following findings:

  • At 2 h, 4 h, and 6 h after the meal, TG in all exercise trials was lower than Ctr but did not differ.
  • All the exercise trials were lower in TG tAUC scores than Ctr, but differences were not observed among the exercise trials.
  • Compared to Ctr, a significant difference in HOMA2-IR in both 60 % T and 70 % T was observed, but not in 40 % T.

“These findings indicate that exercising at low to moderate intensity may be sufficient in preventing metabolic conditions and atherosclerosis among young, healthy, and recreationally active individuals,” the researchers wrote.

“These results may provide exercise-oriented health promotion measures for communities with healthy and at-risk individuals,” they concluded.

Reference:

Ji, L. L., Fretwell, V. S., Escamilla, A., Yao, W., Zhang, T., He, M., & Zhang, J. Q. (2023). An acute exercise at low to moderate intensity attenuated postprandial lipemia and insulin responses. Journal of Exercise Science & Fitness, 22(1), 14-22. https://doi.org/10.1016/j.jesf.2023.10.006

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Hormone Therapy may lower risk of Allergic Rhinitis in Perimenopausal Women

In a recent study conducted between May 2020 and March 2021 at Shijitan Hospital, researchers explored the complex connections between hormone therapy (HT), obesity, and allergic rhinitis (AR) in perimenopausal women. The study found that HT was found to reduce the risk of AR in perimenopausal women and intriguingly an association was also found between HT, BMI, and AR as lean women on HT exhibited a higher risk for AR compared to overweight women on HT.

The study results were published in the journal Allergy, Asthma and Clinical Immunology.

Mounting evidence indicates that both hormone therapy (HT) and obesity play a role in the development of allergic rhinitis (AR). As it is crucial to explore the connections and interplay between HT, body mass index (BMI), and AR specifically in perimenopausal women researchers from China conducted a study to investigate the association and interactions between HT, BMI, and AR in perimenopausal women.

A cross-sectional survey conducted between May 2020 and March 2021 involved patients from the Allergy and Gynecology Departments of Shijitan Hospital. Participants completed a detailed questionnaire, and BMI tertile-stratified analyses were performed. Logistic analyses were employed to assess relationships between HT, BMI, and AR.

Findings:

  • Out of 950 participants, 393 were undergoing HT.
  • HT was associated with elevated risks for AR, asthma, and their respective symptoms.
  • In lean women, HT usage significantly correlated with increased risks for AR, the duration of AR, hay fever, and accompanying symptoms (including canker sores, diarrhea, and stomachache) compared to normal or heavier-weight counterparts.

The study brought to light an interaction effect between HT and BMI concerning AR. Lean women on HT exhibited a higher risk for AR compared to overweight women on HT. The relationship dynamics revealed an intricate interplay, with the course of AR, hay fever, and accompanying symptoms showing statistically significant interactions.

Contrary to previous assumptions, hormone therapy was found to reduce the risk of AR in perimenopausal women. However, the heightened risk in lean women on HT suggests a nuanced relationship that warrants further exploration. The findings not only contribute to a better understanding of the intricate connections between HT, BMI, and AR but also point towards potential shared pathways between hormone therapy and obesity in influencing allergic rhinitis.

Further reading: Liu J, Ma T, Wang X, Bai W, Wang X. Associations between HT, BMI, and allergic rhinitis in perimenopausal women. Allergy Asthma Clin Immunol. 2023;19(1):107. Published 2023 Dec 19. doi:10.1186/s13223-023-00839-7

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